Aspergillus

Short description: Genus of fungi

Aspergillus

Conidial head of Aspergillus niger
Scientific classification
Kingdom:  | Fungi
Division:  | Ascomycota
Class:  | Eurotiomycetes
Order:  | Eurotiales
Family:  | Trichocomaceae
Genus:  | Aspergillus
Micheli (1729)
Species

See List of Aspergillus species

Aspergillus (/ˌæspərˈdʒɪləs/) is a genus consisting of a few hundred mold species found in various climates worldwide.

Aspergillus was first catalogued in 1729 by the Italian priest and biologist Pier Antonio Micheli. Viewing the fungi under a microscope, Micheli was reminded of the shape of an aspergillum (holy water sprinkler), from Latin spargere (to sprinkle), and named the genus accordingly.[1] Aspergillum is an asexual spore-forming structure common to all Aspergillus species; around one-third of species are also known to have a sexual stage.[2] While some species of Aspergillus are known to cause fungal infections, others are of commercial importance.

## Contents

* 1 Taxonomy
* 1.1 Species
* 2 Growth and distribution
* 3 Commercial importance
* 4 Research
* 4.1 Sexual reproduction
* 4.2 Genomics
* 5 Pathogens
* 6 Aspergillosis
* 7 See also
* 8 References
* 9 Further reading
* 10 External links

## Taxonomy

### Species

Main page: Biology:List of Aspergillus species

Aspergillus consists of 837 species of fungi.[3]

## Growth and distribution

Aspergillus on a tomato in detail

Aspergillus is defined as a group of conidial fungi—that is, fungi in an asexual state. Some of them, however, are known to have a teleomorph (sexual state) in the Ascomycota. With DNA evidence, all members of the genus Aspergillus are members of the phylum Ascomycota.

Members of the genus possess the ability to grow where a high osmotic pressure exists (high concentration of sugar, salt, etc.). Aspergillus species are highly aerobic and are found in almost all oxygen-rich environments, where they commonly grow as molds on the surface of a substrate, as a result of the high oxygen tension. Commonly, fungi grow on carbon-rich substrates like monosaccharides (such as glucose) and polysaccharides (such as amylose). Aspergillus species are common contaminants of starchy foods (such as bread and potatoes), and grow in or on many plants and trees.

In addition to growth on carbon sources, many species of Aspergillus demonstrate oligotrophy where they are capable of growing in nutrient-depleted environments, or environments with a complete lack of key nutrients. Aspergillus niger is a prime example of this; it can be found growing on damp walls, as a major component of mildew.

Several species of Aspergillus, including A. niger and A. fumigatus, will readily colonise buildings,[4] favouring warm and damp or humid areas such as bathrooms and around window frames.[5]

Aspergillus are found in millions in pillows.[6]

## Commercial importance

Various Penicillium, Aspergillus spp. and other fungi growing in axenic culture

Historical model of Aspergillus, Botanical Museum Greifswald

Species of Aspergillus are important medically and commercially. Some species can cause infection in humans and other animals. Some infections found in animals have been studied for years, while other species found in animals have been described as new and specific to the investigated disease, and others have been known as names already in use for organisms such as saprophytes. More than 60 Aspergillus species are medically relevant pathogens.[7] For humans, a range of diseases such as infection to the external ear, skin lesions, and ulcers classed as mycetomas are found.

Other species are important in commercial microbial fermentations. For example, alcoholic beverages such as Japanese sake are often made from rice or other starchy ingredients (like manioc), rather than from grapes or malted barley. Typical microorganisms used to make alcohol, such as yeasts of the genus Saccharomyces, cannot ferment these starches. Therefore, koji mold such as Aspergillus oryzae is used to first break down the starches into simpler sugars.[8]

Members of the genus are also sources of natural products that can be used in the development of medications to treat human disease.[9] Aspergillus spp. are known to produce anthraquinone which has commercial importance due to its antibacterial and

antifungal properties. [10]

Perhaps the largest application of Aspergillus niger is as the major source of citric acid; this organism accounts for over 99% of global citric acid production, or more than 1.4 million tonnes (>1.5 million US tons) per year. A. niger is also commonly used for the production of native and foreign enzymes, including glucose oxidase, lysozyme, and lactase.[11] In these instances, the culture is rarely grown on a solid substrate, although this is still common practice in Japan, but is more often grown as a submerged culture in a bioreactor. In this way, the most important parameters can be strictly controlled, and maximal productivity can be achieved. This process also makes it far easier to separate the chemical or enzyme of importance from the medium, and is therefore far more cost-effective.

