Sir William Douglas of Kelhead (died 1673), Scottish Covenanter colonel, son of the 1st Earl of Queensberry
William Hamilton, Duke of Hamilton (born Lord William Douglas, 1634–1694), Scottish nobleman and politician, son of the 1st Marquess of Douglas
William Douglas, 14th of Cavers (c. 1688–1748), Scottish landowner and politician, MP for Roxburghshire 1715–22, 1727–34, 1742–47, and for Dumfries Burghs 1722–27
Sir William Douglas, 4th Baronet (c. 1730–1783), Scottish landowner and politician, MP for Dumfries Burghs, great-great-grandson of Sir William Douglas of Kelhead
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