Ming-Ming Zhou

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Nationality| American
Alma mater| East China University of Science and Technology
Michigan Technological University
Purdue University
Known for| Bromodomain biology and drug discovery
Scientific career
Fields| Structural and Chemical Biology
Epigenetics
Drug Discovery
Institutions| Icahn School of Medicine at Mount Sinai
Mount Sinai Medical Center

Ming-Ming Zhou is an American scientist whose specification is structural and chemical biology, NMR spectroscopy, and drug design. He is the Dr. Harold and Golden Lamport Professor and Chairman of the Department of Pharmacological Sciences.[1] He is also the co-director of the Drug Discovery Institute at the Icahn School of Medicine at Mount Sinai and Mount Sinai Health System in New York City , as well as Professor of Sciences.[2] Zhou is an elected fellow of the American Association for the Advancement of Science.[3]

Zhou has published more than 180 research articles and is an inventor of 28 patents. His research has been funded by grants from federal, state and private research foundations including: the National Institutes of Health, the National Science Foundation, the New York State Stem Cell Science, the Institute for the Study of Aging, the American Foundation for AIDS Research, the American Cancer Society, GlaxoSmithKline, the Michael J. Fox Foundation, the Samuel Waxman Cancer Research Foundation,[4] and the Wellcome Trust. He serves on the board of directors at the New York Structural Biology Center, as well as on the editorial boards of ACS Medicinal Chemistry Letters, the Journal of Molecular Cell Biology,[5] and Cancer Research.[6]

## Contents

* 1 Biography
* 2 Research
* 3 Society membership
* 4 Awards and honors
* 5 Patents
* 6 References
* 7 External links

## Biography

Zhou earned his B.E. in chemical engineering from the East China University of Science and Technology (Shanghai, PRC) in 1984. He earned his M.S. in chemistry from the Michigan Technological University in 1988 and a Ph.D. in chemistry from Purdue University in Indiana in 1993. He completed his postdoctoral fellowship at Abbott Laboratories in Chicago, Illinois, then joined the faculty of the Mount Sinai Medical School in 1997.[citation needed]

## Research

Zhou's research is directed at better understanding the biology of epigenetic control of gene transcription of the human genome to attain both the underlying basic principles and rational design of novel chemical compounds that modulate gene expression in chromatin. His research studies have broad implications in human biology and disease, ranging from cell development, to stem cell self-renewal, differentiation, and re-programming to human cancer and inflammation, as well as neurodegenerative disorders. Among his major contributions to science are the Zhou Lab's discovery of the bromodomain as the acetyl-lysine binding domain ('chromatin reader') in gene transcription (Nature 1999)[7] and the first demonstrations of druggability and therapeutic potential of bromodomain proteins in gene transcription to treat a wide array of human diseases, including cancer and inflammation.[8] This concept has had transformative impacts in epigenetic drug discoveries in the pharmaceutical industry.[9][10]

The Zhou Lab further discovered the tandem PHD finger of DPF3b as a first alternative to the bromodomain for acetyl-lysine binding (Nature 2010),[11] and the PAZ domain as the RNA binding domain in RNAi (Nature 2003).[12] His work also addresses the role of histone lysine methylation (Nature Cell Biol. 2008)[13] and long non-coding RNA in the epigenetic control of gene transcription in human stem cell maintenance and differentiation (Mol. Cell 2010).[14]

Zhou's work in rational design of chemical probes for mechanism-driven research led to the discovery of the HIV Tat/human co-activator PCAF interaction as a potential novel anti-HIV therapy target.[15] His group has developed chemical probes that modulate the transcriptional activity of human tumor suppressor p53 under stress conditions. His recent work includes the development of a novel gene transcriptional silencing technology.[16] Additional research discoveries include structural mechanisms as well as drug target discovery and validation for human cancers, particularly triple-negative breast cancer (TNBC),[17][18] and inflammatory disorders such as inflammatory bowel disease (IBD)[19][20] and multiple sclerosis.[21]

## Society membership

Current and past society memberships include The Harvey Society, the Biophysical Society,[22] the American Chemical Society, the American Society for Biochemistry and Molecular Biology, the American Association for the Advancement of Science and the New York Academy of Sciences. He serves on multiple editorial boards and reviews grants for the American Cancer Society, the American Heart Association, the National Institutes of Health and the National Science Foundation.[citation needed]

## Awards and honors

* 2003 GlaxoSmithKline Drug Discovery and Development Award[23]
* 2009 Elected Member, The Academy of Sciences & Arts at Michigan Technological University[24]
* 2019 The Jacobi Medallion,[25] The Mount Sinai Health System

## Patents

“Methods of Identifying Modulators of the FGF Receptors” | US 7,108,984 B2

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“ZA Loops of Bromodomains” | US 7,589,167 B2
"Method of Suppressing Gene Transcription Through Histone Lysine Methylation" | US 9,249,190 B2; US 10,280,408 B2
"Cyclic Vinylogous Amides as Bromodomain Inhibitors" | US 9,884,806 B2; US 10,351,511 B2
"Methods of Modulating Bromodomains" | US 2004/0009613 A1

