Emily Bernstein

Alma mater| State University of New York at Stony Brook
Scientific career
Institutions| Mount Sinai College of Medicine
Thesis| Dicer, a novel RNase III, is required for RNA interference and development (2003)
Doctoral advisor| Gregory Hannon

Emily Bernstein is a professor at Mount Sinai School of Medicine known for her research on RNA interference, epigenetics, and cancer, especially melanoma.

## Contents

* 1 Education and career
* 2 Research
* 3 Selected publications
* 4 Awards and honors
* 5 References
* 6 External links

## Education and career

Bernstein received her B.S. from McGill University in 1998 and earned a Ph.D. from Stony Brook University in 2003.[1] Following her Ph.D. she was a postdoctoral researcher at Rockefeller University where she worked with David Allis.[2] In 2008 she moved to Mount Sinai School of Medicine where, as of 2022, she is a professor in the department of oncology and dermatology.[3]

## Research

Bernstein is known for her research on RNA interference, epigenetics, and cell development. Her early research examined the enzyme Dicer, its role in cell development in mice,[4] and RNA interference.[5] While a postdoctoral researcher she examined linkages between non-coding RNA and chromatin[6][7] and DNA methylation.[8] Subsequently, she has worked on histones,[9][10] gene silencing,[11] and tumor cell development.[12][13] In 2022 her team discovered alterations to a gene which can lead to melanoma.[14][15]

## Selected publications

* Bernstein, Emily; Caudy, Amy A.; Hammond, Scott M.; Hannon, Gregory J. (2001). "Role for a bidentate ribonuclease in the initiation step of RNA interference" (in en). Nature 409 (6818): 363–366. doi:10.1038/35053110. ISSN 0028-0836. PMID 11201747. http://www.nature.com/articles/35053110.
* Hammond, Scott M.; Bernstein, Emily; Beach, David; Hannon, Gregory J. (2000). "An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells" (in en). Nature 404 (6775): 293–296. doi:10.1038/35005107. ISSN 0028-0836. PMID 10749213. Bibcode: 2000Natur.404..293H. http://www.nature.com/articles/35005107.
* Goldberg, Aaron D.; Allis, C. David; Bernstein, Emily (2007-02-23). "Epigenetics: A Landscape Takes Shape" (in English). Cell 128 (4): 635–638. doi:10.1016/j.cell.2007.02.006. ISSN 0092-8674. PMID 17320500.
* Bernstein, Emily; Kim, Sang Yong; Carmell, Michelle A; Murchison, Elizabeth P; Alcorn, Heather; Li, Mamie Z; Mills, Alea A; Elledge, Stephen J et al. (2003-11-01). "Dicer is essential for mouse development" (in en). Nature Genetics 35 (3): 215–217. doi:10.1038/ng1253. ISSN 1061-4036. PMID 14528307. http://www.nature.com/articles/ng1253.

## Awards and honors

In 2014 Bernstein received a young investigators award from the Pershing Square Foundation.[16]

