Charles Scott Sherrington

Short description: English footballer, neurophysiologist and Nobel Prize recipient (1857–1952)

Sir Charles Scott Sherrington

OM GBE FRS FRCP FRCS

43rd President of the Royal Society
In office
1920–1925
Preceded by| J. J. Thomson
Succeeded by| Ernest Rutherford
Personal details
Born| (1857-11-27)27 November 1857
Islington, Middlesex, England, United Kingdom of Great Britain and Ireland
Died| 4 March 1952(1952-03-04) (aged 94)
Eastbourne, Sussex, England, United Kingdom
Citizenship| British
Alma mater|

* Ipswich School
* Royal College of Surgeons of England
* University of Cambridge

Awards|

* FRS (1893)[1]
* Royal Medal (1905)
* Copley Medal (1927)
* Nobel Prize in Physiology or Medicine (1932)

Scientific career
Fields|

* Physiology
* Pathology
* Histology
* Neurology
* Bacteriology

Institutions|

* King's College, London
* University of Liverpool
* University of Oxford

Academic advisors|

* Michael Foster
* John Newport Langley

Doctoral students|

* John Farquhar Fulton
* John Carew Eccles
* Howard Florey[2]

Sir Charles Scott Sherrington OM GBE FRS FRCP FRCS[1][3] (27 November 1857 – 4 March 1952) was a British neurophysiologist. His experimental research established many aspects of contemporary neuroscience, including the concept of the spinal reflex as a system involving connected neurons (the "neuron doctrine"), and the ways in which signal transmission between neurons can be potentiated or depotentiated. Sherrington himself coined the word "synapse" to define the connection between two neurons. His book The Integrative Action of the Nervous System (1906)[4] is a synthesis of this work, in recognition of which he was awarded the Nobel Prize in Physiology or Medicine in 1932 (along with Edgar Adrian).[5][6][7][8]

In addition to his work in physiology, Sherrington did research in histology, bacteriology, and pathology. He was president of the Royal Society in the early 1920s.

## Contents

* 1 Biography
* 1.1 Early years and education
* 1.1.1 Seventh International Medical Congress
* 1.1.2 Travel
* 1.2 Employment
* 1.2.1 Liverpool
* 1.2.2 Oxford
* 1.3 Retirement
* 2 Family
* 3 Publications
* 3.1 The Integrative Action of the Nervous System
* 3.2 Mammalian Physiology: a Course of Practical Exercises
* 3.3 The Assaying of Brabantius and other Verse
* 3.4 Man on His Nature
* 4 Honours and awards
* 4.1 Eponyms
* 5 See also
* 6 References
* 7 External links

## Biography

### Early years and education

Official biographies claim Charles Scott Sherrington was born in Islington, London, England, on 27 November 1857, and that he was the son of James Norton Sherrington, a country doctor, and his wife, Anne Thurtell.[9] However James Norton Sherrington was an ironmonger and artist's colourman in Great Yarmouth, not a doctor, and died in Yarmouth in 1848, nearly 9 years before Charles was born.[10][11]

In the 1861 census, Charles is recorded as Charles Scott (boarder, 4, born India) with Anne Sherrington (widow) as the head and Caleb Rose (visitor, married, surgeon).[12] He was brought up in this household with Caleb recorded as head in 1871,[13] although Anne and Caleb did not marry until after the death of his wife in 1880.[14]

The relationship between Charles and his childhood family is unknown. During the 1860s the whole family moved to Anglesea Road, Ipswich, reputedly because London exacerbated Caleb Rose's tendency to asthma.[15]

Sherrington's origins have been discussed in several published sources: Chris Moss and Susan Hunter, in the Journal of Medical Biography of January 2018, presented an article discussing the potential origins of Charles Sherrington, i.e. whether he was born in India of unknown parents, or was the illegitimate child of Caleb Rose and Anne Sherrington.[16]

Erling Norrby, PhD, in Nobel Prizes and Notable Discoveries (2016) observed: "His family origin apparently is not properly given in his official biography. Considering that motherhood is a matter of fact and fatherhood a matter of opinion, it can be noted that his father was not James Norton Sherrington, from whom his family name was derived. Charles was born 9 years after the death of his presumed father. Instead Charles and his two brothers were the illegitimate sons of Caleb Rose, a highly regarded Ipswich surgeon."[17]

In Ipswich Town: A History, Susan Gardiner writes: "George and William Sherrington, along with their older brother, Charles, were almost certainly the illegitimate sons of Anne Brookes, née Thurtell and Caleb Rose, a leading surgeon from Ipswich, with whom she was living in College Road, Islington at the time that all three boys were born. No father was named in the baptism register of St James' Church, Clerkenwell, and there is no official record of the registration of any of their births. It was claimed they were the sons of a country doctor, James Norton Sherrington. However, it was with Caleb Rose that Anne and the three Sherrington boys moved to Anglesea Road, Ipswich in 1860 and the couple were married in 1880 after Caleb's first wife had died."[18]

