Holin superfamily I

The Holin Superfamily I (aka the CDD phage holin1 superfamily) is a superfamily of integral membrane transport proteins. It is one of the seven different holin superfamilies in total. In general, these proteins are thought to play a role in regulated cell death, although functionality varies between families and individual members. Its main constituent is the Phi11 Holin (φ11 Holin) Family.[1] This family is made up of over 270 putative pore-forming proteins, all from Bacillota. On average, proteins belonging to the holin I superfamily are about 100 amino acyl residues (aas) in length, although a large size variation exists among proteins of this superfamily. There does not seem to be deviation from the standard two transmembrane segments that these proteins possess.[2][3]

## See also

* Holins
* Lysin
* Transporter Classification Database

## References

1. ↑ "TC 1.E.11". Transporter Classification Database. http://www.tcdb.org/search/result.php?tc=1.E.11.
2. ↑ Reddy, Bhaskara L.; Saier Jr., Milton H. (2013-11-01). "Topological and phylogenetic analyses of bacterial holin families and superfamilies". Biochimica et Biophysica Acta (BBA) - Biomembranes 1828 (11): 2654–2671. doi:10.1016/j.bbamem.2013.07.004. PMID 23856191.
3. ↑ "TCDB » Superfamilies". http://www.tcdb.org/superfamily.php?id=46.

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