Lengsin

Generic protein structure example

Lengsin is a protein that in humans is encoded by the LGSN gene.

Lengsin is a survivor of an ancient family of class I glutamine synthetases in eukaryotes that has undergone evolutionary re-engineering for a tissue-specific, noncatalytic role in the lens of the vertebrate eye.[1] Lengsin is the result of the recruitment of an ancient enzyme may act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. It does not seem to have enzymatic activity.

## References

1. ↑ "A role for lengsin, a recruited enzyme, in terminal differentiation in the vertebrate lens". The Journal of Biological Chemistry 283 (10): 6607–15. March 2008. doi:10.1074/jbc.M709144200. PMID 18178558.

## Further reading

* "Lengsin is a survivor of an ancient family of class I glutamine synthetases re-engineered by evolution for a role in the vertebrate lens". Structure (London, England) 14 (12): 1823–34. December 2006. doi:10.1016/j.str.2006.10.008. PMID 17161372.

## External links

* "Q5TDP6 (LGSN_HUMAN)". UniProtKB. https://www.uniprot.org/uniprot/Q5TDP6.

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