Cefaclor

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This editable Main Article is under development and subject to a disclaimer.

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(CC) Image: David E. Volk

cefaclor (cephaclor)
| IUPAC name:  | see chemistry section

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Synonyms:  | cephaclor
Formula:  | C15H14ClN3O4S

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Uses:  | antibiotic drug

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Properties:  | beta-lactam

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Hazards:  | see drug interactions

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| Mass (g/mol):  | CAS #:

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367.8074  | 53994-73-3

Cefaclor, also spelled as cephaclor, is a semisynthetic broad-spectrum antibiotic drug used to treat a variety of bacterial infections. It is a second generation cephalosporin antibiotic with similar activities. It is similar in structure to cephalexin and is also similar to penicillin-like drugs because it contains a beta-lactam moiety which binds to and interferes with bacterial cell wall synthesis. It can be used to treat a wide variety of both Gram-positive and Gram-negative aerobic bacteria.

## Contents

* 1 Mechanism of action
* 2 Susceptible microbes
* 3 Chemistry
* 4 Synonyms and brand names
* 5 External links

## Mechanism of action[edit]

Because cefaclor is a beta-lactam-based antibiotic, it binds to specific penicillin-binding proteins located inside the bacterial cell wall and inhibits the final stage of bacterial cell wall synthesis. As a consequence of the defective cell walls, the bacteria cells are autolysed by autolysins, autolytic enzymes. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins.

## Susceptible microbes[edit]

Among the Gram-positive bacteria, cefaclor has shown activity against Staphylococci, including coagulase-(±) and penicillinase (+) strains, Streptococcus pneumoniae, and Streptococcus pyogenes. Among the Gram-negative aerobes, cefaclor is active against Escherichia coli, Haemophilus influenzae, including ß-lactamase-producing ampicillin-resistant strains), Klebsiella sp, and Proteus mirabilis.

## Chemistry[edit]

The IUPAC chemical name for cefaclor is (6R,7R)-7-[(2-amino-2-phenylacetyl)amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, and it has chemical formula C15H14ClN3O4S giving it a molecular mass of 367.8074 g/mol.

## Synonyms and brand names[edit]

Synonyms

* CCL
* Cefaclor anhydrous
* Cefaclorum (Latin)
* Cephaclor

Brand names

* Alenfral
* Alfacet
* Alfatil
* Ceclor
* Ceclor CD
* Distaclor
* Kefral
* Panacef
* Panoral
* Raniclor

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## External links[edit]

The most up-to-date information about Cefaclor and other drugs can be found at the following sites.

* Cefaclor \-  FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
* Cefaclor \- Drug information for consumers from MedlinePlus (U.S. National Library of Medicine).
* Cefaclor \- Detailed information from DrugBank.