Judith Swazey, in Reflexes and Motor Integration: Sherrington's Concept of Integrative Action (1969), quotes Charles Scott Sherrington's son, Carr Sherrington: "James N. Sherrington was always called Mr. and I have no knowledge that he was a Dr. either in law or in medicine... [He] was mainly interested in art and was a personal friend of J. B. Crone and other painters."[19]

Caleb Rose was noteworthy as both a classical scholar and an archaeologist. At the family's Edgehill House in Ipswich one could find a fine selection of paintings, books, and geological specimens.[1][20] Through Rose's interest in the Norwich School of Painters, Sherrington gained a love of art.[21] Intellectuals frequented the house regularly. It was this environment that fostered Sherrington's academic sense of wonder. Even before matriculation, the young Sherrington had read Johannes Müller's Elements of Physiology. The book was given to him by Caleb Rose.

Sherrington entered Ipswich School in 1871.[1] Thomas Ashe, a famous English poet, taught at the school. Ashe served as an inspiration to Sherrington, instilling a love of classics and the desire to travel.

Rose had pushed Sherrington towards medicine. Sherrington first began to study with the Royal College of Surgeons of England. He also sought to study at Cambridge, but a bank failure had devastated the family's finances. Sherrington elected to enroll at St Thomas' Hospital in September 1876 as a "perpetual pupil".[1] He did so in order to allow his two younger brothers to do so ahead of him. The two studied law there. Medical studies at St. Thomas's Hospital were intertwined with studies at Gonville and Caius College, Cambridge.[20] Physiology was Sherrington's chosen major at Cambridge. There, he studied under the "father of British physiology," Sir Michael Foster.[22]

Sherrington played football for his grammar school, and for Ipswich Town Football Club; he played rugby for St. Thomas's, was on the rowing team at Oxford.[20][23] During June 1875, Sherrington passed his preliminary examination in general education at the Royal College of Surgeons of England (RCS). This preliminary exam was required for Fellowship, and also exempted him from a similar exam for the Membership. In April 1878, he passed his Primary Examination for the Membership of the RCS, and twelve months later the Primary for Fellowship.

In October 1879, Sherrington entered Cambridge as a non-collegiate student.[24] The following year he entered Gonville and Caius College. Sherrington was a first-rate student. In June 1881, he took Part I in the Natural Sciences Tripos (NST) and was awarded a Starred first in physiology; there were nine candidates in all (eight men, one woman), of whom five gained First-class honours (Firsts); in June 1883, in Part II of the NST, he also gained a First, alongside William Bateson.[25] Walter Holbrook Gaskell, one of Sherrington's tutors, informed him in November 1881 that he had earned the highest marks for his year in botany, human anatomy, and physiology; second in zoology; and highest overall.[20] John Newport Langley was Sherrington's other tutor. The two were interested in how anatomical structure is expressed in physiological function.[22]

Sherrington earned his Membership of the Royal College of Surgeons on 4 August 1884. In 1885, he obtained a First Class in the Natural Science Tripos with the mark of distinction. In the same year, Sherrington earned the degree of M.B., Bachelor of Medicine and Surgery from Cambridge. In 1886, Sherrington added the title of L.R.C.P., Licentiate of the Royal College of Physicians.[1]

#### Seventh International Medical Congress

Charles Scott Sherrington

The 7th International Medical Congress was held in London in 1881. It was at this conference that Sherrington began his work in neurological research. At the conference controversy broke out. Friedrich Goltz of Strasbourg argued that localized function in the cortex did not exist. Goltz came to this conclusion after observing dogs who had parts of their brains removed. David Ferrier, who became a hero of Sherrington's, disagreed. Ferrier maintained that there was localization of function in the brain. Ferrier's strongest evidence was a monkey who suffered from hemiplegia, paralysis affecting one side of the body only, after a cerebral lesion.

A committee, including Langley, was made up to investigate. Both the dog and the monkey were chloroformed. The right hemisphere of the dog was delivered to Cambridge for examination. Sherrington performed a histological examination of the hemisphere, acting as a junior colleague to Langley. In 1884, Langley and Sherrington reported on their findings in a paper. The paper was the first for Sherrington.[1]

#### Travel

In the winter of 1884–1885, Sherrington left England for Strasbourg. There, he worked with Goltz. Goltz, like many others, positively influenced Sherrington. Sherrington later said of Goltz that: "[h]e taught one that in all things only the best is good enough."[1]

A case of asiatic cholera had broken out in Spain in 1885. A Spanish doctor claimed to have produced a vaccine to fight the outbreak. Under the auspices of Cambridge University, the Royal Society of London, and the Association for Research in Medicine, a group was put together to travel to Spain to investigate. C.S. Roy, J. Graham Brown, and Sherrington formed the group. Roy was Sherrington's friend and the newly elected professor of pathology at Cambridge. As the three travelled to Toledo, Sherrington was skeptical of the Spanish doctor.[20] Upon returning, the three presented a report to the Royal Society. The report discredited the Spaniard's claim.

