Neurophysiology

Short description: Study of neurones

Neurophysiology is a branch of physiology and neuroscience that studies nervous system function rather than nervous system architecture.[1] This area aids in the diagnosis and monitoring of neurological diseases. Historically, it has been dominated by electrophysiology—the electrical recording of neural activity ranging from the molar (the electroencephalogram, EEG) to the cellular (intracellular recording of the properties of single neurons), such as patch clamp, voltage clamp, extracellular single-unit recording and recording of local field potentials. However, since the neuron is an electrochemical machine, it is difficult to isolate electrical events from the metabolic and molecular processes that cause them. Thus, neurophysiologists currently utilise tools from chemistry (calcium imaging), physics (functional magnetic resonance imaging, fMRI), and molecular biology (site directed mutations) to examine brain activity.[2]

The word originates from the Greek word νεῦρον meaning "nerve" and physiology meaning knowledge about the function of living systems (φύσις meaning "nature" and -λογία meaning "knowledge").

## Contents

* 1 History
* 2 See also
* 3 References
* 4 Sources

## History

Neurophysiology has been a subject of study since as early as 4,000 B.C.

In the early B.C. years, most studies were of different natural sedatives like alcohol and poppy plants. In 1700 B.C., the Edwin Smith surgical papyrus was written. This papyrus was crucial in understanding how the ancient Egyptians understood the nervous system. This papyrus looked at different case studies about injuries to different parts of the body, most notably the head. Beginning around 460 B.C., Hippocrates began to study epilepsy, and theorized that it had its origins in the brain. Hippocrates also theorized that the brain was involved in sensation, and that it was where intelligence was derived from. Hippocrates, as well as most ancient Greeks, believed that relaxation and a stress free environment was crucial in helping treat neurological disorders. In 280 B.C., Erasistratus of Chios theorized that there were divisions in vestibular processing in the brain, as well as deducing from observation that sensation was located there.

In 177 Galen theorized that human thought occurred in the brain, as opposed to the heart as Aristotle had theorized. The optic chiasm, which is crucial to the visual system, was discovered around 100 C.E. by Marinus. c. 1000, Al-Zahrawi, living in Iberia, began to write about different surgical treatments for neurological disorders. In 1216, the first anatomy textbook in Europe, which included a description of the brain, was written by Mondino de Luzzi. In 1402, St Mary of Bethlehem Hospital (later known as Bedlam in Britain) was the first hospital used exclusively for the mentally ill.

In 1504, Leonardo da Vinci continued his study of the human body with a wax cast of the human ventricle system. In 1536, Nicolo Massa described the effects of different diseases, such as syphilis on the nervous system. He also noticed that the ventricular cavities were filled with cerebrospinal fluid. In 1542, the term physiology was used for the first time by a French physician named Jean Fernel, to explain bodily function in relation to the brain. In 1543, Andreas Vesalius wrote De humani corporis fabrica, which revolutionized the study of anatomy. In this book, he described the pineal gland and what he believed the function was, and was able to draw the corpus striatum which is made up of the basal ganglia and the internal capsule. In 1549, Jason Pratensis published De Cerebri Morbis. This book was devoted to neurological diseases, and discussed symptoms, as well as ideas from Galen and other Greek, Roman and Arabic authors. It also looked into the anatomy and specific functions of different areas. In 1550, Andreas Vesalius worked on a case of hydrocephalus, or fluid filling the brain. In the same year, Bartolomeo Eustachi studied the optic nerve, mainly focusing on its origin in the brain. In 1564, Giulio Cesare Aranzio discovered the hippocampus, naming it such due to its shape resemblance to a sea horse.

In 1621, Robert Burton published The Anatomy of Melancholy, which looked at the loss of important characters in one's life as leading to depression.[3] In 1649, René Descartes studied the pineal gland. He mistakenly believed that it was the "soul" of the brain, and believed it was where thoughts formed. In 1658, Johann Jakob Wepfer studied a patient in which he believed that a broken blood vessel had caused apoplexy, or a stroke.

