Fluticasone propionate

Short description: Medication

For other uses, see Fluticasone.

Fluticasone propionate

Clinical data
Trade names| Flovent, Flixotide, Flonase, others
AHFS/Drugs.com| Monograph
MedlinePlus| a695002
License data|

* EU EMA: by INN
* US DailyMed: Fluticasone_propionate

Pregnancy
category|

* AU: B3[1]

Routes of
administration| Intranasal,[2] inhalation,[3] topical[4]
Drug class| Steroids and steroid derivatives
ATC code|

* D07AC17 (WHO) R01AD08 (WHO) R03BA05 (WHO) R01AD58 (WHO)

Legal status
Legal status|

* UK: P (Pharmacy medicines) / POM[5]
* US: OTC / Rx-only[4]

Pharmacokinetic data
Bioavailability| 0.51% (Intranasal)
Protein binding| 91%
Metabolism| Intranasal
Liver (CYP3A4-mediated)
Elimination half-life| 10 hours
Excretion| Kidney
Identifiers

IUPAC name

* S-(fluoromethyl)-6α,9-difluoro-11β, 17-dihydroxy-16α-methyl-3-oxoandrosta-1, 4-diene-17β-carbothioate, 17-propanoate

CAS Number|

* 80474-14-2 Y

PubChem CID|

* 444036

IUPHAR/BPS|

* 7080

DrugBank|

* DB00588 Y

ChemSpider|

* 392059 Y

UNII|

* O2GMZ0LF5W

KEGG|

* D01708

ChEBI|

* CHEBI:31441 Y

ChEMBL|

* ChEMBL1473 Y

Chemical and physical data
Formula| C25H31F3O5S
Molar mass| 500.57 g·mol−1
3D model (JSmol)|

* Interactive image

SMILES

* CCC(=O)OC1(C(CC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C)C(=O)SCF

InChI

* InChI=1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1 Y

* Key:WMWTYOKRWGGJOA-CENSZEJFSA-N Y

(verify)

Fluticasone propionate, sold under the brand names Flovent and Flonase among others, is a steroid medication.[6] When inhaled it is used for the long term management of asthma and COPD.[6] In the nose it is used for hay fever and nasal polyps.[7][8] It can also be used for mouth ulcers.[9]

Common side effects when inhaled include upper respiratory tract infections, sinusitis, thrush, and cough.[6] Common side effects when used in the nose include nosebleeding and sore throat.[7] It works by decreasing inflammation.[6]

Fluticasone propionate was patented in 1980, and approved for medical use in 1990.[10] It is available as a generic medication.[8] In 2017, fluticasone was the 15th most commonly prescribed medication in the United States, with more than 32 million prescriptions (up from 16th place & 29 million in 2016).[11][12]

## Contents

* 1 Medical uses
* 2 Adverse effects
* 2.1 Nasal spray
* 2.2 Inhaled
* 3 Pharmacology
* 4 Interactions
* 5 See also
* 6 References
* 7 External links

## Medical uses

Fluticasone propionate is used by powder or aerosol inhalation for the prophylaxis of asthma.[3][6] The nasal spray is used for prevention and treatment of allergic rhinitis.[2] Nasal drops are used in the treatment of nasal polyps. The nasal spray can also be used in the mouth for mouth ulcers.[9]

Fluticasone propionate in a topical form can be used to treat skin conditions such as eczema, psoriasis, and rashes.[13]

## Adverse effects

If taken correctly, the nasal spray and oral inhaler formulation have fewer corticosteroid side effects than the tablet formulation because they limit systemic (blood) absorption.[2] However, systemic absorption is not negligible even with correct administration.[2] Using the spray or inhaler at higher than recommended doses or with other corticosteroids can increase the risk for serious, systemic corticosteroid induced side effects.[2][3] These side effects include weakened immune system, increased risk of systemic infections, osteoporosis, and elevated pressure in the eyes.[14]

### Nasal spray

Flonase nasal spray

Common side effects may include nasal irritation (burning, stinging, bleeding), headache, upset stomach (nausea, vomiting), and diarrhea. Rare side effects include infection (evidenced by, for example, fever, sore throat, and cough), vision problems, severe swelling, hoarse voice, and difficulty breathing or swallowing.[15][7][2]

