NEU4

Generic protein structure example

Sialidase-4 is an enzyme that in humans is encoded by the NEU4 gene.[1]

## Contents

* 1 Function
* 2 Interactions
* 3 References
* 4 Further reading

## Function

This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids.[1]

## Interactions

NEU4 has been shown to interact with PLSCR1.[2]

## References

1. ↑ 1.0 1.1 "Entrez Gene: NEU4 sialidase 4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=129807.
2. ↑ "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.

## Further reading

* "Identification and expression of Neu4, a novel murine sialidase.". Gene 321: 155–61. 2004. doi:10.1016/j.gene.2003.08.005. PMID 14637003.
* "Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family.". Genomics 83 (3): 445–53. 2004. doi:10.1016/j.ygeno.2003.08.019. PMID 14962670.
* "Neu4, a novel human lysosomal lumen sialidase, confers normal phenotype to sialidosis and galactosialidosis cells.". J. Biol. Chem. 279 (35): 37021–9. 2004. doi:10.1074/jbc.M404531200. PMID 15213228.
* "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. 2004. doi:10.1073/pnas.0404089101. PMID 15498874. Bibcode: 2004PNAS..10115724W.
* "Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages.". FEBS J. 272 (10): 2545–56. 2005. doi:10.1111/j.1742-4658.2005.04679.x. PMID 15885103.

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Hydrolase: sugar hydrolases (EC 3.2)

3.2.1: Glycoside hydrolases|

| Disaccharidase|

* Sucrase/Sucrase-isomaltase]]/Invertase
* Maltase
* Trehalase
* Lactase

|

Glucosidases|

* Cellulase
* Alpha-glucosidase
* Acid
* Neutral AB
* Neutral C
* Beta-glucosidase
* cytosolic
* Debranching enzyme

Other|

* Amylase
* Alpha-amylase
* Chitinase
* Lysozyme
* Neuraminidase
* NEU1
* NEU2
* NEU3
* NEU4
* Bacterial neuraminidase
* Viral neuraminidase
* Galactosidases
* Alpha
* Beta
* alpha-Mannosidase
* Glucuronidase
* Klotho
* Hyaluronidase
* Pullulanase
* Glucosylceramidase
* lysosomal
* non-lysosomal
* Galactosylceramidase
* Alpha-N-acetylgalactosaminidase
* NAGA
* Alpha-N-acetylglucosaminidase
* Fucosidase
* Hexosaminidase
* HEXA
* HEXB
* Iduronidase
* Maltase-glucoamylase
* Heparanase
* HPSE2

3.2.2: Hydrolysing
N-Glycosyl compounds|

* DNA glycosylases: Oxoguanine glycosylase

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