Vitreous body

"Vitreous humor" redirects here. For the band, see Vitreous Humor (band).

Short description: Gel in eyeballs

Vitreous humor

The vitreous body lies at the back of the eye, between the lens and the retina.

Details
Part of| Eye
System| Visual system
Identifiers
Latin| humor vitreus
Anatomical terminology

[edit on Wikidata]

The vitreous body (vitreous meaning "glass-like"; from la vitreus 'glassy', from vitrum 'glass', and -eus) is the clear gel that fills the space between the lens and the retina of the eyeball (the vitreous chamber) in humans and other vertebrates. It is often referred to as the vitreous humor (also spelled humour), from Latin meaning liquid, or simply "the vitreous". Vitreous fluid or "liquid vitreous" is the liquid component of the vitreous gel, found after a vitreous detachment. It is not to be confused with the aqueous humor, the other fluid in the eye that is found between the cornea and lens.

## Contents

* 1 Structure
* 1.1 Anatomical features
* 1.2 Biochemical properties
* 2 Development
* 3 Clinical significance
* 3.1 Injury
* 3.2 Postmortem and forensic
* 4 Additional images
* 5 See also
* 6 References
* 7 External links

## Structure

The vitreous humor is a transparent, colorless, gelatinous mass that fills the space in the eye between the lens and the retina. It is surrounded by a layer of collagen called the vitreous membrane (or hyaloid membrane or vitreous cortex) separating it from the rest of the eye. It makes up four-fifths of the volume of the eyeball.[1] The vitreous body has an average volume of approximately 4 mL in the adult human eye; however, its volume varies significantly between individuals and depends on axial length and refractive status. Highly myopic eyes, which are characterized by increased axial length, may have vitreous volumes exceeding 9–10 mL, whereas hyperopic eyes with shorter axial length may have vitreous volumes of approximately 3–4 mL.[2][3]The vitreous humour is fluid-like near the centre, and gel-like near the edges.

The vitreous humour is in contact with the vitreous membrane overlying the retina. Collagen fibrils attach the vitreous at the optic nerve disc and the ora serrata[1] (where the retina ends anteriorly), at the Wieger-band, the dorsal side of the lens. The vitreous also firmly attaches to the lens capsule, retinal vessels, and the macula, the area of the retina which provides finer detail and central vision.[4]

Aquaporin 4 in Müller cells in rats transports water to the vitreous body.[5][6]

### Anatomical features

The vitreous has many anatomical landmarks, including the hyaloid membrane, Berger's space, space of Erggelet, Wieger's ligament, Cloquet's canal and the space of Martegiani.[7][8][9]

Surface features:

* Patella fossa: Shallow saucer-like concavity anteriorly, in which the lens rests, separated by Berger's space
* Ligamentum hyaloideocapsulare (Wieger's ligament): Circular thickening of vitreous 8–9mm in diameter, delineates the patella fossa
* Anterior hyaloid: Vitreous surface anterior to ora serrata. Continuous with and invests in the zonular fibres, and extends forward between the ciliary processes
* Vitreous base: Denser cortical area of vitreous. Firmly attached to the posterior 2mm of the pars plana, and the anterior 2–4mm of retina
* Posterior hyaloid surface: Closely applied to retinal internal limiting membrane. Firm attachment sites: Along blood vessels and at sites of retinal degeneration
* Space of Martegioni: A funnel shaped space overlying the optic disc with condensed edge
* Cloquet's canal: A 1–2 mm wide canal within the vitreous, from the space of Martegioni to the space of Berger, along an S-shaped course mainly below the horizontal. It is labelled "hyaloid canal" in the above diagram.
* Mittendorf's dot: A small circular opacity on the posterior lens capsule, which represents the site of attachment of the hyaloid artery before it subsequently regressed.[10]
* Bergmeister's papilla: A tuft of fibrous tissue at the optic disc, which represents a remnant of the sheath associated with the hyaloid artery before it subsequently regressed.

