TRNA (guanine9-N1)-methyltransferase

Identifiers
EC number| 2.1.1.221
Databases
IntEnz| IntEnz view
BRENDA| BRENDA entry
ExPASy| NiceZyme view
KEGG| KEGG entry
MetaCyc| metabolic pathway
PRIAM| profile
PDB structures| RCSB PDB PDBe PDBsum
| Search

PMC| articles
PubMed| articles
NCBI| proteins

TRNA (guanine9-N1)-methyltransferase (EC 2.1.1.221, Trm10p, tRNA(m1G9/m1A9)-methyltransferase, tRNA(m1G9/m1A9)MTase, tRNA (guanine-N(1)-)-methyltransferase, tRNA m1G9-methyltransferase, tRNA m1G9 MTase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine9-N1)-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanine9 in tRNA ⇌ S-adenosyl-L-homocysteine + N1-methylguanine9 in tRNA

The enzyme from Saccharomyces cerevisiae specifically methylates guanine9.

## References

1. ↑ "New archaeal methyltransferases forming 1-methyladenosine or 1-methyladenosine and 1-methylguanosine at position 9 of tRNA". Nucleic Acids Research 38 (19): 6533–43. October 2010. doi:10.1093/nar/gkq451. PMID 20525789.
2. ↑ "Identification of the yeast gene encoding the tRNA m1G methyltransferase responsible for modification at position 9". RNA 9 (5): 574–85. May 2003. doi:10.1261/rna.5070303. PMID 12702816.

## External links

* TRNA+(guanine9-N1)-methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)

* v
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* e

Transferase: one carbon transferases (EC 2.1)

2.1.1: Methyl-|

| N-|

* Histamine N-methyltransferase
* Phenylethanolamine N-methyltransferase
* Amine N-methyltransferase
* Phosphatidylethanolamine N-methyltransferase

|

O-|

* 5-hydroxyindole-O-methyltransferase/Acetylserotonin O-methyltransferase
* Catechol-O-methyl transferase

Homocysteine|

* Betaine-homocysteine methyltransferase
* Homocysteine methyltransferase
* Methionine synthase

Other|

* Phosphatidyl ethanolamine methyltransferase
* DNMT3B
* Histone methyltransferase
* Thymidylate synthase
* DNA methyltransferase
* Thiopurine methyltransferase
* Cyclopropane-fatty-acyl-phospholipid synthase

2.1.2: Hydroxymethyl-,
Formyl\- and Related|

| Hydroxymethyltransferase|

* Serine hydroxymethyltransferase
* 3-methyl-2-oxobutanoate hydroxymethyltransferase

|

Formyltransferase|

* Phosphoribosylglycinamide formyltransferase
* Inosine monophosphate synthase

Other|

* Glutamate formimidoyltransferase
* Aminomethyltransferase

2.1.3: Carboxy-
and Carbamoyl|

| Carboxy|

* methylmalonyl-CoA carboxytransferase

|

Carbamoyl|

* Aspartate carbamoyltransferase
* Ornithine carbamoyltransferase
* Oxamate carbamoyltransferase
* Putrescine carbamoyltransferase
* 3-hydroxymethylcephem carbamoyltransferase
* Lysine carbamoyltransferase
* N-acetylornithine carbamoyltransferase

2.1.4: Amidine|

* Arginine

* v
* t
* e

Enzymes

Activity|

* Active site
* Binding site
* Catalytic triad
* Oxyanion hole
* Enzyme promiscuity
* Catalytically perfect enzyme
* Coenzyme
* Cofactor
* Enzyme catalysis

Regulation|

* Allosteric regulation
* Cooperativity
* Enzyme inhibitor
* Enzyme activator

Classification|

* EC number
* Enzyme superfamily
* Enzyme family
* List of enzymes

Kinetics|

* Enzyme kinetics
* Eadie–Hofstee diagram
* Hanes–Woolf plot
* Lineweaver–Burk plot
* Michaelis–Menten kinetics

Types|

* EC1 Oxidoreductases (list)
* EC2 Transferases (list)
* EC3 Hydrolases (list)
* EC4 Lyases (list)
* EC5 Isomerases (list)
* EC6 Ligases (list)
* EC7 Translocases (list)

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