Outer membrane protein OpcA

Identifiers
Symbol| OpcA
Pfam| PF07239
InterPro| IPR009876
SCOP2| 1k24 / SCOPe / SUPFAM
OPM superfamily| 240
OPM protein| 1k24
| Available protein structures:

Pfam | structures / ECOD
PDB| RCSB PDB; PDBe; PDBj
PDBsum| structure summary

Outer membrane adhesin OpcA protein family consists of several Neisseria species specific outer membrane proteins. Neisseria meningitidis causes meningococcal meningitis and sepsis. Opc (formerly called 5C) is one of the major outer membrane proteins and has been shown to play an important role in meningococcal adhesion and invasion of epithelial and endothelial cells, mediating attachment to host cells by binding proteoglycan cell-surface receptors.[1]

OpcA forms a 10-stranded beta-barrel with five highly mobile extracellular loops that protrude above the surface of the membrane.[2] These extracellular loops combine to form a crevice in the external surface that is lined by positively charged residues, which is predicted to be a binding site for proteoglycan polysaccharides involved in pathogenesis. Conformational changes in the extracellular loops modulate the surface of OpcA, which could affect the proteoglycan binding site.[3] These conformational changes could also lead to pore opening.

## References

1. ↑ "Identification of opcA gene in Neisseria polysaccharea: interspecies diversity of Opc protein family". Gene 307: 31–40. 2003. doi:10.1016/S0378-1119(02)01208-8. PMID 12706886.
2. ↑ "Crystal structure of the OpcA integral membrane adhesin from Neisseria meningitidis". Proc. Natl. Acad. Sci. U.S.A. 99 (6): 3417–21. 2002. doi:10.1073/pnas.062630899. PMID 11891340. Bibcode: 2002PNAS...99.3417P.
3. ↑ "Membrane Simulations of OpcA: Gating in the Loops?". Biophys. J. 92 (2): L23–5. 2007. doi:10.1529/biophysj.106.097311. PMID 17114231. Bibcode: 2007BpJ....92L..23B.

This article incorporates text from the public domain Pfam and InterPro: IPR009876

0.00

(0 votes)

Original source: https://en.wikipedia.org/wiki/Outer membrane protein OpcA. Read more

|

Retrieved from "https://handwiki.org/wiki/index.php?title=Biology:Outer_membrane_protein_OpcA&oldid=799120"