Bacterial vaginosis

Short description: Excessive growth of bacteria in the vagina

Bacterial vaginosis

Other names| Anaerobic vaginositis, non-specific vaginitis, vaginal bacteriosis, Gardnerella vaginitis[1]
Vaginal squamous cell with normal vaginal flora versus bacterial vaginosis on Pap stain. Normal vaginal flora (left) is predominantly rod-shaped Lactobacilli whereas in bacterial vaginosis (right) there is an overgrowth of bacteria which can be of multiple species.
Specialty| Gynecology, infectious disease
Symptoms| Vaginal discharge that often smells like fish, burning with urination[2]
Complications| Early delivery among pregnant women[3]
Causes| Imbalance of the naturally occurring bacteria in the vagina[4][5]
Risk factors| Douching, new or multiple sex partners, antibiotics, using an intrauterine device[5]
Diagnostic method| Testing the vaginal discharge[6]
Differential diagnosis| Vaginal yeast infection, infection with Trichomonas[7]
Prevention| Probiotics[6][8]
Medication| Clindamycin, metronidazole, tinidazole, secnidazole, boric acid, probiotics[9][6][10]
Frequency| ~ 5% to 70% of women[11]

Bacterial vaginosis (BV) is an infection of the vagina caused by excessive growth of bacteria.[6][12] Common symptoms include increased vaginal discharge that often smells like fish.[2] The discharge is usually white or gray in color.[2] Burning with urination may occur.[2] Itching is uncommon.[2][6] Occasionally, there may be no symptoms.[2] Having BV approximately doubles the risk of infection by a number of sexually transmitted infections, including HIV/AIDS.[11][13] It also increases the risk of early delivery among pregnant women.[3][14]

BV is caused by an imbalance of the naturally occurring bacteria in the vagina.[4][5] There is a change in the most common type of bacteria and a hundred to thousandfold increase in total numbers of bacteria present.[6] Typically, bacteria other than Lactobacilli become more common.[15] Risk factors include douching, new or multiple sex partners, antibiotics, and using an intrauterine device, among others.[5] However, it is not considered a sexually transmitted infection and, unlike gonorrhoea and chlamydia, sexual partners are not treated.[16] Diagnosis is suspected based on the symptoms, and may be verified by testing the vaginal discharge and finding a higher than normal vaginal pH, and large numbers of bacteria.[6] BV is often confused with a vaginal yeast infection or infection with Trichomonas.[7]

Usually treatment is with an antibiotic, such as clindamycin or metronidazole.[9][6] These medications may also be used in the second or third trimesters of pregnancy.[6] The antiseptic boric acid can also be effective.[10] BV often recurs following treatment.[6] Probiotics may help prevent re-occurrence.[6][8] It is unclear if the use of probiotics or antibiotics affects pregnancy outcomes.[6][17]

BV is the most common vaginal infection in women of reproductive age.[5] Prevalence differs by countries and demographics, with a systematic review and meta-analysis finding global prevalence in reproductive aged women ranges from 23 to 29%.[18][19] While BV-like symptoms have been described for much of recorded history, the first clearly documented case occurred in 1894.[1]

## Contents

* 1 Signs and symptoms
* 1.1 Complications
* 2 Causes
* 3 Diagnosis
* 3.1 Amsel criteria
* 3.2 Gram stain
* 3.3 Nugent score
* 3.4 Screening
* 4 Prevention
* 5 Treatment
* 5.1 Antibiotics
* 5.2 Antiseptics
* 5.3 Probiotics
* 5.4 Miscellaneous
* 6 Epidemiology
* 7 References
* 8 External links

## Signs and symptoms

Although about 50% of women with BV are asymptomatic,[20] common symptoms include increased vaginal discharge that usually smells like fish. The discharge is often white or gray. There may be burning with urination.

The discharge coats the walls of the vagina, and is usually without significant irritation, pain, or erythema, although mild itching can sometimes occur. By contrast, the normal vaginal discharge will vary in consistency and amount throughout the menstrual cycle and is at its clearest at ovulation—about two weeks before the period starts. Some practitioners claim that BV can be asymptomatic in almost half of affected women,[21] though others argue that this is often a misdiagnosis.[22]

### Complications

Although previously[when?] considered a mere nuisance infection, untreated bacterial vaginosis may cause increased susceptibility to sexually transmitted infections, including HIV, and pregnancy complications.[23][24]

It has been shown that HIV-infected women with bacterial vaginosis (BV) are more likely to transmit HIV to their sexual partners than those without BV.[13] There is evidence of an association between BV and increased rates of sexually transmitted infections such as HIV/AIDS.[23] BV is associated with up to a six-fold increase in HIV shedding. BV is a risk factor for viral shedding and herpes simplex virus type 2 infection. BV may increase the risk of infection with or reactivation of human papillomavirus (HPV).[23][25]

In addition, bacterial vaginosis, as either pre-existing, or acquired, may increase the risk of pregnancy complications, most notably premature birth or miscarriage.[26][27] Pregnant women with BV have a higher risk of chorioamnionitis, miscarriage, preterm birth, premature rupture of membranes, and postpartum endometritis.[28] Women with BV who are treated with in vitro fertilization have a lower implantation rate and higher rates of early pregnancy loss.[23][25]

