Xenon

Xenon is a chemical element; it has symbol Xe and atomic number 54\. It is a dense, colorless, odorless noble gas found in Earth's atmosphere in trace amounts.[1] Although generally unreactive, it can undergo a few chemical reactions such as the formation of xenon hexafluoroplatinate, the first noble gas compound to be synthesized.[2][3][4]

Xenon is used in flash lamps[5] and arc lamps,[6] and as a general anesthetic.[7] The first excimer laser design used a xenon dimer molecule (Xe2) as the lasing medium,[8] and the earliest laser designs used xenon flash lamps as pumps.[9] Xenon is also used to search for hypothetical weakly interacting massive particles[10] and as a propellant for ion thrusters in spacecraft.[11]

Naturally occurring xenon consists of seven stable isotopes and two long-lived radioactive isotopes. More than 40 unstable xenon isotopes undergo radioactive decay, and the isotope ratios of xenon are an important tool for studying the early history of the Solar System.[12] Radioactive xenon-135 is produced by beta decay from iodine-135 (a product of nuclear fission), and is the most significant (and unwanted) neutron absorber in nuclear reactors.[13]

## Contents

* 1 History
* 2 Characteristics
* 3 Occurrence and production
* 3.1 The missing Xe problem
* 3.2 Commercial
* 3.3 Solar System
* 3.4 Stellar
* 3.5 Nuclear fission
* 4 Isotopes
* 4.1 Nuclear spin
* 4.2 From fission
* 4.3 Cosmic processes
* 5 Compounds
* 5.1 Halides
* 5.2 Oxides and oxohalides
* 5.3 Other compounds
* 5.4 Clathrates and excimers
* 6 Applications
* 6.1 Illumination and optics
* 6.1.1 Gas-discharge lamps
* 6.1.2 Lasers
* 6.2 Medical
* 6.2.1 Anesthesia
* 6.2.2 Neuroprotectant
* 6.2.3 Sports doping and mountaineering
* 6.2.4 Imaging
* 6.2.5 Surgery
* 6.3 NMR spectroscopy
* 6.4 Other
* 7 Precautions
* 8 See also
* 9 Notes
* 10 References
* 11 External links

## History

Xenon was discovered in England by the Scottish chemist William Ramsay and English chemist Morris Travers on July 12, 1898,[14] shortly after their discovery of the elements krypton and neon. They found xenon in the residue left over from evaporating components of liquid air.[15][16] Ramsay suggested the name xenon for this gas from the Greek word ξένον xénon, neuter singular form of ξένος xénos, meaning 'foreign(er)', 'strange(r)', or 'guest'.[17][18] In 1902, Ramsay estimated the proportion of xenon in the Earth's atmosphere to be one part in 20 million.[19]

During the 1930s, American engineer Harold Edgerton began exploring strobe light technology for high speed photography. This led him to the invention of the xenon flash lamp in which light is generated by passing brief electric current through a tube filled with xenon gas. In 1934, Edgerton was able to generate flashes as brief as one microsecond with this method.[5][20][21]

In 1939, American physician Albert R. Behnke Jr. began exploring the causes of "drunkenness" in deep-sea divers. He tested the effects of varying the breathing mixtures on his subjects, and discovered that this caused the divers to perceive a change in depth. From his results, he deduced that xenon gas could serve as an anesthetic. Although Russian toxicologist Nikolay V. Lazarev apparently studied xenon anesthesia in 1941, the first published report confirming xenon anesthesia was in 1946 by American medical researcher John H. Lawrence, who experimented on mice. Xenon was first used as a surgical anesthetic in 1951 by American anesthesiologist Stuart C. Cullen, who successfully used it with two patients.[22]

An acrylic cube specially prepared for element collectors containing a glass ampoule of liquefied xenon

Xenon and the other noble gases were for a long time considered to be completely chemically inert and not able to form compounds. However, while teaching at the University of British Columbia, Neil Bartlett discovered that the gas platinum hexafluoride (PtF6) was a powerful oxidizing agent that could oxidize oxygen gas (O2) to form dioxygenyl hexafluoroplatinate (O+2[PtF6]−).[23] Since O2 (1165 kJ/mol) and xenon (1170 kJ/mol) have almost the same first ionization potential, Bartlett realized that platinum hexafluoride might also be able to oxidize xenon. On March 23, 1962, he mixed the two gases and produced the first known compound of a noble gas, xenon hexafluoroplatinate.[24][4]

Bartlett thought its composition to be Xe+[PtF6]−, but later work revealed that it was probably a mixture of various xenon-containing salts.[25][26][27] Since then, many other xenon compounds have been discovered,[28] in addition to some compounds of the noble gases argon, krypton, and radon, including argon fluorohydride (HArF),[29] krypton difluoride (KrF2),[30][31] and radon fluoride.[32] By 1971, more than 80 xenon compounds were known.[33][34]

In November 1989, IBM scientists demonstrated a technology capable of manipulating individual atoms. The program, called IBM in atoms, used a scanning tunneling microscope to arrange 35 individual xenon atoms on a substrate of chilled crystal of nickel to spell out the three-letter company initialism. It was the first-time atoms had been precisely positioned on a flat surface.[35]

## Characteristics

A layer of solid xenon building inside a high voltage apparatus. The layer of solid xenon (white color) is surrounded by liquid xenon (transparent). Liquid (featureless) and crystalline solid Xe nanoparticles produced by implanting Xe+ ions into aluminium at room temperature

Xenon has atomic number 54; that is, its nucleus contains 54 protons. At standard temperature and pressure, pure xenon gas has a density of 5.894 kg/m3, about 4.5 times the density of the Earth's atmosphere at sea level, 1.217 kg/m3.[36] As a liquid, xenon has a density of up to 3.100 g/mL, with the density maximum occurring at the triple point.[37] Liquid xenon has a high polarizability due to its large atomic volume, and thus is an excellent solvent. It can dissolve hydrocarbons, biological molecules, and even water.[38] Under the same conditions, the density of solid xenon, 3.640 g/cm3,[37] is greater than the average density of granite, 2.75 g/cm3. Under gigapascals of pressure, xenon forms a metallic phase.[39]

Solid xenon changes from Face-centered cubic (fcc) to hexagonal close packed (hcp) crystal phase under pressure and begins to turn metallic at about 140 GPa, with no noticeable volume change in the hcp phase.[40] It is completely metallic at 155 GPa.[41] When metallized, xenon appears sky blue because it absorbs red light and transmits other visible frequencies. Such behavior is unusual for a metal and is explained by the relatively small width of the electron bands in that state.[42][better source needed]

Xenon flashing inside a flashtube frame by frame

Liquid or solid xenon nanoparticles can be formed at room temperature by implanting Xe+ ions into a solid matrix. Many solids have lattice constants smaller than solid Xe. This results in compression of the implanted Xe to pressures that may be sufficient for its liquefaction or solidification.[43]

Xenon is a member of the zero-valence elements that are called noble or inert gases. It is inert to most common chemical reactions (such as combustion, for example) because the outer valence shell contains eight electrons. This produces a stable, minimum energy configuration in which the outer electrons are tightly bound.[44]

In a gas-filled tube, xenon emits a blue or lavenderish glow when excited by electrical discharge. Xenon emits a band of emission lines that span the visual spectrum,[45] but the most intense lines occur in the region of blue light, producing the coloration.[46]

## Occurrence and production

Xenon is a trace gas in Earth's atmosphere, occurring at a volume fraction of 87±1 nL/L (parts per billion), or approximately 1 part per 11.5 million.[47] It is also found as a component of gases emitted from some mineral springs. Given a total mass of the atmosphere of 5.15×1018 kilograms (1.135×1019 lb), the atmosphere contains on the order of 2.03 gigatonnes (2.00×109 long tons; 2.24×109 short tons) of xenon in total when taking the average molar mass of the atmosphere as 28.96 g/mol which is equivalent to some 394-mass ppb.