### Inhaled

Common side effects may include upper respiratory tract infection, throat irritation, thrush, cough, and headache. Rare side effects include bruising, swelling of the face/neck, depression, tiredness, and shortness of breath.[16][6][3]

## Pharmacology

Fluticasone propionate is a highly selective agonist at the glucocorticoid receptor with negligible activity at androgen, estrogen, or mineralocorticoid receptors,[4] thereby producing anti-inflammatory and vasoconstriction effects. It has been shown to have a wide range of inhibitory effects on multiple cell types (e.g. mast cell, eosinophil, neutrophil, macrophages, and lymphocytes) and mediators (e.g. histamine, eicosanoids, leukotrienes, and cytokines) involved in inflammation. Fluticasone propionate is stated to exert a topical effect on the lungs without significant systemic effects at usual doses, due to its low systemic bioavailability.

## Interactions

Fluticasone propionate is broken down by CYP3A4 (Cytochrome P450 3A4), and has been shown to interact with strong CYP3A4 inhibitors such as ritonavir and ketoconazole.[2][3]

Ritonavir is a common drug used in the treatment of HIV. Coadministration of ritonavir and fluticasone may lead to increased levels of fluticasone in the body, which may lead to Cushing's Syndrome and adrenal insufficiency.[17]

Ketoconazole, an antifungal drug, has also been shown to increase fluticasone concentration leading to systemic corticosteroid side effects.[2][3]

## See also

* Fluticasone

## References

1. ↑ "Fluticasone Use During Pregnancy". 9 January 2019. https://www.drugs.com/pregnancy/fluticasone.html.
2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 "Flonase Allergy Relief- fluticasone propionate spray, metered". 30 May 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b6134ba0-b70a-4eac-9a82-cef64b242c1d.
3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 "Flovent Diskus- fluticasone propionate powder, metered". 7 January 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=001f22f8-a83d-495f-9196-d0264ef4d76e.
4. ↑ 4.0 4.1 4.2 "Cutivate- fluticasone propionate lotion". 8 August 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cc79e200-ce69-4ffd-be5b-8c1a6bb88c5c.
5. ↑ "Flixonase Aqueous Nasal Spray - Summary of Product Characteristics (SmPC)". 25 October 2019. https://www.medicines.org.uk/emc/product/845/smpc.
6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 "Fluticasone Propionate Monograph for Professionals". American Society of Health-System Pharmacists. https://www.drugs.com/monograph/fluticasone-propionate.html.
7. ↑ 7.0 7.1 7.2 "Fluticasone Propionate eent Monograph for Professionals". American Society of Health-System Pharmacists. https://www.drugs.com/monograph/fluticasone-propionate-eent.html.
8. ↑ 8.0 8.1 British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 262, 1172. ISBN 9780857113382.
9. ↑ 9.0 9.1 "Flixonase aqueous spray". June 2018. https://publicdocuments.sth.nhs.uk/pil2057.pdf.
10. ↑ Fischer, János; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 487. ISBN 9783527607495. https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA487.
11. ↑ "The Top 300 of 2020". https://clincalc.com/DrugStats/Top300Drugs.aspx.
12. ↑ "Fluticasone - Drug Usage Statistics". https://clincalc.com/DrugStats/Drugs/Fluticasone.
13. ↑ "Drugs & Medications" (in en). https://www.webmd.com/drugs/2/drug-8786/fluticasone-propionate-topical/details.
14. ↑ "Prednisone and other corticosteroids: Balance the risks and benefits". http://www.mayoclinic.org/steroids/art-20045692?pg=2.
15. ↑ "Fluticasone Nasal Spray". AHFS Consumer Medication Information [Internet].. Bethesda (MD): American Society of Health-System Pharmacists, Inc.. 1 September 2010. https://www.nlm.nih.gov/medlineplus/druginfo/meds/a695002.html.
16. ↑ "Fluticasone Oral Inhalation". AHFS Consumer Medication Information [Internet].. Bethesda (MD): American Society of Health-System Pharmacists, Inc.. 1 September 2010. https://www.nlm.nih.gov/medlineplus/druginfo/meds/a601056.html.
17. ↑ "Adrenal suppression and Cushing's syndrome secondary to an interaction between ritonavir and fluticasone: a review of the literature". HIV Medicine 9 (6): 389–96. July 2008. doi:10.1111/j.1468-1293.2008.00579.x. PMID 18459946.

