Bacillus atrophaeus

Short description: Species of bacterium

Bacillus atrophaeus

Scientific classification
Domain:  | Bacteria
Phylum:  | Bacillota
Class:  | Bacilli
Order:  | Bacillales
Family:  | Bacillaceae
Genus:  | Bacillus
Species:  |

B. atrophaeus

Binomial name
Bacillus atrophaeus

Nakamura 1989

Synonyms[1]

Heterotypic synonyms

* "Bacillus globigii" Migula 1900
* "red strain" Migula 1900
* "Bacillus niger" Migula 1900
* "Bacillus subtilis var. niger" (Migula 1900) Smith et al. 1946

Bacillus atrophaeus is a species of black-pigmented bacteria. Its type strain is NRRL NRS-213.[2] B. atrophaeus strains have been used extensively in biomedicine as indicator strains for heat- and chemical-based decontamination regimens. Most of the strains in use are derivatives of a lineage of B. atrophaeus that originated at Camp Detrick in the 1950s, where many modern biocontainment procedures were developed.[3][4][5]

B. atrophaeus has historically been known by several other names, including B. globigii (the origin of its military moniker "BG") and B. subtilis var. niger. Modern phylogenetic analyses using multiple genetic methods have placed B. atrophaeus close to B. subtilis.[4][6][7]

Its original and still most prominent use is as a surrogate organism for pathogenic B. anthracis,[7] beginning in the U.S. bio-weapons program, as its pigmentation readily facilitated discrimination from non-pigmented background organisms in environmental samples. Subsequent genomic and phenotypic analysis of strains derived from the Camp Detrick isolates revealed that they had been deliberately selected to exhibit elevated rates of sporulation.[4][8]

## References

1. ↑ "Species: Bacillus atrophaeus" (in en). https://lpsn.dsmz.de/species/bacillus-atrophaeus.
2. ↑ Nakamura, L. K. (1989). "Taxonomic Relationship of Black-pigmented Bacillus subtilis Strains and a Proposal for Bacillus atrophaeus sp. nov.". International Journal of Systematic Bacteriology 39 (3): 295–300. doi:10.1099/00207713-39-3-295. ISSN 0020-7713. https://naldc-legacy.nal.usda.gov/naldc/download.xhtml?id=24081&content=PDF.
3. ↑ Wedum, Arnold. "Special Report No. 185 (Declassified)". United States Chemical Corps. http://www.dtic.mil/dtic/tr/fulltext/u2/310671.pdf.
4. ↑ 4.0 4.1 4.2 Gibbons, Henry (25 Mar 2011). "Genomic signatures of strain selection and enhancement in Bacillus atrophaeus var. globigii, a historical biowarfare simulant". PLOS ONE 6 (3): e17836. doi:10.1371/journal.pone.0017836. PMID 21464989. Bibcode: 2011PLoSO...617836G.
5. ↑ HAYWARD, AE; MARCHETTA, JA; HUTTON, RS (July 1946). "Strain variation as a factor in the sporulating properties of the so-called Bacillus globigii.". Journal of Bacteriology 52: 51–4. doi:10.1128/JB.52.1.51-54.1946. PMID 20994868.
6. ↑ Burke, SA; Wright, JD; Robinson, MK; Bronk, BV; Warren, RL (May 2004). "Detection of molecular diversity in Bacillus atrophaeus by amplified fragment length polymorphism analysis.". Applied and Environmental Microbiology 70 (5): 2786–90. doi:10.1128/aem.70.5.2786-2790.2004. PMID 15128533. Bibcode: 2004ApEnM..70.2786B.
7. ↑ 7.0 7.1 Greenberg, DL; Busch, JD; Keim, P; Wagner, DM (1 September 2010). "Identifying experimental surrogates for Bacillus anthracis spores: a review.". Investigative Genetics 1 (1): 4. doi:10.1186/2041-2223-1-4. PMID 21092338.
8. ↑ Zhelev, DV; Hunt, M; Le, A; Dupuis, C; Ren, S; Gibbons, HS (December 2012). "Effect of the Bacillus atrophaeus subsp. globigii Spo0F H101R mutation on strain fitness.". Applied and Environmental Microbiology 78 (24): 8601–10. doi:10.1128/aem.01922-12. PMID 23042165. Bibcode: 2012ApEnM..78.8601Z.

## Further reading

* Fritze, Dagmar, and Rüdiger Pukall. "Reclassification of bioindicator strains Bacillus subtilis DSM 675 and Bacillus subtilis DSM 2277 as Bacillus atrophaeus". International Journal of Systematic and Evolutionary Microbiology51.1 (2001): 35–37.
* Youssef, Nabil N., and Joyce Knoblett. "Culture filtrate of Bacillus atrophaeus induced abnormalities in Ascosphaera apis". Mycologia (1998): 937–946.
* Burke, S. A.; Wright, J. D.; Robinson, M. K.; Bronk, B. V.; Warren, R. L. (2004). "Detection of Molecular Diversity in Bacillus atrophaeus by Amplified Fragment Length Polymorphism Analysis". Applied and Environmental Microbiology 70 (5): 2786–2790. doi:10.1128/AEM.70.5.2786-2790.2004. ISSN 0099-2240. PMID 15128533. Bibcode: 2004ApEnM..70.2786B.
* Luftman, Henry S., and Michael A. Regits. "B. Atrophaeus and G. Stearothermophilus biological indicators for chlorine dioxide gas decontamination". Applied Biosafety: Journal of the American Biological Safety Association 13.3 (2008): 143–157.
* Lighthart, Bruce; Prier, Kevin R. S.; Bromenshenk, Jerry J. (2004). "Detection of aerosolized bacterial spores (Bacillus atrophaeus) using free-flying honey bees (Hymenoptera: Apidae) as collectors". Aerobiologia 20 (3–4): 191–195. doi:10.1007/s10453-004-1182-3. ISSN 0393-5965. Bibcode: 2004Aerob..20..191L.

## External links

* LPSN
* Type strain of Bacillus atrophaeus at BacDive \- the Bacterial Diversity Metadatabase

Wikidata ☰ Q16836690 entry

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