Wen-Hsiung Li

李文雄

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Born|

Wen Hsiung Li

(1942-09-22) September 22, 1942 (age 83)

Pingtung, Taiwan

Citizenship|

* Taiwan
* United States

Education| Chung Yuan Christian University (BS)
National Central University (MS)
Brown University (PhD)
Known for| Male-Driven Evolution[1][2][3]
Molecular clock[4]
Genomics[5]
Awards| Balzan Prize for Genetics and Evolution (2003)[6]
Mendel Medal (2009)[7]
Scientific career
Fields| Applied mathematics
Institutions| University of Chicago
Academia Sinica
University of Texas
University of Wisconsin-Madison
Thesis| Mathematical Studies On Mutational Damages In Finite Populations (1972)
Doctoral advisor| Wendell Fleming
Other academic advisors| Masatoshi Nei
Website| Li Laboratory at University of Chicago
Wen Hsiung Li Profile at Academia Sinica

Wen-Hsiung Li (Chinese: 李文雄; pinyin: Lǐ Wénxióng; born September 22, 1942) is a Taiwanese-American scientist working in the fields of molecular evolution, population genetics, and genomics. He is currently the James Watson Professor of Ecology and Evolution at the University of Chicago and a Principal Investigator at the Institute of Information Science and Genomics Research Center, Academia Sinica, Taiwan.

## Contents

* 1 Biography
* 2 Scientific contributions
* 3 Honors
* 4 Selected publications
* 5 Selected books
* 6 References
* 7 External links

## Biography

Li was born in 1942 in Taiwan. In 1968, he received a M.S. in geophysics from National Central University. In 1972, he received his Ph.D. in applied mathematics at Brown University in Providence, Rhode Island. From 1972 to 1973, he was a post-doctoral researcher at the University of Wisconsin Madison (genetics), working with James F. Crow. In 1973, he moved to the University of Texas, where he was appointed as a professor in 1984. Since 1998, he has been a professor at the University of Chicago.

## Scientific contributions

Li is best known for his studies on the molecular clock (i.e. rates and patterns of DNA sequence evolution[8]) and on the patterns and consequences of gene duplication.[9]

In 2003, he received the international Balzan Prize for his contribution to genetics and evolutionary biology, and was elected to the National Academy of Sciences, who cited his role in "establishing theoretical foundations for molecular phylogenetics and evolutionary genomics"[1]. He is the author of the first textbook in the field of molecular evolution, Molecular Evolution and Fundamentals of Molecular Evolution (co-authored with Dan Graur), and an author on more than 200 peer-reviewed publications.

## Honors

* Academician, Academia Sinica Taiwan, 1998
* Member, American Academy of Arts and Sciences, 1999
* President of the “Society for Molecular Biology and Evolution”, 2000
* Member, National Academy of Sciences, 2003
* Balzan Prize 2003 for genetics and evolution (The third recipient, following Sewall Wright (1984) and John Maynard Smith (1991)).
* Inaugural Chen Award for Achievement in Human Genetic and Genomic Research, Human Genome Organisation, 2008
* 2019 SMBE Motoo Kimura Lifetime Contribution Award[10]

## Selected publications

* Chu, T. -C.; Lu, C. -H.; Liu, T.; Lee, G. C.; Li, W. -H.; Shih, A. C. -C. (2013). "Assembler for de novo assembly of large genomes". Proceedings of the National Academy of Sciences 110 (36): E3417–E3424. doi:10.1073/pnas.1314090110. PMID 23966565. Bibcode: 2013PNAS..110E3417C.
* Gu, Z.; Steinmetz, L. M.; Gu, X.; Scharfe, C.; Davis, R. W.; Li, W. H. (2003). "Role of duplicate genes in genetic robustness against null mutations". Nature 421 (6918): 63–6. doi:10.1038/nature01198. PMID 12511954. Bibcode: 2003Natur.421...63G.
* Makova, K. D.; Li, W. H. (2002). "Strong male-driven evolution of DNA sequences in humans and apes". Nature 416 (6881): 624–6. doi:10.1038/416624a. PMID 11948348. Bibcode: 2002Natur.416..624M.
* Li, W. H.; Gu, Z.; Wang, H.; Nekrutenko, A. (2001). "Evolutionary analyses of the human genome". Nature 409 (6822): 847–9. doi:10.1038/35057039. PMID 11237007. Bibcode: 2001Natur.409..847G.
* Tan, Y.; Li, W. H. (1999). "Vision: Trichromatic vision in prosimians". Nature 402 (6757): 36. doi:10.1038/46947. PMID 10573416. Bibcode: 1999Natur.402...36T.
* Shyue, S.; Hewett-Emmett, D.; Sperling, H.; Hunt, D.; Bowmaker, J.; Mollon, J.; Li, W.H. (1995). "Adaptive evolution of color vision genes in higher primates". Science 269 (5228): 1265–7. doi:10.1126/science.7652574. PMID 7652574. Bibcode: 1995Sci...269.1265S.
* Shimmin, L. C.; Chang, B. H. J.; Li, W. H. (1993). "Male-driven evolution of DNA sequences". Nature 362 (6422): 745–7. doi:10.1038/362745a0. PMID 8469284. Bibcode: 1993Natur.362..745S.
* Graur, D.; Hide, W. A.; Li, W. H. (1991). "Is the guinea-pig a rodent?". Nature 351 (6328): 649–52. doi:10.1038/351649a0. PMID 2052090. Bibcode: 1991Natur.351..649G.
* Graur, D. A. N.; Li, W.H. (1991). "Neutral mutation hypothesis test". Nature 354 (6349): 114–6. doi:10.1038/354114e0. PMID 1944591. Bibcode: 1991Natur.354..114G.
* Wolfe, K. H.; Sharp, P. M.; Li, W. H. (1989). "Mutation rates differ among regions of the mammalian genome". Nature 337 (6204): 283–5. doi:10.1038/337283a0. PMID 2911369. Bibcode: 1989Natur.337..283W.
* Gouy, M.; Li, W. H. (1989). "Phylogenetic analysis based on rRNA sequences supports the archaebacterial rather than the eocyte tree". Nature 339 (6220): 145–7. doi:10.1038/339145a0. PMID 2497353. Bibcode: 1989Natur.339..145G.
* Sharp, P.; Shields, D.; Wolfe, K.; Li, W.H. (1989). "Chromosomal location and evolutionary rate variation in enterobacterial genes". Science 246 (4931): 808–10. doi:10.1126/science.2683084. PMID 2683084. Bibcode: 1989Sci...246..808S.
* Sharp, P. M.; Li, W.H. (1988). "Understanding the origins of AIDS viruses". Nature 336 (6197): 315. doi:10.1038/336315a0. PMID 3194016. Bibcode: 1988Natur.336Q.315S.
* Li, W. H.; Tanimura, M. (1987). "The molecular clock runs more slowly in man than in apes and monkeys". Nature 326 (6108): 93–6. doi:10.1038/326093a0. PMID 3102974. Bibcode: 1987Natur.326...93L.
* Li, W. H.; Gojobori, T.; Nei, M. (1981). "Pseudogenes as a paradigm of neutral evolution". Nature 292 (5820): 237–9. doi:10.1038/292237a0. PMID 7254315. Bibcode: 1981Natur.292..237L.
* Nei, M.; Li, W. H. (1979). "Mathematical model for studying genetic variation in terms of restriction endonucleases". Proceedings of the National Academy of Sciences 76 (10): 5269–73. doi:10.1073/pnas.76.10.5269. PMID 291943. Bibcode: 1979PNAS...76.5269N.

