Cytochrome P450 BM3

Short description: Enzyme

Bifunctional cytochrome P450/NADPH--P450 reductase

Identifiers
Organism| Bacillus megaterium
Symbol| P450BM3
Alt. symbols| CYP102A1
PDB| 2IJ2 (ECOD)
RefSeq (mRNA)| NZ_JJMH01000056.1
RefSeq (Prot)| WP_034650526.1
UniProt| P14779
Other data
EC number| 1.6.2.4
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Structures| Swiss-model
Domains| InterPro

Cytochrome P450 BM3 is a Prokaryote Cytochrome P450 enzyme originally from Bacillus megaterium catalyzes the hydroxylation of several long-chain fatty acids at the ω–1 through ω–3 positions. This bacterial enzyme belongs to CYP family CYP102, with the CYP Symbol CYP102A1.This CYP family constitutes a natural fusion between the CYP domain and an NADPH-dependent cytochrome P450 reductase.[1][2]

## References

1. ↑ "Characterization of a catalytically self-sufficient 119,000-dalton cytochrome P-450 monooxygenase induced by barbiturates in Bacillus megaterium". The Journal of Biological Chemistry 261 (16): 7160–9. June 1986. doi:10.1016/S0021-9258(17)38369-2. PMID 3086309. http://www.jbc.org/cgi/pmidlookup?view=long&pmid=3086309.
2. ↑ "Flavocytochrome P450 BM3 and the origin of CYP102 fusion species". Biochemical Society Transactions 34 (Pt 6): 1173–7. December 2006. doi:10.1042/BST0341173. PMID 17073779.

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Cytochromes, oxygenases: cytochrome P450 (EC 1.14)

CYP1|

* A1
* A2
* B1

CYP2|

* A6
* A7
* A13
* B6
* C8
* C9
* *3
* *13
* C18
* C19
* D6
* E1
* F1
* J2
* R1
* S1
* U1
* W1

CYP3 (CYP3A)|

* A4
* A5
* A7
* A43

CYP4|

* A11
* A22
* B1
* F2
* F3
* F8
* F11
* F12
* F22
* V2
* X1
* Z1

CYP5-20|

* CYP5 (A1)
* CYP6 (G1)
* CYP7 (A1, B1)
* CYP8 (A1, B1)
* CYP11 (A1, B1, B2)
* CYP17 (A1)
* CYP19 (A1)
* CYP20 (A1)

CYP21-51|

* CYP21 (A2)
* CYP22 (A1)
* CYP24 (A1)
* CYP26 (A1, B1, C1)
* CYP27 (A1, 25-Hydroxyvitamin D3 1-alpha-hydroxylase

CYP101-120|

* CYP101
* CYP102A1
* CYP107A1
* CYP119A1

CYP201-300|

* CYP255A

CYP301-320|

* CYP305M2
* Halloween genes ( CYP302A1, CYP306A1, CYP307A1, CYP307A2, CYP314A1, CYP315A1)

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