Langat virus

Microscopy of cells infected with Langat virus
Virus classification
(unranked):  | Virus
Realm:  | Riboviria
Kingdom:  | Orthornavirae
Phylum:  | Kitrinoviricota
Class:  | Flasuviricetes
Order:  | Amarillovirales
Family:  | Flaviviridae
Genus:  | Flavivirus
Species:  |

Langat virus

Langat virus (LGTV) is a virus of the genus Flavivirus. The virus was first isolated in Malaysia in 1956 from a hard tick of the Ixodes genus.[1] This virus is antigenically related to Omsk hemorrhagic fever virus, Kyasanur forest disease virus, Alkhurma virus, Louping ill virus and other viruses of the tick-borne encephalitis virus (TBEV) complex. The Langat virus does not pose a significant epidemiological threat in comparison with TBEV. There are no known cases of human diseases associated with LGTV.[2] The Malaysian strain (LGT strain TP21, also known as the Yelantsev virus) is naturally attenuated and induces neutralizing antibodies to tick-borne encephalitis virus (TBEV) and protection against other TBEV complex viruses in animals.[3]

## LGTV-based vaccine[edit | edit source]

In the 1970s a live attenuate LGTV-based vaccine against tick-borne encephalitis was made. At the same time, another vaccine was tested, but the group vaccinated with the LGTV-based vaccine had the lowest level of developing infection decease.[4] However, there were two major problems: the relatively high rate of incidents of encephalitis (1:10,000) and lack of absolute protection from infection in endemic regions.[citation needed]

## References[edit | edit source]

1. ↑ Smith, CE (15 September 1956). "A virus resembling Russian spring-summer encephalitis virus from an ixodid tick in Malaya". Nature. 178 (4533): 581–2. Bibcode:1956Natur.178..581G. doi:10.1038/178581a0. PMID 13369466. S2CID 4272594.
2. ↑ Gritsun TS, Lashkevich VA, Gould EA (January 2003). "Tick-borne encephalitis". Antiviral Res. 57 (1–2): 129–46. doi:10.1016/S0166-3542(02)00206-1. PMID 12615309.
3. ↑ Rumyantsev, A. A.; Murphy, B. R.; Pletnev, A. G. (13 January 2006). "A Tick-Borne Langat Virus Mutant That Is Temperature Sensitive and Host Range Restricted in Neuroblastoma Cells and Lacks Neuroinvasiveness for Immunodeficient Mice". Journal of Virology. 80 (3): 1427–39. doi:10.1128/JVI.80.3.1427-1439.2006. PMC 1346960. PMID 16415020.
4. ↑ Shapoval AN; Kamalov II; Denisova EIu; Sokolova ED; Luzin PM; Shamarina AG; Gusmanova AG; Pinaeva NI (1989). "Study of the distant consequences of immunizing people with a live vaccine against tick-borne encephalitis". Tr Inst Im Pastera (in Russian). 65: 133–5. PMID 2629181.`{{cite journal}}`: CS1 maint: unrecognized language (link)

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Zoonotic viral diseases (A80–B34, 042–079)

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Tick
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|

Flaviviridae|

* Arbovirus encephalitides: Tick-borne encephalitis
* TBEV
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* OHFV
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Orthomyxoviridae|

* Bourbon virus

Reoviridae|

* Colorado tick fever
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Sandfly
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* Adria virus (ADRV)
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* Simian foamy virus
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* Tanapox
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Multiple
vectors|

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* Rabies
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Poxviridae|

* Monkeypox

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