TNF receptor associated factor

TNF receptor associated factors (TRAFs) are a family of proteins primarily involved in the regulation of inflammation, antiviral responses and apoptosis.[1]

Currently, seven TRAF proteins have been characterized in mammals: TRAF1, TRAF2, TRAF3, TRAF4, TRAF5, TRAF6 and TRAF7.

Except for TRAF7, these proteins share a relatively conserved secondary structure, including a namesake C-terminal TRAF domain that mediates interactions with other signaling components such as the transmembrane TNF receptors and CD40.

## See also

* Tumor necrosis factors

## References

1. ↑ "Tumor necrosis factor receptor-associated factor (TRAF) family: adapter proteins that mediate cytokine signaling". Exp. Cell Res. 254 (1): 14–24. January 2000. doi:10.1006/excr.1999.4733. PMID 10623461.

## External links

* TRAF+Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)

* v
* t
* e

Cell signaling: carrier proteins: signal transducing adaptor proteins

JAK-STAT|

* see JAK-STAT signaling pathway

Growth factor receptor-bound protein|

* GRB2
* GRB7
* GRB10

Other|

* 14-3-3
* YWHAE
* YWHAZ
* Caveolin
* Cortactin
* Death-inducing signaling complex
* Paxillin
* MYD88
* SMAD
* TRAF
* TRAF1
* TRAF2
* TRAF3
* TRAF4
* TRAF5
* TRAF6)
* BIN1
* SH3BP2
* LDB3

* CHM
* CHML

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