## External links

* "Fluticasone propionate". Drug Information Portal. U.S. National Library of Medicine. https://druginfo.nlm.nih.gov/drugportal/name/fluticasone propionate.
* "Fluticasone". Drug Information Portal. U.S. National Library of Medicine. https://druginfo.nlm.nih.gov/drugportal/name/fluticasone.
* "Fluticasone Topical". https://medlineplus.gov/druginfo/meds/a601057.html.

* v
* t
* e

Glucocorticoids and antiglucocorticoids (H02)

Glucocorticoids|

| Natural|

* Cortisone
* Cortisone acetate
* Cortodoxone (cortexolone, 11-deoxycortisol)
* Desoxycortone (deoxycortone, cortexone, 11-deoxycorticosterone)
* Desoxycortone esters
* Hydrocortisone (cortisol)#
* Hydrocortisone esters
* Prebediolone acetate
* Pregnenolone
* Pregnenolone acetate
* Pregnenolone succinate

|

Synthetic|

* Cortisol-like and related (16-unsubstituted): Chloroprednisone
* Cloprednol
* Difluprednate
* Fludrocortisone
* Flugestone acetate (flurogestone acetate)
* Fluocinolone
* Fluorometholone
* Fluorometholone acetate
* Fluperolone
* Fluperolone acetate
* Fluprednisolone
* Fluprednisolone esters
* Loteprednol
* Medrysone
* Methylprednisolone
* Methylprednisolone esters
* Prednicarbate
* Prednisolone#
* Prednisone
* Tixocortol
* Tixocortol pivalate

* Methasones and related (16-substituted): Alclometasone
* Beclometasone
* Beclometasone esters
* Betamethasone#
* Betamethasone esters
* Clobetasol
* Clobetasol propionate
* Clobetasone
* Clocortolone
* Clocortolone esters
* Cortivazol
* Desoximetasone
* Dexamethasone
* Dexamethasone esters
* Diflorasone
* Diflucortolone
* Diflucortolone valerate
* Fluclorolone
* Flumetasone
* Fluocortin
* Fluocortolone
* Fluocortolone esters
* Fluprednidene acetate
* Fluticasone
* Fluticasone furoate
* Fluticasone propionate
* Halometasone
* Meprednisone
* Mometasone
* Mometasone furoate
* Paramethasone
* Prednylidene
* Rimexolone
* Triamcinolone
* Ulobetasol (halobetasol)

* Cyclic ketals (16,17-cyclized): Amcinonide
* Budesonide
* Ciclesonide
* Deflazacort
* Desonide
* Fluclorolone acetonide (flucloronide)
* Fludroxycortide (flurandrenolone, flurandrenolide)
* Flunisolide
* Fluocinolone acetonide
* Fluocinonide
* Formocortal (fluoroformylone)
* Halcinonide
* Triamcinolone acetonide
* Triamcinolone acetonide esters

Antiglucocorticoids|

* Antagonists: Aglepristone
* Ketoconazole
* Mifepristone
* Ulipristal acetate

Synthesis modifiers|

* Acetoxolone
* Aminoglutethimide
* Carbenoxolone
* Enoxolone
* Ketoconazole
* Metyrapone
* Mitotane
* Trilostane

* #WHO-EM
* ‡Withdrawn from market
* Clinical trials:
* †Phase III
* §Never to phase III

See also
Glucocorticoid receptor modulators
Mineralocorticoids and antimineralocorticoids
List of corticosteroids

* v
* t
* e

Decongestants and other nasal preparations (R01)

Topical|

| Sympathomimetics, plain|

* Cyclopentamine
* Ephedrine
* Epinephrine
* Fenoxazoline
* Levomethamphetamine
* Metizoline
* Naphazoline
* Oxymetazoline
* Phenylephrine
* Propylhexedrine
* Tetryzoline
* Tramazoline
* Tuaminoheptane
* Tymazoline
* Xylometazoline

|

Antiallergic agents,
excluding corticosteroids|

* Spaglumic acid

* histamine antagonists (Levocabastine
* Antazoline
* Thonzylamine)