## Research

Four three-day-old Aspergillus colonies. Clockwise from top-left: an A. nidulans laboratory strain; a similar strain with a mutation in the yA marker gene involved in green pigmentation; an A. oryzae strain used in soy fermentation; A. oryzae RIB40

A scan of Aspergillus taken at 235 magnifications under a scanning electron microscope

A. nidulans (Emericella nidulans) has been used as a research organism for many years and was used by Guido Pontecorvo to demonstrate parasexuality in fungi. Recently, A. nidulans was one of the pioneering organisms to have its genome sequenced by researchers at the Broad Institute. As of 2008, a further seven Aspergillus species have had their genomes sequenced: the industrially useful A. niger (two strains), A. oryzae, and A. terreus, and the pathogens A. clavatus, A. fischerianus (Neosartorya fischeri), A. flavus, and A. fumigatus (two strains).[12] A. fischerianus is hardly ever pathogenic, but is very closely related to the common pathogen A. fumigatus; it was sequenced in part to better understand A. fumigatus pathogenicity.[13]

### Sexual reproduction

Of the 250 species of aspergilli, about 64% have no known sexual state.[14] However, many of these species likely have an as yet unidentified sexual stage.[14] Sexual reproduction occurs in two fundamentally different ways in fungi. These are outcrossing (in heterothallic fungi) in which two different individuals contribute nuclei, and self-fertilization or selfing (in homothallic fungi) in which both nuclei are derived from the same individual. In recent years, sexual cycles have been discovered in numerous species previously thought to be asexual. These discoveries reflect recent experimental focus on species of particular relevance to humans.

A. fumigatus is the most common species to cause disease in immunodeficient humans. In 2009, A. fumigatus was shown to have a heterothallic, fully functional sexual cycle.[15] Isolates of complementary mating types are required for sex to occur.

A. flavus is the major producer of carcinogenic aflatoxins in crops worldwide. It is also an opportunistic human and animal pathogen, causing aspergillosis in immunocompromised individuals. In 2009, a sexual state of this heterothallic fungus was found to arise when strains of opposite mating types were cultured together under appropriate conditions.[16]

A. lentulus is an opportunistic human pathogen that causes invasive aspergillosis with high mortality rates. In 2013, A. lentulus was found to have a heterothallic functional sexual breeding system.[17]

A. terreus is commonly used in industry to produce important organic acids and enzymes, and was the initial source for the cholesterol-lowering drug lovastatin. In 2013, A. terreus was found to be capable of sexual reproduction when strains of opposite mating types were crossed under appropriate culture conditions.[18]

These findings with Aspergillus species are consistent with accumulating evidence, from studies of other eukaryotic species, that sex was likely present in the common ancestor of all eukaryotes.[19][20]

A. nidulans, a homothallic fungus, is capable of self-fertilization. Selfing involves activation of the same mating pathways characteristic of sex in outcrossing species, i.e. self-fertilization does not bypass required pathways for outcrossing sex, but instead requires activation of these pathways within a single individual.[21]

Among those Aspergillus species that exhibit a sexual cycle, the overwhelming majority in nature are homothallic (self-fertilizing).[22] This observation suggests Aspergillus species can generally maintain sex though little genetic variability is produced by homothallic self-fertilization. A. fumigatus, a heterothallic (outcrossing) fungus that occurs in areas with widely different climates and environments, also displays little genetic variability either within geographic regions or on a global scale,[23] again suggesting sex, in this case outcrossing sex, can be maintained even when little genetic variability is produced.