## References

1. ↑ "Speakers". 2022-05-15. https://wistar.org/speakers-0.
2. ↑ "Investigator | Bernstein Laboratory". 2015-04-16. https://labs.icahn.mssm.edu/bernsteinlab/team/investigator/.
3. ↑ "Emily Bernstein | Mount Sinai – New York" (in en-US). https://www.mountsinai.org/profiles/emily-bernstein.
4. ↑ Bernstein, Emily; Kim, Sang Yong; Carmell, Michelle A; Murchison, Elizabeth P; Alcorn, Heather; Li, Mamie Z; Mills, Alea A; Elledge, Stephen J et al. (2003-11-01). "Dicer is essential for mouse development" (in en). Nature Genetics 35 (3): 215–217. doi:10.1038/ng1253. ISSN 1061-4036. PMID 14528307. http://www.nature.com/articles/ng1253.
5. ↑ Bernstein, Emily; Caudy, Amy A.; Hammond, Scott M.; Hannon, Gregory J. (2001). "Role for a bidentate ribonuclease in the initiation step of RNA interference" (in en). Nature 409 (6818): 363–366. doi:10.1038/35053110. ISSN 0028-0836. PMID 11201747. http://www.nature.com/articles/35053110.
6. ↑ Bernstein, Emily; Allis, C. David (2005-07-15). "RNA meets chromatin" (in en). Genes & Development 19 (14): 1635–1655. doi:10.1101/gad.1324305. ISSN 0890-9369. PMID 16024654.
7. ↑ Bernstein, Emily; Duncan, Elizabeth M.; Masui, Osamu; Gil, Jesus; Heard, Edith; Allis, C. David (2006). "Mouse Polycomb Proteins Bind Differentially to Methylated Histone H3 and RNA and Are Enriched in Facultative Heterochromatin" (in en). Molecular and Cellular Biology 26 (7): 2560–2569. doi:10.1128/MCB.26.7.2560-2569.2006. ISSN 0270-7306. PMID 16537902.
8. ↑ Ooi, Steen K. T.; Qiu, Chen; Bernstein, Emily; Li, Keqin; Jia, Da; Yang, Zhe; Erdjument-Bromage, Hediye; Tempst, Paul et al. (2007). "DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA" (in en). Nature 448 (7154): 714–717. doi:10.1038/nature05987. ISSN 0028-0836. PMID 17687327. Bibcode: 2007Natur.448..714O.
9. ↑ Gaspar-Maia, Alexandre; Qadeer, Zulekha A.; Hasson, Dan; Ratnakumar, Kajan; Adrian Leu, N.; Leroy, Gary; Liu, Shichong; Costanzi, Carl et al. (2013-06-26). "MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency" (in en). Nature Communications 4 (1): 1565. doi:10.1038/ncomms2582. ISSN 2041-1723. PMID 23463008. Bibcode: 2013NatCo...4.1565G.
10. ↑ Vardabasso, Chiara; Hasson, Dan; Ratnakumar, Kajan; Chung, Chi-Yeh; Duarte, Luis F.; Bernstein, Emily (2014). "Histone variants: emerging players in cancer biology" (in en). Cellular and Molecular Life Sciences 71 (3): 379–404. doi:10.1007/s00018-013-1343-z. ISSN 1420-682X. PMID 23652611.
11. ↑ Chicas, Agustin; Kapoor, Avnish; Wang, Xiaowo; Aksoy, Ozlem; Evertts, Adam G.; Zhang, Michael Q.; Garcia, Benjamin A.; Bernstein, Emily et al. (2012-06-05). "H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence" (in en). Proceedings of the National Academy of Sciences 109 (23): 8971–8976. doi:10.1073/pnas.1119836109. ISSN 0027-8424. PMID 22615382. Bibcode: 2012PNAS..109.8971C.
12. ↑ Sosa, Maria Soledad; Parikh, Falguni; Maia, Alexandre Gaspar; Estrada, Yeriel; Bosch, Almudena; Bragado, Paloma; Ekpin, Esther; George, Ajish et al. (2015). "NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes" (in en). Nature Communications 6 (1): 6170. doi:10.1038/ncomms7170. ISSN 2041-1723. PMID 25636082. Bibcode: 2015NatCo...6.6170S.
13. ↑ Strub, Thomas; Ghiraldini, Flavia G.; Carcamo, Saul; Li, Man; Wroblewska, Aleksandra; Singh, Rajendra; Goldberg, Matthew S.; Hasson, Dan et al. (2018). "SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling" (in en). Nature Communications 9 (1): 3440. doi:10.1038/s41467-018-05966-z. ISSN 2041-1723. PMID 30143629. Bibcode: 2018NatCo...9.3440S.
14. ↑ "Scientists discover gene mutation that signals aggressive melanoma" (in en). April 6, 2022. https://www.sciencedaily.com/releases/2022/04/220406160555.htm.
15. ↑ Carcamo, Saul; Nguyen, Christie B.; Grossi, Elena; Filipescu, Dan; Alpsoy, Aktan; Dhiman, Alisha; Sun, Dan; Narang, Sonali et al. (2022-04-05). "Altered BAF occupancy and transcription factor dynamics in PBAF-deficient melanoma" (in English). Cell Reports 39 (1). doi:10.1016/j.celrep.2022.110637. ISSN 2211-1247. PMID 35385731.
16. ↑ Benson, Barbara (May 5, 2014). "Wall Street funds cancer-research up-and-comers". Crain's New York Business; New York 30 (18): p. 22. .

## External links

* Emily Bernstein publications indexed by Google Scholar
* Emily Bernstein PhD – 2014 Pershing Square Sohn Prize Winner on YouTube, May 14, 2016

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