## Causes

Main article: Biology:List of bacterial vaginosis microbiota

Healthy vaginal microbiota consists of species that neither cause symptoms or infections, nor negatively affect pregnancy. It is dominated mainly by Lactobacillus species.[15][29] BV is defined by the disequilibrium in the vaginal microbiota, with decline in the number of lactobacilli. While the infection involves several bacteria, it is believed that most infections start with Gardnerella vaginalis creating a biofilm, which allows other opportunistic bacteria, such as Prevotella and Bacteroides, to thrive.[30][12][31]

One of the main risks for developing BV is douching, which alters the vaginal microbiota and predisposes women to developing BV.[32] Douching is strongly discouraged by the U.S. Department of Health and Human Services and various medical authorities, for this and other reasons.[32]

BV is a risk factor for pelvic inflammatory disease, HIV, sexually transmitted infections (STIs), endometriosis, and reproductive and obstetric disorders or negative outcomes. Although BV can be associated with sexual activity, there is no clear evidence of sexual transmission.[30][33][34] It is possible for sexually inactive persons to develop bacterial vaginosis.[33][12]

Subclinical iron deficiency may correlate with bacterial vaginosis in early pregnancy.[35] A longitudinal study published in February 2006, in the American Journal of Obstetrics and Gynecology, showed a link between psychosocial stress and bacterial vaginosis persisted even when other risk factors were taken into account.[36] Exposure to the spermicide nonoxynol-9 does not affect the risk of developing bacterial vaginosis.[37]

The cause of the fishy smell of BV is mainly due to reduction of trimethylamine oxide (TMAO) to trimethylamine (TMA) by bacteria in vaginal secretion.[38][39][40] TMA is the same compound that is predominantly responsible for the smell of decomposing fish.[38][39] The diamines putrescine and cadaverine, which are the decarboxylation products of arginine and lysine amino acid metabolism, respectively, are also present in BV and may contribute to the fishy smell of the condition as well.[38]

## Diagnosis

Phase contrast microscopy of clue cells in a vaginal swab A pH indicator to detect vaginal alkalinization (here showing approximately pH 8), and a microscope slide to detect clue cells microscopically Gram stain of cells from the vagina (the same magnification) with normal bacterial flora (top) and the bacteria that cause vaginosis (bottom).

To make a diagnosis of bacterial vaginosis, a swab from inside the vagina should be obtained. These swabs can be tested for:

* Gram stain which shows the depletion of lactobacilli and overgrowth of Gardnerella vaginalis bacteria. A Gram stain of vaginal secretions usually confirms bacterial vaginosis.[41]
* A characteristic "fishy" odor on wet mount. This test, called the whiff test, is performed by adding a small amount of potassium hydroxide to a microscope slide containing the vaginal discharge. A characteristic fishy odor is considered a positive whiff test and is suggestive of bacterial vaginosis.[42] Addition of a base to vaginal secretion with the diamines putrescine and cadaverine causes them to become volatile and thereby produce a more intense fishy smell.[38]
* The presence of clue cells on wet mount. Similar to the whiff test, the test for clue cells is performed by placing a drop of sodium chloride solution on a slide containing vaginal discharge. If present, clue cells can be visualized under a microscope. They are so-named because they give a clue to the reason behind the discharge. These are epithelial cells that are coated with bacteria.

Differential diagnosis for bacterial vaginosis includes the following:[43]

* Normal vaginal discharge.
* Candidiasis (thrush, or a yeast infection).
* Trichomoniasis, an infection caused by Trichomonas vaginalis.
* Aerobic vaginitis[44]

The Centers for Disease Control and Prevention (CDC) defines STIs as "a variety of clinical syndromes and infections caused by pathogens that can be acquired and transmitted through sexual activity."[45] But the CDC does not specifically identify BV as a sexually transmitted infection.[16]

### Amsel criteria

In clinical practice, BV can be diagnosed using the Amsel criteria:[46]

1. Thin, white, yellow, homogeneous discharge
2. Clue cells on microscopy
3. pH of vaginal fluid >4.5
4. Release of a fishy odor on adding alkali—10% potassium hydroxide (KOH) solution.

At least three of the four criteria should be present for a confirmed diagnosis.[47] A modification of the Amsel criteria accepts the presence of two instead of three factors and is considered equally diagnostic.[48]

### Gram stain

An alternative is to use a Gram-stained vaginal smear, with the Hay/Ison[49] criteria or the Nugent[28] criteria. The Hay/Ison criteria are defined as follows:[47]

* Grade 1 (Normal): Lactobacillus morphotypes predominate.
* Grade 2 (Intermediate): Some lactobacilli present, but Gardnerella or Mobiluncus morphotypes also present.
* Grade 3 (Bacterial Vaginosis): Predominantly Gardnerella and/or Mobiluncus morphotypes. Few or absent lactobacilli. (Hay et al., 1994)

Gardnerella vaginalis is the main culprit in BV. Gardnerella vaginalis is a short, Gram-variable rod (coccobacillus). Hence, the presence of clue cells and gram variable coccobacilli is indicative or diagnostic of bacterial vaginosis.[50]

### Nugent score

The Nugent score is now rarely used by physicians due to the time it takes to read the slides and requires the use of a trained microscopist.[4] A score of 0–10 is generated from combining three other scores. The scores are as follows:[28]

* 0–3 is considered negative for BV
* 4–6 is considered intermediate
* 7+ is considered indicative of BV.

