ProP (transporter)

Proline/betaine transporter

Identifiers
Organism| Escherichia coli
Symbol| ProP
PDB| 1R48 (ECOD)
UniProt| P0C0L7
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Structures| Swiss-model
Domains| InterPro

ProP is a bacterial membrane protein that is a member of the major facilitator superfamily. It functions as an osmosensory and osmoregulatory transporter, responding to changes in osmotic pressure by importing compatible solutes such as proline or glycine betaine;[1] most substrates for ProP are zwitterions.[2] The activity of ProP increases with osmotic pressure in cells and proteoliposomes.[3][4] ProP is a symporter of hydrogen ions and compatible solutes, and is responsive to potassium concentrations.[2]

Activity of ProP has been associated with the ability of pathogenic E. coli to colonize the urinary tract.[3]

## References

1. ↑ "Isolation and sequencing of Escherichia coli gene proP reveals unusual structural features of the osmoregulatory proline/betaine transporter, ProP". Journal of Molecular Biology 229 (1): 268–76. January 1993. doi:10.1006/jmbi.1993.1030. PMID 8421314.
2. ↑ 2.0 2.1 "The ion coupling and organic substrate specificities of osmoregulatory transporter ProP in Escherichia coli". Biochimica et Biophysica Acta (BBA) - Biomembranes 1420 (1–2): 30–44. August 1999. doi:10.1016/s0005-2736(99)00085-1. PMID 10446288.
3. ↑ 3.0 3.1 "Osmoregulatory transporter ProP influences colonization of the urinary tract by Escherichia coli". Microbiology 144 ( Pt 1) (1): 91–102. January 1998. doi:10.1099/00221287-144-1-91. PMID 9467901.
4. ↑ "Purification and reconstitution of an osmosensor: transporter ProP of Escherichia coli senses and responds to osmotic shifts". Biochemistry 38 (6): 1676–84. February 1999. doi:10.1021/bi981279n. PMID 10026245.

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