Holin superfamily VI

The Holin superfamily VI is a superfamily of integral membrane transport proteins. It is one of the seven different holin superfamilies in total. In general, these proteins are thought to play a role in regulated cell death, although functionality varies between families and individual members. The Holin superfamily VI includes two TC families:[1]

* 1.E.12 \- The φAdh Holin (φAdh Holin) Family
* 1.E.26 \- The Holin LLH (Holin LLH) Family

Superfamily VI includes families with members only from Bacillota. These proteins appear to have one N-terminal transmembrane segment (TMS), followed by an amphipathic, weakly hydrophobic peak that was not predicted to be transmembrane by the topological programs used by Reddy and Saier (2013).[2] The average sizes of the members of the two families belonging to the Holin superfamily VI are 135 ± 11 and 130 ± 26 amino acyl residues (aas), respectively.[2]

## See also

* Holin
* Lysin
* Transporter Classification Database

## References

1. ↑ "Holin Superfamily VI". http://www.tcdb.org/superfamily.php?id=51.
2. ↑ 2.0 2.1 Reddy, Bhaskara L.; Saier Jr., Milton H. (2013-11-01). "Topological and phylogenetic analyses of bacterial holin families and superfamilies". Biochimica et Biophysica Acta (BBA) - Biomembranes 1828 (11): 2654–2671. doi:10.1016/j.bbamem.2013.07.004. PMID 23856191.

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