Richard Laurence Millington Synge

FRS FRSE FRIC FRSC

Born| (1914-10-28)28 October 1914

Liverpool, England

Died| 18 August 1994(1994-08-18) (aged 79)

Norwich, England

Alma mater| Winchester College
Trinity College, Cambridge
Known for| Paper chromatography
Partition chromatography
Awards| FRS (1950)
Nobel Prize in Chemistry (1952)
John Price Wetherill Medal (1959)
Scientific career
Fields| biochemist

Richard Laurence Millington Synge (28 October 1914 – 18 August 1994) was a British biochemist, and shared the 1952 Nobel Prize in Chemistry for the invention of partition chromatography with Archer Martin.

## Contents

* 1 Life
* 2 Personal life
* 3 See also
* 4 References
* 5 External links

## Life

Richard Laurence Millington Synge was born in West Kirby on 28 October 1914, the son of Lawrence Millington Synge, a Liverpool stock-broker, and his wife, Katherine C. Swan.[1]

Synge was educated at the Old Hall in Wellington, Shropshire and at Winchester College. He then studied Chemistry at Trinity College, Cambridge.

He spent his entire career in research, at the Wool Industries Research Association, Leeds (1941–1943), Lister Institute for Preventive Medicine, London (1943–1948), Rowett Research Institute, Aberdeen (1948–1967), and Food Research Institute, Norwich (1967–1976).[2]

It was during his time in Leeds that he worked with Archer Martin, developing partition chromatography, a technique used in the separation mixtures of similar chemicals, that revolutionised analytical chemistry.[3] Between 1942 and 1948 he studied peptides of the protein group gramicidin, work later used by Frederick Sanger in determining the structure of insulin. In March 1950 he was elected a Fellow of the Royal Society for which his candidature citation read:

> Distinguished as a biochemist. Was the first to show the possibility of using counter-current liquid-liquid extraction in the separation of N-acetylamino acids. In collaboration with A.J.P. Martin this led to the development of partition chromatography, which they have applied with conspicuous success in problems related to the composition and structure of proteins, particularly wool keratin. Synge's recent work on the composition and structure of gramicidins is outstanding and illustrates vividly the great advances in technique for which he and Martin are responsible.

— "Library and Archive catalogue". Royal Society. http://www2.royalsociety.org/DServe/dserve.exe?dsqIni=Dserve.ini&dsqApp=Archive&dsqCmd=Show.tcl&dsqDb=Persons&dsqPos=1&dsqSearch=(Surname='synge').

In 1963 he was elected a Fellow of the Royal Society of Edinburgh. His proposers were Magnus Pyke, Andrew Phillipson, Sir David Cuthbertson and John Andrew Crichton.[4]

He was for several years the treasurer of the Chemical Information Group of the Royal Society of Chemistry, and was an honorary Professor in Biological Sciences at the University of East Anglia from 1968 to 1984. He was awarded an honorary Doctor of Science (ScD) from the University of East Anglia in 1977, and an honorary doctorate from the Faculty of Mathematics and Science at Uppsala University, Sweden in 1980.[5][6]

## Personal life

In 1943 Synge married Ann Davies Stephen (1916–1997).[7] Ann Stephen was the daughter of psychologist Karin Stephen and psychoanalyst Adrian Stephen.[8] Ann's sister Judith (1918–1972) was married to documentary artist and photographer Nigel Henderson.