At least 10–20 high power (1000× oil immersion) fields are counted and an average determined.[51]

Lactobacillus morphotypes – average per high-powered (1000× oil immersion) field. View multiple fields.

Gardnerella / Bacteroides morphotypes – average per high powered (1000× oil immersion) field. View multiple fields.

Curved Gram variable rods – average per high-powered (1000× oil immersion) field. View multiple fields (note that this factor is less important – scores of only 0–2 are possible)

|
|

* Score 0 for >30
* Score 1 for 15–30
* Score 2 for 14
* Score 3 for <1 (this is an average, so results can be >0, yet <1)
* Score 4 for 0

* Score 0 for 0
* Score 1 for <1 (this is an average, so results can be >0, yet <1)
* Score 2 for 1–4
* Score 3 for 5–30
* Score 4 for >30

* Score 0 for 0
* Score 1 for <5

DNA hybridization testing with Affirm VPIII was compared to the Gram stain using the Nugent criteria.[52] The Affirm VPIII test may be used for the rapid diagnosis of BV in symptomatic women but uses expensive proprietary equipment to read results, and does not detect other pathogens that cause BV, including Prevotella spp, Bacteroides spp, and Mobiluncus spp.[53] The cervicovaginal microbiome measured using 16S rRNA sequencing has the capacity to increase throughput of the Nugent Score and has demonstrate to be directly comparable to clinical Nugent Score measurement.[54]

### Screening

Screening during pregnancy is not recommended in the United States as of 2020, because "the US Preventive Services Task Force concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for bacterial vaginosis in pregnant persons at increased risk for preterm delivery".[55]

## Prevention

Some steps suggested to lower the risk include not douching, not using perfumed soaps[56] and limiting the number of sex partners.[57]

Systematic reviews and meta-analyses from 2022 to 2023 have concluded that probiotics may help prevent re-occurrence.[8][58][59]

Early evidence suggested that antibiotic treatment of male partners could re-establish the normal microbiota of the male urogenital tract and prevent the recurrence of infection.[23] However, a 2016 Cochrane review found high-quality evidence that treating the sexual partners of women with bacterial vaginosis had no effect on symptoms, clinical outcomes, or recurrence in the affected women. It also found that such treatment may lead treated sexual partners to report increased adverse events.[23]

## Treatment

### Antibiotics

Treatment is typically with the antibiotics metronidazole or clindamycin.[60] They can be either given by mouth or applied inside the vagina with similar efficacy.[20][60] Other antibiotics related to metronidazole, including tinidazole and the newer secnidazole, are also approved and used to treat BV.[9][61][62] When clindamycin is given to pregnant women symptomatic with BV before 22 weeks of gestation the risk of pre-term birth before 37 weeks of gestation is lower.[63] Additional antibiotics that are not approved for treatment of BV but might work include macrolides, lincosamides, and penicillins.[23]

Although antibiotics are effective, about 10% to 15% of people do not improve with the first course of antibiotics, and recurrence rates of up to 80% have been documented.[25] Recurrence rates are increased with sexual activity with the same pre-/post-treatment partner and inconsistent condom use.[64]

BV is not considered a sexually transmitted infection, and antibiotic treatment of a male sexual partner of a woman with BV is not recommended.[65][66]

### Antiseptics

Topical antiseptics, for example dequalinium chloride, policresulen, hexetidine, povidone-iodine, or boric acid vaginal suppositories may be applied, if the risk of ascending infections is low (outside of pregnancy and in immunocompetent people without histories of upper genital tract infections).[67][68]

Dequalinium chloride is available as a prescription vaginal tablet, for instance in Europe and Canada, is given as a 6-day course, and is non-inferior to metronidazole in the treatment of bacterial vaginosis.[69][70][71][72] Povidone-iodine is approved as a vaginal gel to treat bacterial vaginosis under the brand name Astrodimer, among others.[73][68][74] One study found that vaginal irrigations with hydrogen peroxide (3%) resulted in a slight improvement, but this was much less than with the use of oral metronidazole.[75] Dequalinium chloride and povidone-iodine (as Astrodimer) have the best evidence of effectiveness.[68] Neither of these are available in the United States, though they are available in other countries.[68] Intravaginal boric acid, alone or in conjunction with other medications, may be helpful in the treatment of recurrent BV.[76][77][10]

TOL-463, an experimental formulation of boric acid enhanced with ethylenediaminetetraacetic acid (EDTA), is under development as an intravaginal medication for the treatment of BV and has shown preliminary effectiveness in clinical trials.[78][77][79][80]