### The missing Xe problem

The concentration of Xe in the atmosphere is much lower than Ar and Kr, a geological mystery known as "the missing Xe problem". Numerous proposals have been made to explain the mystery, including formation of Xe–Fe oxides in the Earth's lower mantle,[48] formation of xenon dioxide in silica,[49] and reactions between Xe and Fe/Ni in the Earth's core.[50]

### Commercial

Xenon is obtained commercially as a by-product of the separation of air into oxygen and nitrogen.[51] After this separation, generally performed by fractional distillation in a double-column plant, the liquid oxygen produced will contain small quantities of krypton and xenon. By additional fractional distillation, the liquid oxygen may be enriched to contain 0.1–0.2% of a krypton/xenon mixture, which is extracted either by adsorption onto silica gel or by distillation. Finally, the krypton/xenon mixture may be separated into krypton and xenon by further distillation.[52][53]

Worldwide production of xenon in 1998 was estimated at 5,000–7,000 cubic metres (180,000–250,000 cu ft).[54] At a density of 5.894 grams per litre (0.0002129 lb/cu in) this is equivalent to roughly 30 to 40 tonnes (30 to 39 long tons; 33 to 44 short tons). Because of its scarcity, xenon is much more expensive than the lighter noble gases—approximate prices for the purchase of small quantities in Europe in 1999 were 10 €/L (=~€1.7/g) for xenon, 1 €/L (=~€0.27/g) for krypton, and 0.20 €/L (=~€0.22/g) for neon,[54] while the much more plentiful argon, which makes up over 1% by volume of earth's atmosphere, costs less than a cent per liter.

### Solar System

Within the Solar System, the nucleon fraction of xenon is 1.56×10−8, for an abundance of approximately one part in 630 thousand of the total mass.[55] Xenon is relatively rare in the Sun's atmosphere, on Earth, and in asteroids and comets. The abundance of xenon in the atmosphere of planet Jupiter is unusually high, about 2.6 times that of the Sun.[56][lower-alpha 1] This abundance remains unexplained, but may have been caused by an early and rapid buildup of planetesimals—small, sub-planetary bodies—before the heating of the presolar disk;[57] otherwise, xenon would not have been trapped in the planetesimal ices. The problem of the low terrestrial xenon may be explained by covalent bonding of xenon to oxygen within quartz, reducing the outgassing of xenon into the atmosphere.[58]

### Stellar

Unlike the lower-mass noble gases, the normal stellar nucleosynthesis process inside a star does not form xenon. Nucleosynthesis consumes energy to produce nuclides more massive than iron-56, and thus the synthesis of xenon represents no energy gain for a star.[59] Instead, xenon is formed during supernova explosions during the r-process,[60] by the slow neutron-capture process (s-process) in red giant stars that have exhausted their core hydrogen and entered the asymptotic giant branch,[61] and from radioactive decay, for example by beta decay of extinct iodine-129 and spontaneous fission of thorium, uranium, and plutonium.[62]

### Nuclear fission

Fission product yields from nuclear fission of 235U with thermal neutrons. Xenon is represented by the tallest blue bar in the graph

Xenon-135 is a notable neutron poison with a high fission product yield. As it is relatively short lived, it decays at the same rate it is produced during steady operation of a nuclear reactor. However, if power is reduced or the reactor is scrammed, less xenon is destroyed than is produced from the beta decay of its parent nuclides. This phenomenon called xenon poisoning can cause significant problems in restarting a reactor after a scram or increasing power after it had been reduced and it was one of several contributing factors in the Chernobyl nuclear accident.[63][64]

Stable or extremely long lived isotopes of xenon are also produced in appreciable quantities in nuclear fission. Xenon-136 is produced both as a fission product and when xenon-135 undergoes neutron capture before it can decay. The ratio of xenon-136 to xenon-135 (or its decay products) can give hints as to the power history of a given reactor or identify a nuclear explosion, as xenon-135 is mostly produced by successive beta decays of more neutron-rich fission products. These short-lived nuclides do not share its neutron-absorbing prowess, and so absorb fewer neutrons during the brief moment of a nuclear explosion, lowering the ratio of mass-136 to mass-135 products.[65]

The stable isotope xenon-132 has a fission product yield of over 4% in the thermal neutron fission of 235U which means that stable or nearly stable xenon isotopes have a higher mass fraction in spent nuclear fuel (which is about 3% fission products in the case of light water reactors) than it does in air. However, there is as of 2022 no commercial effort to extract xenon from spent fuel during nuclear reprocessing.[66][67]

## Isotopes

Main article: Physics:Isotopes of xenon

Naturally occurring xenon is composed of seven stable and two almost stable isotopes: 126Xe, 128–132Xe, and 134Xe are stable, 124Xe and 136Xe have very long half-lives, trillions of times the age of the universe. The isotopes 126Xe[68] and 134Xe[69] are also predicted by theory to undergo double beta decay, but this has never been observed so they are considered stable.

More than 40 unstable isotopes are known. The longest-lived of these isotopes are the primordial 124Xe, which undergoes double electron capture with a half-life of 1.1×1022 yr, and 136Xe, which undergoes double beta decay with a half-life of 2.18×1021 yr.[70]

129Xe is produced by beta decay of 129I, which has a half-life of 16.1 million years. 131mXe, 133Xe, 133mXe, and 135Xe are some of the fission products of 235U and 239Pu,[62] and are used to detect and monitor nuclear explosions.

### Nuclear spin

Nuclei of the stable isotopes with odd mass number, 129Xe and 131Xe have non-zero intrinsic angular momenta (nuclear spins, suitable for nuclear magnetic resonance). The nuclear spins can be aligned beyond ordinary polarization levels by means of circularly polarized light and rubidium vapor.[71] The resulting spin polarization of xenon nuclei can surpass 50% of its maximum possible value, greatly exceeding the thermal equilibrium value dictated by paramagnetic statistics (typically 0.001% of the maximum value at room temperature, even in the strongest magnets). Such non-equilibrium alignment of spins is a temporary condition, and is called hyperpolarization. The process of hyperpolarizing the xenon is called optical pumping (although the process is different from pumping a laser).[72]

Because a 129Xe nucleus has a spin of 1/2, and therefore a zero electric quadrupole moment, the 129Xe nucleus does not experience any quadrupolar interactions during collisions with other atoms, and the hyperpolarization persists for long periods even after the engendering light and vapor have been removed. Spin polarization of 129Xe can persist from several seconds for xenon atoms dissolved in blood[73] to several hours in the gas phase[74] and several days in deeply frozen solid xenon.[75] In contrast, 131Xe has a nuclear spin value of ​3⁄2 and a nonzero quadrupole moment, and has t1 relaxation times in the millisecond and second ranges.[76]

### From fission

Some radioactive isotopes of xenon (for example, 133Xe and 135Xe) are produced by neutron irradiation of fissionable material within nuclear reactors.[2] 135Xe is of considerable significance in the operation of nuclear fission reactors. 135Xe has a huge cross section for thermal neutrons, 2.6 million barns,[13] and operates as a neutron absorber or "poison" that can slow or stop the chain reaction after a period of operation. This was discovered in the earliest nuclear reactors built by the American Manhattan Project for plutonium production. However, the designers had made provisions in the design to increase the reactor's reactivity (the number of neutrons per fission that go on to fission other atoms of nuclear fuel).[77]

