Proteus (bacterium)

Short description: Genus of bacteria

Proteus

Proteus vulgaris growth in MacConkey agar culture plate
Scientific classification
Domain:  | Bacteria
Phylum:  | Pseudomonadota
Class:  | Gammaproteobacteria
Order:  | Enterobacterales
Family:  | Enterobacteriaceae
Genus:  | Proteus
Hauser, 1885
Species

* P. hauseri
* P. mirabilis
* P. myxofaciens
* P. penneri
* P. vulgaris

Proteus is a genus of Gram-negative bacteria. It is a rod shaped, aerobic and motile bacteria, which is able to migrate across surfaces due its “swarming” characteristic in temperatures between 20 and 37 °C.[1] Their size generally ranges from 0.4–0.8 μm in diameter and 1.0–3.0 μm in length. They tend to have an ammonia smell.[2] Proteus bacilli are widely distributed in nature as saprophytes, being found in decomposing animal matter, sewage, manure soil, the mammalian intestine, and human and animal feces. They are opportunistic pathogens, commonly responsible for urinary and septic infections, often nosocomial.

The term Proteus signifies changeability of form, as personified in the Homeric poems in Proteus, "the old man of the sea", who tends the sealflocks of Poseidon and has the gift of endless transformation. The first use of the term “Proteus” in bacteriological nomenclature was made by Hauser (1885), who described under this term three types of organisms which he isolated from putrefied meat.

## Contents

* 1 Clinical significance
* 2 Identification
* 3 Food industry
* 4 References

## Clinical significance

Three species--P. vulgaris, P. mirabilis, and P. penneri--are opportunistic human pathogens. Proteus includes pathogens responsible for many human urinary tract infections.[3] P. mirabilis causes wound and urinary tract infections. Most strains of P. mirabilis are sensitive to ampicillin and cephalosporins. P. vulgaris is not sensitive to these antibiotics but ticarcillin. However, this organism is isolated less often in the laboratory and usually only targets immunosuppressed individuals. P. vulgaris occurs naturally in the intestines of humans and a wide variety of animals, and in manure, soil, and polluted waters. P. mirabilis, once attached to the urinary tract, infects the kidney more commonly than E. coli. P. mirabilis is often found as a free-living organism in soil and water.

About 10–15% of kidney stones are struvite stones, caused by alkalinization of the urine by the action of the urease enzyme (which splits urea into ammonia and carbon dioxide) of Proteus (and other) bacterial species.

## Identification

Proteus species do not usually ferment lactose. Similar to other members of the Enterobacterales order, bacteria from the Proteus genus are glucose fermenting, oxidase-negative, catalase-positive, and nitrate-positive. Glucose fermentation in this species can be demonstrated through the triple sugar iron (TSI) test. Specific tests include positive urease (which is the fundamental test to differentiate Proteus from Salmonella) and phenylalanine deaminase tests.

On the species level, indole was considered reliable, as it is positive for P. vulgaris, but negative for P. mirabilis. However, further biochemical testing is now required to speciate Proteus since the discovery of the indole positive Proteus hauseri [4] Most strains produce a powerful urease enzyme, which rapidly hydrolyzes urea to ammonia and carbon monoxide; exceptions are some Providencia strains. Species can be motile,[5] and have characteristic "swarming" patterns.[6][7] Underlying these behaviors are the somatic O and flagellar H antigens, so named based on Kauffman–White classification. This system is based on historic observations of Edmund Weil (1879–1922) and Arthur Felix (1887–1956) of a thin surface film produced by agar-grown flagellated Proteus strains, a film that resembled the mist produced by breath on a glass. Flagellated (swarming, motile) variants were therefore designated H forms (German Hauch, for film, literally breath or mist); nonflagellated (nonswarming, nonmotile) variants growing as isolated colonies and lacking the surface film were designated as O forms (German ohne Hauch, without film [i.e., without surface film of mist droplets]).[8][9][10][11]

The cell wall O-antigen of certain strains of Proteus, such as OX-2, OX-19, OX-k, crossreact with several species of Rickettsia. These antigens can be used in laboratory to detect the presence of antibodies against certain Rickettsia species in patients' sera. This test is called Weil-Felix reaction after its originators.