### Probiotics

A 2009 Cochrane review found tentative but insufficient evidence for probiotics as a treatment for BV.[25] A 2014 review reached the same conclusion.[81] A 2013 review found some evidence supporting the use of probiotics during pregnancy.[82] The preferred probiotics for BV are those containing high doses of lactobacilli (around 109 CFUs) given in the vagina.[83] Intravaginal administration is preferred to taking them by mouth.[83] Prolonged repetitive courses of treatment appear to be more promising than short courses.[83]

The lack of effectiveness of commercially available Lactobacillus probiotics may be because most do not contain vaginal lactobacilli strains.[84] LACTIN-V is a live biopharmaceutical medication containing the vaginally important Lactobacillus crispatus which is under development for the treatment of bacterial vaginosis and recurrent urinary tract infections.[84][85][76] It has shown initial effectiveness in considerably reducing recurrence of bacterial vaginosis following antibiotic treatment.[84][76] LACTIN-V is not yet Food and Drug Administration (FDA)-approved or commercially available.[76][85]

### Miscellaneous

Estrogen-containing contraceptives have been found to decrease recurrence of BV.[64]

## Epidemiology

BV is the most common infection of the vagina in women of reproductive age.[5] The percentage of women affected at any given time varies between 5% and 70%.[11] BV is most common in parts of Africa, and least common in Asia and Europe.[11] In the United States, about 30% of those between the ages of 14 and 49 are affected.[86] Rates vary considerably between ethnic groups within a country.[11]

