EDANS

EDANS
Names
	Preferred IUPAC name 5-[(2-Aminoethyl)amino]naphthalene-1-sulfonic acid
	Other names EDANS
Identifiers
CAS Number	50402-56-7 ;
3D model (JSmol)	Interactive image;
ChemSpider	83355 ;
PubChem CID	92329;
UNII	3JBY896YZF ;
	InChI InChI=1S/C12H14N2O3S/c13-7-8-14-11-5-1-4-10-9(11)3-2-6-12(10)18(15,16)17/h1-6,14H,7-8,13H2,(H,15,16,17) Key: SJQRQOKXQKVJGJ-UHFFFAOYSA-N ; InChI=1/C12H14N2O3S/c13-7-8-14-11-5-1-4-10-9(11)3-2-6-12(10)18(15,16)17/h1-6,14H,7-8,13H2,(H,15,16,17) Key: SJQRQOKXQKVJGJ-UHFFFAOYAN;
	SMILES c1cc2c(cccc2S(=O)(=O)O)c(c1)NCCN;
Properties
Chemical formula	C12H14N2O3S
Molar mass	266.32
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

EDANS (5-((2-Aminoethyl)amino)naphthalene-1-sulfonic acid) is a donor for FRET-based nucleic acid probes and protease substrates. EDANS is often paired with DABCYL or DABSYL. The combination can be used in enzyme assays. When the two compounds are in close proximity, most of the energy emitted from EDANS will be quenched by DABCYL. However, if the compounds are separated (for example, by substrate cleavage) EDANS will fluoresce, giving an indication of enzyme presence.^[1]

References

↑ Guo, Jiubiao (30 November 2014). "Spectral properties of EDANS-Dabcyl pair [45 and the flowchart of the experimental design."]. PLOS ONE 9 (12). doi:10.1371/journal.pone.0114124.g001. https://figshare.com/articles/_Spectral_properties_of_EDANS_Dabcyl_pair_45_and_the_flowchart_of_the_experimental_design_/1255607.

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[1] Guo, Jiubiao (30 November 2014). "Spectral properties of EDANS-Dabcyl pair [45 and the flowchart of the experimental design."]. PLOS ONE 9 (12). doi:10.1371/journal.pone.0114124.g001. https://figshare.com/articles/_Spectral_properties_of_EDANS_Dabcyl_pair_45_and_the_flowchart_of_the_experimental_design_/1255607.

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EDANS

Topic: Chemistry

See also

References