Sherrington did not meet Santiago Ramón y Cajal on this trip. While Sherrington and his group remained in Toledo, Cajal was hundreds of miles away in Zaragoza.[20]

Later that year Sherrington travelled to Rudolf Virchow in Berlin to inspect the cholera specimens he procured in Spain. Virchow later on sent Sherrington to Robert Koch for a six weeks' course in technique. Sherrington ended up staying with Koch for a year to do research in bacteriology. Under these two, Sherrington parted with a good foundation in physiology, morphology, histology, and pathology.[22] During this period he may have also studied with Waldeyer and Zuntz.

In 1886, Sherrington went to Italy to again investigate a cholera outbreak. While in Italy, Sherrington spent much time in art galleries. It was in this country that Sherrington's love for rare books became an obsession.[20]

### Employment

C.S. Roy and Charles Scott Sherrington (right), at the door of the Old Pathological Laboratory, Cambridge, 1893

In 1891, Sherrington was appointed as superintendent of the Brown Institute for Advanced Physiological and Pathological Research of the University of London, a center for human and animal physiological and pathological research.[20][21] Sherrington succeeded Sir Victor Alexander Haden Horsley.[26] There, Sherrington worked on segmental distribution of the spinal dorsal and ventral roots, he mapped the sensory dermatomes, and in 1892 discovered that muscle spindles initiated the stretch reflex. The institute allowed Sherrington to study many animals, both small and large. The Brown Institute had enough space to work with large primates such as apes.

#### Liverpool

Sherrington's first job of full-professorship came with his appointment as Holt Professor of Physiology at Liverpool in 1895, succeeding Francis Gotch.[20] With his appointment to the Holt Chair, Sherrington ended his active work in pathology.[1] Working on cats, dogs, monkeys, and apes that had been bereaved of their cerebral hemispheres, he found that reflexes must be considered integrated activities of the total organism, not just the result of activities of the so-called reflex-arcs, a concept then generally accepted.[26] There he continued his work on reflexes and reciprocal innervation. His papers on the subject were synthesized into the Croonian lecture of 1897.

Sherrington showed that muscle excitation was inversely proportional to the inhibition of an opposing group of muscles. Speaking of the excitation-inhibition relationship, Sherrington said "desistence from action may be as truly active as is the taking of action." Sherrington continued his work on reciprocal innervation during his years at Liverpool. Come 1913, Sherrington was able to say that "the process of excitation and inhibition may be viewed as polar opposites [...] the one is able to neutralize the other." Sherrington's work on reciprocal innervation was a notable contribution to the knowledge of the spinal cord.[1]

#### Oxford

As early as 1895, Sherrington had tried to gain employment at Oxford University. By 1913, the wait was over. Oxford offered Sherrington the Waynflete Chair of Physiology at Magdalen College.[1] The electors to that chair unanimously recommended Sherrington without considering any other candidates.[20] Sherrington enjoyed the honor of teaching many bright students at Oxford, including Wilder Penfield, who he introduced to the study of the brain. Several of his students were Rhodes scholars, three of whom – Sir John Eccles, Ragnar Granit, and Howard Florey – went on to be Nobel laureates.[27] Sherrington also influenced American pioneer brain surgeon Harvey Williams Cushing.

Sherrington's philosophy as a teacher can be seen in his response to the question of what was the real function of Oxford University in the world. Sherrington said:

> "After some hundreds of years of experience we think that we have learned here in Oxford how to teach what is known. But now with the undeniable upsurge of scientific research, we cannot continue to rely on the mere fact that we have learned how to teach what is known. We must learn to teach the best attitude to what is not yet known. This also may take centuries to acquire but we cannot escape this new challenge, nor do we want to."[20]

Box of microscope slides carrying the plaque:"Sir Charles Sherrington's Histology Demonstration Slides: St Thomas's Hospital: 1886–1895; Liverpool University: 1895–1915; Oxford University: 1914–1935"

While at Oxford, Sherrington kept hundreds of microscope slides in a specially constructed box labelled "Sir Charles Sherrington's Histology Demonstration Slides". As well as histology demonstration slides, the box contains slides which may be related to original breakthroughs such as cortical localization in the brain; slides from contemporaries such as Angelo Ruffini and Gustav Fritsch; and slides from colleagues at Oxford such as John Burdon-Sanderson – the first Waynflete Chair of Physiology – and Derek Denny-Brown, who worked with Sherrington at Oxford (1924–1928)).[28]

Sherrington's teachings at Oxford were interrupted by World War I. When the war started, it left his classes with only nine students. During the war, he laboured at a shell factory to support the war and to study fatigue in general, but specifically industrial fatigue. His weekday work hours were from 7:30am to 8:30pm; and from 7:30am to 6:00pm on the weekends.[20]

In March 1916, Sherrington fought for women to be admitted to the medical school at Oxford.