## References

1. ↑ 1.0 1.1 Sexually transmitted diseases: epidemiology, pathology, diagnosis, and treatment. Boca Raton [u.a.]: CRC Press. 1997. p. 4. ISBN 978-0-8493-9476-8. https://books.google.com/books?id=k_9sjs-n0nIC&pg=PA4.
2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 "What are the symptoms of bacterial vaginosis?". National Institute of Child Health and Human Development. 2013-05-21. https://www.nichd.nih.gov/health/topics/bacterialvag/conditioninfo/symptoms.
3. ↑ 3.0 3.1 Queenan's management of high-risk pregnancy: an evidence-based approach (6th ed.). Chichester, West Sussex: Willey-Blackwell. 2012. p. 262. ISBN 978-0-470-65576-4.
4. ↑ 4.0 4.1 4.2 Mandell, Douglas, and Bennett's principles and practice of infectious diseases. Philadelphia, PA: Elsevier/Saunders. 2015. ISBN 978-1-4557-4801-3.
5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 "Bacterial Vaginosis (BV): Condition Information". National Institute of Child Health and Human Development. 2013-05-21. https://www.nichd.nih.gov/health/topics/bacterialvag/conditioninfo.
6. ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 6.11 "Treatment of bacterial vaginosis: what we have and what we miss". Expert Opinion on Pharmacotherapy 15 (5): 645–57. April 2014. doi:10.1517/14656566.2014.881800. PMID 24579850.
7. ↑ 7.0 7.1 "Etiology, diagnosis, and management of vaginitis". Journal of Midwifery & Women's Health 51 (6): 423–30. 2006. doi:10.1016/j.jmwh.2006.07.005. PMID 17081932.
8. ↑ 8.0 8.1 8.2 "Probiotics, a promising therapy to reduce the recurrence of bacterial vaginosis in women? a systematic review and meta-analysis of randomized controlled trials". Front Nutr 9. 2022. doi:10.3389/fnut.2022.938838. PMID 36204368.
9. ↑ 9.0 9.1 9.2 "Characterization and Treatment of Recurrent Bacterial Vaginosis". J Womens Health (Larchmt) 28 (9): 1218–1226. September 2019. doi:10.1089/jwh.2018.7383. PMID 31403349.
10. ↑ 10.0 10.1 10.2 Lærkeholm Müller, Matilde; Damsted Petersen, Christina; Saunte, Ditte Marie L. (2024). "Boric Acid for the Treatment of Vaginitis: New Possibilities Using an Old Anti-Infective Agent: A Systematic Review". Dermatologic Therapy (Wiley) 2024 (1). doi:10.1155/2024/2807070. ISSN 1396-0296.
11. ↑ 11.0 11.1 11.2 11.3 11.4 "The global epidemiology of bacterial vaginosis: a systematic review". American Journal of Obstetrics and Gynecology 209 (6): 505–23. December 2013. doi:10.1016/j.ajog.2013.05.006. PMID 23659989.
12. ↑ 12.0 12.1 12.2 "Microbiota and pelvic inflammatory disease". Seminars in Reproductive Medicine 32 (1): 43–9. January 2014. doi:10.1055/s-0033-1361822. PMID 24390920.
13. ↑ 13.0 13.1 "Making inroads into improving treatment of bacterial vaginosis - striving for long-term cure". BMC Infectious Diseases 15. July 2015. doi:10.1186/s12879-015-1027-4. PMID 26219949.
14. ↑ "What are the treatments for bacterial vaginosis (BV)?". National Institute of Child Health and Human Development. 2013-07-15. https://www.nichd.nih.gov/health/topics/bacterialvag/conditioninfo/treatments.
15. ↑ 15.0 15.1 "Vaginal microbiota and viral sexually transmitted diseases". Annali di Igiene 25 (5): 443–56. September–October 2013. doi:10.7416/ai.2013.1946. PMID 24048183.
16. ↑ 16.0 16.1 "Bacterial Vaginosis – CDC Fact Sheet". Centers for Disease Control and Prevention. 11 March 2014. https://www.cdc.gov/std/bv/stdfact-bacterial-vaginosis.htm.
17. ↑ "Probiotics for preventing preterm labour". The Cochrane Database of Systematic Reviews 2012 (1). January 2007. doi:10.1002/14651858.CD005941.pub2. PMID 17253567.
18. ↑ "Bacterial vaginosis" (in en). https://www.who.int/news-room/fact-sheets/detail/bacterial-vaginosis.
19. ↑ Peebles, Kathryn; Velloza, Jennifer; Balkus, Jennifer E.; McClelland, R. Scott; Barnabas, Ruanne V. (May 2019). "High Global Burden and Costs of Bacterial Vaginosis: A Systematic Review and Meta-Analysis" (in en-US). Sexually Transmitted Diseases 46 (5): 304–311. doi:10.1097/OLQ.0000000000000972. ISSN 0148-5717. PMID 30624309. https://journals.lww.com/stdjournal/abstract/2019/05000/high_global_burden_and_costs_of_bacterial.5.aspx. Retrieved 19 July 2025.
20. ↑ 20.0 20.1 "Non-antibiotic treatment of bacterial vaginosis-a systematic review". Archives of Gynecology and Obstetrics 303 (1): 37–45. January 2021. doi:10.1007/s00404-020-05821-x. PMID 33025086.
21. ↑ "Asymptomatic bacterial vaginosis: response to therapy". American Journal of Obstetrics and Gynecology 183 (6): 1434–9. December 2000. doi:10.1067/mob.2000.107735. PMID 11120507.
22. ↑ "The vaginal flora of healthy women is not always dominated by Lactobacillus species". The Journal of Infectious Diseases 194 (10): 1468–9; author reply 1469–70. November 2006. doi:10.1086/508497. PMID 17054080.
23. ↑ 23.0 23.1 23.2 23.3 23.4 23.5 23.6 "Antibiotic treatment for the sexual partners of women with bacterial vaginosis". The Cochrane Database of Systematic Reviews 2016 (10). October 2016. doi:10.1002/14651858.CD011701.pub2. PMID 27696372.
24. ↑ "STD Facts — Bacterial Vaginosis (BV)". CDC. https://www.cdc.gov/std/bv/STDFact-Bacterial-Vaginosis.htm#Complications.
25. ↑ 25.0 25.1 25.2 25.3 "Probiotics for the treatment of bacterial vaginosis". The Cochrane Database of Systematic Reviews (4). October 2009. doi:10.1002/14651858.CD006289.pub2. PMID 19821358.
26. ↑ "Bacterial vaginosis". National Health Service, UK.. http://www.nhs.uk/conditions/bacterialvaginosis/Pages/Introduction.aspx.
27. ↑ "Association between bacterial vaginosis and preterm delivery of a low-birth-weight infant. The Vaginal Infections and Prematurity Study Group". The New England Journal of Medicine 333 (26): 1737–42. December 1995. doi:10.1056/NEJM199512283332604. PMID 7491137.
28. ↑ 28.0 28.1 28.2 "Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation". Journal of Clinical Microbiology 29 (2): 297–301. February 1991. doi:10.1128/JCM.29.2.297-301.1991. PMID 1706728.
29. ↑ "Lactobacillus species as biomarkers and agents that can promote various aspects of vaginal health". Frontiers in Physiology 6: 81. 2015. doi:10.3389/fphys.2015.00081. PMID 25859220.