## See also

* Monolithic HPLC column

## References

1. ↑ Biographical Index of Former Fellows of the Royal Society of Edinburgh 1783–2002. The Royal Society of Edinburgh. July 2006. ISBN 0-902-198-84-X. https://www.royalsoced.org.uk/cms/files/fellows/biographical_index/fells_indexp2.pdf. Retrieved 16 October 2018.
2. ↑ "Richard Lawrence Millington Synge". Royal Society of Edinburgh. https://www.royalsoced.org.uk/cms/files/fellows/obits_alpha/synge_richard.pdf.
3. ↑ Ettre, C. (2001). "Milestones in Chromatography: The Birth of Partition Chromatography". LCGC 19 (5): 506–512. http://images.alfresco.advanstar.com/alfresco_images/pharma/2014/08/22/1598ed6f-5bbe-400b-bc08-ff07d2c59826/article-2090.pdf. Retrieved 26 February 2016.
4. ↑ Biographical Index of Former Fellows of the Royal Society of Edinburgh 1783–2002. The Royal Society of Edinburgh. July 2006. ISBN 0-902-198-84-X. https://www.royalsoced.org.uk/cms/files/fellows/biographical_index/fells_indexp2.pdf. Retrieved 16 October 2018.
5. ↑ "Honorary Graduates of the University". University of East Anglia. https://portal.uea.ac.uk/documents/6207125/7409549/Honorary+Graduates+Of+UEA+(updated+Nov13).pdf/a28a0862-1178-474e-b921-5f7621f6ed79.
6. ↑ "Honorary doctorates – Uppsala University, Sweden". http://www.uu.se/en/about-uu/traditions/prizes/honorary-doctorates/.
7. ↑ Biographical Index of Former Fellows of the Royal Society of Edinburgh 1783–2002. The Royal Society of Edinburgh. July 2006. ISBN 0-902-198-84-X. https://www.royalsoced.org.uk/cms/files/fellows/biographical_index/fells_indexp2.pdf. Retrieved 16 October 2018.
8. ↑ "National Portrait Gallery: Adrian Stephen". https://www.npg.org.uk/collections/search/person/mp96464/ann-davies-synge-nee-stephen.

## External links

* Miss nobel-id as parameter
* Synge's Nobel Lecture Applications of Partition Chromatography
* Sidney Elsden (21 June 2016), Richard Laurence Millington Synge, http://www.royalsoced.org.uk/fellowship/obits/obits_alpha/synge_richard.pdf, retrieved 17 October 2007

* v
* t
* e

Laureates of the Nobel Prize in Chemistry

1901–1925|

* 1901: Jacobus van 't Hoff
* 1902: Emil Fischer
* 1903: Svante Arrhenius
* 1904: William Ramsay
* 1905: Adolf von Baeyer
* 1906: Henri Moissan
* 1907: Eduard Buchner
* 1908: Ernest Rutherford
* 1909: Wilhelm Ostwald
* 1910: Otto Wallach
* 1911: Marie Curie
* 1912: Victor Grignard / Paul Sabatier
* 1913: Alfred Werner
* 1914: Theodore Richards
* 1915: Richard Willstätter
* 1916
* 1917
* 1918: Fritz Haber
* 1919
* 1920: Walther Nernst
* 1921: Frederick Soddy
* 1922: Francis Aston
* 1923: Fritz Pregl
* 1924
* 1925: Richard Zsigmondy

1926–1950|

* 1926: Theodor Svedberg
* 1927: Heinrich Wieland
* 1928: Adolf Windaus
* 1929: Arthur Harden / Hans von Euler-Chelpin
* 1930: Hans Fischer
* 1931: Carl Bosch / Friedrich Bergius
* 1932: Irving Langmuir
* 1933
* 1934: Harold Urey
* 1935: Frédéric Joliot-Curie / Irène Joliot-Curie
* 1936: Peter Debye
* 1937: Norman Haworth / Paul Karrer
* 1938: Richard Kuhn
* 1939: Adolf Butenandt / Leopold Ružička
* 1940
* 1941
* 1942
* 1943: George de Hevesy
* 1944: Otto Hahn
* 1945: Artturi Virtanen
* 1946: James B. Sumner / John Northrop / Wendell Meredith Stanley
* 1947: Robert Robinson
* 1948: Arne Tiselius
* 1949: William Giauque
* 1950: Otto Diels / Kurt Alder

