maleate hydratase

Identifiers
EC number| 4.2.1.31
CAS number| 37290-71-4
Databases
IntEnz| IntEnz view
BRENDA| BRENDA entry
ExPASy| NiceZyme view
KEGG| KEGG entry
MetaCyc| metabolic pathway
PRIAM| profile
PDB structures| RCSB PDB PDBe PDBsum
Gene Ontology| AmiGO  / QuickGO
| Search

PMC| articles
PubMed| articles
NCBI| proteins

The enzyme maleate hydratase (EC 4.2.1.31) catalyzes the chemical reaction

(R)-malate ⇌ maleate + H2O

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (R)-malate hydro-lyase (maleate-forming). Other names in common use include D-malate hydro-lyase, malease, and (R)-malate hydro-lyase. This enzyme participates in butanoate metabolism.

## References

* "Anion activation of maleate hydratase". Biochim. Biophys. Acta 185 (1): 220-7. 1969. doi:10.1016/0005-2744(69)90296-4. PMID 5796106.
* "Malease, a hydrase from corn kernels". J. Biol. Chem. 192 (1): 231-6. 1951. PMID 14917669.

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Carbon–oxygen lyases (EC 4.2) (primarily dehydratases)

4.2.1: Hydro-Lyases|

* Carbonic anhydrase
* Fumarase
* Aconitase
* Enolase
* Alpha
* Enolase 2
* Enoyl-CoA hydratase/3-Hydroxyacyl ACP dehydrase
* Methylglutaconyl-CoA hydratase
* Tryptophan synthase
* Cystathionine beta synthase
* Porphobilinogen synthase
* 3-Isopropylmalate dehydratase
* Urocanase
* Uroporphyrinogen III synthase
* Nitrile hydratase

4.2.2: Acting on polysaccharides|

* Hyaluronate lyase

4.2.3: Acting on phosphates|

* Threonine synthase

4.2.99: Other|

* Carboxymethyloxysuccinate lyase
* Hydroperoxide lyase

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Enzymes

Activity|

* Active site
* Binding site
* Catalytic triad
* Oxyanion hole
* Enzyme promiscuity
* Catalytically perfect enzyme
* Coenzyme
* Cofactor
* Enzyme catalysis

Regulation|

* Allosteric regulation
* Cooperativity
* Enzyme inhibitor
* Enzyme activator

Classification|

* EC number
* Enzyme superfamily
* Enzyme family
* List of enzymes

Kinetics|

* Enzyme kinetics
* Eadie–Hofstee diagram
* Hanes–Woolf plot
* Lineweaver–Burk plot
* Michaelis–Menten kinetics

Types|

* EC1 Oxidoreductases (list)
* EC2 Transferases (list)
* EC3 Hydrolases (list)
* EC4 Lyases (list)
* EC5 Isomerases (list)
* EC6 Ligases (list)
* EC7 Translocases (list)

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