30. ↑ 30.0 30.1 "Intricate Connections between the Microbiota and Endometriosis". International Journal of Molecular Sciences 22 (11): 5644. May 2021. doi:10.3390/ijms22115644. PMID 34073257.
31. ↑ "Analysis of adherence, biofilm formation and cytotoxicity suggests a greater virulence potential of Gardnerella vaginalis relative to other bacterial-vaginosis-associated anaerobes". Microbiology 156 (Pt 2): 392–399. February 2010. doi:10.1099/mic.0.034280-0. PMID 19910411.
32. ↑ 32.0 32.1 "An updated review of evidence to discourage douching". MCN: The American Journal of Maternal/Child Nursing 35 (2): 102–7; quiz 108–9. 2010. doi:10.1097/NMC.0b013e3181cae9da. PMID 20215951.
33. ↑ 33.0 33.1 "The contribution of bacteriophages to the aetiology and treatment of the bacterial vaginosis syndrome". Faculty Reviews 11: 8. 2022. doi:10.12703/r/11-8. PMID 35509673.
34. ↑ "High recurrence rates of bacterial vaginosis over 12 months after oral metronidazole therapy and factors associated with recurrence". J. Infect. Dis. 193 (11): 1478–86. 2006. doi:10.1086/503780. PMID 16652274.
35. ↑ "Subclinical iron deficiency is a strong predictor of bacterial vaginosis in early pregnancy". BMC Infectious Diseases 5 (1). July 2005. doi:10.1186/1471-2334-5-55. PMID 16000177.
36. ↑ "The association of psychosocial stress and bacterial vaginosis in a longitudinal cohort". American Journal of Obstetrics and Gynecology 194 (2): 381–6. February 2006. doi:10.1016/j.ajog.2005.07.047. PMID 16458633.
37. ↑ "Nonoxynol-9 for preventing vaginal acquisition of sexually transmitted infections by women from men". The Cochrane Database of Systematic Reviews 2012 (4). 2002. doi:10.1002/14651858.CD003939. PMID 12519623.
38. ↑ 38.0 38.1 38.2 38.3 "Bacterial vaginosis". Clin Microbiol Rev 4 (4): 485–502. October 1991. doi:10.1128/CMR.4.4.485. PMID 1747864.
39. ↑ 39.0 39.1 "Trimethylamine: the substance mainly responsible for the fishy odor often associated with bacterial vaginosis". Obstet Gynecol 68 (5): 682–685. November 1986. PMID 3763085.
40. ↑ "Trimethylamine content in vaginal secretion and its relation to bacterial vaginosis". APMIS 110 (11): 819–824. November 2002. doi:10.1034/j.1600-0463.2002.1101108.x. PMID 12588422.
41. ↑ "A Narrative Review of Current Challenges in the Diagnosis and Management of Bacterial Vaginosis". Sexually Transmitted Diseases 47 (7): 441–446. July 2020. doi:10.1097/OLQ.0000000000001178. PMID 32235174.
42. ↑ Kelly, Karen G. (1990), Walker, H. Kenneth; Hall, W. Dallas; Hurst, J. Willis, eds., "Tests on Vaginal Discharge", Clinical Methods: The History, Physical, and Laboratory Examinations (Boston: Butterworths), ISBN 978-0-409-90077-4, PMID 21250131, https://www.ncbi.nlm.nih.gov/books/NBK288/, retrieved 2024-09-18
43. ↑ "Diseases Characterized by Vaginal Discharge". Centers for Disease Control and Prevention. https://www.cdc.gov/std/treatment/2010/vaginal-discharge.htm.
44. ↑ "Definition of a type of abnormal vaginal flora that is distinct from bacterial vaginosis: aerobic vaginitis". BJOG 109 (1): 34–43. January 2002. doi:10.1111/j.1471-0528.2002.00432.x. PMID 11845812. https://repository.uantwerpen.be/docman/irua/30bd6b/6019.pdf.
45. ↑ "Sexually transmitted diseases treatment guidelines, 2015". MMWR. Recommendations and Reports 64 (RR-03): 1–137. June 2015. PMID 26042815.
46. ↑ "Nonspecific vaginitis. Diagnostic criteria and microbial and epidemiologic associations". The American Journal of Medicine 74 (1): 14–22. January 1983. doi:10.1016/0002-9343(83)91112-9. PMID 6600371.
47. ↑ 47.0 47.1 "National guideline for the management of bacterial vaginosis (2006)". Clinical Effectiveness Group, British Association for Sexual Health and HIV (BASHH). http://www.guideline.gov/summary/summary.aspx?doc_id=11602.
48. ↑ "Development of modified diagnostic criteria for bacterial vaginosis at peripheral health centres in developing countries". Journal of Infection in Developing Countries 6 (5): 373–377. May 2012. doi:10.3855/jidc.1625. PMID 22610702.
49. ↑ "Validation of a simplified grading of Gram-stained vaginal smears for use in genitourinary medicine clinics". Sexually Transmitted Infections 78 (6): 413–5. December 2002. doi:10.1136/sti.78.6.413. PMID 12473800.
50. ↑ Paladine, H. L.; Desai, U. A. (2018). "Vaginitis: Diagnosis and Treatment". American Family Physician 97 (5): 321–329. PMID 29671516.
51. ↑ "Prevalence of bacterial vaginosis and associated risk factors in pregnant women receiving antenatal care at the Kumba Health District (KHD), Cameroon". BMC Pregnancy and Childbirth 19 (1). May 2019. doi:10.1186/s12884-019-2312-9. PMID 31077161.
52. ↑ "Use of DNA hybridization test for diagnosing bacterial vaginosis in women with symptoms suggestive of infection". APMIS 114 (11): 784–787. November 2006. doi:10.1111/j.1600-0463.2006.apm_485.x. PMID 17078859.
53. ↑ "Clinical evaluation of affirm VPIII in the detection and identification of Trichomonas vaginalis, Gardnerella vaginalis, and Candida species in vaginitis/vaginosis". Infectious Diseases in Obstetrics and Gynecology 12 (1): 17–21. 2004. doi:10.1080/1064744042000210375. PMID 15460191.
54. ↑ "molBV reveals immune landscape of bacterial vaginosis and predicts human papillomavirus infection natural history". Nature Communications 13 (1). January 2022. doi:10.1038/s41467-021-27628-3. PMID 35017496. Bibcode: 2022NatCo..13..233U.
55. ↑ "Screening for Bacterial Vaginosis in Pregnant Persons to Prevent Preterm Delivery: US Preventive Services Task Force Recommendation Statement". JAMA 323 (13): 1286–1292. April 2020. doi:10.1001/jama.2020.2684. PMID 32259236.
56. ↑ "Bacterial vaginosis" (in en). 2018-01-19. https://www.nhs.uk/conditions/bacterial-vaginosis/.
57. ↑ "Bacterial Vaginosis – CDC Fact Sheet". Centers for Disease Control and Prevention. 11 March 2014. https://www.cdc.gov/std/bv/stdfact-bacterial-vaginosis.htm.
