Receptor editing

Receptor editing is a process that occurs during the maturation of B cells, which are part of the adaptive immune system. This process forms part of central tolerance to attempt to change the specificity of the antigen receptor of self reactive immature B-cells, in order to rescue them from programmed cell death, called apoptosis.[1] It is thought that 20-50% of all peripheral naive B cells have undergone receptor editing making it the most common method of removing self reactive B cells.[2] During maturation in the bone marrow, B cells are tested for interaction with self antigens, which is called negative selection. If the maturing B cells strongly interact with these self antigens, they undergo death by apoptosis. Negative selection is important to avoid the production of B cells that could cause autoimmune diseases. They can avoid apoptosis by modifying the sequence of light chain V and J genes (components of the antigen receptor) so that it has a different specificity and may not recognize self antigens anymore. This process of changing the specificity of the immature B cell receptor is called receptor editing.

## References

1. ↑ Meffre, E; Wardemann, H (2008). "B-cell tolerance checkpoints in health and autoimmunity.". Current Opinion in Immunology 20 (6): 632–638. doi:10.1016/j.coi.2008.09.001. PMID 18848883.
2. ↑ "Receptor editing is the main mechanism of B cell tolerance toward membrane antigens". Nature Immunology 5 (6): 645–650. 2004. doi:10.1038/ni1076. PMID 15156139.

3. Kleinfield R, Hardy RR, Tarlinton, D (1986). 'Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a
Ly1+ B-cell lymphoma'. Nature 322 (6082): 843-6.

0.00

(0 votes)

Original source: https://en.wikipedia.org/wiki/Receptor editing. Read more

|

Retrieved from "https://handwiki.org/wiki/index.php?title=Biology:Receptor_editing&oldid=500776"