135Xe reactor poisoning was a major factor in the Chernobyl disaster.[78] A shutdown or decrease of power of a reactor can result in buildup of 135Xe, with reactor operation going into a condition known as the iodine pit. Under adverse conditions, relatively high concentrations of radioactive xenon isotopes may emanate from cracked fuel rods,[79] or fissioning of uranium in cooling water.[80]

Isotope ratios of xenon produced in natural nuclear fission reactors at Oklo in Gabon reveal the reactor properties during the chain reaction that took place about 2 billion years ago.[81]

### Cosmic processes

Because xenon is a tracer for two parent isotopes, xenon isotope ratios in meteorites are a powerful tool for studying the formation of the Solar System. The iodine–xenon method of dating gives the time elapsed between nucleosynthesis and the condensation of a solid object from the solar nebula. In 1960, physicist John H. Reynolds discovered that certain meteorites contained an isotopic anomaly in the form of an overabundance of xenon-129. He inferred that this was a decay product of radioactive iodine-129. This isotope is produced slowly by cosmic ray spallation and nuclear fission, but is produced in quantity only in supernova explosions.[82][83]

Because the half-life of 129I is comparatively short on a cosmological time scale (~16 million years), this demonstrated that only a short time had passed between the supernova and the time the meteorites had solidified and trapped the 129I. These two events (supernova and solidification of gas cloud) were inferred to have happened during the early history of the Solar System, because the 129I isotope was likely generated shortly before the Solar System was formed, seeding the solar gas cloud with isotopes from a second source. This supernova source may also have caused collapse of the solar gas cloud.[82][83]

In a similar way, xenon isotopic ratios such as 129Xe/130Xe and 136Xe/130Xe are a powerful tool for understanding planetary differentiation and early outgassing.[12] For example, the atmosphere of Mars shows a xenon abundance similar to that of Earth (0.08 parts per million[84]) but Mars shows a greater abundance of 129Xe than the Earth or the Sun. Since this isotope is generated by radioactive decay, the result may indicate that Mars lost most of its primordial atmosphere, possibly within the first 100 million years after the planet was formed.[85][86] In another example, excess 129Xe found in carbon dioxide well gases from New Mexico is believed to be from the decay of mantle-derived gases from soon after Earth's formation.[62][87]

## Compounds

See also: Category:Xenon compounds

After Neil Bartlett's discovery in 1962 that xenon can form chemical compounds, a large number of xenon compounds have been discovered and described. Almost all known xenon compounds contain the electronegative atoms fluorine or oxygen. The chemistry of xenon in each oxidation state is analogous to that of the neighboring element iodine in the immediately lower oxidation state.[88]

### Halides

Xenon tetrafluoride XeF4 crystals, 1962

Three fluorides are known: XeF2, XeF4, and XeF6. These are the starting points for the synthesis of almost all xenon compounds.

The solid, crystalline difluoride XeF2 is formed when a mixture of fluorine and xenon gases is exposed to ultraviolet light.[89] The ultraviolet component of ordinary daylight is sufficient.[90] Long-term heating of XeF2 at high temperatures under an NiF2 catalyst yields XeF6.[91] Pyrolysis of XeF6 in the presence of NaF yields high-purity XeF4.[92]

The xenon fluorides behave as both fluoride acceptors and fluoride donors, forming salts that contain such cations as XeF+ and Xe2F+3, and anions such as XeF−5, XeF−7, and XeF2−8. The green, paramagnetic Xe+2 is formed by the reduction of XeF2 by xenon gas.[88]

XeF2 also forms coordination complexes with transition metal ions. More than 30 such complexes have been synthesized and characterized.[91]

Whereas the xenon fluorides are well characterized, the other halides are not. Xenon dichloride, formed by the high-frequency irradiation of a mixture of xenon, fluorine, and silicon or carbon tetrachloride,[93] is reported to be an endothermic, colorless, crystalline compound that decomposes into the elements at 80 °C. However, XeCl2 may be merely a van der Waals molecule of weakly bound Xe atoms and Cl2 molecules and not a real compound.[94] Theoretical calculations indicate that the linear molecule XeCl2 is less stable than the van der Waals complex.[95] Xenon tetrachloride and xenon dibromide are even more unstable and they cannot be synthesized by chemical reactions. They were created by radioactive decay of 129ICl−4 and 129IBr−2, respectively.[96][97]

### Oxides and oxohalides

Three oxides of xenon are known: xenon trioxide (XeO3) and xenon tetroxide (XeO4), both of which are dangerously explosive and powerful oxidizing agents, and xenon dioxide (XeO2), which was reported in 2011 with a coordination number of four.[98] XeO2 forms when xenon tetrafluoride is poured over ice. Its crystal structure may allow it to replace silicon in silicate minerals.[99] The XeOO+ cation has been identified by infrared spectroscopy in solid argon.[100]

Xenon does not react with oxygen directly; the trioxide is formed by the hydrolysis of XeF6:[101]

XeF6 \+ 3 H2O → XeO3 \+ 6 HF

XeO3 is weakly acidic, dissolving in alkali to form unstable xenate salts containing the HXeO−4 anion. These unstable salts easily disproportionate into xenon gas and perxenate salts, containing the XeO4−6 anion.[102]

Barium perxenate, when treated with concentrated sulfuric acid, yields gaseous xenon tetroxide:[93]

Ba2XeO6 \+ 2 H2SO4 → 2 BaSO4 \+ 2 H2O \+ XeO4

To prevent decomposition, the xenon tetroxide thus formed is quickly cooled into a pale-yellow solid. It explodes above −35.9 °C into xenon and oxygen gas, but is otherwise stable.

A number of xenon oxyfluorides are known, including XeOF2, XeOF4, XeO2F2, and XeO3F2. XeOF2 is formed by reacting OF2 with xenon gas at low temperatures. It may also be obtained by partial hydrolysis of XeF4. It disproportionates at −20 °C into XeF2 and XeO2F2.[103] XeOF4 is formed by the partial hydrolysis of XeF6...[104]

XeF6 \+ H2O → XeOF4 \+ 2 HF

...or the reaction of XeF6 with sodium perxenate, Na4XeO6. The latter reaction also produces a small amount of XeO3F2.

XeO2F2 is also formed by partial hydrolysis of XeF6.[105]

XeF6 \+ 2 H2O → XeO2F2 \+ 4 HF

XeOF4 reacts with CsF to form the XeOF−5 anion,[103][106] while XeOF3 reacts with the alkali metal fluorides KF, RbF and CsF to form the XeOF−4 anion.[107]

### Other compounds

Xenon can be directly bonded to a less electronegative element than fluorine or oxygen, particularly carbon.[108] Electron-withdrawing groups, such as groups with fluorine substitution, are necessary to stabilize these compounds.[102] Numerous such compounds have been characterized, including:[103][109]

* C6F5–Xe+–N≡C–CH3, where C6F5 is the pentafluorophenyl group.
* [C6F5]2Xe
* C6F5–Xe–C≡N
* C6F5–Xe–F
* C6F5–Xe–Cl
* C2F5–C≡C–Xe+
* [CH3]3C–C≡C–Xe+
* C6F5–XeF+2
* (C6F5Xe)2Cl+

Other compounds containing xenon bonded to a less electronegative element include F–Xe–N(SO2F)2 and F–Xe–BF2. The latter is synthesized from dioxygenyl tetrafluoroborate, O2BF4, at −100 °C.[103][110]