58. ↑ "Probiotics are a good choice for the treatment of bacterial vaginosis: a meta-analysis of randomized controlled trial". Reprod Health 19 (1). June 2022. doi:10.1186/s12978-022-01449-z. PMID 35698149.
59. ↑ "Antibiotics therapy combined with probiotics administered intravaginally for the treatment of bacterial vaginosis: A systematic review and meta-analysis". Open Med (Wars) 18 (1). 2023. doi:10.1515/med-2023-0644. PMID 37724125.
60. ↑ 60.0 60.1 "The effects of antimicrobial therapy on bacterial vaginosis in non-pregnant women". The Cochrane Database of Systematic Reviews (3). July 2009. doi:10.1002/14651858.CD006055.pub2. PMID 19588379.
61. ↑ "Tinidazole". 2 October 2021. https://adisinsight.springer.com/drugs/800024976.
62. ↑ "Secnidazole". 12 September 2024. https://adisinsight.springer.com/drugs/800040719.
63. ↑ "Treatment of abnormal vaginal flora in early pregnancy with clindamycin for the prevention of spontaneous preterm birth: a systematic review and metaanalysis". American Journal of Obstetrics and Gynecology 205 (3): 177–90. September 2011. doi:10.1016/j.ajog.2011.03.047. PMID 22071048.
64. ↑ 64.0 64.1 "Recurrence of bacterial vaginosis is significantly associated with posttreatment sexual activities and hormonal contraceptive use". Clinical Infectious Diseases 56 (6): 777–786. March 2013. doi:10.1093/cid/cis1030. PMID 23243173.
65. ↑ "Systematic review of randomized trials of treatment of male sexual partners for improved bacteria vaginosis outcomes in women". Sexually Transmitted Diseases 39 (10): 822–30. October 2012. doi:10.1097/OLQ.0b013e3182631d89. PMID 23007709. https://figshare.com/articles/journal_contribution/10755290.
66. ↑ "Should sexual partners of women with bacterial vaginosis receive treatment?". The British Journal of General Practice 49 (448): 913–8. November 1999. PMID 10818662.
67. ↑ "Spezielle Arzneimitteltherapie in der Schwangerschaft" (in de). Arzneiverordnung in Schwangerschaft und Stillzeit (7th ed.). Urban & Fischer. January 2006. pp. 33–557. doi:10.1016/B978-343721332-8.50004-1. ISBN 978-3-437-21332-8.
68. ↑ 68.0 68.1 68.2 68.3 "Bacterial vaginosis: a review of approaches to treatment and prevention". Front Reprod Health 5. 2023. doi:10.3389/frph.2023.1100029. PMID 37325243. "Astodrimer Sodium, also referred to as Astodrimer 1% Vaginal gel, is a polyanionic dendrimer that prevents formation of bacterial biofilms through blocking bacterial adhesion (27). Randomized, placebo-controlled studies have demonstrated greater clinical cure rates for BV compared to placebo (46.2% vs. 11.5%) (101) and comparable to current antibiotic treatments (102). A recent randomized controlled trial (N = 864) demonstrated that Astodrimer, when applied every other day for 16 weeks following antibiotic therapy, was associated with a 20% reduction in recurrent BV compared to placebo during 16-week follow-up (27). This product is not commercially available in the United States, but is sold over the counter in the United Kingdom (Betafem), Europe (Betadine BV) and also in Australia, New Zealand, Southeast Asia and South Africa.".
69. ↑ "Dequalinium Chloride-An Emerging Option in the Sparse Landscape of Bacterial Vaginosis Therapies". JAMA Netw Open 7 (5): e248606. May 2024. doi:10.1001/jamanetworkopen.2024.8606. PMID 38696175.
70. ↑ "Use of locally delivered dequalinium chloride in the treatment of vaginal infections: a review". Arch Gynecol Obstet 293 (3): 469–484. March 2016. doi:10.1007/s00404-015-3914-8. PMID 26506926.
71. ↑ "Dequalinium Is Noninferior to Metronidazole for Bacterial Vaginosis". Am Fam Physician 110 (5): 543. November 2024. PMID 39556645.
72. ↑ "Dequalinium chloride vaginal tablet". 23 June 2022. https://adisinsight.springer.com/drugs/800041300.
73. ↑ "Astodrimer". 28 February 2024. https://adisinsight.springer.com/drugs/800015746.
74. ↑ "Astrodimer". 9 March 2023. https://isidog.com/2023/03/09/astrodimer/.
75. ↑ "Antiseptics and disinfectants for the treatment of bacterial vaginosis: a systematic review". BMC Infectious Diseases 12. June 2012. doi:10.1186/1471-2334-12-148. PMID 22742642.
76. ↑ 76.0 76.1 76.2 76.3 "Bacterial Vaginosis - STI Treatment Guidelines". Centers for Disease Control and Prevention. 19 July 2021. https://www.cdc.gov/std/treatment-guidelines/bv.htm.
77. ↑ 77.0 77.1 "Bacterial vaginosis: Initial treatment". UpToDate. 28 November 2022. https://www.uptodate.com/contents/bacterial-vaginosis-treatment.
78. ↑ "TOL 463". AdisInsight. Springer Nature Switzerland AG. https://adisinsight.springer.com/drugs/800047491.
79. ↑ "Current and emerging pharmacotherapy for recurrent bacterial vaginosis". Expert Opin Pharmacother 22 (12): 1593–1600. August 2021. doi:10.1080/14656566.2021.1904890. PMID 33750246.
80. ↑ "Safety and Efficacy of a Novel Vaginal Anti-infective, TOL-463, in the Treatment of Bacterial Vaginosis and Vulvovaginal Candidiasis: A Randomized, Single-blind, Phase 2, Controlled Trial". Clin Infect Dis 68 (5): 803–809. February 2019. doi:10.1093/cid/ciy554. PMID 30184181.
81. ↑ "Effects of probiotics for the treatment of bacterial vaginosis in adult women: a meta-analysis of randomized clinical trials". Archives of Gynecology and Obstetrics 289 (6): 1225–34. June 2014. doi:10.1007/s00404-013-3117-0. PMID 24318276.
82. ↑ "Perinatal outcomes of prenatal probiotic and prebiotic administration: an integrative review". The Journal of Perinatal & Neonatal Nursing 27 (4): 288–301; quiz E1-2. 2013. doi:10.1097/jpn.0b013e3182a1e15d. PMID 24164813.
83. ↑ 83.0 83.1 83.2 "Bacterial vaginosis: a review on clinical trials with probiotics". The New Microbiologica 36 (3): 229–38. July 2013. PMID 23912864.
84. ↑ 84.0 84.1 84.2 "Connecting the Dots: Translating the Vaginal Microbiome Into a Drug". J Infect Dis 223 (12 Suppl 2): S296–S306. June 2021. doi:10.1093/infdis/jiaa676. PMID 33330916.
85. ↑ 85.0 85.1 "CTV 05". AdisInsight. Springer Nature Switzerland AG. https://adisinsight.springer.com/drugs/800013396.
86. ↑ "Bacterial Vaginosis (BV) Statistics Prevalence". 14 September 2010. https://www.cdc.gov/std/bv/stats.htm.