## Selected books

* Li, W.-H. (2006). Molecular Evolution. Sinauer. ISBN 0-87893-480-4.
* Dan Graur; Wen-Hsiung Li (2000). Fundamentals of Molecular Evolution: Second Edition.. Sinauer Associates, Inc.. 1st edition. 1991. [11]

## References

1. ↑ Shimmin, L. C.; Chang, B. H. J.; Li, W. H. (1993). "Male-driven evolution of DNA sequences". Nature 362 (6422): 745–7. doi:10.1038/362745a0. PMID 8469284. Bibcode: 1993Natur.362..745S.
2. ↑ Makova, K. D.; Li, W. H. (2002). "Strong male-driven evolution of DNA sequences in humans and apes". Nature 416 (6881): 624–6. doi:10.1038/416624a. PMID 11948348. Bibcode: 2002Natur.416..624M.
3. ↑ "Males' DNA propels evolution, study says". Chicago Tribune. 11 April 2002. https://www.chicagotribune.com/2002/04/11/males-dna-propels-evolution-study-says/.
4. ↑ Lewin, R. (1985). "Molecular clocks scrutinized". Science 228 (4699): 571. doi:10.1126/science.3983640. PMID 3983640. Bibcode: 1985Sci...228..571L.
5. ↑ Li, W. H.; Gu, Z.; Wang, H.; Nekrutenko, A. (2001). "Evolutionary analyses of the human genome". Nature 409 (6822): 847–9. doi:10.1038/35057039. PMID 11237007. Bibcode: 2001Natur.409..847G.
6. ↑ "Balzan Prize for Genetics and Evolution". International Balzan Prize Foundation website. International Balzan Prize Foundation. http://www.balzan.org/en/prizewinners/wen-hsiung-li. Retrieved February 8, 2014.
7. ↑ "Mendel Medal". The Genetics Society website. The Genetics Society. http://www.genetics.org.uk/Prizes/MendelMedal.aspx/. Retrieved February 8, 2014.
8. ↑ Li, Wen-Hsiung; Tanimura, Masako (March 1987). "The molecular clock runs more slowly in man than in apes and monkeys" (in en). Nature 326 (6108): 93–96. doi:10.1038/326093a0. ISSN 1476-4687. PMID 3102974. Bibcode: 1987Natur.326...93L. https://www.nature.com/articles/326093a0.
9. ↑ Li, Wen-Hsiung; Gu, Zhenglong; Cavalcanti, AndreR.O.; Nekrutenko, Anton (2003-03-01). "Detection of gene duplications and block duplications in eukaryotic genomes" (in en). Journal of Structural and Functional Genomics 3 (1): 27–34. doi:10.1023/A:1022644628861. ISSN 1570-0267. PMID 12836682. https://doi.org/10.1023/A:1022644628861.
10. ↑ "SMBE Motoo Kimura Lifetime Contribution Award". Society of Molecular Biology and Evolution. https://www.smbe.org/smbe/AWARDS/FacultyAwards/MotooKimuraLifetimeContributionAward.aspx. Retrieved April 12, 2019.
11. ↑ Clegg, Michael T. (10 May 1991). "Review of Fundamentals of Molecular Evolution by Wen-Hsiung Li and Dan Graur". Science 252 (5007): 864–865. doi:10.1126/science.252.5007.864.b. p. 865

## External links

* Official research profile
* Lab web site
* National Academy of Sciences citation
* Balzan Foundation profile
* Academia Sinica website reference for the HUGO/ "Chen Award" 2008

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