3-(3-hydroxyphenyl)propanoate hydroxylase

Short description: Class of enzymes

3-(3-hydroxyphenyl)propanoate hydroxylase

Identifiers
EC number| 1.14.13.127
Databases
IntEnz| IntEnz view
BRENDA| BRENDA entry
ExPASy| NiceZyme view
KEGG| KEGG entry
MetaCyc| metabolic pathway
PRIAM| profile
PDB structures| RCSB PDB PDBe PDBsum
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PMC| articles
PubMed| articles
NCBI| proteins

3-(3-hydroxyphenyl)propanoate hydroxylase (EC 1.14.13.127, mhpA (gene)) is an enzyme with systematic name 3-(3-hydroxyphenyl)propanoate,NADH:oxygen oxidoreductase (2-hydroxylating).[1][2][3][4] This enzyme catalyses the following chemical reaction

(1) 3-(3-hydroxyphenyl)propanoate + NADH + H+ \+ O2 ⇌ 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD+
(2) (2E)-3-(3-hydroxyphenyl)prop-2-enoate + NADH + H+ \+ O2 ⇌ (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD+

3-(3-hydroxyphenyl)propanoate hydroxylase is a flavoprotein (FAD).

## References

1. ↑ "Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli". Journal of Bacteriology 155 (1): 113–21. July 1983. PMID 6345502.
2. ↑ "Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation". Journal of Bacteriology 168 (1): 55–64. October 1986. PMID 3531186.
3. ↑ "Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12". Journal of Bacteriology 179 (8): 2573–81. April 1997. PMID 9098055.
4. ↑ "Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12". Journal of Bacteriology 180 (11): 2915–23. June 1998. PMID 9603882.

## External links

* 3-(3-hydroxyphenyl)propanoate+hydroxylase at the US National Library of Medicine Medical Subject Headings (MeSH)

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Oxidoreductases: dioxygenases, including steroid hydroxylases (EC 1.14)

1.14.11: 2-oxoglutarate|

* Prolyl hydroxylase
* HIF prolyl-hydroxylase
* EGLN1
* EGLN2
* EGLN3
* P4HTM
* Lysyl hydroxylase

1.14.13: NADH or NADPH|

* Flavin-containing monooxygenase
* FMO1
* FMO2
* FMO3
* FMO4
* FMO5
* Nitric oxide synthase
* NOS1
* NOS2
* NOS3
* Cholesterol 7 alpha-hydroxylase
* Methane monooxygenase
* 3A4
* Lanosterol 14 alpha-demethylase
* 24-hydroxycholesterol 7α-hydroxylase

1.14.14: reduced flavin or flavoprotein|

* 19A1
* 2D6
* 2E1

1.14.15: reduced iron-sulfur protein|

* 11B1
* 11B2
* 11A1

1.14.16: reduced pteridine (BH4 dependent)|

* Phenylalanine hydroxylase
* Tyrosine hydroxylase
* Tryptophan hydroxylase

1.14.17: reduced ascorbate|

* Dopamine beta-hydroxylase

1.14.18-19: other|

* Tyrosinase
* Stearoyl-CoA desaturase-1

1.14.99 \- miscellaneous|

* Cyclooxygenase
* Heme oxygenase (HMOX1)
* Squalene monooxygenase
* 17A1
* 21A2
* Ecdysone 20-monooxygenase

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Enzymes

Activity|

* Active site
* Binding site
* Catalytic triad
* Oxyanion hole
* Enzyme promiscuity
* Catalytically perfect enzyme
* Coenzyme
* Cofactor
* Enzyme catalysis

Regulation|

* Allosteric regulation
* Cooperativity
* Enzyme inhibitor
* Enzyme activator

Classification|

* EC number
* Enzyme superfamily
* Enzyme family
* List of enzymes

Kinetics|

* Enzyme kinetics
* Eadie–Hofstee diagram
* Hanes–Woolf plot
* Lineweaver–Burk plot
* Michaelis–Menten kinetics

Types|

* EC1 Oxidoreductases (list)
* EC2 Transferases (list)
* EC3 Hydrolases (list)
* EC4 Lyases (list)
* EC5 Isomerases (list)
* EC6 Ligases (list)
* EC7 Translocases (list)

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