* mast cell stabilizer (some are also antihistamines) (Cromoglicic acid
* Nedocromil
* Azelastine
* Olopatadine
* Lodoxamide)

Corticosteroids|

* Beclometasone dipropionate
* Betamethasone#
* Budesonide
* Ciclesonide
* Dexamethasone
* Flunisolide
* Fluticasone (Fluticasone furoate, Fluticasone propionate)
* Mometasone furoate
* Prednisolone#
* Tixocortol
* Triamcinolone
* Triamcinolone acetonide

Other nasal preparations|

* Cafaminol
* Calcium hexamine thiocyanate
* Eucalyptus oil
* Framycetin
* Hexamidine
* Hyaluronan
* Ipratropium bromide
* Mupirocin
* Retinol
* Ritiometan
* Saline water

Systemic use:
Sympathomimetics|

* Phenylephrine
* Phenylpropanolamine
* Pseudoephedrine (+loratadine)

* #WHO-EM
* ‡Withdrawn from market
* Clinical trials:
* †Phase III
* §Never to phase III

* v
* t
* e

Drugs for obstructive airway diseases: asthma/Chronic obstructive pulmonary disease

Adrenergics, inhalants|

| Short-acting β2 agonists|

* Bitolterol
* Carbuterol
* Fenoterol
* Isoetarine
* Pirbuterol
* Procaterol
* Reproterol
* Rimiterol
* Salbutamol (albuterol)#/Levosalbutamol (levalbuterol)
* Terbutaline
* Tulobuterol

|

Long-acting β2 agonists|

* Bambuterol
* Clenbuterol
* Formoterol/Arformoterol
* Salmeterol
* Salmefamol

Ultra-long-acting β2 agonists|

* Abediterol
* Carmoterol
* Indacaterol
* Olodaterol
* Vilanterol

Other|

* Epinephrine#
* Hexoprenaline
* Isoprenaline (isoproterenol)
* Orciprenaline (metaproterenol)

Glucocorticoids|

* Beclometasone#
* Betamethasone#
* Budesonide
* Ciclesonide
* Flunisolide
* Fluticasone propionate
* Mometasone
* Triamcinolone

Anticholinergics/
muscarinic antagonist|

* Aclidinium bromide
* Glycopyrronium bromide
* Ipratropium bromide#
* Oxitropium bromide
* Tiotropium bromide
* Umeclidinium bromide

Mast cell stabilizers|

* Cromoglicate
* Nedocromil

Xanthines|

* Acefylline
* Ambuphylline
* Bamifylline
* Doxofylline
* Enprofylline
* Etamiphylline
* Proxyphylline
* Theophylline/Aminophylline/Choline theophyllinate

Eicosanoid inhibition|

| Leukotriene antagonists|

* Montelukast
* Pranlukast
* Zafirlukast

|

Arachidonate 5-lipoxygenase inhibitors|

* Zileuton

Thromboxane receptor antagonists|

* Ramatroban
* Seratrodast

Non-xanthine PDE4 inhibitors|

* Ibudilast
* Roflumilast

Others/unknown|

* Amlexanox
* Eprozinol
* Fenspiride
* Omalizumab

Combination products|

* Aclidinium/formoterol
* Beclometasone/formoterol
* Beclometasone/formoterol/glycopyrronium
* Budesonide/formoterol
* Fluticasone furoate/vilanterol
* Fluticasone propionate/salmeterol
* Indacaterol/glycopyrronium bromide
* Ipratropium bromide/salbutamol
* Mometasone/formoterol
* Umeclidinium bromide/vilanterol

* #WHO-EM
* ‡Withdrawn from market
* Clinical trials:
* †Phase III
* §Never to phase III