An unusual ion containing xenon is the tetraxenonogold(II) cation, AuXe2+4, which contains Xe–Au bonds.[111] This ion occurs in the compound AuXe4(Sb2F11)2, and is remarkable in having direct chemical bonds between two notoriously unreactive atoms, xenon and gold, with xenon acting as a transition metal ligand. A similar mercury complex (HgXe)(Sb3F17) (formulated as [HgXe2+][Sb2F11–][SbF6–]) is also known.[112]

The compound Xe2Sb2F11 contains a Xe–Xe bond, the longest element-element bond known (308.71 pm = 3.0871 Å).[113]

In 1995, M. Räsänen and co-workers, scientists at the University of Helsinki in Finland, announced the preparation of xenon dihydride (HXeH), and later xenon hydride-hydroxide (HXeOH), hydroxenoacetylene (HXeCCH), and other Xe-containing molecules.[114] In 2008, Khriachtchev et al. reported the preparation of HXeOXeH by the photolysis of water within a cryogenic xenon matrix.[115] Deuterated molecules, HXeOD and DXeOH, have also been produced.[116]

### Clathrates and excimers

In addition to compounds where xenon forms a chemical bond, xenon can form clathrates—substances where xenon atoms or pairs are trapped by the crystalline lattice of another compound. One example is xenon hydrate (Xe·​5 3⁄4H2O), where xenon atoms occupy vacancies in a lattice of water molecules.[117] This clathrate has a melting point of 24 °C.[118] The deuterated version of this hydrate has also been produced.[119] Another example is xenon hydride (Xe(H2)8), in which xenon pairs (dimers) are trapped inside solid hydrogen.[120] Such clathrate hydrates can occur naturally under conditions of high pressure, such as in Lake Vostok underneath the Antarctic ice sheet.[121] Clathrate formation can be used to fractionally distill xenon, argon and krypton.[122]

Xenon can also form endohedral fullerene compounds, where a xenon atom is trapped inside a fullerene molecule. The xenon atom trapped in the fullerene can be observed by 129Xe nuclear magnetic resonance (NMR) spectroscopy. Through the sensitive chemical shift of the xenon atom to its environment, chemical reactions on the fullerene molecule can be analyzed. These observations are not without caveat, however, because the xenon atom has an electronic influence on the reactivity of the fullerene.[123]

When xenon atoms are in the ground energy state, they repel each other and will not form a bond. When xenon atoms becomes energized, however, they can form an excimer (excited dimer) until the electrons return to the ground state. This entity is formed because the xenon atom tends to complete the outermost electronic shell by adding an electron from a neighboring xenon atom. The typical lifetime of a xenon excimer is 1–5 nanoseconds, and the decay releases photons with wavelengths of about 150 and 173 nm.[124][125] Xenon can also form excimers with other elements, such as the halogens fluorine, chlorine, and bromine.[126][127] The diatomic molecule XeF, present in xenon fluoride excimer lasers, has a ground state that is bound, but only very weakly, with an Xe–F bond dissociation energy of ~3 kcal·mol-1.[128][129]

## Applications

Although xenon is rare and relatively expensive to extract from the Earth's atmosphere, it has a number of applications.

### Illumination and optics

#### Gas-discharge lamps

Xenon short-arc lamp Space Shuttle Atlantis bathed in xenon lights Xenon gas discharge tube

Xenon is used in light-emitting devices called xenon flash lamps, used in photographic flashes and stroboscopic lamps;[5] to excite the active medium in lasers which then generate coherent light;[130] and, occasionally, in bactericidal lamps.[131] The first solid-state laser, invented in 1960, was pumped by a xenon flash lamp,[9] and lasers used to power inertial confinement fusion are also pumped by xenon flash lamps.[132]

Continuous, short-arc, high pressure xenon arc lamps have a color temperature closely approximating noon sunlight and are used in solar simulators. That is, the chromaticity of these lamps closely approximates a heated black body radiator at the temperature of the Sun. First introduced in the 1940s, these lamps replaced the shorter-lived carbon arc lamps in movie projectors.[6] They are also employed in typical 35mm, IMAX, and digital film projection systems. They are an excellent source of short wavelength ultraviolet radiation and have intense emissions in the near infrared used in some night vision systems. Xenon is used as a starter gas in metal halide lamps for automotive HID headlights, and high-end "tactical" flashlights.

The individual cells in a plasma display contain a mixture of xenon and neon ionized with electrodes. The interaction of this plasma with the electrodes generates ultraviolet photons, which then excite the phosphor coating on the front of the display.[133][134]

Xenon is used as a "starter gas" in high pressure sodium lamps. It has the lowest thermal conductivity and lowest ionization potential of all the non-radioactive noble gases. As a noble gas, it does not interfere with the chemical reactions occurring in the operating lamp. The low thermal conductivity minimizes thermal losses in the lamp while in the operating state, and the low ionization potential causes the breakdown voltage of the gas to be relatively low in the cold state, which allows the lamp to be more easily started.[135]

#### Lasers

In 1962, a group of researchers at Bell Laboratories discovered laser action in xenon,[136] and later found that the laser gain was improved by adding helium to the lasing medium.[137][138] The first excimer laser used a xenon dimer (Xe2) energized by a beam of electrons to produce stimulated emission at an ultraviolet wavelength of 176 nm.[8] Xenon chloride and xenon fluoride have also been used in excimer (or, more accurately, exciplex) lasers.[139]

### Medical

XenonClinical data

License data|

* US DailyMed: Xenon

ATC code|

* V04CX12 (WHO)

Legal status
Legal status|

* US: ℞-only [140][141][142]

Identifiers
CAS Number|

* 7440-63-3

PubChem CID|

* 23991

DrugBank|

* DB13453

UNII|

* 3H3U766W84

ChEBI|

* CHEBI:49956

ChEMBL|

* ChEMBL1236802

Chemical and physical data
3D model (JSmol)|

* Interactive image

SMILES

* [Xe]

InChI

* InChI=1S/Xe

* Key:FHNFHKCVQCLJFQ-UHFFFAOYSA-N

Template:Infobox drug/maintenance categories/container only

#### Anesthesia

Xenon has been used as a general anesthetic, but it is more expensive than conventional anesthetics.[143]

Xenon interacts with many different receptors and ion channels, and like many theoretically multi-modal inhalation anesthetics, these interactions are likely complementary. Xenon is a high-affinity glycine-site NMDA receptor antagonist.[144] However, xenon is different from certain other NMDA receptor antagonists in that it is not neurotoxic and it inhibits the neurotoxicity of ketamine and nitrous oxide (N2O), while actually producing neuroprotective effects.[145][146] Unlike ketamine and nitrous oxide, xenon does not stimulate a dopamine efflux in the nucleus accumbens.[147]

Like nitrous oxide and cyclopropane, xenon activates the two-pore domain potassium channel TREK-1. A related channel TASK-3 also implicated in the actions of inhalation anesthetics is insensitive to xenon.[148] Xenon inhibits nicotinic acetylcholine α4β2 receptors which contribute to spinally mediated analgesia.[149][150] Xenon is an effective inhibitor of plasma membrane Ca2+ ATPase. Xenon inhibits Ca2+ ATPase by binding to a hydrophobic pore within the enzyme and preventing the enzyme from assuming active conformations.[151]

Xenon is a competitive inhibitor of the serotonin 5-HT3 receptor. While neither anesthetic nor antinociceptive, this reduces anesthesia-emergent nausea and vomiting.[152]

Xenon has a minimum alveolar concentration (MAC) of 72% at age 40, making it 44% more potent than N2O as an anesthetic.[153] Thus, it can be used with oxygen in concentrations that have a lower risk of hypoxia. Unlike nitrous oxide, xenon is not a greenhouse gas and is viewed as environmentally friendly.[154] Though recycled in modern systems, xenon vented to the atmosphere is only returning to its original source, without environmental impact.