Internal structures of the vitreous

* The vitreous body at birth is homogenous with a finely striated pattern.
* With early aging the vitreous develops narrow transvitreal "channels".
* The cortex is denser than the centre with development.
* From adolescence, vitreous tracts form from anterior to posterior.
* These vitreous tracts are fine sheet-like condensations of vitreous.

Named tracts

* Retrolental tract: Extends posteriorly from the hyaloideocapsular ligament into central vitreous
* Coronary tract: External to the retrolental tract, and excluding posteriorly from a circular zone overlying the posterior 1/3rd of the ciliary processes
* Median tract: Extends back from a circular zone external to the coronary tract, at the anterior margin of the vitreous base
* Preretinal tract: Extends back from the ora serrata and vitreous base

### Biochemical properties

Its composition is similar to that of the cornea, but the vitreous contains very few cells. It is composed mostly of phagocytes, which remove unwanted cellular debris in the visual field, and hyalocytes, which turn over the hyaluronan.

The vitreous humour contains no blood vessels, and 98–99% of its volume is water. In addition to water, the vitreous consists of salts, sugars, vitrosin (a type of collagen), a network of collagen type II fibrils with glycosaminoglycan, hyaluronan, opticin, and a wide array of proteins. Despite having little solid matter, the fluid is substantial enough to fill the eye and give it its spherical shape. This contrasts with the aqueous humour, which is more fluid, and the lens, on the other hand, which is elastic in nature and is tightly packed with cells.[11] The vitreous humour has a viscosity two to four times that of water, giving it a gelatinous consistency. It has a refractive index of 1.336.[12]

Inorganic ion content of vitreous body

Inorganic ion content of vitreous  | Solute | Mean concentration | Units | Reference | Data from living humans?

|
|
|
|

Sodium | 146.7 | mmol/L | [13] | Yes
Potassium | 5.73 | mmol/L | [13] | Yes
Chloride | 121.6 | mmol/L | [13] | Yes
Calcium | 1.13 | mmol/L | [13] | Yes
Magnesium | 0.9 | mmol/L | [13] | Yes
Phosphate | 0.1 to 3.3 | mEq/dm3 | [14] | No
Bicarbonate | 1.2 to 3.0 | g/kg water | [14] | No
Inorganic coenzyme content of vitreous  Solute | Mean concentration | Units | Reference | Data from living humans?

|
|
|
|

Copper | 0.52 | μmol/L | [13] | Yes
Selenium | 0.104 | μmol/L | [13] | Yes
Iron | 3.11 | μmol/L | [13] | Yes
Manganese | 110.7 | nmol/L | [15] | Yes

Organic content of vitreous body

Organic content of vitreous  | Solute | Mean concentration | Units | Reference | Data from living humans?

|
|
|
|

Glucose | 2.97 | mmol/L | [13] | Yes
Lactate | 3.97 | mmol/L | [13] | Yes
Lipids | 2 | μg/mL | [14] | No
Total protein content | 280–1360 | μg/cm3 | [14] | No
Hyaluronan | 42–400 | μg/cm3 | [14] | No
Versican | 60 | μg/cm3 | [14] | No
Collagen | 300 | μg/mL | [16] | No
Albumin | 293 ± 18 | μg/cm3 | [14] | No
Immunoglobulin (IgG) | 33.5 ± 3 | μg/cm3 | [14] | No
α1-Antitrypsin | 141 ± 2.9 | μg/cm3 | [14] | No
α1-Acid glycoprotein | 4 ± 0.7 | μg/cm3 | [14] | No
Beta-hydroxybutyrate | 0.094 | mmol/L | [13] | Yes
Ferritin | 19.52 | μg/L | [13] | Yes
Transferrin | 0.088 | g/L | [13] | Yes
Urea | 24–172 | mg/dL water | [14] | No
Creatinine | 0.3–3.0 | mg/dL water | [14] | No
Citrate | 1.9 | mg/dL water | [14] | No
Pyruvic acid | 7.3 | mg/dL water | [14] | No
Ascorbic acid | 36 | mg/100g | [14] | No

