Basil Lythgoe

Short description: British organic chemist

Basil Lythgoe

FRS

Born| (1913-08-18)18 August 1913

Leigh, Greater Manchester

Died| 18 April 2009(2009-04-18) (aged 95)

Wychbold

Education| Leigh Grammar School
Alma mater| University of Manchester
Known for| Work on taxine alkaloids and calciferols
Spouse(s)| Kathleen (Kate) Cameron Hallum
Children| 2
Awards| See list
Scientific career
Institutions| ICI in Huddersfield
University of Manchester
University of Cambridge
University of Leeds
Thesis|  (1936)
Doctoral advisor| Professor I W Heilbron, FRS
Doctoral students| Dudley Williams

Basil Lythgoe FRS (18 August 1913 — 18 April 2009) was a British organic chemist who investigated the structure of many natural substances including nucleosides, plant toxins, and vitamin D2. He was Professor of Organic Chemistry at the University of Leeds.[1][2]

## Contents

* 1 Biography
* 2 Honours
* 3 Family
* 4 References

## Biography

Basil Lythgoe was born in Leigh, the second of three children of Peter Whittaker Lythgoe (company secretary of a local textile firm) and Agnes Lily Lythgoe (née Shepherd). Basil, like his father, attended Leigh Grammar School. Aided by a county grant he progressed to the University of Manchester in 1930. His final degree examinations were delayed by a severe throat infection; he graduated in 1934, with first class honours.

Lythgoe stayed at Manchester to work or his PhD, supervised by Professor I W Heilbron, FRS; it was awarded in 1936. He then joined ICI in Huddersfield, where he worked on a synthetic dye. But he soon returned to the University of Manchester as an assistant lecturer, where he worked with Alexander Todd, successor to Heibron.

In 1946 Lythgoe accompanied Todd to the Cambridge as an “assistant in research’” – he was later promoted to Lecturer. Their main area of research was nucleosides. Their findings, and those of others in the group, contributed to determining the correct structure of DNA.[3] By 1948 Lythgoe was working independently, although still on nucleosides. Later, he turned his attention to the structure of macrozamin, a very toxic natural substance.[4][5]

In 1953 Basil Lythgoe moved to the University of Leeds to take up the professorship of organic chemistry.[6] One of his principal research areas for many years was taxine alkaloids. Lythgoe was an early user of nuclear magnetic resonance (NMR), which helped him determine the correct structure of taxine-I.[7]

Another extensive area of research was calciferols. In one paper he described the synthesis of cholecalciferol, which involved the use of the Wittig reaction.[8] It was “early days for Wittig reagents, and possibly Lythgoe saw this as one of the strengths of the work in the 1958 paper”.[6]

Basil Lythgoe retired in 1978.

## Honours

Lythgoe was elected Fellow of the Royal Society (FRS) in 1958.[6] He also was appointed to the Tilden Lectureship of the Chemical Society in 1958, received the Synthetic Organic Chemistry Award of the Chemical Society and the Simonsen Lectureship of the Chemical Society in 1978 and the Chemical Society Award for Organic Synthesis in 1979.

## Family

The engagement of Basil Lythgoe and the mathematician Kathleen (Kate) Cameron Hallum was announced in April 1946.[9] They had met at Manchester and were married on 29 June.[10] They had two sons: John Cameron (1948) and Andrew Hallum (1950). John graduated in electrical and electronic engineering at the University of Birmingham and Andrew in materials science at the University of Liverpool. Both followed industrial careers and were to marry and have families.[6]

Kate died in Leeds on 10 July 2003. Basil Lythgoe developed dementia in later life. He died on 18 April 2009 at a nursing home in Wychbold.

## References

1. ↑ The University of Leeds, obituary of Basil Lythgoe
2. ↑ The Royal Society, biographical memoirs, Basil Lythgoe, published 3 March 2021
3. ↑ "Todd, Alexander Robertus, Baron Todd". Oxford Dictionary of National Biography (online ed.). Oxford University Press. doi:10.1093/ref:odnb/64697. (Subscription or UK public library membership required.)
4. ↑ "Macrozamin". https://pubchem.ncbi.nlm.nih.gov/compound/Macrozamin.
5. ↑ Lythgoe, B; Riggs, N V (15 December 1949). "Macrozamin, a toxic nitrogen-containing primeveroside". Experientia 5 (12): 472. doi:10.1007/BF02165424. PMID 15397410.
6. ↑ 6.0 6.1 6.2 6.3 Jones, J. C. (2021). "Basil Lythgoe. 18 August 1913—18 April 2009". Biographical Memoirs of Fellows of the Royal Society 70: 283–295. doi:10.1098/rsbm.2019.0043. https://royalsocietypublishing.org/doi/10.1098/rsbm.2019.0043. Retrieved 22 May 2023.
7. ↑ Harrison, J W; Scrowston, R M; Lythgoe, B (1966). "Taxine. Part IV. The constitution of taxine-I". J. Chem. Soc. C: 1933–1945. doi:10.1039/j39660001933.
8. ↑ Harrison, I T; Lythgoe, B (1958). "163. Calciferol and its relatives. Part IV. A non-photo-chemical synthesis of a model cis-triene". J. Chem. Soc.: 843–848. doi:10.1039/jr9580000843.
9. ↑ "Dr B Lythgoe — Miss K C Hallum". The Scotsman: p. 4. 26 April 1946.
10. ↑ "Marriage: Lythgoe-Hallum". The St Andrews Citizen. 6 July 1946.

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