#### Neuroprotectant

Xenon induces robust cardioprotection and neuroprotection through a variety of mechanisms. Through its influence on Ca2+, K+, KATP\HIF, and NMDA antagonism, xenon is neuroprotective when administered before, during and after ischemic insults.[155][156] Xenon is a high affinity antagonist at the NMDA receptor glycine site.[144] Xenon is cardioprotective in ischemia-reperfusion conditions by inducing pharmacologic non-ischemic preconditioning. Xenon is cardioprotective by activating PKC-epsilon and downstream p38-MAPK.[157] Xenon mimics neuronal ischemic preconditioning by activating ATP sensitive potassium channels.[158] Xenon allosterically reduces ATP mediated channel activation inhibition independently of the sulfonylurea receptor1 subunit, increasing KATP open-channel time and frequency.[159]

#### Sports doping and mountaineering

Inhaling a xenon/oxygen mixture activates production of the transcription factor HIF-1-alpha, which may lead to increased production of erythropoietin. The latter hormone is known to increase red blood cell production and athletic performance. Reportedly, doping with xenon inhalation has been used in Russia since 2004 and perhaps earlier.[160] On August 31, 2014, the World Anti Doping Agency (WADA) added xenon (and argon) to the list of prohibited substances and methods, although no reliable doping tests for these gases have yet been developed.[161] In addition, effects of xenon on erythropoietin production in humans have not been demonstrated, so far.[162]

In 2025, four UK mountaineers, including Alistair Carns, climbed Mount Everest in an expedition lasting only one week, claiming their inhalation of xenon gas to stimulate erythropoietin production had obviated the usual several weeks' altitude acclimatisation. The International Climbing and Mountaineering Federation (UIAA) criticised the decision, citing that there is no evidence that the inhalation of xenon improves performance in high elevation environments. Furthermore, the UIAA warned that as an anesthetic, xenon gas could result in impaired brain function, respiratory compromise, and death if used in an unmonitored setting.[163][164][165]

#### Imaging

Main article: Physics:Xenon gas MRI

Gamma emission from the radioisotope 133Xe of xenon can be used to image the heart, lungs, and brain, for example, by means of single photon emission computed tomography. 133Xe has also been used to measure blood flow.[166][167][168]

Xenon, particularly hyperpolarized 129Xe, is a useful contrast agent for magnetic resonance imaging (MRI). In the gas phase, it can image cavities in a porous sample, alveoli in lungs, or the flow of gases within the lungs.[169][170] Because xenon is soluble both in water and in hydrophobic solvents, it can image various soft living tissues.[171][172][173]

Xenon-129 is used as a visualization agent in MRI scans. When a patient inhales hyperpolarized xenon-129 ventilation and gas exchange in the lungs can be imaged and quantified. Unlike xenon-133, xenon-129 is non-ionizing and is safe to be inhaled with no adverse effects.[174]

#### Surgery

The xenon chloride excimer laser has certain dermatological uses.[175]

### NMR spectroscopy

Because of the xenon atom's large, flexible outer electron shell, the NMR spectrum changes in response to surrounding conditions and can be used to monitor the surrounding chemical circumstances. For instance, xenon dissolved in water, xenon dissolved in hydrophobic solvent, and xenon associated with certain proteins can be distinguished by NMR.[176][177]

Hyperpolarized xenon can be used by surface chemists. Normally, it is difficult to characterize surfaces with NMR because signals from a surface are overwhelmed by signals from the atomic nuclei in the bulk of the sample, which are much more numerous than surface nuclei. However, nuclear spins on solid surfaces can be selectively polarized by transferring spin polarization to them from hyperpolarized xenon gas. This makes the surface signals strong enough to measure and distinguish from bulk signals.[178][179]

### Other

A prototype of a xenon ion engine being tested at NASA's Jet Propulsion Laboratory

In nuclear energy studies, xenon is used in bubble chambers,[180] probes, and in other areas where a high molecular weight and inert chemistry is desirable. A by-product of nuclear weapon testing is the release of radioactive xenon-133 and xenon-135. These isotopes are monitored to ensure compliance with nuclear test ban treaties,[181] and to confirm nuclear tests by states such as North Korea.[182]

Liquid xenon is used in calorimeters[183] to measure gamma rays, and as a detector of hypothetical weakly interacting massive particles, or WIMPs. When a WIMP collides with a xenon nucleus, theory predicts it will impart enough energy to cause ionization and scintillation. Liquid xenon is useful for these experiments because its density makes dark matter interaction more likely and it permits a quiet detector through self-shielding.

Xenon is the preferred propellant for ion propulsion of spacecraft because it has low ionization potential per atomic weight and can be stored as a liquid at near room temperature (under high pressure), yet easily evaporated to feed the engine. Xenon is inert, environmentally friendly, and less corrosive to an ion engine than other fuels such as mercury or caesium. Xenon was first used for satellite ion engines during the 1970s.[184] It was later employed as a propellant for JPL's Deep Space 1 probe, Europe's SMART-1 spacecraft[11] and for the three ion propulsion engines on NASA's Dawn Spacecraft.[185]

Chemically, the perxenate compounds are used as oxidizing agents in analytical chemistry. Xenon difluoride is used as an etchant for silicon, particularly in the production of microelectromechanical systems (MEMS).[186] The anticancer drug 5-fluorouracil can be produced by reacting xenon difluoride with uracil.[187] Xenon is also used in protein crystallography. Applied at pressures from 0.5 to 5 MPa (5 to 50 atm) to a protein crystal, xenon atoms bind in predominantly hydrophobic cavities, often creating a high-quality, isomorphous, heavy-atom derivative that can be used for solving the phase problem.[188][189]

## Precautions

Xenon  Hazards

NFPA 704 (fire diamond)  |

[190]

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Infobox references

Xenon gas can be safely kept in normal sealed glass or metal containers at standard temperature and pressure. However, it readily dissolves in most plastics and rubber, and will gradually escape from a container sealed with such materials.[191] Xenon is non-toxic, although it does dissolve in blood and belongs to a select group of substances that penetrate the blood–brain barrier, causing mild to full surgical anesthesia when inhaled in high concentrations with oxygen.[192]

The speed of sound in xenon gas (169 m/s) is less than that in air[193] because the average velocity of the heavy xenon atoms is less than that of nitrogen and oxygen molecules in air. Hence, xenon vibrates more slowly in the vocal cords when exhaled and produces lowered voice tones (low-frequency-enhanced sounds, but the fundamental frequency or pitch does not change), an effect opposite to the high-toned voice produced in helium. Specifically, when the vocal tract is filled with xenon gas, its natural resonant frequency becomes lower than when it is filled with air. Thus, the low frequencies of the sound wave produced by the same direct vibration of the vocal cords would be enhanced, resulting in a change of the timbre of the sound amplified by the vocal tract. Like helium, xenon does not satisfy the body's need for oxygen, and it is both a simple asphyxiant and an anesthetic more powerful than nitrous oxide; consequently, and because xenon is expensive, many universities have prohibited the voice stunt as a general chemistry demonstration.[194] The gas sulfur hexafluoride is similar to xenon in molecular weight (146 versus 131), less expensive, and though an asphyxiant, not toxic or anesthetic; it is often substituted in these demonstrations.[195]

Dense gases such as xenon and sulfur hexafluoride can be breathed safely when mixed with at least 20% oxygen. Xenon at 80% concentration along with 20% oxygen rapidly produces the unconsciousness of general anesthesia. Breathing mixes gases of different densities very effectively and rapidly so that heavier gases are purged along with the oxygen, and do not accumulate at the bottom of the lungs.[196] There is, however, a danger associated with any heavy gas in large quantities: it may sit invisibly in a container, and a person who enters an area filled with an odorless, colorless gas may be asphyxiated without warning. Xenon is rarely used in large enough quantities for this to be a concern, though the potential for danger exists any time a tank or container of xenon is kept in an unventilated space.[197]

Water-soluble xenon compounds such as monosodium xenate are moderately toxic, but have a very short half-life of the body – intravenously injected xenate is reduced to elemental xenon in about a minute.[192]

## See also

* Buoyant levitation
* Noble gases
* Penning mixture

## Notes

1. ↑ Mass fraction calculated from the average mass of an atom in the Solar System of about 1.29 atomic mass units.

