David Eisner (physiologist)

David Eisner

David A. Eisner in 2016

Born|

David Alfred Eisner

(1955-01-03) 3 January 1955 (age 71)

Manchester[1]

Awards| Physiological Society Annual Review Prize Lecture (2017)
Scientific career
Institutions| University College London, University of Liverpool, University of Manchester
Thesis| The effects of sodium pump inhibition on the electrical and mechanical properties of mammalian cardiac muscle. (1979)
Doctoral advisor| Denis Noble

David Alfred Eisner, FRCP (Hon), FMedSci,[2] (born 3 January 1955)[1][3] is British Heart Foundation Professor of Cardiac Physiology at the University of Manchester and editor-in-chief of The Journal of General Physiology (JGP).[4]

## Contents

* 1 Education
* 2 Career
* 3 Research
* 4 Personal life
* 5 Honours and awards
* 6 References

## Education

Eisner was born in 1955 in Manchester, the son of the physicist and writer Herbert Eisner.[5][3][6] After attending Manchester Grammar School, he received his B.A. in natural sciences at King's College, Cambridge in 1976. In 1979 he obtained a D.Phil. in physiology at Oxford University in the laboratory of Denis Noble for work on the sodium pump in cardiac muscle.

## Career

Following postdoctoral research at the University of Cambridge on the kinetics of the sodium pump[7] in the laboratory of Ian Glynn, he took up a lectureship in the Department of Physiology at University College London in 1980. In 1990 he moved to The University of Liverpool as professor of veterinary biology. In 1999 he took up a chair of cardiac physiology at the University of Manchester and, in 2000, was awarded the BHF Chair of Cardiac Physiology.[8]

Eisner was chair of the editorial board of The Journal of Physiology from 1997 to 2000[9] and editor-in chief of the Journal of Molecular and Cellular Cardiology from 2007 to 2016. He was president of The Physiological Society from 2016 to 2018.

## Research

Eisner's early research focused on the regulation of intracellular sodium in cardiac muscle and the effects on contraction.[10] He then investigated the control of intracellular calcium concentration[11] and its role in the production of arrhythmias.[12] He has identified the factors that regulate the calcium content of the sarcoplasmic reticulum[13][14] and how this is altered in disease.[15] His recent research has focused on the control of diastolic calcium[16][17] and the effects of calcium buffering.[18] He has also written [19] and spoken [20] about scientific reproducibility and fraud.

## Personal life

Eisner is married to Susan Wray, professor of cellular and molecular physiology at the University of Liverpool, with whom he has three children.[6]

## Honours and awards

Eisner was elected as a Fellow of The Academy of Medical Sciences in 1999[21] and The International Society for Heart Research in 2001.[22] and as a Member of Academia Europaea in 2007.[23] He was elected to Honorary Fellowship of The Royal College of Physicians in 2010. In 2018 he received an honorary doctorate, Doctor Honoris Causa, from The University of Debrecen.[24] Prizes awarded to him include: The GL Brown[25][26] and Annual Review Lecture[27] of The Physiological Society; the Keith Reimer Lecture[28][29] and the Peter Harris Distinguished Scientist Award of the International Society for Heart Research; the Carmeliet-Coraboeuf-Weidmann Lecture of the European Working Group on Cardiac Cellular Electrophysiology[30]; the Fabio Ruzzier Lecture of The Italian Physiological Society. [31] He has also delivered the Burdon-Sanderson Lecture (Oxford) in 2013.[32]

