Keratin 16

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Keratin 16 is a protein that in humans is encoded by the KRT16 gene.[1][2][3]

Keratin 16 is a type I cytokeratin. It is paired with keratin 6 in a number of epithelial tissues, including nail bed, esophagus, tongue, and hair follicles. Mutations in the gene encoding this protein are associated with the genetic skin disorders including pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus.[4]

## References

1. ↑ "A group of type I keratin genes on human chromosome 17: characterization and expression". Mol. Cell. Biol. 8 (2): 722–36. February 1988. doi:10.1128/mcb.8.2.722. PMID 2451124.
2. ↑ "Three epidermal and one simple epithelial type II keratin genes map to human chromosome 12". Cytogenet. Cell Genet. 57 (1): 33–8. 1991. doi:10.1159/000133109. PMID 1713141.
3. ↑ "New consensus nomenclature for mammalian keratins". J. Cell Biol. 174 (2): 169–74. July 2006. doi:10.1083/jcb.200603161. PMID 16831889.
4. ↑ "Novel mutations in keratin 16 gene underlie focal non-epidermolytic palmoplantar keratoderma (NEPPK) in two families". Hum. Mol. Genet. 4 (10): 1875–81. October 1995. doi:10.1093/hmg/4.10.1875. PMID 8595410.

## External links

* GeneReviews/NCBI/NIH/UW entry on Pachyonychia Congenita

## Further reading

* "A spectrum of mutations in keratins K6a, K16 and K17 causing pachyonychia congenita". J. Dermatol. Sci. 48 (3): 199–205. 2007. doi:10.1016/j.jdermsci.2007.07.003. PMID 17719747.
* "Comparative analysis of the expression of cytokeratins (1, 10, 14, 16, 4), involucrin, filaggrin and e-cadherin in plane warts and epidermodysplasia verruciformis plane wart-type lesions". J. Cutan. Pathol. 36 (6): 647–54. 2009. doi:10.1111/j.1600-0560.2008.01127.x. PMID 19515043.
* "Induction of disease-associated keratin 16 gene expression by epidermal growth factor is regulated through cooperation of transcription factors Sp1 and c-Jun". J. Biol. Chem. 278 (46): 45848–57. 2003. doi:10.1074/jbc.M302630200. PMID 12954631.
* "Mutations of KRT6A are more frequent than those of KRT16 in pachyonychia congenita type 1: report of a novel and a recently reported mutation in two unrelated Chinese families". Br. J. Dermatol. 159 (1): 238–40. 2008. doi:10.1111/j.1365-2133.2008.08603.x. PMID 18489596.
* "Cluster analysis of an extensive human breast cancer cell line protein expression map database". Proteomics 2 (2): 212–23. 2002. doi:10.1002/1615-9861(200202)2:2<212::AID-PROT212>3.0.CO;2-H. PMID 11840567.
* "Distribution of dipeptidyl-peptidase IV on keratinocytes in the margin zone of a psoriatic lesion: a comparison with hyperproliferation and aberrant differentiation markers". Arch. Dermatol. Res. 300 (10): 561–7. 2008. doi:10.1007/s00403-008-0862-1. PMID 18496701.
* "Identification of trichoplein, a novel keratin filament-binding protein". J. Cell Sci. 118 (Pt 5): 1081–90. 2005. doi:10.1242/jcs.01667. PMID 15731013.
* "K16 expression in uninvolved psoriatic skin: a possible marker of pre-clinical psoriasis". J. Cutan. Pathol. 31 (7): 471–6. 2004. doi:10.1111/j.0303-6987.2004.0220.x. PMID 15239676.
* "A mutation in the V1 domain of K16 is responsible for unilateral palmoplantar verrucous nevus". J. Invest. Dermatol. 114 (6): 1136–40. 2000. doi:10.1046/j.1523-1747.2000.00983.x. PMID 10844556.
* "Keratin and filaggrin expression in keratoacanthoma". J Eur Acad Dermatol Venereol 22 (3): 353–5. 2008. doi:10.1111/j.1468-3083.2007.02440.x. PMID 18005116.
* "Novel keratin 16 mutations and protein expression studies in pachyonychia congenita type 1 and focal palmoplantar keratoderma". Exp. Dermatol. 9 (3): 170–7. 2000. doi:10.1034/j.1600-0625.2000.009003170.x. PMID 10839714.
* "Small urine leak after renal transplantation: detection by delayed 99mTc-DTPA renography--a case report". J Nucl Med Technol 33 (1): 31–3. 2005. PMID 15731018.
* "Innate immune modulation of keratinocytes by antikeratin 16 antibodies". Exp. Dermatol. 17 (8): 645–52. 2008. doi:10.1111/j.1600-0625.2007.00682.x. PMID 18557933.
* "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
* "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
* "Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita". J. Invest. Dermatol. 117 (6): 1391–6. 2001. doi:10.1046/j.0022-202x.2001.01565.x. PMID 11886499.
* "ERK2-mediated C-terminal serine phosphorylation of p300 is vital to the regulation of epidermal growth factor-induced keratin 16 gene expression". J. Biol. Chem. 282 (37): 27215–28. 2007. doi:10.1074/jbc.M700264200. PMID 17623675.
* "Delayed-onset pachyonychia congenita associated with a novel mutation in the central 2B domain of keratin 16". Br. J. Dermatol. 144 (5): 1058–62. 2001. doi:10.1046/j.1365-2133.2001.04199.x. PMID 11359398.

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