1951–1975|

* 1951: Edwin McMillan / Glenn T. Seaborg
* 1952: Archer Martin / Richard Synge
* 1953: Hermann Staudinger
* 1954: Linus Pauling
* 1955: Vincent du Vigneaud
* 1956: Cyril Hinshelwood / Nikolay Semyonov
* 1957: Alexander Todd
* 1958: Frederick Sanger
* 1959: Jaroslav Heyrovský
* 1960: Willard Libby
* 1961: Melvin Calvin
* 1962: Max Perutz / John Kendrew
* 1963: Karl Ziegler / Giulio Natta
* 1964: Dorothy Hodgkin
* 1965: Robert Woodward
* 1966: Robert S. Mulliken
* 1967: Manfred Eigen / Ronald Norrish / George Porter
* 1968: Lars Onsager
* 1969: Derek Barton / Odd Hassel
* 1970: Luis Federico Leloir
* 1971: Gerhard Herzberg
* 1972: Christian B. Anfinsen / Stanford Moore / William Stein
* 1973: Ernst Otto Fischer / Geoffrey Wilkinson
* 1974: Paul Flory
* 1975: John Cornforth / Vladimir Prelog

1976–2000|

* 1976: William Lipscomb
* 1977: Ilya Prigogine
* 1978: Peter D. Mitchell
* 1979: Herbert C. Brown / Georg Wittig
* 1980: Paul Berg / Walter Gilbert / Frederick Sanger
* 1981: Kenichi Fukui / Roald Hoffmann
* 1982: Aaron Klug
* 1983: Henry Taube
* 1984: Robert Merrifield
* 1985: Herbert A. Hauptman / Jerome Karle
* 1986: Dudley R. Herschbach / Yuan T. Lee / John Polanyi
* 1987: Donald J. Cram / Jean-Marie Lehn / Charles J. Pedersen
* 1988: Johann Deisenhofer / Robert Huber / Hartmut Michel
* 1989: Sidney Altman / Thomas Cech
* 1990: Elias Corey
* 1991: Richard R. Ernst
* 1992: Rudolph A. Marcus
* 1993: Kary Mullis / Michael Smith
* 1994: George Olah
* 1995: Paul J. Crutzen / Mario J. Molina / F. Sherwood Rowland
* 1996: Robert Curl / Harold Kroto / Richard Smalley
* 1997: Paul D. Boyer / John E. Walker / Jens Christian Skou
* 1998: Walter Kohn / John Pople
* 1999: Ahmed Zewail
* 2000: Alan J. Heeger / Alan MacDiarmid / Hideki Shirakawa

2001–present|

* 2001: William Knowles / Ryoji Noyori / K. Barry Sharpless
* 2002: John B. Fenn / Koichi Tanaka / Kurt Wüthrich
* 2003: Peter Agre / Roderick MacKinnon
* 2004: Aaron Ciechanover / Avram Hershko / Irwin Rose
* 2005: Robert H. Grubbs / Richard R. Schrock / Yves Chauvin
* 2006: Roger D. Kornberg
* 2007: Gerhard Ertl
* 2008: Osamu Shimomura / Martin Chalfie / Roger Y. Tsien
* 2009: Venkatraman Ramakrishnan / Thomas A. Steitz / Ada E. Yonath
* 2010: Richard F. Heck / Akira Suzuki / Ei-ichi Negishi
* 2011: Dan Shechtman
* 2012: Robert Lefkowitz / Brian Kobilka
* 2013: Martin Karplus / Michael Levitt / Arieh Warshel
* 2014: Eric Betzig / Stefan Hell / William E. Moerner
* 2015: Tomas Lindahl / Paul L. Modrich / Aziz Sancar
* 2016: Jean-Pierre Sauvage / Fraser Stoddart / Ben Feringa
* 2017: Jacques Dubochet / Joachim Frank / Richard Henderson
* 2018: Frances Arnold / Gregory Winter / George Smith
* 2019: John B. Goodenough / M. Stanley Whittingham / Akira Yoshino

* v
* t
* e

1952 Nobel Prize laureates

Chemistry|

* Archer John Porter Martin (United Kingdom)
* Richard Laurence Millington Synge (United Kingdom)

Literature|

* François Mauriac (France)

Peace|

* Albert Schweitzer (France)

Physics|

* Felix Bloch (United States)
* Edward Mills Purcell (Unites States)

Physiology or Medicine|

* Selman Waksman (United States)

Nobel Prize recipients
1990

2000

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