Segmental duplication

Segmental duplications (SDs) are segments of DNA with near-identical sequences.[1] Segmental duplications, also known as low copy repeats (LCRs), are believed to have played a role in creating new primate genes as reflected in human genetic variation. In humans, chromosomes Y and 22 have the greatest proportion of SDs: 50.4% and 11.9% respectively.[2]

## Detection method

The two widely accepted methods for SD detection are whole genome assembly comparison (WGAC) and whole genome shotgun sequence detection (WSSD).

## See also

* Copy number variation
* Pseudogenes
* Molecular evolution
* Human genome
* Comparative genomics
* Inparanoid
* Tandem exon duplication

## References

1. ↑ Genome-wide detection of segmental duplications
2. ↑ Bailey, Jeffrey A.; Eichler, EE (2006). "Primate segmental duplications: crucibles of evolution, diversity and disease". Nature Reviews Genetics 7 (7): 552–64. doi:10.1038/nrg1895. PMID 16770338.

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