Hans Thoenen

Born| (1928-05-05)May 5, 1928

Zweisimmen, Switzerland

Died| June 23, 2012(2012-06-23) (aged 84)

Munich, Germany

Citizenship| Switzerland
Education| University of Bern (MD 1957)
Awards| Ernst Jung Gold Medal (2007)
Bristol-Myers Squibb Award (1997)
Ralph W. Gerard Prize (1995)
Neuronal Plasticity Prize (1994)
Charles A. Dana Award (1994)
Cloëtta Prize (1985)
Feldberg Award (1980)
Scientific career
Fields| neurobiology
Institutions| Max Planck Institute for Neurobiology
Max Planck Institute for Psychiatry
Biozentrum University of Basel
Hoffman-LaRoche

Hans Thoenen (born 5 May 1928 in Zweisimmen, Switzerland; died 23 June 2012 in Munich, Germany) was a Swiss neurobiologist best known for his work on neurotrophins.[1][2][3]

## Contents

* 1 Biography
* 2 Research
* 3 Awards
* 4 References

## Biography

Thoenen studied medicine at the Universities of Bern and Innsbruck, graduating in 1953 and receiving his doctorate from Bern in 1957. In 1961 he joined the research laboratories of the Swiss pharmaceutical company Hoffmann LaRoche, leaving in 1968 to spend a year working with the Axelrod group at NIMH. In 1971 he joined the newly-formed Biocentre at the University of Basel as research group leader in Neurobiology. In 1977 he relocated to Munich where the Max Planck Institute for Psychiatry had offered him the directorship of a new institute -- what is now the Max Planck Institute for Neurobiology -- which he led until his retirement in 1996.[1][3]

## Research

While testing dopamine analogues at Hoffman-LaRoche, he was surprised by the toxicity of 6-hydroxydopamine on sympathetic nerves and investigated its mechanisms of action. Its selective effect on dopaminergic neurons has made it a useful tool in animal models of Parkinson's disease.[2]

This line of research had an unexpected payoff. While working with Axelrod at NIMH, Thoenen discovered that repeated stimulation of the adrenal medulla led to increased levels of the monoamine synthesis enzyme tyrosine hydroxylase. Trans-synaptic enzyme induction had never previously been detected: it transpired that it was a general phenomenon.[2]

At Basel, his attention turned to nerve growth factor and other neurotrophins. His laboratory made a series of groundbreaking contributions to the field, including including the cloning of brain derived neurotrophic factor and ciliary neurotrophic factor. Almost all his subsequent research focused on this class of proteins, the elucidation of their physiological functions, and the factors that influenced their expression and release -- including other growth factors, the presynaptic release of neurotransmitters, glucocorticosteroids, and stress.[2] His work has been instrumental in demonstrating the importance of neurotrophins for brain plasticity (the formation and pruning of synaptic connections in, for example, learning and memory), and has pursued their relevance for remediating nerve damage and dementia.[3]

## Awards

Thoenen won the Feldberg Award (1980),[4] the Cloëtta Prize (1985),[5] the Charles A. Dana Award for Pioneering Achievement in Health (1994) and the Neuronal Plasticity Prize (1994).[6] He received the Ralph W. Gerard Prize of the Society for Neuroscience (1995)[7] and the Bristol-Myers Squibb Award for Distinguished Achievement in Neuroscience Research (1997)[8] jointly with Eric M. Shooter. He was awarded the Ernst Jung Gold Medal in 2007.[9] He was a member of the German Academy of Sciences Leopoldina[10] and a foreign member of the National Academy of Sciences.[11] He received honorary doctorates from the Universities of Würzburg and Zurich.[1]

## References

1. ↑ 1.0 1.1 1.2 "Hans Thoenen, 1928 - 2012" (in de). http://www.neuro.mpg.de/272975/1206_Thoenen.
2. ↑ 2.0 2.1 2.2 2.3 Iversen, L. L. (17 December 2012). "Hans Thoenen: A modest man whose discoveries had a lasting impact on modern neuroscience". Proceedings of the National Academy of Sciences (Proceedings of the National Academy of Sciences) 110 (1): 4–4. doi:10.1073/pnas.1218423110. ISSN 0027-8424.
3. ↑ 3.0 3.1 3.2 Squire, Larry R. (1 March 2009). "Hans Thoenen". The History of Neuroscience in Autobiography Volume 6. Oxford University Press. pp. 515–568. doi:10.1093/acprof:oso/9780195380101.003.0014. ISBN 978-0-19-538010-1. http://www.sfn.org/~/media/SfN/Documents/TheHistoryofNeuroscience/Volume 6/c14.ashx.
4. ↑ "Previous prizewinners of the Feldberg Foundation". https://www.feldbergfoundation.org/prizewinners/previous/.
5. ↑ "Cloëtta Prize" (in de). http://www.cloetta-foundation.ch/en/cloetta-prize/.
6. ↑ "Our Prizes (1983-2018)". p. 3. https://www.fondation-ipsen.org/wp-content/uploads/2018/09/Prizes-FI.pdf.
7. ↑ "Society for Neuroscience - Ralph W. Gerard Prize in Neuroscience". 15 June 2018. https://web.sfn.org:443/sfn/awards-and-funding/individual-prizes-and-fellowships/outstanding-research-and-career-awards/ralph-w-gerard-prize-in-neuroscience.
8. ↑ "Shooter honored by Bristol-Myers Squibb: 9/10/97". 1 September 2005. https://news.stanford.edu/news/1997/september10/shooter.html.
9. ↑ Grosse, Angela (12 May 2007). "Ernst-Jung-Preis für Medizin vergeben" (in de). https://www.abendblatt.de/hamburg/article107236548/Ernst-Jung-Preis-fuer-Medizin-vergeben.html.
10. ↑ "List of Members". 4 June 2018. http://www.leopoldina.org/en/members/list-of-members/member/226/.
11. ↑ "Hans Thoenen". 2 July 2015. http://www.nasonline.org/member-directory/deceased-members/3001742.html.

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