### Genomics

The simultaneous publication of three Aspergillus genome manuscripts in Nature in December 2005 established the genus as the leading filamentous fungal genus for comparative genomic studies. Like most major genome projects, these efforts were collaborations between a large sequencing centre and the respective community of scientists. For example, the Institute for Genome Research (TIGR) worked with the A. fumigatus community. A. nidulans was sequenced at the Broad Institute. A. oryzae was sequenced in Japan at the National Institute of Advanced Industrial Science and Technology. The Joint Genome Institute of the Department of Energy has released sequence data for a citric acid-producing strain of A. niger. TIGR, now renamed the J. Craig Venter Institute, is currently spearheading a project on the A. flavus genome.[24]

Aspergillus is characterized by high levels of genetic diversity and, using protostome divergence as a scale, is as diverse as the Vertebrates phylum although both inter and intra-specific genome structure is relatively plastic.[25] The genomes of some Aspergillus species, such as A. flavus and A. oryzae, are more rich and around 20% larger than others, such as A. nidulans and A. fumigatus. Several mechanisms could explain this difference, although the combination of segmental duplication, genome duplication, and horizontal gene transfer acting in a piecemeal fashion is well-supported.[26]

Genome sizes for sequenced species of Aspergillus range from about 29.3 Mb for A. fumigatus to 37.1 Mb for A. oryzae, while the numbers of predicted genes vary from about 9926 for A. fumigatus to about 12,071 for A. oryzae. The genome size of an enzyme-producing strain of A. niger is of intermediate size at 33.9 Mb.[1]

## Pathogens

Some Aspergillus species cause serious disease in humans and animals. The most common pathogenic species are A. fumigatus and A. flavus, which produces aflatoxin which is both a toxin and a carcinogen, and which can contaminate foods such as nuts. The most common species causing allergic disease are A. fumigatus and A. clavatus. Other species are important as agricultural pathogens. Aspergillus spp. cause disease on many grain crops, especially maize, and some variants synthesize mycotoxins, including aflatoxin. Aspergillus can cause neonatal infections.[27]

A. fumigatus (the most common species) infections are primary pulmonary infections and can potentially become a rapidly necrotizing pneumonia with a potential to disseminate. The organism can be differentiated from other common mold infections based on the fact that it takes on a mold form both in the environment and in the host (unlike Candida albicans which is a dimorphic mold in the environment and a yeast in the body).

## Aspergillosis

Main page: Medicine:Aspergillosis

Pulmonary aspergillosis

Aspergillosis is the group of diseases caused by Aspergillus. The most common species among paranasal sinus infections associated with aspergillosis is A. fumigatus.[28] The symptoms include fever, cough, chest pain, or breathlessness, which also occur in many other illnesses, so diagnosis can be difficult. Usually, only patients with already weakened immune systems or who suffer other lung conditions are susceptible.

In humans, the major forms of disease are:[29][30]

* Allergic bronchopulmonary aspergillosis, which affects patients with respiratory diseases such as asthma, cystic fibrosis, and sinusitis
* Acute invasive aspergillosis, a form that grows into surrounding tissue, more common in those with weakened immune systems such as AIDS or chemotherapy patients
* Disseminated invasive aspergillosis, an infection spread widely through the body
* Aspergilloma, a "fungus ball" that can form within cavities such as the lung

Fungal infections from Aspergillus spores remain one theory of sickness and untimely death of some early Egyptologists and tomb explorers. Ancient spores which grew on the remains of food offerings and mummies sealed in tombs and chambers may have been blown around and inhaled by the excavators, ultimately linked to the notion of the curse of the pharaohs.[31]

Aspergillosis of the air passages is also frequently reported in birds, and certain species of Aspergillus have been known to infect insects.[7]

