Conformon

From a biological standpoint, the goal-directed molecular motions inside living cells are carried out by biopolymers acting like molecular machines (e.g. myosin, RNA/DNA polymerase, ion pumps, etc.). These molecular machines are driven by conformons, that is sequence-specific mechanical strains generated by free energy released in chemical reactions or stress induced destabilisations in supercoiled biopolymer chains. Therefore, conformons can be defined as packets of conformational energy generated from substrate binding or chemical reactions and confined within biopolymers.[1]

On the other hand, from a physics standpoint, the conformon is a localization of elastic and electronic energy which may propagate in space with or without dissipation.[2] The mechanism which involves dissipationless propagation is a form of molecular superconductivity.[3] On quantum mechanical level both elastic/vibrational and electronic energy can be quantised, therefore the conformon carries a fixed portion of energy. This has led to the definition of quantum of conformation (shape).[4]

## References

1. ↑ Ji, Sungchul (2012) (in en). Molecular Theory of the Living Cell - Springer. doi:10.1007/978-1-4614-2152-8. ISBN 978-1-4614-2151-1. Bibcode: 2012mtlc.book.....J. http://cds.cern.ch/record/1453271.
2. ↑ Atanasov, Victor; Dandoloff, Rossen (2017). "Quantum-elastic bump on a surface". European Journal of Physics 38 (1): 015405. doi:10.1088/0143-0807/38/1/015405. Bibcode: 2017EJPh...38a5405A. http://stacks.iop.org/0143-0807/38/i=1/a=015405?key=crossref.1c8a808e8c6ca8672e53732ec813d2f7.
3. ↑ Balakrishnan, Radha; Dandoloff, Rossen (2008-01-01). "Effect of conformations on charge transport in a thin elastic tube" (in en). Nonlinearity 21 (1): 1–11. doi:10.1088/0951-7715/21/1/001. ISSN 0951-7715. Bibcode: 2008Nonli..21....1B. http://stacks.iop.org/0951-7715/21/i=1/a=001.
4. ↑ Atanasov, Victor; Omar, Yasser (2010-01-01). "Quanta of local conformational change: conformons in α-helical proteins" (in en). New Journal of Physics 12 (5): 055003. doi:10.1088/1367-2630/12/5/055003. ISSN 1367-2630. Bibcode: 2010NJPh...12e5003A. http://stacks.iop.org/1367-2630/12/i=5/a=055003.

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