## References

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93. ↑ 93.0 93.1 "Xenon Compounds". Concise encyclopedia chemistry. Walter de Gruyter. 1994. pp. 1183. ISBN 978-3-11-011451-5. https://books.google.com/books?id=Owuv-c9L_IMC&pg=PA1183.
94. ↑ "The xenon-chlorine conundrum: van der Waals complex or linear molecule?". Journal of the American Chemical Society 113 (19): 7184–7189. 1991. doi:10.1021/ja00019a014. Bibcode: 1991JAChS.113.7184P.
95. ↑ "The potential energy surface of xenon dichloride". The Journal of Physical Chemistry 97 (42): 10952–10954. 1993. doi:10.1021/j100144a009. Bibcode: 1993JPhCh..9710952R.
96. ↑ Syntheses and Physical Studies of Inorganic Compounds. Elsevier Science. 2013. pp. 143. ISBN 978-1-4832-8060-8.
97. ↑ The Chemistry of the Monatomic Gases: Pergamon Texts in Inorganic Chemistry. Elsevier Science. 2013. pp. 292. ISBN 978-1-4831-5736-8.
98. ↑ "Synthesis of the missing oxide of xenon, XeO2, and its implications for Earth's missing xenon". Journal of the American Chemical Society 133 (16): 6265–6269. Apr 2011. doi:10.1021/ja110618g. PMID 21341650. Bibcode: 2011JAChS.133.6265B.
99. ↑ "Chemistry: Where did the xenon go?". Nature 471 (7337): 138. 2011. doi:10.1038/471138d. Bibcode: 2011Natur.471T.138..
100. ↑ "Formation and Characterization of the XeOO+ Cation in Solid Argon". Journal of the American Chemical Society 128 (8): 2504–2505. Mar 2006. doi:10.1021/ja055650n. PMID 16492012. Bibcode: 2006JAChS.128.2504Z.
101. ↑ Advances in Inorganic Chemistry Press. Academic. 1998. pp. 65. ISBN 978-0-12-023646-6. https://books.google.com/books?id=6iqXRtz6p3QC&pg=PA65.
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103. ↑ 103.0 103.1 103.2 103.3 Introduction to modern inorganic chemistry (6th ed.). CRC Press. 2002. pp. 497–501. ISBN 978-0-7487-6420-4. https://books.google.com/books?id=LpJPWKT3PNcC&pg=PA497.
104. ↑ "Xenon Oxyfluoride". Science 140 (3569): 899–900. May 1963. doi:10.1126/science.140.3569.899. PMID 17810680. Bibcode: 1963Sci...140..899S.
105. ↑ "P Block Elements" (in English). Chemistry Textbook Part – 1 for Class XII (October 2022 ed.). NCERT. 2007. pp. 204. ISBN 978-81-7450-648-1. https://ncert.nic.in/ncerts/l/lech107.pdf.
106. ↑ "On the Structure of the [XeOF5]− Anion and of Heptacoordinated Complex Fluorides Containing One or Two Highly Repulsive Ligands or Sterically Active Free Valence Electron Pairs". inorg. Chem. 34 (7): 1868–1874. 1995. doi:10.1021/ic00111a039.
107. ↑ "Chlorine trifluoride oxide. V. Complex formation with Lewis acids and bases". inorg. Chem. 11 (9): 2205–2208. 1972. doi:10.1021/ic50115a044.
108. ↑ Advances in Inorganic Chemistry. Contributor A. G. Sykes. Academic Press. 1998. pp. 61–90. ISBN 978-0-12-023646-6. https://books.google.com/books?id=6iqXRtz6p3QC&pg=PA61.
109. ↑ "C6F5XeF, a versatile starting material in xenon–carbon chemistry". Journal of Fluorine Chemistry 125 (6): 981–988. 2004. doi:10.1016/j.jfluchem.2004.01.019.
110. ↑ "Reaction of xenon with dioxygenyl tetrafluoroborate. Preparation of FXe–BF2". Journal of the American Chemical Society 94 (9): 3018–3021. 1972. doi:10.1021/ja00764a022. Bibcode: 1972JAChS..94.3018G.
111. ↑ Advanced Structural Inorganic Chemistry. Oxford University Press. 2008. pp. 678. ISBN 978-0-19-921694-9. https://books.google.com/books?id=2qAa5hp6KX4C&pg=PA678.
112. ↑ "Gold( I ) and Mercury( II ) Xenon Complexes" (in en). Angewandte Chemie International Edition 42 (36): 4392–4395. September 22, 2003. doi:10.1002/anie.200351208. ISSN 1433-7851. PMID 14502720. Bibcode: 2003ACIE...42.4392H. https://onlinelibrary.wiley.com/doi/10.1002/anie.200351208.
113. ↑ Advanced Structural Inorganic Chemistry. Oxford University Press. 2008. pp. 674. ISBN 978-0-19-921694-9. https://archive.org/details/advancedstructur00liwa.
114. ↑ "Formation of novel rare-gas molecules in low-temperature matrices". Annual Review of Physical Chemistry 55 (1): 55–78. 2004. doi:10.1146/annurev.physchem.55.091602.094420. PMID 15117247. Bibcode: 2004ARPC...55...55G.
115. ↑ "A Small Neutral Molecule with Two Noble-Gas Atoms: HXeOXeH". Journal of the American Chemical Society 130 (19): 6114–6118. May 2008. doi:10.1021/ja077835v. PMID 18407641. Bibcode: 2008JAChS.130.6114K.
116. ↑ "A Chemical Compound Formed from Water and Xenon: HXeOH". Journal of the American Chemical Society 121 (50): 11904–11905. 1999. doi:10.1021/ja9932784. Bibcode: 1999JAChS.12111904P.
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118. ↑ Main group chemistry. Great Britain: Royal Society of Chemistry. 2000. pp. 148. ISBN 978-0-85404-617-1. https://books.google.com/books?id=twdXz1jfVOsC&pg=PA148.
119. ↑ "Distortion of Host Lattice in Clathrate Hydrate as a Function of Guest Molecule and Temperature". Journal of Physical Chemistry A 104 (46): 10623–10630. November 23, 2000. doi:10.1021/jp001313j. Bibcode: 2000JPCA..10410623I.
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124. ↑ Laser Fundamentals. Cambridge University Press. 2004. ISBN 978-0-521-83345-5. https://books.google.com/books?id=x3VB2iwSaxsC&pg=RA1-PA152.
125. ↑ The Measurement, Instrumentation, and Sensors Handbook. Springer. 1998. ISBN 978-3-540-64830-7. https://books.google.com/books?id=b7UuZzf9ivIC&pg=PT2427.
126. ↑ "Rare Gas Halogen Excimers". Excimer Lasers. Topics in Applied Physics. 30. New York: Springer-Verlag. 1979. ISBN 978-0-387-09017-7.
127. ↑ Excimer Lasers in Ophthalmology. Informa Health Care. 1997. ISBN 978-1-85317-253-3. https://archive.org/details/excimerlasersino0000unse/page/4/mode/2up?q=XeF.
128. ↑ "High level ab initio thermochemistry of XeF radical". Journal of Fluorine Chemistry 209: 1–5. May 2018. doi:10.1016/j.jfluchem.2018.02.003. Bibcode: 2018JFluC.209....1O.
129. ↑ "Precise Characterization of the B (1/2) and C (3/2) States of XeF from a Deperturbation Analysis of the B → X Spectrum of 136XeF". The Journal of Physical Chemistry A 106 (36): 8317–8322. 1 September 2002. doi:10.1021/jp0156221.