## See also

* List of Aspergillus species
* Mold health issues
* Sick building syndrome

## References

1. ↑ 1.0 1.1 Bennett JW (2010). "An Overview of the Genus Aspergillus". Aspergillus: Molecular Biology and Genomics. Caister Academic Press. ISBN 978-1-904455-53-0. http://www.open-access-biology.com/aspergillus/aspergillusch1.pdf.
2. ↑ "Sexual structures in Aspergillus: morphology, importance and genomics". Medical Mycology. 47 47 (Suppl 1): S21-6. 2009. doi:10.1080/13693780802139859. PMID 18608901.
3. ↑ "Naming Aspergillus species: progress towards one name for each species". Medical Mycology 49 Suppl 1 (S1): S70-6. April 2011. doi:10.3109/13693786.2010.504753. PMID 20718610.
4. ↑ "Aspergillus fumigatus and aspergillosis". Clinical Microbiology Reviews 12 (2): 310–50. April 1999. doi:10.1128/CMR.12.2.310. PMID 10194462.
5. ↑ "What are fungal spores?". https://www.worcester.ac.uk/about/academic-schools/school-of-science-and-the-environment/science-and-the-environment-research/national-pollen-and-aerobiology-research-unit/What-are-fungal-spores.aspx.
6. ↑ "Pillows: A Hot Bed Of Fungal Spores". https://www.sciencedaily.com/releases/2005/10/051015093046.htm.
7. ↑ 7.0 7.1 The Aspergilli. Baltimore: The Williams & Wilkins Company. 1926.
8. ↑ "Are You Using The Right Soy Sauce? Here's How To Find Out". April 8, 2014. http://www.huffingtonpost.com/2014/04/08/soy-sauce_n_5105861.html. "...to make soy sauce, first you add aspergillus mold to the soy beans and grains to produce a mixture called koji."
9. ↑ US patent 6069146
10. ↑ Toma, Maria Afroz; Nazir, K. H. M. Nazmul Hussain; Mahmud, Md Muket; Mishra, Pravin; Ali, Md Kowser; Kabir, Ajran; Shahid, Md Ahosanul Haque; Siddique, Mahbubul Pratik et al. (2021). "Isolation and Identification of Natural Colorant Producing Soil-Borne Aspergillus niger from Bangladesh and Extraction of the Pigment" (in en). Foods 10 (6): 1280. doi:10.3390/foods10061280. PMID 34205202.
11. ↑ "GRAS Notification for Acid Lactase from Aspergillus oryzae Expressed in Aspergillus niger". https://www.fda.gov/downloads/Food/IngredientsPackagingLabeling/GRAS/NoticeInventory/UCM400718. Section 2.
12. ↑ "The 2008 update of the Aspergillus nidulans genome annotation: a community effort". Fungal Genetics and Biology. 46 46 Suppl 1 (1): S2-13. March 2009. doi:10.1016/j.fgb.2008.12.003. PMID 19146970.
13. ↑ "Descriptions – Aspergillus Comparative". Broad Institute. http://www.broadinstitute.org/annotation/genome/aspergillus_group/GenomeDescriptions.html.
14. ↑ 14.0 14.1 "A fungal sexual revolution: Aspergillus and Penicillium show the way". Current Opinion in Microbiology 14 (6): 649–54. December 2011. doi:10.1016/j.mib.2011.10.001. PMID 22032932.
15. ↑ "Discovery of a sexual cycle in the opportunistic fungal pathogen Aspergillus fumigatus". Nature 457 (7228): 471–4. January 2009. doi:10.1038/nature07528. PMID 19043401. Bibcode: 2009Natur.457..471O.
16. ↑ "Sexual reproduction in Aspergillus flavus". Mycologia 101 (3): 423–9. 2009. doi:10.3852/09-011. PMID 19537215. http://www.mycologia.org/cgi/pmidlookup?view=short&pmid=19537215.
17. ↑ "Discovery of a sexual cycle in Aspergillus lentulus, a close relative of A. fumigatus". Eukaryotic Cell 12 (7): 962–9. July 2013. doi:10.1128/EC.00040-13. PMID 23650087.
18. ↑ "Sexual reproduction in the opportunistic human pathogen Aspergillus terreus". Mycologia 105 (1): 71–9. 2013. doi:10.3852/11-426. PMID 23074177. http://www.mycologia.org/cgi/pmidlookup?view=short&pmid=23074177.
19. ↑ "An expanded inventory of conserved meiotic genes provides evidence for sex in Trichomonas vaginalis". PLOS ONE 3 (8): e2879. August 2007. doi:10.1371/journal.pone.0002879. PMID 18663385.
20. ↑ "Evolution of fungal sexual reproduction". Mycologia 105 (1): 1–27. 2013. doi:10.3852/12-253. PMID 23099518. http://www.mycologia.org/cgi/pmidlookup?view=short&pmid=23099518.
21. ↑ "Mating type and the genetic basis of self-fertility in the model fungus Aspergillus nidulans". Current Biology 17 (16): 1384–9. August 2007. doi:10.1016/j.cub.2007.07.012. PMID 17669651.
22. ↑ "Sexual development and cryptic sexuality in fungi: insights from Aspergillus species". FEMS Microbiology Reviews 36 (1): 165–92. January 2012. doi:10.1111/j.1574-6976.2011.00308.x. PMID 22091779.
23. ↑ "Low genetic variation and no detectable population structure in aspergillus fumigatus compared to closely related Neosartorya species". Eukaryotic Cell 5 (4): 650–7. April 2006. doi:10.1128/EC.5.4.650-657.2006. PMID 16607012.
24. ↑ Aspergillus: Molecular Biology and Genomics. Caister Academic Press. 2010. ISBN 978-1-904455-53-0.
25. ↑ "The function and evolution of the Aspergillus genome". Trends in Microbiology 21 (1): 14–22. January 2013. doi:10.1016/j.tim.2012.09.005. PMID 23084572.
26. ↑ "Elusive origins of the extra genes in Aspergillus oryzae". PLOS ONE 3 (8): e3036. August 2008. doi:10.1371/journal.pone.0003036. PMID 18725939. Bibcode: 2008PLoSO...3.3036K.
27. ↑ Manual of neonatal care. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. 2012. ISBN 978-1-60831-777-6; Access provided by the University of Pittsburgh.
28. ↑ "[A case of isolated aspergillosis of the maxillary sinus]" (in tr). Kulak Burun Bogaz Ihtisas Dergisi 18 (1): 53–5. 2008. PMID 18443405.
29. ↑ "Aspergillosis". MedScape. http://emedicine.medscape.com/article/296052-overview.
30. ↑ Current diagnosis & treatment in infectious diseases.. Lange Medical Books/McGraw-Hill. 2001.
31. ↑ "Inhaled mycotoxins lead to acute renal failure". Nephrology, Dialysis, Transplantation 9 Suppl 4: 116–20. 1994. PMID 7800243.

