ABLIM3

Generic protein structure example

Actin-binding LIM protein 3 is a protein that in humans is encoded by the ABLIM3 gene.[1]

## Contents

* 1 Function
* 2 Clinical relevance
* 3 References
* 4 External links
* 5 Further reading

## Function

The LIM domain is a double zinc finger structure that promotes protein-protein interactions. LIM domain proteins, such as ABLIM3, play roles in embryonic development, cell lineage determination, and cancer.[2] An important paralog of this gene is LIMS1.

## Clinical relevance

Diseases associated with ABLIM3 include hepatoblastoma, and among its related super-pathways are axon guidance and DCC mediated attractive signaling.

## References

1. ↑ "Entrez Gene: ABLIM3 actin binding LIM protein family, member 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22885.
2. ↑ "Actin binding LIM protein 3 (abLIM3)". International Journal of Molecular Medicine 17 (1): 129–33. Jan 2006. doi:10.3892/ijmm.17.1.129. PMID 16328021.

## External links

* Human ABLIM3 genome location and ABLIM3 gene details page in the UCSC Genome Browser.

## Further reading

* "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. Jan 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
* "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. Oct 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
* "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 5 (6): 355–64. Dec 1998. doi:10.1093/dnares/5.6.355. PMID 10048485.
* "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–95. Nov 2000. doi:10.1101/gr.143000. PMID 11076863.
* "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research 11 (3): 422–35. Mar 2001. doi:10.1101/gr.GR1547R. PMID 11230166.
* "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas". Oncogene 23 (35): 5901–5911. Aug 2004. doi:10.1038/sj.onc.1207782. PMID 15221005.
* "hhLIM protein is involved in cardiac hypertrophy". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1690 (1): 1–10. Sep 2004. doi:10.1016/j.bbadis.2004.04.009. PMID 15337165.
* "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research 14 (9): 1711–8. Sep 2004. doi:10.1101/gr.2435604. PMID 15342556.
* "From ORFeome to biology: a functional genomics pipeline". Genome Research 14 (10B): 2136–44. Oct 2004. doi:10.1101/gr.2576704. PMID 15489336.
* "Actin binding LIM protein 3 (abLIM3)". International Journal of Molecular Medicine 17 (1): 129–33. Jan 2006. doi:10.3892/ijmm.17.1.129. PMID 16328021. http://www.spandidos-publications.com/ijmm/17/1/129/download.
* "The LIFEdb database in 2006". Nucleic Acids Research 34 (Database issue): D415–8. Jan 2006. doi:10.1093/nar/gkj139. PMID 16381901.
* "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. Nov 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
* "Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin". The Journal of Biological Chemistry 282 (11): 8393–8403. Mar 2007. doi:10.1074/jbc.M607549200. PMID 17194709.

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PDB gallery

* 1ujs: Solution structure of the Villin headpiece domain of human actin-binding LIM protein homologue (KIAA0843 protein)

* 2dj7: Solution Structure of 3rd LIM Domain of Actin-binding LIM Protein 3

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