## Food industry

Cheese makers have found Proteus bacterium’s species Proteus vulgaris, growing on cheese rinds in purple color, making the cheese inedible. It is successful in implanting itself in a complex cheese ecosystem and substantially contributed to the organoleptic properties of cheese during ripening. It does not interact well with other bacteria in the same ecosystem.[12]

See also

* Dienes phenomenon

## References

1. ↑ Buckle, Jane (2015), "How Essential Oils Work", Clinical Aromatherapy (Elsevier): pp. 15–36, http://dx.doi.org/10.1016/b978-0-7020-5440-2.00002-4, retrieved 2023-05-02
2. ↑ Veflen Olsen, N.; Motarjemi, Y (2014), "Food Safety Assurance Systems: Food Safety and Ethics", Encyclopedia of Food Safety (Elsevier): pp. 340–344, http://dx.doi.org/10.1016/b978-0-12-378612-8.00437-6, retrieved 2023-05-02
3. ↑ Guentzel MN (1996). Baron S. ed. Escherichia, Klebsiella, Enterobacter, Serratia, Citrobacter, and Proteus. In: Barron's Medical Microbiology (4th ed.). Univ of Texas Medical Branch. (via NCBI Bookshelf). ISBN 978-0-9631172-1-2.
4. ↑ O'Hara, C. M.; Brenner, F. W.; Steigerwalt, A. G.; Hill, B. C.; Holmes, B.; Grimont, P. A.; Hawkey, P. M.; Penner, J. L. et al. (September 2000). "Classification of Proteus vulgaris biogroup 3 with recognition of Proteus hauseri sp. nov., nom. rev. and unnamed Proteus genomospecies 4, 5 and 6". International Journal of Systematic and Evolutionary Microbiology 50 Pt 5: 1869–1875. doi:10.1099/00207713-50-5-1869. ISSN 1466-5026. PMID 11034498. https://pubmed.ncbi.nlm.nih.gov/11034498/.
5. ↑ Ryan KJ, ed (2004). Sherris Medical Microbiology (4th ed.). McGraw Hill. ISBN 978-0-8385-8529-0.
6. ↑ "Periodic phenomena in Proteus mirabilis swarm colony development". J. Bacteriol. 178 (22): 6525–38. November 1996. doi:10.1128/jb.178.22.6525-6538.1996. PMID 8932309.
7. ↑ "Dynamic aspects of the structured cell population in a swarming colony of Proteus mirabilis". J. Bacteriol. 182 (2): 385–93. January 2000. doi:10.1128/JB.182.2.385-393.2000. PMID 10629184.
8. ↑ See also :de:Kauffmann-White-Schema in the German Wikipedia.
9. ↑ Weil, E. & Felix, A. (1917) Wien. Klin. Wschr. 30, 1509, cited in Smith, R.W. & Koffler, H., Bacterial Flagella, In Advances in Microbial Physiology, Vol. 6 (A.H. Rose & J.F. Wilkinson, Eds.), p. 251, Academic Press, 1971
10. ↑ Rietschel, E.T. & Westphal, O. Endotoxin: Historical Perspectives, In Endotoxin in Health Disease (H. Brade, Ed.), p. 11, CRC Press, 1999.
11. ↑ Hahon, N., Ed. Selected Papers on the Pathogenic Rickettsiae, p. 79, Harvard University Press, 1968.
12. ↑ Deetae, P.; Mounier, J.; Bonnarme, P.; Spinnler, H.E.; Irlinger, F.; Helinck, S. (2009-04-24). "Effects of Proteus vulgaris growth on the establishment of a cheese microbial community and on the production of volatile aroma compounds in a model cheese". Journal of Applied Microbiology 107 (4): 1404–1413. doi:10.1111/j.1365-2672.2009.04315.x. ISSN 1364-5072. http://dx.doi.org/10.1111/j.1365-2672.2009.04315.x.

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