## Further reading

* "A wheat biorefining strategy based on solid-state fermentation for fermentative production of succinic acid". Bioresource Technology 99 (17): 8310–5. November 2008. doi:10.1016/j.biortech.2008.03.019. PMID 18434138.
* "Steroid-sparing effect of omalizumab for allergic bronchopulmonary aspergillosis and cystic fibrosis". Pediatric Pulmonology 43 (6): 607–10. June 2008. doi:10.1002/ppul.20804. PMID 18433040.
* Asan A. (February 10, 2015). "Aspergillus, Penicillium, and Related Species Reported from Turkey". Mycotaxon 89 (1): 155–7. http://www.mycotaxon.com/resources/checklists/asan-v89-checklist.pdf.
* "Secondary Metabolite Diversity of the Genus Aspergillus.". Recent Advances New and Future Developments in Microbial Biotechnology and Bioengineering: Aspergillus System Properties and Applications. 2016. pp. 275–292.

## External links

* FungiDB: An integrated functional genomics database for fungi and oomycetes
* Aspergillus Genome Resources (NIH)
* Aspergillus Comparative Database Comparative genomic resource at the Broad Institute
* Central Aspergillus Data Repository
* The Fungal Genetics Stock Center
* The Aspergillus/Aspergillosis Website An encyclopedia of Aspergillus for patients, doctors and scientists
* Aspergillus surveillance project at a large tertiary-care hospital. (PDF).
* The Aspergillus Genome Database
* Mold and Mildew

See also Wikidata entry Q335130.

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