130. ↑ "Xenon Applications". Praxair Technology. 2007. http://www.praxair.com/praxair.nsf/1928438066cae92d85256a63004b880d/32f3a328e11bb600052565660052c139?OpenDocument.
131. ↑ "A xenon-iodine electric discharge bactericidal lamp". Technical Physics Letters 29 (10): 871–872. 2003. doi:10.1134/1.1623874. Bibcode: 2003TePhL..29..871S.
132. ↑ "Thermal distortions in laser-diode- and flash-lamp-pumped Nd:YLF laser rods". LLE Review 71: 137–144. 1997. http://www.lle.rochester.edu/pub/review/v71/6_thermal.pdf. Retrieved February 4, 2007.
133. ↑ "The plasma behind the plasma TV screen". Plasma TV Science. http://www.plasmatvscience.org/theinnerworkings.html.
134. ↑ "Plasma TV: That New Object Of Desire". The New York Times. March 21, 2001. https://www.nytimes.com/2001/03/25/style/plasma-tv-that-new-object-of-desire.html?sec=&spon=.
135. ↑ Electric Discharge Lamps. Cambridge, MA: MIT Press. 1971. ISBN 978-0-262-23048-3. https://archive.org/details/electricdischarg00waym.
136. ↑ "Infrared spectroscopy using stimulated emission techniques". Physical Review Letters 9 (3): 102–104. August 1, 1962. doi:10.1103/PhysRevLett.9.102. Bibcode: 1962PhRvL...9..102P.
137. ↑ "High gain gaseous (Xe–He) optical masers". Applied Physics Letters 1 (4): 84–85. December 1, 1962. doi:10.1063/1.1753707. Bibcode: 1962ApPhL...1...84P.
138. ↑ "Gaseous optical masers". Applied Optics 1 (S1): 24–61. 1962. doi:10.1364/AO.1.000024. Bibcode: 1962ApOpt...1S..24B.
139. ↑ "Laser Output". University of Waterloo. http://www.safetyoffice.uwaterloo.ca/hse/laser/documents/laser_types.html.
140. ↑ "Xenon, Xe-133- xenon gas". October 16, 2024. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5eb971be-8808-4aeb-9898-0d22d5dffe04.
141. ↑ "Xenon- xenon xe-133 gas". November 28, 2022. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=35bdc182-2a41-41d2-8fe7-aa0c140d4425.
142. ↑ "Xenoview- xenon xe 129 hyperpolarized gas". December 30, 2022. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=70e33fe3-c722-439b-b3db-c2a22f229c8a.
143. ↑ "Xenon anaesthesia for all, or only a select few?". Anaesthesia 71 (11): 1267–1272. Nov 2016. doi:10.1111/anae.13569. PMID 27530275.
144. ↑ 144.0 144.1 "Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor mediates xenon neuroprotection against hypoxia-ischemia". Anesthesiology 112 (3): 614–622. Mar 2010. doi:10.1097/ALN.0b013e3181cea398. PMID 20124979.
145. ↑ "Neuroprotective and neurotoxic properties of the 'inert' gas, xenon". British Journal of Anaesthesia 89 (5): 739–746. Nov 2002. doi:10.1093/bja/89.5.739. PMID 12393773.
146. ↑ "Xenon inhibits but N2O enhances ketamine-induced c-Fos expression in the rat posterior cingulate and retrosplenial cortices". Anesthesia & Analgesia 92 (2): 362–368. Feb 2001. doi:10.1213/00000539-200102000-00016. PMID 11159233.
147. ↑ "The differential effects of nitrous oxide and xenon on extracellular dopamine levels in the rat nucleus accumbens: a microdialysis study". Anesthesia & Analgesia 103 (6): 1459–1463. Dec 2006. doi:10.1213/01.ane.0000247792.03959.f1. PMID 17122223.
148. ↑ "Two-pore-domain K+ channels are a novel target for the anesthetic gases xenon, nitrous oxide, and cyclopropane". Molecular Pharmacology 65 (2): 443–452. Feb 2004. doi:10.1124/mol.65.2.443. PMID 14742687.
149. ↑ "Effects of gaseous anesthetics nitrous oxide and xenon on ligand-gated ion channels. Comparison with isoflurane and ethanol". Anesthesiology 93 (4): 1095–1101. Oct 2000. doi:10.1097/00000542-200010000-00034. PMID 11020766.
150. ↑ "Tonic inhibitory role of α4β2 subtype of nicotinic acetylcholine receptors on nociceptive transmission in the spinal cord in mice". Pain 125 (1–2): 125–135. Nov 2006. doi:10.1016/j.pain.2006.05.011. PMID 16781069.
151. ↑ "How Do Volatile Anesthetics Inhibit Ca2+–ATPases?". The Journal of Biological Chemistry 270 (47): 28239–28245. Nov 1995. doi:10.1074/jbc.270.47.28239. PMID 7499320.
152. ↑ "The diverse actions of volatile and gaseous anesthetics on human-cloned 5-hydroxytryptamine3 receptors expressed in Xenopus oocytes". Anesthesiology 96 (3): 699–704. Mar 2002. doi:10.1097/00000542-200203000-00028. PMID 11873047.
153. ↑ "Age-related iso-MAC charts for isoflurane, sevoflurane and desflurane in man". British Journal of Anaesthesia 91 (2): 170–174. August 2003. doi:10.1093/bja/aeg132. PMID 12878613.
154. ↑ "Will xenon be a stranger or a friend?: the cost, benefit, and future of xenon anesthesia". Anesthesiology 98 (1): 1–2. Jan 2003. doi:10.1097/00000542-200301000-00002. PMID 12502969.
155. ↑ "Xenon Attenuates Cerebral Damage after Ischemia in Pigs". Anesthesiology 102 (5): 929–936. May 2005. doi:10.1097/00000542-200505000-00011. PMID 15851879.
156. ↑ "Xenon Provides Short-Term Neuroprotection in Neonatal Rats When Administered After Hypoxia-Ischemia". Stroke 37 (2): 501–506. Feb 2006. doi:10.1161/01.STR.0000198867.31134.ac. PMID 16373643. http://www.reanimatology.com/rmt/article/view/1340.
157. ↑ "The noble gas xenon induces pharmacological preconditioning in the rat heart in vivo via induction of PKC-epsilon and p38 MAPK". Br J Pharmacol 144 (1): 123–132. Jan 2005. doi:10.1038/sj.bjp.0706063. PMID 15644876.
158. ↑ "Neuronal preconditioning by inhalational anesthetics: evidence for the role of plasmalemmal adenosine triphosphate-sensitive potassium channels". Anesthesiology 110 (5): 986–995. May 2009. doi:10.1097/ALN.0b013e31819dadc7. PMID 19352153.
159. ↑ "Noble gas xenon is a novel adenosine triphosphate-sensitive potassium channel opener". Anesthesiology 112 (3): 623–630. Mar 2010. doi:10.1097/ALN.0b013e3181cf894a. PMID 20179498.
160. ↑ "Breathe it in". The Economist. February 8, 2014. https://www.economist.com/news/science-and-technology/21595890-obscure-gas-improves-athletes-performance-breathe-it.
161. ↑ "WADA amends Section S.2.1 of 2014 Prohibited List". August 31, 2014. https://www.wada-ama.org/en/media/2014-05/wada-amends-section-s21-of-2014-prohibited-list.