He lived at 9 Chadlington Road in north Oxford from 1916 to 1934, and on 28 April 2022 an Oxfordshire blue plaque in his honour was unveiled on this house.[29]

### Retirement

Charles Sherrington retired from Oxford in the year of 1936.[1] He then moved to his boyhood town of Ipswich, where he built a house.[22] There, he kept up a large correspondence with pupils and others from around the world. He also continued to work on his poetic, historical, and philosophical interests.[27] From 1944 until his death he was President of the Ipswich Museum, on the committee he had previously served.[30]

Sherrington's mental faculties were crystal clear up to the time of his sudden death, which was caused by a sudden heart failure at age 94. His bodily health, however, did suffer in old age. Arthritis was a major burden.[22] Speaking of his condition, Sherrington said "old age isn't pleasant[,] one can't do things for oneself."[1] The arthritis put Sherrington in a nursing home in the year before his death, in 1951.[27]

## Family

On 27 August 1891, Sherrington married Ethel Mary Wright (died 1933), daughter of John Ely Wright of Preston Manor, Suffolk, England. They had one child, a son named Charles ("Carr") E.R. Sherrington, who was born in 1897.[22]

On weekends during the Oxford years the couple would frequently host a large group of friends and acquaintances at their house for an enjoyable afternoon.[1]

## Publications

### The Integrative Action of the Nervous System

Published in 1906,[4] this was a compendium of ten of Sherrington's Silliman lectures, delivered at Yale University in 1904.[31]

The book discussed neuron theory, the "synapse" (a term he had introduced in 1897, the word itself suggested by classicist A. W. Verrall[32]), communication between neurons, and a mechanism for the reflex-arc function.[7] The work effectively resolved the debate between neuron and reticular theory in mammals, thereby shaping our understanding of the central nervous system.[31]

He theorized that the nervous system coordinates various parts of the body and that the reflexes are the simplest expressions of the interactive action of the nervous system, enabling the entire body to function toward a definite purpose. Sherrington pointed out that reflexes must be goal-directive and purposive. Furthermore, he established the nature of postural reflexes and their dependence on the anti-gravity stretch reflex and traced the afferent stimulus to the proprioceptive end organs, which he had previously shown to be sensory in nature ("proprioceptive" was another term he had coined[7]). The work was dedicated to Ferrier.[22]

### Mammalian Physiology: a Course of Practical Exercises

The textbook was published in 1919 at the first possible moment after Sherrington's arrival at Oxford and the end of the War.[1]

### The Assaying of Brabantius and other Verse

This collection of previously published war-time poems was Sherrington's first major poetic release, published in 1925. Sherrington's poetic side was inspired by Johann Wolfgang von Goethe. Sherrington was fond of Goethe the poet, but not Goethe the scientist. Speaking of Goethe's scientific writings, Sherrington said "to appraise them is not a congenial task."[1]

### Man on His Nature

A reflection on Sherrington's philosophical thought. Sherrington had long studied the 16th century French physician Jean Fernel, and grew so familiar with him that he considered him a friend. During the academic year 1937-38, Sherrington delivered the Gifford lectures at the University of Edinburgh. They focused on Fernel and his times, and formed the basis of Man on His Nature. The book was published in 1940, with a revised edition in 1951. It explores philosophical thoughts about the mind, human existence, and God, in accordance with natural theology.[33] In the original edition, each of the twelve chapters begins with one of the twelve zodiac signs; Sherrington discusses astrology in Fernel's time in Chapter 2.[34] In his ideas on mind and cognition, Sherrington introduced the idea that neurons work as groups in a "million-fold democracy" to produce outcomes rather than with central control.[35]

## Honours and awards

Stained glass window in the dining hall of Gonville and Caius College, in Cambridge (UK), commemorating Charles Scott Sherrington

Sherrington was elected a Fellow of the Royal Society (FRS) in 1893.[1]

* 1899 Baly Gold Medal of the Royal College of Physicians of London[20]
* 1905 Royal Medal of the Royal Society of London
* 1922 Knight Grand Cross of the Most Excellent Order of the British Empire[36]
* 1922 President of the British Association for the year 1922–1923[37]
* 1924 Order of Merit
* 1927 Copley Medal
* 1932 Nobel Prize for Physiology or Medicine

At the time of his death Sherrington received honoris causa Doctors from twenty-two universities: Oxford, Paris, Manchester, Strasbourg, Louvain, Uppsala, Lyon, Budapest, Athens, London, Toronto, Harvard, Dublin, Edinburgh, Montreal, Liverpool, Brussels, Sheffield, Bern, Birmingham, Glasgow, and the University of Wales.[1]

### Eponyms

Liddell-Sherrington reflex
Associated with Edward George Tandy Liddell and Charles Scott Sherrington, the Liddell-Sherrington reflex is the tonic contraction of muscle in response to its being stretched. When a muscle lengthens beyond a certain point, the myotatic reflex causes it to tighten and attempt to shorten. This can be felt as tension during stretching exercises.

Schiff-Sherrington reflex
Associated with Moritz Schiff and Charles Scott Sherrington, describes a grave sign in animals: rigid extension of the forelimbs after damage to the spine. It may be accompanied by paradoxical respiration – the intercostal muscles are paralysed and the chest is drawn passively in and out by the diaphragm.