* v
* t
* e

Glucocorticoid receptor modulators

GR|

| Agonists|

* Cortisol-like and related (16-unsubstituted): 3α,5α-Tetrahydrocorticosterone
* 5α-Dihydrocorticosterone
* 9α-Fluorocortisone (alfluorone)
* 11-Dehydrocorticosterone (11-oxocorticosterone, 17-deoxycortisone)
* 11-Dehydrocorticosterone acetate
* 11-Deoxycorticosterone (desoxycortone, deoxycortone, desoxycorticosterone)
* Desoxycortone esters
* 11-Deoxycortisol (cortodoxone, cortexolone)
* Cortifen (cortiphen, kortifen)
* Cortodoxone acetate
* 21-Deoxycortisol
* Δ7-Prednisolone
* Δ7-Prednisolone 21-acetate
* Amebucort
* Chloroprednisone
* Chloroprednisone acetate
* Cloprednol
* Cloprednol acetate
* Corticosterone
* Corticosterone acetate
* Corticosterone benzoate
* Cortisol (hydrocortisone)
* Benzodrocortisone (hydrocortisone benzoate)
* Hydrocortamate (hydrocortisone diethylaminoacetate)
* Hydrocortisone esters
* Cortisone
* Cortisone acetate
* Deprodone
* Deprodone propionate
* Dichlorisone
* Dichlorisone acetate
* Dichlorisone diacetate
* Difluprednate
* Endrisone (endrysone)
* Etiprednol
* Etiprednol dicloacetate (etiprednol dichloroacetate)
* Fludrocortisone (fludrocortone)
* Fludrocortisone acetate
* Fluorometholone
* Fluorometholone acetate
* Fluperolone
* Fluperolone acetate
* Fluprednisolone
* Fluprednisolone esters
* Halopredone
* Halopredone acetate (halopredone diacetate)
* Isoflupredone (9α-fluoroprednisolone)
* Isoflupredone acetate
* Loteprednol
* Mazipredone (depersolone)
* Medrysone
* Methylprednisolone
* Methylprednisolone esters
* Prebediolone
* Prebediolone acetate
* Prednisolone
* Prednazate
* Prednazoline
* Prednicarbate (prednisolone ethylcarbonate propionate)
* Prednimustine
* Prednisolamate (prednisolone diethylaminoacetate)
* Prednisolone esters
* Prednisone
* Prednisone esters
* Pregnenolone
* Pregnenolone acetate
* Pregnenolone succinate (pregnenolone hemisuccinate)
* Resocortol
* Tipredane
* Tixocortol
* Butixocort (tixocortol butyrate)
* Butixocort propionate
* Tixocortol pivalate

* Methasones and related (16-substituted): 16α-Methyl-11-oxoprednisolone
* Alclometasone
* Alclometasone dipropionate
* Amelometasone
* Beclometasone (beclomethasone)
* Beclometasone esters
* Betamethasone (betametasone)
* Betamethasone esters
* Cortobenzolone (betamethasone salicylate)
* Ciclometasone (ciclomethasone, cyclomethasone)
* Clobetasol
* Clobetasol propionate
* Clobetasone
* Clobetasone butyrate
* Clocortolone
* Clocortolone esters
* Cloticasone
* Cloticasone propionate
* Cormetasone (cormethasone)
* Cormetasone acetate
* Descinolone
* Desoximetasone (desoxymethasone)
* Dexamethasone (dexametasone)
* Dexamethasone esters
* Diflorasone
* Diflorasone diacetate
* Diflucortolone
* Diflucortolone pivalate
* Diflucortolone valerate
* Dimesone
* Dimesone acetate
* Doxibetasol (doxybetasol)
* Fluclorolone
* Flumetasone (flumethasone)
* Flumetasone acetate
* Flumetasone pivalate
* Fluocinolone
* Fluocortin
* Fluocortin butyl (fluocortin butylate)
* Fluocortolone
* Fluocortolone esters
* Fluprednidene (fluprednylidene)
* Fluprednidene acetate
* Fluticasone
* Fluticasone furoate
* Fluticasone propionate
* Halocortolone
* Halometasone
* Icometasone
* Icometasone enbutate (icometasone butyrate acetate)
* Isoprednidene
* Locicortolone (locicortone)
* Locicortolone dicibate (locicortone dicibate)
* Meclorisone
* Meclorisone dibutyrate
* Meprednisone (methylprednisone)
* Meprednisone acetate
* Meprednisone hydrogen succinate (methylprednisone hemisuccinate)
* Mometasone
* Mometasone furoate
* Paramethasone
* Paramethasone acetate
* Paramethasone disodium phosphate
* Paramethasone phosphate
* Prednylidene
* Prednylidene diethylaminoacetate
* Rimexolone
* Ticabesone
* Ticabesone propionate
* Timobesone
* Timobesone acetate
* Triamcinolone
* Triamcinolone diacetate
* Ulobetasol (halobetasol)
* Ulobetasol propionate
* Vamorolone

