STCH

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Heat shock 70 kDa protein 13 is a protein that in humans is encoded by the HSPA13 gene.[1][2]

The protein encoded by this gene is a member of the heat shock protein 70 family and is found associated with microsomes. Members of this protein family play a role in the processing of cytosolic and secretory proteins, as well as in the removal of denatured or incorrectly folded proteins. The encoded protein contains an ATPase domain and has been shown to associate with a ubiquitin-like protein.[2]

## References

1. ↑ "Localization of STCH to human chromosome 21q11.1". Genomics 30 (3): 627–8. Feb 1997. doi:10.1006/geno.1995.1291. PMID 8825657. https://zenodo.org/record/1229673.
2. ↑ 2.0 2.1 "Entrez Gene: STCH stress 70 protein chaperone, microsome-associated, 60kDa". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6782.

## Further reading

* "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
* "Stch encodes the 'ATPase core' of a microsomal stress 70 protein.". EMBO J. 13 (5): 1216–25. 1994. doi:10.1002/j.1460-2075.1994.tb06371.x. PMID 8131751.
* "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548.
* "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. 1997. doi:10.1101/gr.6.9.807. PMID 8889549.
* "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
* "A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch.". FEBS Lett. 467 (2–3): 348–55. 2000. doi:10.1016/S0014-5793(00)01135-2. PMID 10675567. https://zenodo.org/record/1259585.
* "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. 2000. doi:10.1038/35012518. PMID 10830953. Bibcode: 2000Natur.405..311H.
* "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants.". Mol. Vis. 8: 205–20. 2002. PMID 12107410.
* "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
* "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
* "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
* "A genetic variant in the gene encoding the stress70 protein chaperone family member STCH is associated with gastric cancer in the Japanese population.". Biochem. Biophys. Res. Commun. 335 (2): 566–74. 2005. doi:10.1016/j.bbrc.2005.07.110. PMID 16087163.
* "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.

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