Physical properties of the vitreous body

Physical properties of vitreous  | Property | Value | Units | Reference | Data from living humans?

|
|
|
|

Volume | 3.9 | mL | [14] | No
Weight | 3.9 | g | [14] | No
Water content | 99 to 99.7 | % | [14] | No
pH | 7.4 to 7.52 |  | [14] | No
Osmolality | 289.5 | mOsm/kg | [13] | Yes
Osmotic pressure (Freezing-point depression) | -0.554 to -0.518 | °C | [14] | No
Density | 1.0053 to 1.0089 | g/cm3 | [14] | No
Intrinsic viscosity | 3–5 × 103 | cm3/g | [14] | No
Dynamic viscosity | 1.6 | cP | [14] | No
Refractive index | 1.3345 to 1.337 |  | [14] | No

## Development

The vitreous fluid is not present at birth (the eye being filled with only the gel-like vitreous body), but found after age 4–5, and increases in size thereafter.[1]

Produced by cells in the non-pigmented portion of the ciliary body, the vitreous humour is derived from embryonic mesenchyme cells, which degenerate after birth.[1]

Coarse strands develop with ageing. The gel volume decreases with age, and the liquid volume increases.[14] The cortex may disappear at sites, allowing liquid vitreous to extrude adjacently into the potential space between vitreous cortex and retina (vitreous detachment).

## Clinical significance

### Injury

If the vitreous pulls away from the retina, it is known as a vitreous detachment. As the human body ages, the vitreous often liquefies and may collapse. This is more likely to occur, and occurs much earlier, in eyes that are nearsighted (myopia). It can also occur after injuries to the eye or inflammation in the eye (uveitis).

The collagen fibres of the vitreous are held apart by electrical charges. With aging, these charges tend to reduce, and the fibres may clump together. Similarly, the gel may liquefy, a condition known as synaeresis, allowing cells and other organic clusters to float freely within the vitreous humour. These allow floaters which are perceived in the visual field as spots or fibrous strands. Floaters are generally harmless, but the sudden onset of recurring floaters may signify a posterior vitreous detachment or other diseases of the eye.

Posterior vitreous detachment: Once liquid vitreous enters the sub-hyaloid space between the vitreous cortex and the retina, it may strip the vitreous cortex off the retina with each eye movement (see Saccade).

### Postmortem and forensic

After death, the vitreous resists putrefaction longer than other body fluids. Within the hours, days and weeks after death, the vitreous potassium concentration rises, at such a predictable speed that vitreous potassium levels are frequently used to estimate the time since death (post-mortem interval) of a corpse.[17][18][19]

The metabolic exchange and equilibration between systemic circulation and vitreous humour is so slow that vitreous humour is sometimes the fluid of choice for postmortem analysis of glucose levels or substances which would be more rapidly diffused, degraded, excreted or metabolized from general circulation.

According to Judaism, extracting the vitreous fluid for forensic chemical analysis is preferred to blood analysis (in case a forensic or post-mortem toxicology test is deemed necessary). This avoids the loss of even a few droplets of blood from the body prior to burial.[citation needed]

## Additional images

* Structures of the eye labeled

* This image shows another labeled view of the structures of the eye.