## References

1. ↑ 1.0 1.1 "CURRICULUM VITAE – David Alfred Eisner". Academia Europaea. November 2009. http://www.ae-info.org/attach/User/Eisner_David/CV/eisner_david_november2009_cv.pdf.
2. ↑ "Professor of Cardiac Physiology: Prof David Eisner M.A. D.Phil, FRCP (Hon), FMedSci". University of Manchester. https://www.research.manchester.ac.uk/portal/eisner.html.
3. ↑ 3.0 3.1 ‘EISNER, Prof. David Alfred’, Who's Who 2017, A & C Black, an imprint of Bloomsbury Publishing plc, 2017; online edn, Oxford University Press, 2016 ; online edn, Nov 2016
4. ↑ "Editors and Staff". https://rupress.org/jgp/pages/editors-and-staff.
5. ↑ "Herbert Eisner". The Daily Telegraph. 28 July 2011. ISSN 0307-1235. https://www.telegraph.co.uk/news/obituaries/science-obituaries/8668910/Herbert-Eisner.html.
6. ↑ 6.0 6.1 "European Perspectives". Circulation 122 (3). 20 July 2010. doi:10.1161/cir.0b013e3181e8eb7f. ISSN 0009-7322.
7. ↑ "The interaction of potassium ions and ATP on the sodium pump of resealed red cell ghosts". The Journal of Physiology 319: 403–18. 1981. doi:10.1113/jphysiol.1981.sp013917. PMID 7320919.
8. ↑ "BHF Professor David Eisner – heart attack and arrhythmias". British Heart Foundation. https://www.bhf.org.uk/research/our-top-professors/professor-david-eisner.
9. ↑ "Past Officers of the Physiological Society (1876–2001)". physoc.org. http://www.physoc.org/sites/default/files/page/Past Officers.pdf.
10. ↑ "The dependence of sodium pumping and tension on intracellular sodium activity in voltage-clamped sheep Purkinje fibres". The Journal of Physiology 317: 163–87. August 1981. doi:10.1113/jphysiol.1981.sp013819. PMID 7310731.
11. ↑ "Factors influencing free intracellular calcium concentration in quiescent ferret ventricular muscle". The Journal of Physiology 350: 615–30. May 1984. doi:10.1113/jphysiol.1984.sp015221. PMID 6747860.
12. ↑ "Oscillations of intracellular Ca2+ in mammalian cardiac muscle". Nature 304 (5928): 735–8. 1983. doi:10.1038/304735a0. PMID 6888540. Bibcode: 1983Natur.304..735O.
13. ↑ "The control of Ca release from the cardiac sarcoplasmic reticulum: regulation versus autoregulation". Cardiovascular Research 38 (3): 589–604. June 1998. doi:10.1016/s0008-6363(98)00062-5. PMID 9747428.
14. ↑ "Coordinated control of cell Ca(2+) loading and triggered release from the sarcoplasmic reticulum underlies the rapid inotropic response to increased L-type Ca(2+) current". Circulation Research 88 (2): 195–201. February 2001. doi:10.1161/01.res.88.2.195. PMID 11157672.
15. ↑ "In the RyR2(R4496C) mouse model of CPVT, β-adrenergic stimulation induces Ca waves by increasing SR Ca content and not by decreasing the threshold for Ca waves". Circulation Research 107 (12): 1483–9. December 2010. doi:10.1161/CIRCRESAHA.110.227744. PMID 20966392.
16. ↑ Eisner, David A.; Caldwell, Jessica L.; Trafford, Andrew W.; Hutchings, David C. (31 January 2020). "The Control of Diastolic Calcium in the Heart: Basic Mechanisms and Functional Implications". Circulation Research 126 (3): 395–412. doi:10.1161/CIRCRESAHA.119.315891. ISSN 0009-7330. PMID 31999537.
17. ↑ "i regulates diastolic levels in rat ventricular myocytes". The Journal of Physiology 595 (16): 5545–5555. August 2017. doi:10.1113/JP274366. PMID 28617952.
18. ↑ "Calcium Buffering in the Heart in Health and Disease". Circulation 139 (20): 2358–2371. May 2019. doi:10.1161/CIRCULATIONAHA.118.039329. PMID 31082292.
19. ↑ Eisner, D. A. (January 2018). "Reproducibility of science: Fraud, impact factors and carelessness". Journal of Molecular and Cellular Cardiology 114: 364–368. doi:10.1016/j.yjmcc.2017.10.009. ISSN 1095-8584. PMID 29079076.
20. ↑ "Does the 'system' reward fraud?". https://www.youtube.com/watch?v=vAlDrx5IJ2c.
21. ↑ "Professor David Eisner | The Academy of Medical Sciences". Acmedsci.ac.uk. https://acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/fellow/Professor-David-Eisner-0005695.
22. ↑ "Fellows of the ISHR". International Society for Heart Research. http://www.ishrworld.org/?page=Fellows.
23. ↑ "Academy of Europe: Eisner David". Ae-info.org. http://www.ae-info.org/ae/Member/Eisner_David.
24. ↑ születnek, www.WebDeb.hu – ahol a weblapok. "University of Debrecen -". https://edu.unideb.hu/news.php?id=476.
25. ↑ "GL Brown Prize Lecture | Physiological Society". Physoc.org. 29 May 2011. http://www.physoc.org/gl-brown-prize-lecture.
26. ↑ "Calcium in the heart: from physiology to disease – David Eisner (GL Brown Lecture 2014)". 16 May 2014. https://www.youtube.com/watch?v=VXSJkq5Dk8o.
27. ↑ "Ups and downs of calcium in the heart". The Journal of Physiology 596 (1): 19–30. January 2018. doi:10.1113/JP275130. PMID 29071725.
28. ↑ "ISHR Hall of Fame". International Society for Heart Research. http://www.ishrworld.org/?page=PastAwardRecipients#Reimer.
29. ↑ "What role does modulation of the ryanodine receptor play in cardiac inotropy and arrhythmogenesis?". Journal of Molecular and Cellular Cardiology 46 (4): 474–81. April 2009. doi:10.1016/j.yjmcc.2008.12.005. PMID 19150449.
30. ↑ escardio (25 October 2013). The Carmeliet-Coraboeuf-Weidmann Lecture – David Eisner. https://www.slideshare.net/escardio/eisner-ccw-lecture-for-website.
31. ↑ "Lectures". https://www.feps-sif2019.com/lectures/.
32. ↑ "Sir John Burdon-Sanderson Prize Lecture Series – Physiology, Anatomy and Genetics". University of Oxford. https://www.dpag.ox.ac.uk/about-us/john-burdon-sanderson-lecture.

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