* Cyclic ketals (16,17-cyclized): Acrocinonide (triamcinolone acroleinide)
* Amcinafal (triamcinolone pentanonide)
* Amcinafide (triamcinolone acetophenide)
* Amcinonide (triamcinolone acetate cyclopentanonide)
* Budesonide
* Ciclesonide
* Cicortonide
* Deflazacort (azacort)
* Descinolone acetonide
* Desonide (hydroxyprednisolone acetonide)
* Desonide disodium phosphate
* Desonide pivalate
* Dexbudesonide
* Drocinonide
* Drocinonide phosphate
* Fluazacort
* Fluclorolone acetonide (flucloronide)
* Fludroxycortide (flurandrenolone, flurandrenolide)
* Flumoxonide
* Flunisolide
* Flunisolide acetate
* Fluocinolone acetonide
* Ciprocinonide (fluocinolone acetonide cyclopropylcarboxylate)
* Fluocinonide (fluocinolide, fluocinolone acetonide acetate)
* Procinonide (fluocinolone acetonide propionate)
* Formocortal
* Halcinonide
* Itrocinonide
* Rofleponide
* Rofleponide palmitate
* Tralonide
* Triamcinolone acetonide
* Flupamesone (triamcinolone acetonide metembonate)
* Triamcinolone acetonide esters
* Triamcinolone aminobenzal benzamidoisobutyrate (TBI-PAB)
* Triclonide

* Others/atypical (other expanded steroid ring systems, homosteroids, and non-pregnane steroids): Cortisuzol
* Cortivazol
* Domoprednate
* Naflocort
* Nicocortonide
* Nicocortonide acetate
* Nivacortol (nivazol)
* Oxisopred
* RU-26988
* RU-28362

* Non-corticosteroids with some glucocorticoid activity: 15β-Hydroxycyproterone acetate
* 17α-Hydroxyprogesterone
* Bromoketoprogesterone
* Chlormadinone acetate
* Cyproterone
* Cyproterone acetate
* Danazol
* Delmadinone acetate
* Desogestrel
* DU-41165
* Etonogestrel
* Flugestone
* Flugestone acetate (flurogestone acetate)
* Fluoromedroxyprogesterone acetate
* Fluoxymesterone
* Gestodene
* Medrogestone
* Medroxyprogesterone acetate
* Megestrol acetate
* Metribolone
* Norgestomet
* Osaterone acetate
* Progesterone
* Promegestone
* RU-2309
* Quingestrone
* Segesterone acetate (nestorone)
* Tetrahydrogestrinone

* Nonsteroidal glucocorticoids: AZD-5423
* GSK-9027

|

Mixed
(SEGRMs)|

* Dagrocorat
* Fosdagrocorat
* Mapracorat

Antagonists|

* 7α-Hydroxy-DHEA
* 17α-Methylprogesterone
* Aglepristone
* Asoprisnil
* Asoprisnil ecamate
* C108297
* C113176
* CORT-108297
* Cyproterone acetate
* Exicorilant (CORT-125281)
* Guggulsterone
* Ketoconazole
* Lilopristone
* LLY-2707
* Metapristone (RU-42633)
* Miconazole
* Mifepristone (RU-486)
* Miricorilant (CORT-118335)
* Onapristone
* ORG-34116
* ORG-34517 (SCH-900636)
* ORG-34850
* Pregnenolone 16α-carbonitrile
* Relacorilant (CORT-125134)
* RTI 3021–012
* RTI 3021–022
* Telapristone
* Tibolone
* Toripristone
* Ulipristal acetate

Others|

* Antisense oligonucleotides: IONIS-GCCRRx (ISIS-426115)

See also
Receptor/signaling modulators
Glucocorticoids and antiglucocorticoids
Mineralocorticoid receptor modulators
List of corticosteroids

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*[GR]: Glucocorticoid receptor
*[SEGRMs]: Selective glucocorticoid receptor agonists