Sherrington's First Law
Every posterior spinal nerve root supplies a particular area of the skin, with a certain overlap of adjacent dermatomes.

Sherrington's Second Law
The law of reciprocal innervation. When contraction of a muscle is stimulated, there is a simultaneous inhibition of its antagonist. It is essential for coordinated movement.

Vulpian-Heidenhain-Sherrington phenomenon
Associated with Rudolf Peter Heinrich Heidenhain, Edmé Félix Alfred Vulpian, and Charles Scott Sherrington. Describes the slow contraction of denervated skeletal muscle by stimulating autonomic cholinergic fibres innervating its blood vessels.

## See also

* List of presidents of the Royal Society

## References

1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 Liddell, E. G. T. (1952). "Charles Scott Sherrington. 1857-1952". Obituary Notices of Fellows of the Royal Society 8 (21): 241–270. doi:10.1098/rsbm.1952.0016.
2. ↑ Todman, Donald (2008). "Howard Florey and research on the cerebral circulation". Journal of Clinical Neuroscience 15 (6): 613–616. doi:10.1016/j.jocn.2007.04.017. PMID 18280740. "His mentor was the neurophysiologist and Nobel Laureate, Sir Charles Sherrington who directed him in neuroscience research. Florey's initial studies on the cerebral circulation represent an original contribution to medical knowledge and highlight his remarkable scientific method. The mentorship and close personal relationship with Sherrington was a crucial factor in Florey's early research career.".
3. ↑ Sherrington, C. E. (1975). "Charles Scott Sherrington (1857–1952)". Notes and Records of the Royal Society of London 30 (1): 45–63. doi:10.1098/rsnr.1975.0005. PMID 11615580.
4. ↑ 4.0 4.1 Sherrington, Charles Scott (1906). The integrative action of the nervous system (1st ed.). Oxford University Press: H. Milford. pp. xvi, 411 p., [19] leaves of plates.
5. ↑ ""Sir Charles Sherrington – Nobel Lecture: Inhibition as a Coordinative Factor".". https://www.nobelprize.org/nobel_prizes/medicine/laureates/1932/sherrington-lecture.html.
6. ↑ "Sir Charles Scott Sherrington". Encyclopædia Britannica, Inc. http://www.britannica.com/nobelprize/article-9067325.
7. ↑ 7.0 7.1 7.2 Pearce, J. M. (2004). "Sir Charles Scott Sherrington (1857–1952) and the synapse". Journal of Neurology, Neurosurgery, and Psychiatry 75 (4): 544. doi:10.1136/jnnp.2003.017921. PMID 15026492.
8. ↑ Penfield, W. (1962). "Sir Charles Sherrington, O.M., F.R.S. (1857–1952): An Appreciation". Notes and Records of the Royal Society 17 (2): 163–168. doi:10.1098/rsnr.1962.0015.
9. ↑ Miss nobel-id as parameter , accessed 11 October 2020
10. ↑ GRO index: 1848 Dec, Yarmouth 13, 258
11. ↑ Will of James Norton Sherrington, proved at London 5 March 1849, National Archives Catalogue Reference:Prob 11/2090, image 171
12. ↑ "1861 England, Wales & Scotland Census Transcription". Findmypast. 1861. http://search.findmypast.co.uk/record?id=gbc/1861/0000814743.
13. ↑ "1871 England, Wales & Scotland Census Transcription". Findmypast. 1871. http://search.findmypast.co.uk/record?id=gbc/1871/0007481271.
14. ↑ GRO marriages index: 1880 Dec, Ipswich 4a, 1377
15. ↑ Anon (1895). "Obituary: Mr. Caleb Rose". BMJ 2 (1820): 1266. doi:10.1136/bmj.2.1820.1266-a.