## See also

* Anterior chamber of eyeball
* Eye floaters

## References

1. ↑ 1.0 1.1 1.2 1.3 Gray's anatomy: the anatomical basis of clinical practice (40th ed.). London: Churchill Livingstone. 2008. ISBN 978-0-8089-2371-8.
2. ↑ Schulz, A; Keskar, M; Swindle-Reilly, KE; Junge, V; Parikh, BH; Su, X; Liu, Z; Seah, I (September 2025). "Replacing the vitreous body with hydrogels: Rationale and strategies.". Progress in retinal and eye research 108. doi:10.1016/j.preteyeres.2025.101389. PMID 40645475. https://www.sciencedirect.com/science/article/pii/S135094622500062X?via=ihub.
3. ↑ Borkenstein, AF; Borkenstein, EM; Langenbucher, A (January 2024). "VIVEX: A Formula for Calculating Individual Vitreous Volume: A New Approach Towards Tailored Patient Dosing Regime in Intravitreal Therapy.". Ophthalmology and therapy 13 (1): 205-219. doi:10.1007/s40123-023-00838-2. PMID 37938450. https://link.springer.com/article/10.1007/s40123-023-00838-2.
4. ↑ Retina and vitreous.. American Academy of Ophthalmology (2017-2018 ed.). San Francisco, CA. 2017. ISBN 978-1-61525-818-5. OCLC 1003266782.
5. ↑ Sim?, Rafael; Villarroel, Marta; Corraliza, L?dia; Hern?ndez, Cristina; Garcia-Ram?rez, Marta (2010). "The Retinal Pigment Epithelium: Something More than a Constituent of the Blood-Retinal Barrier? Implications for the Pathogenesis of Diabetic Retinopathy". Journal of Biomedicine and Biotechnology 2010. doi:10.1155/2010/190724. PMID 20182540.
6. ↑ Nagelhus, EA; Veruki, ML; Torp, R; Haug, FM; Laake, JH; Nielsen, S; Agre, P; Ottersen, OP (1 April 1998). "Aquaporin-4 water channel protein in the rat retina and optic nerve: polarized expression in Müller cells and fibrous astrocytes.". The Journal of Neuroscience 18 (7): 2506–19. doi:10.1523/JNEUROSCI.18-07-02506.1998. PMID 9502811. "These data suggest that Muller cells play a prominent role in the water handling in the retina and that they direct osmotically driven water flux to the vitreous body and vessels rather than to the subretinal space".
7. ↑ Anatomical relation (of the lens) image.slidesharecdn.com, accessed 3 December 2019
8. ↑ shaded cross-section of eye, labelling structures in the posterior capsule www.oculist.net, accessed 3 December 2019
9. ↑ line drawing cross-section of eye, with details of structures in the posterior capsule www.oculist.net, accessed 3 December 2019
10. ↑ Mittendorf dot webeye.ophth.uiowa.edu, accessed 3 December 2019
11. ↑ "eye, human" Encyclopædia Britannica -from Encyclopædia Britannica 2006 Ultimate Reference Suite DVD 2009
12. ↑ The Vitreous Humor retina.anatomy.upenn.edu
13. ↑ 13.00 13.01 13.02 13.03 13.04 13.05 13.06 13.07 13.08 13.09 13.10 13.11 13.12 13.13 "Biochemical analysis of the living human vitreous". ResearchGate. https://www.researchgate.net/publication/295078459.
14. ↑ 14.00 14.01 14.02 14.03 14.04 14.05 14.06 14.07 14.08 14.09 14.10 14.11 14.12 14.13 14.14 14.15 14.16 14.17 14.18 14.19 14.20 14.21 14.22 14.23 14.24 Murphy, William; Black, Jonathan; Hastings, Garth (11 June 2016). Handbook of Biomaterial Properties. Springer. ISBN 978-1-4939-3305-1. https://books.google.com/books?id=WwBkDAAAQBAJ.
15. ↑ "Manganese in the Human Vitreous". ResearchGate. 1 March 2016. https://www.researchgate.net/publication/297283508.
16. ↑ Velpandian, Thirumurthy (29 February 2016). Pharmacology of Ocular Therapeutics. Springer. ISBN 978-3-319-25498-2. https://books.google.com/books?id=9BGoCwAAQBAJ.
17. ↑ Zilg, B.; Bernard, S.; Alkass, K.; Berg, S.; Druid, H. (17 July 2015). "A new model for the estimation of time of death from vitreous potassium levels corrected for age and temperature". Forensic Science International 254: 158–66. doi:10.1016/j.forsciint.2015.07.020. PMID 26232848. https://www.researchgate.net/publication/280613862.
18. ↑ Kokavec, Jan; Min, San H.; Tan, Mei H.; Gilhotra, Jagjit S.; Newland, Henry S.; Durkin, Shane R.; Casson, Robert J. (19 March 2016). "Antemortem vitreous potassium may strengthen postmortem interval estimates". Forensic Science International 263: e18. doi:10.1016/j.forsciint.2016.03.027. PMID 27080618. https://www.researchgate.net/publication/299008560.
19. ↑ Postmortem Vitreous Analyses: Overview, Vitreous Procurement and Pretreatment, Performable Postmortem Vitreous Analyses. 30 June 2020. http://emedicine.medscape.com/article/1966150-overview.

