Organ care system

The Organ Care System (OCS) is a medical device designed by Transmedics to allow donor organs to be maintained for longer periods of time prior to transplant. The system mimics the elements of human physiology and keeps organs in an environment and temperature similar to the human body. The system allows for organ preservation that last longer than the standard organ preservation method of putting organs on ice, static cold storage, which can cause cold ischemia. When put on ice, organs begin to deteriorate about three to four hours after retrieval.[1][2]

## Contents

* 1 Organ Care System Heart
* 2 Organ Care System Lung
* 3 Organ Care System Liver
* 4 References
* 5 External links

## Organ Care System Heart

A portable system designed for “extracorporeal heart perfusion, assessment, and resuscitation”, the system allows for the heart to remain beating though a process of retrograde perfusion. The process involves oxygenated donor blood moves through the coronary arteries via the aorta and returns to the circuit through the pulmonary artery.[3]

## Organ Care System Lung

Referred to colloquially as “lung-in-a-box,” the OCS Lung System, designed to mimic the human system, keeps the lungs “breathing,” blood pumping through the vessels, and is kept at a human body-regulated temperature while in transportation to a donor patient.[4]

## Organ Care System Liver

The OCS Liver System was granted pre-market approval by the FDA in September 2021.[5] The system is designed to preserve the organ by keeping it at temperatures similar to a human body and maintains its function by perfusing the liver with blood, oxygen, and vital nutrients like bile salts. The device also assists in monitoring and regulating the pressure and flow of the perfusion.[6]

## References

1. ↑ Batcheldor, Matt. "Four heart transplants performed in whirlwind 48 hours" (in en). https://news.vumc.org/2020/08/26/four-heart-transplants-performed-in-whirlwind-48-hours/.
2. ↑ Alomari, Mohammad; Garg, Pankaj; Yazji, John H; Wadiwala, Ishaq J; Alamouti-fard, Emad; Hussain, Md Walid Akram; Elawady, Mohamed S; Jacob, Samuel (2022). "Is the Organ Care System (OCS) Still the First Choice With Emerging New Strategies for Donation After Circulatory Death (DCD) in Heart Transplant?". Cureus 14 (6): e26281. doi:10.7759/cureus.26281. ISSN 2168-8184. PMID 35754437.
3. ↑ "Improving Heart Transplantation by Expanding the Donor Pool". https://www.acc.org/latest-in-cardiology/articles/2021/06/01/18/33/http://www.acc.org/latest-in-cardiology/articles/2021/06/01/18/33/improving-heart-transplantation-by-expanding-the-donor-pool.
4. ↑ "'Lung-in-a-Box' Offers Hope, Options for Patients Awaiting Lung Transplants". 2022-04-22. https://uknow.uky.edu/uk-healthcare/lung-box-offers-hope-options-patients-awaiting-lung-transplants.
5. ↑ Chang, Donald D. (November 15, 2022). "The TrnsMedics Organ Care System for the liver receives FDA pre-market approval". Artificial Organs 46 (1): 25–26. doi:10.1111/aor.14115. PMID 34802155. https://onlinelibrary.wiley.com/doi/epdf/10.1111/aor.14115.
6. ↑ Health, Center for Devices and Radiological (2021-11-08). "Organ Care System (OCS) Liver – P200031" (in en). FDA. https://www.fda.gov/medical-devices/recently-approved-devices/organ-care-system-ocs-liver-p200031.

## External links

* Transmedics homepage

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