Ying E. Zhang

Short description: Chinese-American biochemist

Ying E. Zhang

Alma mater| Peking University (BS, MS)
University of Wisconsin–Madison (PhD)
Scientific career
Fields| Biochemistry, cancer biology
Institutions| National Cancer Institute
Thesis| Insights into mechanisms of F1F0ATP synthase by genetic analysis of subunit C from Escherichia coli (1995)
Doctoral advisor| Robert H. Fillingame [Wikidata]

Ying E. Zhang is a Chinese-American biochemist specialized in TGF-beta signaling and functions of ubiquitin E3 ligase Smurfs to better understand cancer cells and metastasis. She is a senior investigator in the Laboratory of Cellular and Molecular Biology at the National Cancer Institute.

## Education

Zhang received her B.S. degree in chemistry and M.S. degree in biochemistry from Peking University. She obtained her Ph.D. degree from University of Wisconsin–Madison in 1995.[1][2] Her dissertation was titled, Insights into mechanisms of F1F0ATP synthase by genetic analysis of subunit C from Escherichia coli. Zhang's doctoral advisor was Robert H. Fillingame [Wikidata].[3] She completed her postdoctoral training with Rik Derynck [Wikidata] in University of California, San Francisco.[1][2]

## Career and research

Zhang joined the National Cancer Institute's (NCI) Laboratory of Cellular and Molecular Biology in 2000 as a tenure-track investigator and became a senior investigator in 2007.[1][2]

Zhang's research focuses on understanding TGF-beta signaling and functions of ubiquitin E3 ligase Smurfs. She identified and characterized several key molecules in the TGF-beta signaling pathway, including Smads and Smurfs. Discoveries from her group generated mechanistic insight into how TGF-beta controls cellular responses through Smad-dependent and -independent pathways in normal and cancer cells. On the front of Smurf E3 ligases, their findings extended the function of Smurfs beyond TGF-beta pathway to genome stability and metastasis.[1] In 2020, she was elected Fellow of the American Institute for Medical and Biological Engineering.[4] She was elected a Fellow of the American Association for the Advancement of Science in 2021.[5]

## References

1. ↑ 1.0 1.1 1.2 1.3 "Ying E. Zhang, Ph.D." (in en). 2014-08-12. https://ccr.cancer.gov/laboratory-of-cellular-and-molecular-biology/ying-e-zhang. This article incorporates text from this source, which is in the public domain.
2. ↑ 2.0 2.1 2.2 "Principal Investigators" (in en). https://irp.nih.gov/pi/ying-zhang. This article incorporates text from this source, which is in the public domain.
3. ↑ Zhang, Ying (1995) (in English). Insights into mechanisms of F1F0ATP synthase by genetic analysis of subunit C from Escherichia coli. OCLC 620713432. http://catalog.hathitrust.org/api/volumes/oclc/32878255.html.
4. ↑ "Ying E. Zhang, Ph.D. COF-5148 - AIMBE" (in en). https://aimbe.org/college-of-fellows/cof-5148/.
5. ↑ "Six NIH'ers Elected 2021 AAAS Fellows" (in EN). 2022-02-18. https://nihrecord.nih.gov/2022/02/18/six-nih-ers-elected-2021-aaas-fellows.

This article incorporates public domain material from websites or documents of the National Institutes of Health.

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