In 1749, David Hartley published Observations on Man, which focused on frame (neurology), duty (moral psychology) and expectations (spirituality) and how these integrated within one another. This text was also the first to use the English term psychology. In 1752, the Society of Friends created an asylum in Philadelphia, Pennsylvania. The asylum intended to give not only medical treatment to those mentally ill, but also provide with caretakers and comfortable living conditions. In 1755, Jean-Baptiste Le Roy began using electroconvulsive therapy for the mentally ill, a treatment still used today in specific cases. In 1760, Arne-Charles studied how different lesions in the cerebellum could affect motor movements. In 1776, Vincenzo Malacarne [it; it] studied the cerebellum intensely, and published a book solely based on its function and appearance.

In 1784, Félix Vicq-d'Azyr, discovered a black colored structure in the midbrain.[4] In 1791 Samuel Thomas von Sömmerring alluded to this structure, calling it the substantia nigra.[5] In the same year, Luigi Galvani described the role of electricity in nerves of dissected frogs. In 1808, Franz Joseph Gall studied and published work on phrenology. Phrenology was the faulty science of looking at head shape to determine different aspects of personality and brain function. In 1811, Julien Jean César Legallois studied respiration in animal dissection and lesions and found the center of respiration in the medulla oblongata. In the same year, Charles Bell finished work on what would later become known as the Bell–Magendie law, which compared functional differences between dorsal and ventral roots of the spinal cord. In 1822, Karl Friedrich Burdach distinguished between the lateral and medial geniculate bodies, as well as named the cingulate gyrus. In 1824, F. Magendie studied and produced the first evidence of the cerebellum's role in equilibration to complete the Bell–Magendie law. In 1838, Theodor Schwann began studying white and grey matter in the brain, and discovered the myelin sheath. These cells, which cover the axons of the neurons in the brain, are named Schwann cells after him. In 1843 Carlo Matteucci and Emil du Bois-Reymond demonstrated that nerves transmit signals electrically. In 1848, Phineas Gage, the classical neurophysiology patient, had his brain pierced by an iron tamping rod in a blasting accident. He became an excellent case study in the connection between the prefrontal cortex and behavior, decision making and consequences. In 1849, Hermann von Helmholtz studied the speed of frog nerve impulses while studying electricity in the body.

While these are not all the developments in neurophysiology before 1849, these developments were significant to the study of the brain and body.

## See also

* Brain
* History of the pineal gland
* Neuroscience
* Neural coding
* Neurology
* Repetitive visual stimulus

## References

1. ↑ "Neurophysiology". Encyclopedia of Sciences and Religions. Encyclopedia of Sciences and Religions. 2013. pp. 1497–1500. doi:10.1007/978-1-4020-8265-8_779. ISBN 978-1-4020-8264-1. https://link.springer.com/referenceworkentry/10.1007/978-1-4020-8265-8_779.
2. ↑ Teyler, T. J. (2001-01-01), Smelser, Neil J.; Baltes, Paul B., eds. (in en), In Vitro Neurophysiology, Oxford: Pergamon, pp. 7251–7254, ISBN 978-0-08-043076-8, https://www.sciencedirect.com/science/article/pii/B0080430767034136, retrieved 2022-04-03
3. ↑ Horwitz, Allan V.; Wakefield, Jerome C.; Lorenzo-Luaces, Lorenzo (2016-04-07). "History of Depression". in DeRubeis, Robert J. (in en). The Oxford Handbook of Mood Disorders. 1. Oxford University Press. pp. 10–23. doi:10.1093/oxfordhb/9780199973965.013.2. ISBN 978-0-19-997396-5. https://www.researchgate.net/publication/301219610.
4. ↑ "Félix Vicq d'Azyr (1746-1794): early founder of neuroanatomy and royal French physician". Childs Nerv Syst 27 (7): 1031–4. July 2011. doi:10.1007/s00381-011-1424-y. PMID 21445631.
5. ↑ Swanson, LW. Neuroanatomical terminology : a lexicon of classical origins and historical foundations. Oxford University Press, 2014. England ISBN 9780195340624