16. ↑ Moss, Chris; Hunter, Susan (2020). "Charles Scott Sherrington's origins". Journal of Medical Biography 28 (1): 3–7. doi:10.1177/0967772017746271. PMID 29998781.
17. ↑ Nobel Prizes and Notable Discoveries, Erling Norrby, The Royal Swedish Academy of Sciences, Sweden, World Scientific Publishing, 2016, p. 24
18. ↑ Ipswich Town: A History, Susan Gardiner, Amberley Publishing, 2009, Chapter 2: Origins.
19. ↑ Reflexes and Motor Integration: Sherrington's Concept of Integrative Action, Judith P. Swazey, Harvard University Press, 1969, p. 211
20. ↑ 20.00 20.01 20.02 20.03 20.04 20.05 20.06 20.07 20.08 20.09 20.10 20.11 20.12 Eccles, J.; Gibson, W. (1979). Sherrington: His Life and Thought. Berlin; New York: Springer International. pp. 1–6, 15, 24–25. ISBN 978-0-387-09063-4. https://archive.org/details/sherringtonhisli0000eccl/page/1.
21. ↑ 21.0 21.1 Karl Grandin, ed (1932). "Sir Charles Sherrington Biography". Les Prix Nobel. The Nobel Foundation. http://nobelprize.org/nobel_prizes/medicine/laureates/1932/sherrington-bio.html.
22. ↑ 22.0 22.1 22.2 22.3 22.4 22.5 22.6 Kusurkar, R. A. (2004). "Sir Charles Sherrington (1857–1952)". Journal of Postgraduate Medicine 50 (3): 238–239. PMID 15377819.
23. ↑ Granit, R. (1967). Charles Scott Sherrington: An Appraisal. Garden City, NY: Doubleday. pp. 3. OCLC 573353.
24. ↑ "Sherrington, Charles Scott (SHRN879CS)". A Cambridge Alumni Database. University of Cambridge. http://venn.lib.cam.ac.uk/cgi-bin/search-2018.pl?sur=&suro=w&fir=&firo=c&cit=&cito=c&c=all&z=all&tex=SHRN879CS&sye=&eye=&col=all&maxcount=50.
25. ↑ University of Cambridge Calendar, 1894-95, p. 330
26. ↑ 26.0 26.1 "Sir Charles Scott Sherrington". Who Named It?. 2008. http://www.whonamedit.com/doctor.cfm/2266.html-30k-.
27. ↑ 27.0 27.1 27.2 Gibson, W.C. (2001). "Chapter 1: Sir Charles Sherrington, O.M., P.R.S. (1857–1952)". Twentieth Century Neurology: The British Contribution. London: Imperial College Press. pp. 4–6. ISBN 978-1-86094-245-7. http://www.worldscibooks.com/medsci/etextbook/p210/p210_chap1.pdf. Retrieved 27 April 2008.
28. ↑ Molnar, Zoltan; Brown, Richard (June 2010). "Insights into the life and work of Sir Charles Sherrington". Nature Reviews Neuroscience 11 (6): 429–436. doi:10.1038/nrn2835. PMID 20445541.
29. ↑ "Sir Charles Sherrington". http://www.oxonblueplaques.org.uk/plaques/sherrington.html.
30. ↑ Ipswich Museum Records.
31. ↑ 31.0 31.1 Burke, RE (April 2007). "Sir Charles Sherrington's the integrative action of the nervous system: a centenary appreciation". Brain 130 (Pt 4): 887–94. doi:10.1093/brain/awm022. PMID 17438014.
32. ↑ Cowan, W. Maxwell; Südhof, Thomas C.; Stevens, Charles F. (2003). Synapses. JHU Press. p. 11. ISBN 9780801871184. https://books.google.com/books?id=FO5efrKGVQoC&q=Sherrington. Retrieved 9 June 2020.
33. ↑ Charles Scott Sherrington R. Scott Spurlock, University of Edinburgh
34. ↑ Sherrington, Man on his Nature (Cambridge, 1940), pp. 51–61
35. ↑ Quiroga, Rodrigo Quian (2013). "Gnostic cells in the 21st century". Acta Neurobiol. Exp. 73 (4): 1–9. PMID 24457638. https://www2.le.ac.uk/centres/csn/documents/gnostic-cells-in-the-xxi-century.
36. ↑ No. 32563. 31 December 1921. p. 10716. https://www.thegazette.co.uk/London/issue/32563/supplement/10716
37. ↑ Sherrington's Presidential Address to the British Association Meeting, held at Hull in 1922