## External links

* WHO fact sheet on bacterial vaginosis

Classification|

* ICD-11: GA00, GA02
* ICD-10: N76
* ICD-9-CM: 616.1
* MeSH: D016585

|

* v
* t
* e

Female diseases of the pelvis and genitals (N70–N99, 614–629)

Internal|

| Adnexa|

| Ovary|

* Endometriosis of ovary
* Female infertility
* Anovulation
* Poor ovarian reserve
* Mittelschmerz
* Oophoritis
* Ovarian apoplexy
* Ovarian cyst
* Corpus luteum cyst
* Follicular cyst of ovary
* Theca lutein cyst
* Ovarian hyperstimulation syndrome
* Ovarian torsion

|

Fallopian tube|

* Female infertility
* Fallopian tube obstruction
* Hematosalpinx
* Hydrosalpinx
* Salpingitis

Uterus|

| Endometrium|

* Asherman's syndrome
* Dysfunctional uterine bleeding
* Endometrial hyperplasia
* Endometrial polyp
* Endometriosis
* Endometritis

menstruation|

* flow
* Amenorrhoea
* Hypomenorrhea
* Oligomenorrhea
* pain
* Dysmenorrhea
* PMS
* timing
* Menometrorrhagia
* Menorrhagia
* Metrorrhagia

* Female infertility
* Recurrent miscarriage

Myometrium|

* Adenomyosis

Parametrium|

* Parametritis

Cervix|

* Cervical dysplasia
* Cervical incompetence
* Cervical polyp
* Cervicitis
* Female infertility
* Cervical stenosis
* Nabothian cyst

General|

* Hematometra / Pyometra
* Retroverted uterus

Vagina|

* Hematocolpos / Hydrocolpos
* Leukorrhea / Vaginal discharge
* Vaginitis
* Atrophic vaginitis
* Bacterial vaginosis
* Candidal vulvovaginitis
* Hydrocolpos

Sexual dysfunction|

* Dyspareunia
* Hypoactive sexual desire disorder
* Sexual arousal disorder
* Vaginismus

* Urogenital fistulas
* Ureterovaginal
* Vesicovaginal
* Obstetric fistula
* Rectovaginal fistula
* Prolapse
* Cystocele
* Enterocele
* Rectocele
* Sigmoidocele
* Urethrocele

* Vaginal bleeding
* Postcoital bleeding

Other / general|

* Pelvic congestion syndrome
* Pelvic inflammatory disease

External|

| Vulva|

* Bartholin's cyst
* Kraurosis vulvae
* Vestibular papillomatosis
* Vulvitis
* Vulvodynia

|

Clitoral hood or clitoris|

* Persistent genital arousal disorder

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