## Sources

* Fye WB (October 1995). "Julien Jean César Legallois". Clinical Cardiology 18 (10): 599–600. doi:10.1002/clc.4960181015. PMID 8785909.
* "NEUROSURGERY://ON-CALL®". http://www.neurosurgery.org/cybermuseum/pre20th/epapyrus.html.
* Gallistel, C. R. (1981). "Bell, Magendie and the Proposals to Restrict the Use of Animals in Neurobehavioral Research". The American Psychologist (Ruccs.rutgers.edu.) 36 (4): 357–60. doi:10.1037/0003-066x.36.4.357. PMID 7023302. http://ruccs.rutgers.edu/~galliste/Gallistel_1981_Bell_Magendie_and_the_Proposal_to_Restrict_the_Use_of_Animals.pdf. Retrieved 30 April 2012.
* "History of Biology 1800-1849". 26 October 2011. http://www.normalesup.org/~adanchin/history/dates_1800.html.
* "History of Neuroscience". University of Washington. http://faculty.washington.edu/chudler/hist.html.
* Duque-Parra JE (September 2004). "Perspective on the vestibular cortex throughout history". The Anatomical Record Part B: The New Anatomist 280 (1): 15–9. doi:10.1002/ar.b.20031. PMID 15382110.
* "Article Number: EONS : 0736 : Cerebellum". http://prism.bham.ac.uk/pdf_files/Miall_2002_Encycl_Neurol_Sci.pdf.
* "David Hartley". http://plato.stanford.edu/entries/hartley/.
* Frank, Leonard R. (2006). "The Electroshock Quotationary". http://www.endofshock.com/Final version Quotationary.pdf.
* Pearce JM (April 1997). "Johann Jakob Wepfer (1620-95) and cerebral haemorrhage". Journal of Neurology, Neurosurgery, and Psychiatry 62 (4): 387. doi:10.1136/jnnp.62.4.387. PMID 9120455.
* Finger, Stanley (2001). Origins of Neuroscience. Oxford University Press. ISBN 9780195146943. https://books.google.com/books?id=_GMeW9E1IB4C. Retrieved 30 April 2012.
* "Anatomy Words". http://anatomyalmanac.blogspot.com/2007/08/hippocampus-half-horsehalf-fish-sea.html.
* "Andreas Vesalius and Modern Human Anatomy". http://www.experiment-resources.com/andreas-vesalius.html.
* O'Malley, Charles Donald (1964). Andreas Vesalius of Brussels, 1514-1564. University of California Press. https://archive.org/details/andreasvesaliuso0063omal. Retrieved 30 April 2012.
* Pestronk A (March 1988). "The first neurology book. De Cerebri Morbis...(1549) by Jason Pratensis". Archives of Neurology 45 (3): 341–4. doi:10.1001/archneur.1988.00520270123032. PMID 3277602.
* "Descartes and the Pineal Gland". http://plato.stanford.edu/entries/pineal-gland/.
* McCaffrey, Patrick. "Chapter 5. The Corpus Striatum, Rhinencephalon, Connecting Fibers, and Diencephalon". CSU. http://www.csuchico.edu/~pmccaffrey/syllabi/CMSD 320/362unit5.html.
* Brink A (December 1979). "Depression and loss: a theme in Robert Burton's 'Anatomy of melancholy' (1621)". Canadian Journal of Psychiatry 24 (8): 767–72. doi:10.1177/070674377902400811. PMID 391384.
* "Al-Zahrawi - Father of Surgery". http://www.factofarabs.net/ERA.aspx?Id=99.
* "Andreas Vesalius". http://www.encyclopedia.com/topic/Andreas_Vesalius.aspx.
* Jeffery G (October 2001). "Architecture of the optic chiasm and the mechanisms that sculpt its development". Physiological Reviews 81 (4): 1393–414. doi:10.1152/physrev.2001.81.4.1393. PMID 11581492.
* "Mondino De' Luzzi". http://www.encyclopedia.com/topic/Mondino_de_Luzzi.aspx.
* "A History of the Brain". Stanford University.. http://www.stanford.edu/class/history13/earlysciencelab/body/brainpages/brain.html.

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