GABRE

Short description: Protein-coding gene in humans

Generic protein structure example

Gamma-aminobutyric acid receptor subunit epsilon is a protein that in humans is encoded by the GABRE gene.[1][2][3]

The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]

Brainstem expression of ε subunit-containing GABAA receptors is upregulated during pregnancy, particularly in the ventral respiratory group.[4]

## Contents

* 1 See also
* 2 References
* 3 Further reading
* 4 External links

## See also

* GABAA receptor

## References

1. ↑ "Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit". Nature 385 (6619): 820–823. Mar 1997. doi:10.1038/385820a0. PMID 9039914. Bibcode: 1997Natur.385..820D.
2. ↑ "An mRNA encoding a putative GABA-gated chloride channel is expressed in the human cardiac conduction system". J Neurochem 68 (4): 1382–1389. Apr 1997. doi:10.1046/j.1471-4159.1997.68041382.x. PMID 9084408. https://hal.archives-ouvertes.fr/hal-02862782/file/J Neurochem 1997 Garret.pdf.
3. ↑ 3.0 3.1 "Entrez Gene: GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2564.
4. ↑ "Increased GABA(A) receptor ε-subunit expression on ventral respiratory column neurons protects breathing during pregnancy". PLOS ONE 7 (1): e30608. 2012. doi:10.1371/journal.pone.0030608. PMID 22303446.

## Further reading

* "Trafficking and potential assembly patterns of epsilon-containing GABAA receptors". J. Neurochem. 103 (3): 1258–1271. 2007. doi:10.1111/j.1471-4159.2007.04833.x. PMID 17714454.
* "Channel opening by anesthetics and GABA induces similar changes in the GABAA receptor M2 segment". Biophys. J. 92 (9): 3130–3139. 2007. doi:10.1529/biophysj.106.094490. PMID 17293408. Bibcode: 2007BpJ....92.3130R.
* "Proton modulation of recombinant GABA(A) receptors: influence of GABA concentration and the beta subunit TM2-TM3 domain". J. Physiol. 567 (Pt 2): 365–377. 2005. doi:10.1113/jphysiol.2005.088823. PMID 15946973.
* "Heterogeneous GABAA receptor subunit expression in pediatric epilepsy patients". Neurobiol. Dis. 18 (3): 484–491. 2005. doi:10.1016/j.nbd.2004.12.010. PMID 15755675.
* "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. 2004. doi:10.1038/ng1285. PMID 14702039.
* "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
* "Alternative transcripts of the GABA(A) receptor epsilon subunit in human and rat". Neuropharmacology 43 (4): 467–475. 2002. doi:10.1016/S0028-3908(02)00153-3. PMID 12367593.
* "GABA(A) receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus". J. Neurosci. 20 (10): 3588–3595. 2000. doi:10.1523/jneurosci.20-10-03588.2000. PMID 10804200.
* Russek SJ (1999). "Evolution of GABA(A) receptor diversity in the human genome". Gene 227 (2): 213–222. doi:10.1016/S0378-1119(98)00594-0. PMID 10023064.
* "A gene in human chromosome band Xq28 (GABRE) defines a putative new subunit class of the GABAA neurotransmitter receptor". Genomics 45 (1): 1–10. 1997. doi:10.1006/geno.1997.4885. PMID 9339354.
* "Neuronally restricted RNA splicing regulates the expression of a novel GABAA receptor subunit conferring atypical functional properties [corrected; erratum to be published"]. J. Neurosci. 17 (13): 5027–5037. 1997. doi:10.1523/jneurosci.17-13-05027.1997. PMID 9185540.

## External links

* GABRE+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

* v
* t
* e

Ion channel, cell surface receptor: ligand-gated ion channels

Cys-loop receptors|

| 5-HT/serotonin|

* 5-HT3
* A
* B
* C
* D
* E

|

GABA|

* GABAA
* α1
* α2
* α3
* α4
* α5
* α6
* β1
* β2
* β3
* γ1
* γ2
* γ3
* δ
* ε
* π
* θ
* GABAA-ρ
* ρ1
* ρ2
* ρ3

Glycine|

* α1
* α2
* α3
* α4
* β

Nicotinic acetylcholine|

* monomers: α1
* α2
* α3
* α4
* α5
* α6
* α7
* α9
* α10
* β1
* β2
* β3
* β4
* δ
* ε

* pentamers: (α3)2(β4)3
* (α4)2(β2)3
* (α7)5
* (α1)2(β4)3 \- Ganglion type
* (α1)2β1δε - Muscle type

Zinc|

* Zinc-activated

Ionotropic glutamates|

| Ligand-gated only|

* AMPA (1
* 2
* 3
* 4)
* Kainate
* 1
* 2
* 3
* 4
* 5

|

Voltage- and ligand-gated|

* NMDA
* 1
* 2A
* 2B
* 2C
* 2D
* 3A
* 3B
* L1A
* L1B

‘Orphan’|

* GluD
* δ1
* δ2

ATP-gated channels|

| Purinergic receptors|

* P2X
* 1
* 2
* 3
* 4
* 5
* 6
* 7

|

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