Opticin

Generic protein structure example

Opticin is a protein that in humans is encoded by the OPTC gene.[1][2]

Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1).[2]

## References

1. ↑ "Identification in vitreous and molecular cloning of opticin, a novel member of the family of leucine-rich repeat proteins of the extracellular matrix". J Biol Chem 275 (3): 2123–9. Feb 2000. doi:10.1074/jbc.275.3.2123. PMID 10636917.
2. ↑ 2.0 2.1 "Entrez Gene: OPTC opticin". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26254.

## Further reading

* "Cloning, modeling, and chromosomal localization for a small leucine-rich repeat proteoglycan (SLRP) family member expressed in human eye.". Mol. Vis. 6: 72–8. 2000. PMID 10837509.
* "Isolation of a novel iris-specific and leucine-rich repeat protein (oculoglycan) using differential selection.". Invest. Ophthalmol. Vis. Sci. 41 (8): 2059–66. 2000. PMID 10892843.
* "Tonsillar B cells do not express PSGL-1, but a significant fraction displays the cutaneous lymphocyte antigen and exhibits effective E- and P-selectin ligand activity.". Int. Arch. Allergy Immunol. 126 (1): 78–90. 2001. doi:10.1159/000049497. PMID 11641609.
* "Protein localization in the human eye and genetic screen of opticin.". Hum. Mol. Genet. 11 (11): 1333–42. 2002. doi:10.1093/hmg/11.11.1333. PMID 12019215.
* "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
* "Characterization of opticin and evidence of stable dimerization in solution.". J. Biol. Chem. 278 (46): 45280–7. 2003. doi:10.1074/jbc.M303117200. PMID 12951322.
* "Immunolocalisation of opticin in the human eye.". The British Journal of Ophthalmology 88 (5): 697–702. 2004. doi:10.1136/bjo.2003.031989. PMID 15090426.
* "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
* "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. 2006. doi:10.1021/pr0502065. PMID 16335952.
* "Evaluation of the OPTC gene in primary open angle glaucoma: functional significance of a silent change.". BMC Mol. Biol. 8: 21. 2007. doi:10.1186/1471-2199-8-21. PMID 17359525.

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