## External links

* The Eye - explanations and diagrams from a McGill University Web site

* v
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Anatomy of the globe of the human eye

Fibrous tunic (outer)|

| Sclera|

* Episcleral layer
* Schlemm's canal
* Trabecular meshwork

|

Cornea|

* Limbus
* layers
* Epithelium
* Bowman's
* Stroma
* Dua's layer
* Descemet's
* Endothelium

1:posterior segment 2:ora serrata 3:ciliary muscle 4:ciliary zonules 5:Schlemm's canal 6:pupil 7:anterior chamber 8:cornea 9:iris 10:lens cortex 11:lens nucleus 12:ciliary process 13:conjunctiva 14:inferior oblique muscule 15:inferior rectus muscule 16:medial rectus muscle 17:retinal arteries and veins 18:optic disc 19:dura mater 20:central retinal artery 21:central retinal vein 22:optic nerve 23:vorticose vein 24:bulbar sheath 25:macula 26:fovea 27:sclera 28:choroid 29:superior rectus muscle 30:retina

Uvea/vascular tunic (middle)|

| Choroid|

* Capillary lamina of choroid
* Bruch's membrane
* Sattler's layer

|

Ciliary body|

* Ciliary processes
* Ciliary muscle
* Pars plicata
* Pars plana

Iris|

* Stroma
* Pupil
* Iris dilator muscle
* Iris sphincter muscle

Retina (inner)|

| Layers|

* Inner limiting membrane
* Nerve fiber layer
* Ganglion cell layer
* Inner plexiform layer
* Inner nuclear layer

* Outer plexiform layer
* Outer nuclear layer

* External limiting membrane
* Layer of rods and cones
* Retinal pigment epithelium

|

Cells|

* Photoreceptor cells (Cone cell, Rod cell) → (Horizontal cell) → Bipolar cell → (Amacrine cell) → Retina ganglion cell (Midget cell, [[Biology:Parasol cParasol cell, [[Bistratified cell]], Giant retina ganglion cells, Photosensitive ganglion cell) → Diencephalon: P cell, M cell, K cell, Muller glia

Other|

* Macula
* Perifoveal area
* Parafoveal area
* Fovea
* Foveal avascular zone
* Foveola
* Optic disc
* Optic cup
* Ora serrata

Anatomical regions of the eye|

| Anterior segment|

* Adnexa
* Fibrous tunic
* Anterior chamber
* Aqueous humour
* Iris
* Posterior chamber
* Ciliary body
* Lens
* Capsule of lens
* Zonule of Zinn

|

Posterior segment|

* Vitreous chamber
* Vitreous body
* Retina
* Choroid

Other|

* Keratocytes
* Ocular immune system
* Optical coherence tomography
* Eye care professional
* Eye disease
* Refractive error
* Accommodation
* Physiological Optics
* Visual perception

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