Wimberger sign

The proximal tibial metaphyses reveals loss of density on the medial aspect along with periosteal reaction, suggestive of osteochondritis (Wimberger's sign). Distal metaphyses of the humerus also showed periosteal reaction
Differential diagnosis| Congenital syphilis

The Wimberger sign refers to localized bilateral metaphyseal destruction of the medial proximal tibia.[1] It is a pathognomonic sign for congenital syphilis.[2]

## References[edit | edit source]

1. ↑ Medoro, Alexandra K.; Sánchez, Pablo J. (June 2021). "Syphilis in Neonates and Infants". Clinics in Perinatology. 48 (2): 293–309. doi:10.1016/j.clp.2021.03.005. ISSN 1557-9840. PMID 34030815. Archived from the original on 2022-07-20. Retrieved 2023-05-10.
2. ↑ Stephens, John R.; Arenth, Joshua (December 2015). "Wimberger Sign in Congenital Syphilis". The Journal of Pediatrics. 167 (6): 1451. doi:10.1016/j.jpeds.2015.09.005. ISSN 1097-6833. PMID 26427966.

## Further reading[edit | edit source]

* Wimberger H. Klinisch-radiologische Diagnostik v. Rachitis, Scorbut u. Lues im Kindesalter. Ergebn. d. inner. Med. u. Kinderheilkunde. 1925;28:264.

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