## External links

* Miss nobel-id as parameter
* Gibson, W.C. (2001). Twentieth Century Neurology, The British Contribution – first chapter. Imperial College Press. ISBN 978-1-86094-245-7. http://www.worldscibooks.com/medsci/etextbook/p210/p210_chap1.pdf. Retrieved 27 April 2008.
* "Sir Charles Sherrington's Histology Demonstration Slides". History of Medical Sciences. University of Oxford. https://history.medsci.ox.ac.uk/cslide/collections/index/77.

Professional and academic associations

Preceded by
J. J. Thomson | 43rd President of the Royal Society
1920–1925  | Succeeded by
Ernest Rutherford

* v
* t
* e

Copley Medallists (1901–1950)

* Josiah Willard Gibbs (1901)
* Joseph Lister (1902)
* Eduard Suess (1903)
* William Crookes (1904)
* Dmitri Mendeleev (1905)
* Élie Metchnikoff (1906)
* Albert A. Michelson (1907)
* Alfred Russel Wallace (1908)
* George William Hill (1909)
* Francis Galton (1910)
* George Darwin (1911)
* Felix Klein (1912)
* Ray Lankester (1913)
* J. J. Thomson (1914)
* Ivan Pavlov (1915)
* James Dewar (1916)
* Pierre Paul Émile Roux (1917)
* Hendrik Lorentz (1918)
* William Bayliss (1919)
* Horace Tabberer Brown (1920)
* Joseph Larmor (1921)
* Ernest Rutherford (1922)
* Horace Lamb (1923)
* Edward Albert Sharpey-Schafer (1924)
* Albert Einstein (1925)
* Frederick Gowland Hopkins (1926)
* Charles Scott Sherrington (1927)
* Charles Algernon Parsons (1928)
* Max Planck (1929)
* William Henry Bragg (1930)
* Arthur Schuster (1931)
* George Ellery Hale (1932)
* Theobald Smith (1933)
* John Scott Haldane (1934)
* Charles Thomson Rees Wilson (1935)
* Arthur Evans (1936)
* Henry Hallett Dale (1937)
* Niels Bohr (1938)
* Thomas Hunt Morgan (1939)
* Paul Langevin (1940)
* Thomas Lewis (1941)
* Robert Robinson (1942)
* Joseph Barcroft (1943)
* Geoffrey Ingram Taylor (1944)
* Oswald Avery (1945)
* Edgar Douglas Adrian (1946)
* G. H. Hardy (1947)
* Archibald Hill (1948)
* George de Hevesy (1949)
* James Chadwick (1950)

* v
* t
* e

Laureates of the Nobel Prize in Physiology or Medicine

1901–1925|

* 1901: Emil Behring
* 1902: Ronald Ross
* 1903: Niels Finsen
* 1904: Ivan Pavlov
* 1905: Robert Koch
* 1906: Camillo Golgi / Santiago Ramón y Cajal
* 1907: Alphonse Laveran
* 1908: Élie Metchnikoff / Paul Ehrlich
* 1909: Emil Kocher
* 1910: Albrecht Kossel
* 1911: Allvar Gullstrand
* 1912: Alexis Carrel
* 1913: Charles Richet
* 1914: Róbert Bárány
* 1915
* 1916
* 1917
* 1918
* 1919: Jules Bordet
* 1920: August Krogh
* 1921
* 1922: Archibald Hill / Otto Meyerhof
* 1923: Frederick Banting / John Macleod
* 1924: Willem Einthoven
* 1925

1926–1950|

* 1926: Johannes Fibiger
* 1927: Julius Wagner-Jauregg
* 1928: Charles Nicolle
* 1929: Christiaan Eijkman / Frederick Gowland Hopkins
* 1930: Karl Landsteiner
* 1931: Otto Warburg
* 1932: Charles Scott Sherrington / Edgar Adrian
* 1933: Thomas Morgan
* 1934: George Whipple / George Minot / William Murphy
* 1935: Hans Spemann
* 1936: Henry Dale / Otto Loewi
* 1937: Albert Szent-Györgyi
* 1938: Corneille Heymans
* 1939: Gerhard Domagk
* 1940
* 1941
* 1942
* 1943: Henrik Dam / Edward Doisy
* 1944: Joseph Erlanger / Herbert Gasser
* 1945: Alexander Fleming / Ernst Chain / Howard Florey
* 1946: Hermann Muller
* 1947: Carl Cori / Gerty Cori / Bernardo Houssay
* 1948: Paul Müller
* 1949: Walter Hess / António Egas Moniz
* 1950: Edward Kendall / Tadeusz Reichstein / Philip Hench

1951–1975|

* 1951: Max Theiler
* 1952: Selman Waksman
* 1953: Hans Krebs / Fritz Lipmann
* 1954: John Enders / Thomas Weller / Frederick Robbins
* 1955: Hugo Theorell
* 1956: André Cournand / Werner Forssmann / Dickinson W. Richards
* 1957: Daniel Bovet
* 1958: George Beadle / Edward Tatum / Joshua Lederberg
* 1959: Severo Ochoa / Arthur Kornberg
* 1960: Frank Burnet / Peter Medawar
* 1961: Georg von Békésy
* 1962: Francis Crick / James Watson / Maurice Wilkins
* 1963: John Eccles / Alan Hodgkin / Andrew Huxley
* 1964: Konrad Bloch / Feodor Lynen
* 1965: François Jacob / André Lwoff / Jacques Monod
* 1966: Francis Rous / Charles B. Huggins
* 1967: Ragnar Granit / Haldan Hartline / George Wald
* 1968: Robert W. Holley / Har Khorana / Marshall Nirenberg
* 1969: Max Delbrück / Alfred Hershey / Salvador Luria
* 1970: Bernard Katz / Ulf von Euler / Julius Axelrod
* 1971: Earl Sutherland Jr.
* 1972: Gerald Edelman / Rodney Porter
* 1973: Karl von Frisch / Konrad Lorenz / Nikolaas Tinbergen
* 1974: Albert Claude / Christian de Duve / George Palade
* 1975: David Baltimore / Renato Dulbecco / Howard Temin