## References

1. ↑ "Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai". https://icahn.mssm.edu/about/departments/pharmacological-sciences.
2. ↑ "Mount Sinai School of Medicine - Ming-Ming Zhou". http://mssm.edu/profiles/ming-ming-zhou#bot.
3. ↑ AAAS.org staff report (30 November 2012). "AAAS Members Elected as Fellows". https://www.aaas.org/news/aaas-members-elected-fellows-1.
4. ↑ "The Samuel Waxman Cancer Research Foundation". https://www.waxmancancer.org.
5. ↑ "Journal of Molecular Cell Biology - Editorial Board". http://www.oxfordjournals.org/our_journals/jmcb/editorial_board.html.
6. ↑ "Cancer Research: Editorial Board". http://cancerres.aacrjournals.org/site/misc/edboard.xhtml.
7. ↑ "Structure and ligand of a histone acetyltransferase bromodomain". Nature 399 (6735): 491–6. June 1999. doi:10.1038/20974. PMID 10365964. Bibcode: 1999Natur.399..491D.
8. ↑ "Selective Small Molecules Blocking HIV-1 Tat and Coactivator PCAF Association". Journal of the American Chemical Society 127 (8): 2376–7. 2005. doi:10.1021/ja044885g. PMID 15724976.
9. ↑ "50 Years of Protein Acetylation: From Gene Regulation to Epigenetics, metabolism and Beyond". Nature Reviews Molecular Cell Biology 16 (4): 258–64. April 2015. doi:10.1038/nrm3931. PMID 25549891.
10. ↑ "Bromodomain Biology and Drug Discovery". Nature Structural & Molecular Biology 26 (10): 870–9. 2019. doi:10.1038/s41594-019-0309-8. PMID 31582847.
11. ↑ "Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b". Nature 466 (7303): 258–62. July 2010. doi:10.1038/nature09139. PMID 20613843. Bibcode: 2010Natur.466..258Z.
12. ↑ "Structure and conserved RNA binding of the PAZ domain". Nature 426 (6965): 468–74. November 2003. doi:10.1038/nature02129. PMID 14615802. Bibcode: 2003Natur.426..468Y.
13. ↑ "Epigenetic transcriptional repression of cellular genes by a viral SET protein". Nature Cell Biology 10 (9): 1114–1122. August 2008. doi:10.1038/ncb1772. PMID 19160493.
14. ↑ "Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a". Molecular Cell 38 (5): 662–74. June 2010. doi:10.1016/j.molcel.2010.03.021. PMID 20541999.
15. ↑ "Selective small molecules blocking HIV-1 Tat and coactivator PCAF association". Journal of the American Chemical Society 127 (8): 2376–7. March 2005. doi:10.1021/ja044885g. PMID 15724976.
16. ↑ "Mount Sinai researchers discover technology that silences genes". http://www.eurekalert.org/pub_releases/2008-08/tmsh-msr081608.php.
17. ↑ "Disrupting the Interaction of BRD4 with Diacetylated Twist Suppresses Tumorigenesis in Basal-like Breast Cancer". Cancer Cell 25 (2): 210–25. Feb 2014. doi:10.1016/j.ccr.2014.01.028. PMID 24525235.
18. ↑ "Kinase and BET Inhibitors Together Clamp Inhibition of PI3K Signaling and Overcome Resistance to Therapy". Cancer Cell 27 (6): 837–851. 2015. doi:10.1016/j.ccell.2015.05.006. PMID 26058079.
19. ↑ "Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation". Molecular Cell 65 (6): 1068–80. March 2017. doi:10.1016/j.molcel.2016.12.022. PMID 28262505.
20. ↑ "Selective BET Bromodomain Inhibition Blocks Th17 Cell Differentiation and Ameliorates Colitis in Mice". Proceedings of the National Academy of Sciences of the United States of America 114 (11): 2952–7. March 2017. doi:10.1073/pnas.1615601114. PMID 28265070.
21. ↑ "Selective Chemical Modification of Gene Transcription Favors Oligodendrocyte Lineage Progression". Chemistry & Biology 21 (7): 841–54. July 2014. doi:10.1016/j.chembiol.2014.05.009. PMID 24954007.
22. ↑ "Biophysical Society". http://www.biophysics.org/AboutUs/Committees/Program/tabid/896/Default.aspx.
23. ↑ "GlaxoSmithKline Drug Discovery and Development Research Grant Program 2003". http://www.scienceblog.com/community/older/2003/G/20034901.html.
24. ↑ "Michigan Technological University - College of Sciences and Arts". http://www.csa.mtu.edu/.
25. ↑ "Zhou Jacobi Video on Youtube". https://www.youtube.com/watch?v=rhKXrCBfSY4.

## External links

* The Mount Sinai Hospital homepage
* The Icahn School of Medicine at Mount Sinai homepage
* Drug Discovery Institute at The Icahn School of Medicine at Mount Sinai

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