beta-diketone hydrolase

Identifiers
EC number| 3.7.1.7
CAS number| 97955-12-9
Databases
IntEnz| IntEnz view
BRENDA| BRENDA entry
ExPASy| NiceZyme view
KEGG| KEGG entry
MetaCyc| metabolic pathway
PRIAM| profile
PDB structures| RCSB PDB PDBe PDBsum
Gene Ontology| AmiGO  / QuickGO
| Search

PMC| articles
PubMed| articles
NCBI| proteins

In enzymology, a beta-diketone hydrolase (EC 3.7.1.7) is an enzyme that catalyzes the chemical reaction

nonane-4,6-dione + H2O ⇌ pentan-2-one + butanoate

Thus, the two substrates of this enzyme are nonane-4,6-dione and H2O, whereas its two products are 2-pentanone and butanoate.

This enzyme belongs to the family of hydrolases, specifically those acting on carbon-carbon bonds in ketonic substances. The systematic name of this enzyme class is nonane-4,6-dione acylhydrolase. This enzyme is also called oxidized PVA hydrolase.

## Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2J5G and 2J5S.

## References

* "Separation of secondary alcohol oxidase and oxidized poly(vinyl alcohol) hydrolase by hydrophobic and dye-ligand chromatographies". Agric. Biol. Chem. 47: 153-155. 1983. doi:10.1271/bbb1961.47.153.
* "A new enzyme, beta-diketone hydrolase: a component of a poly(vinyl alcohol)-degrading enzyme preparation". Agric. Biol. Chem. 49 (6): 1901-1902. 1985. doi:10.1271/bbb1961.49.1901.

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Hydrolases: carbon-carbon (EC 3.7)

3.7.1|

* Fumarylacetoacetate hydrolase
* Kynureninase

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Enzymes

Activity|

* Active site
* Binding site
* Catalytic triad
* Oxyanion hole
* Enzyme promiscuity
* Catalytically perfect enzyme
* Coenzyme
* Cofactor
* Enzyme catalysis

Regulation|

* Allosteric regulation
* Cooperativity
* Enzyme inhibitor
* Enzyme activator

Classification|

* EC number
* Enzyme superfamily
* Enzyme family
* List of enzymes

Kinetics|

* Enzyme kinetics
* Eadie–Hofstee diagram
* Hanes–Woolf plot
* Lineweaver–Burk plot
* Michaelis–Menten kinetics

Types|

* EC1 Oxidoreductases (list)
* EC2 Transferases (list)
* EC3 Hydrolases (list)
* EC4 Lyases (list)
* EC5 Isomerases (list)
* EC6 Ligases (list)
* EC7 Translocases (list)

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Original source: https://en.wikipedia.org/wiki/Beta-diketone hydrolase. Read more

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