Cytochrome P450 cam

Camphor 5-monooxygenase

Identifiers
Organism| Pseudomonas putida
Symbol| camC
Alt. symbols| cyp101
UniProt| P00183
Other data
EC number| 1.14.15.1
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Structures| Swiss-model
Domains| InterPro
Putidaredoxin

Identifiers
Organism| Pseudomonas putida
Symbol| camB
Alt. symbols| PDX
UniProt| P00259
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Structures| Swiss-model
Domains| InterPro
Putidaredoxin reductase CamA

Identifiers
Organism| Pseudomonas putida
Symbol| camA
Alt. symbols| Pdr
UniProt| P16640
Other data
EC number| 1.18.1.5
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Structures| Swiss-model
Domains| InterPro

Cytochrome P450 camphor 5-monooxygenase is a bacterial enzyme originally from Pseudomonas putida, which catalyzes a critical step in the metabolism of camphor. In 1987, Cytochrome P450cam was the first cytochrome P450 three-dimensional protein structure solved by X-ray crystallography.[1]

It is a heterotrimeric protein derived from the products of three genes: a cytochrome P450 enzyme (encoded by the CamC gene from the CYP family CYP101), a Putidaredoxin (encoded by the CamB gene) complexed with cofactors 2Fe-2S, a NADH-dependent Putidaredoxin reductase (encoded by the CamA gene).[2]

## References

1. ↑ Poulos, Thomas L.; Finzel, Barry C.; Howard, Andrew J. (June 1987). "High-resolution crystal structure of cytochrome P450cam". Journal of Molecular Biology 195 (3): 687–700. doi:10.1016/0022-2836(87)90190-2.
2. ↑ Li, Shuying; Wackett, Lawrence P. (1993). "Reductive dehalogenation by cytochrome P450CAM: Substrate binding and catalysis". Biochemistry 32 (36): 9355–9361. doi:10.1021/bi00087a014.

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Cytochromes, oxygenases: cytochrome P450 (EC 1.14)

CYP1|

* A1
* A2
* B1

CYP2|

* A6
* A7
* A13
* B6
* C8
* C9
* *3
* *13
* C18
* C19
* D6
* E1
* F1
* J2
* R1
* S1
* U1
* W1

CYP3 (CYP3A)|

* A4
* A5
* A7
* A43

CYP4|

* A11
* A22
* B1
* F2
* F3
* F8
* F11
* F12
* F22
* V2
* X1
* Z1

CYP5-20|

* CYP5 (A1)
* CYP6 (G1)
* CYP7 (A1, B1)
* CYP8 (A1, B1)
* CYP11 (A1, B1, B2)
* CYP17 (A1)
* CYP19 (A1)
* CYP20 (A1)

CYP21-51|

* CYP21 (A2)
* CYP22 (A1)
* CYP24 (A1)
* CYP26 (A1, B1, C1)
* CYP27 (A1, 25-Hydroxyvitamin D3 1-alpha-hydroxylase

CYP101-120|

* CYP101
* CYP102A1
* CYP107A1
* CYP119A1

CYP201-300|

* CYP255A

CYP301-320|

* CYP305M2
* Halloween genes ( CYP302A1, CYP306A1, CYP307A1, CYP307A2, CYP314A1, CYP315A1)

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