1976–2000|

* 1976: Baruch Blumberg / Daniel Gajdusek
* 1977: Roger Guillemin / Andrew Schally / Rosalyn Yalow
* 1978: Werner Arber / Daniel Nathans / Hamilton O. Smith
* 1979: Allan Cormack / Godfrey Hounsfield
* 1980: Baruj Benacerraf / Jean Dausset / George Snell
* 1981: Roger Sperry / David H. Hubel / Torsten Wiesel
* 1982: Sune Bergström / Bengt I. Samuelsson / John Vane
* 1983: Barbara McClintock
* 1984: Niels Jerne / Georges Köhler / César Milstein
* 1985: Michael Brown / Joseph L. Goldstein
* 1986: Stanley Cohen / Rita Levi-Montalcini
* 1987: Susumu Tonegawa
* 1988: James W. Black / Gertrude B. Elion / George H. Hitchings
* 1989: J. Michael Bishop / Harold E. Varmus
* 1990: Joseph Murray / E. Donnall Thomas
* 1991: Erwin Neher / Bert Sakmann
* 1992: Edmond Fischer / Edwin G. Krebs
* 1993: Richard J. Roberts / Phillip Sharp
* 1994: Alfred G. Gilman / Martin Rodbell
* 1995: Edward B. Lewis / Christiane Nüsslein-Volhard / Eric F. Wieschaus
* 1996: Peter C. Doherty / Rolf M. Zinkernagel
* 1997: Stanley B. Prusiner
* 1998: Robert F. Furchgott / Louis Ignarro / Ferid Murad
* 1999: Günter Blobel
* 2000: Arvid Carlsson / Paul Greengard / Eric Kandel

2001–present|

* 2001: Leland H. Hartwell / Tim Hunt / Paul Nurse
* 2002: Sydney Brenner / H. Robert Horvitz / John E. Sulston
* 2003: Paul Lauterbur / Peter Mansfield
* 2004: Richard Axel / Linda B. Buck
* 2005: Barry Marshall / Robin Warren
* 2006: Andrew Fire / Craig Mello
* 2007: Mario Capecchi / Martin Evans / Oliver Smithies
* 2008: Harald zur Hausen / Luc Montagnier / Françoise Barré-Sinoussi
* 2009: Elizabeth Blackburn / Carol W. Greider / Jack W. Szostak
* 2010: Robert G. Edwards
* 2011: Bruce Beutler / Jules A. Hoffmann / Ralph M. Steinman (posthumously)
* 2012: John Gurdon / Shinya Yamanaka
* 2013: James Rothman / Randy Schekman / Thomas C. Südhof
* 2014: John O'Keefe / May-Britt Moser / Edvard Moser
* 2015: William C. Campbell / Satoshi Ōmura / Tu Youyou
* 2016: Yoshinori Ohsumi
* 2017: Jeffrey C. Hall / Michael Rosbash / Michael W. Young
* 2018: James P. Allison / Tasuku Honjo
* 2019: Gregg L. Semenza / Peter J. Ratcliffe / William Kaelin Jr.

* v
* t
* e

Presidents of the Royal Society

17th century|

* Viscount Brouncker (1662)
* Joseph Williamson (1677)
* Christopher Wren (1680)
* John Hoskyns (1682)
* Cyril Wyche (1683)
* Samuel Pepys (1684)
* Earl of Carbery (1686)
* Earl of Pembroke (1689)
* Robert Southwell (1690)
* Charles Montagu (1695)
* Lord Somers (1698)

18th century|

* Isaac Newton (1703)
* Hans Sloane (1727)
* Martin Folkes (1741)
* Earl of Macclesfield (1752)
* Earl of Morton (1764)
* James Burrow (1768)
* James West (1768)
* James Burrow (1772)
* John Pringle (1772)
* Joseph Banks (1778)

19th century|

* William Hyde Wollaston (1820)
* Humphry Davy (1820)
* Davies Gilbert (1827)
* Duke of Sussex (1830)
* Marquess of Northampton (1838)
* Earl of Rosse (1848)
* Lord Wrottesley (1854)
* Benjamin Collins Brodie (1858)
* Edward Sabine (1861)
* George Biddell Airy (1871)
* Joseph Dalton Hooker (1873)
* William Spottiswoode (1878)
* Thomas Henry Huxley (1883)
* George Gabriel Stokes (1885)
* William Thomson (1890)
* Joseph Lister (1895)

20th century|

* William Huggins (1900)
* Lord Rayleigh (1905)
* Archibald Geikie (1908)
* William Crookes (1913)
* J. J. Thomson (1915)
* Charles Scott Sherrington (1920)
* Ernest Rutherford (1925)
* Frederick Gowland Hopkins (1930)
* William Henry Bragg (1935)
* Henry Hallett Dale (1940)
* Robert Robinson (1945)
* Lord Adrian (1950)
* Cyril Norman Hinshelwood (1955)
* Howard Florey (1960)
* Patrick Blackett (1965)
* Alan Lloyd Hodgkin (1970)
* Lord Todd (1975)
* Andrew Huxley (1980)
* George Porter (1985)
* Sir Michael Atiyah (1990)
* Sir Aaron Klug (1995)

21st century|

* Lord May (2000)
* Lord Rees (2005)
* Sir Paul Nurse (2010)
* Venki Ramakrishnan (2015)

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Original source: https://en.wikipedia.org/wiki/Charles Scott Sherrington. Read more

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