162. ↑ "Xenon Misuse in Sports". Deutsche Zeitschrift für Sportmedizin (Deutsche Zeitschrift für Sportmedizin/German Journal of Sports Medicine) 2014 (10): 267–271. 2014. doi:10.5960/dzsm.2014.143.
163. ↑ "They want to climb Everest in a week using an anesthetic gas. Critics warn it's dangerous" (in en). 2025-05-13. https://www.cnn.com/2025/05/13/travel/climb-everest-one-week-xenon-intl.
164. ↑ "Can Mount Everest really be climbed in a week?" (in en-GB). 2025-04-29. https://www.bbc.com/future/article/20250428-can-mount-everest-really-be-climbed-in-a-week.
165. ↑ "They Inhaled a Gas and Scaled Everest in Days. Is It the Future of Mountaineering?" (in en-US). The New York Times. 2025-05-27. https://www.nytimes.com/2025/05/27/world/europe/mount-everest-xenon-gas-nepal-uk-climbers.html.
166. ↑ What's New in Cardiac Imaging?: SPECT, PET, and MRI. Springer. 1992. ISBN 978-0-7923-1615-2. https://books.google.com/books?id=PypZMUhqnK8C&pg=PA41.
167. ↑ "Introduction to imaging: The chest". Student BMJ 12: 1–44. 1999. http://student.bmj.com/issues/04/01/education/8.php. Retrieved June 4, 2008.
168. ↑ "Brain SPECT: Xenon-133". Brigham RAD. July 20, 1995. http://brighamrad.harvard.edu/education/online/BrainSPECT/Theory/Xenon133.html.
169. ↑ "Development of hyperpolarized noble gas MRI". Nuclear Instruments and Methods in Physics Research A 402 (2–3): 441–453. 1998. doi:10.1016/S0168-9002(97)00888-7. PMID 11543065. Bibcode: 1998NIMPA.402..441A.
170. ↑ "Head Full of Xenon?". Science News. March 23, 1999. http://sciencenow.sciencemag.org/cgi/content/full/1999/323/3. Retrieved October 8, 2007.
171. ↑ "Intravascular delivery of hyperpolarized 129Xenon for in vivo MRI". Applied Magnetic Resonance 15 (3–4): 343–352. 1998. doi:10.1007/BF03162020.
172. ↑ "Pulmonary perfusion and xenon gas exchange in rats: MR imaging with intravenous injection of hyperpolarized 129Xe". Radiology 252 (2): 386–393. 2009. doi:10.1148/radiol.2522081550. PMID 19703880.
173. ↑ "Continuously infusing hyperpolarized 129Xe into flowing aqueous solutions using hydrophobic gas exchange membranes". The Journal of Physical Chemistry 113 (37): 12489–12499. 2009. doi:10.1021/jp9049582. PMID 19702286. Bibcode: 2009JPCB..11312489C.
174. ↑ "In vivo methods and applications of xenon-129 magnetic resonance" (in en). Progress in Nuclear Magnetic Resonance Spectroscopy 122: 42–62. February 1, 2021. doi:10.1016/j.pnmrs.2020.11.002. ISSN 0079-6565. PMID 33632417. Bibcode: 2021PNMRS.122...42M.
175. ↑ "Treatment of atopic dermatitis with the xenon chloride excimer laser". Journal of the European Academy of Dermatology and Venereology 20 (6): 657–660. Jul 2006. doi:10.1111/j.1468-3083.2006.01495.x. PMID 16836491.
176. ↑ "Interpretation of the solvent effect on the screening constant of Xe-129". Magnetic Resonance in Chemistry 27 (10): 950–952. 1989. doi:10.1002/mrc.1260271009.
177. ↑ "Evidence of nonspecific surface interactions between laser-polarized xenon and myoglobin in solution". Proceedings of the National Academy of Sciences USA 97 (17): 9472–9475. August 15, 2000. doi:10.1073/pnas.170278897. PMID 10931956. Bibcode: 2000PNAS...97.9472R.
178. ↑ "Optical Pumping and Magic Angle Spinning: Sensitivity and Resolution Enhancement for Surface NMR Obtained with Laser-Polarized Xenon". Journal of the American Chemical Society 119 (37): 8746–8747. 1997. doi:10.1021/ja972035d. Bibcode: 1997JAChS.119.8746R.
179. ↑ "High-field cross polarization NMR from laser-polarized xenon to surface nuclei". Applied Magnetic Resonance 8 (3–4): 373–384. 1995. doi:10.1007/BF03162652.
180. ↑ Image and Logic: A Material Culture of Microphysics. University of Chicago Press. 1997. pp. 339. ISBN 978-0-226-27917-6. https://books.google.com/books?id=HnRDiDtO5yoC&pg=PA339.
181. ↑ "Atmospheric xenon radioactive isotope monitoring". Journal of Environmental Radioactivity 72 (1–2): 129–135. 2004. doi:10.1016/S0265-931X(03)00194-2. PMID 15162864. Bibcode: 2004JEnvR..72..129F.
182. ↑ "A Technical Analysis: Deconstructing North Korea's October 9 Nuclear Test". Arms Control Today (Arms Control Association) 38 (9). November 2006. http://www.armscontrol.org/act/2006_11/tech. Retrieved March 26, 2009.
183. ↑ "The MEG liquid xenon calorimeter". Journal of Physics: Conference Series 160 (1). 2009. doi:10.1088/1742-6596/160/1/012011. Bibcode: 2009JPhCS.160a2011G.
184. ↑ "Innovative Engines: Glenn Ion Propulsion Research Tames the Challenges of 21st century Space Travel". NASA. March 17, 2006. http://www.nasa.gov/centers/glenn/about/fs08grc.html.
185. ↑ "Dawn Launch: Mission to Vesta and Ceres". NASA. http://www.jpl.nasa.gov/news/press_kits/dawn-launch.pdf.
186. ↑ "Modeling and Characterization of Sacrificial Polysilicon Etching Using Vapor-Phase Xenon Difluoride". Maastricht, Netherlands: IEEE. August 1, 1975. pp. 737–740. ISBN 978-0-7803-8265-7.
187. ↑ "Neil Bartlett and the Reactive Noble Gases". American Chemical Society. 2007. https://www.acs.org/content/acs/en/education/whatischemistry/landmarks/bartlettnoblegases.html.
188. ↑ "Protein Crystallography: Xenon and Krypton Derivatives for Phasing". Daresbury Laboratory, PX. December 21, 2004. http://www.srs.ac.uk/px/facilities/xenon_notes_1.html.
189. ↑ "The Solution of the Phase Problem by the Isomorphous Replacement Method". Principles of Protein X-Ray Crystallography (3rd ed.). New York: Springer. 2007. pp. 123–171. doi:10.1007/0-387-33746-6_7. ISBN 978-0-387-33334-2. https://archive.org/details/principlesprotei00dren_066.
190. ↑ ﻿Safety Data Sheet: Xenon﻿ (Report). Airgas. February 15, 2018. https://www.airgas.com/msds/001050.pdf.
191. ↑ "The handling of xenon-133 in clinical studies". Physics in Medicine and Biology 16 (1): 105–109. Jan 1971. doi:10.1088/0031-9155/16/1/310. PMID 5579743. Bibcode: 1971PMB....16..105L.
192. ↑ 192.0 192.1 "Metabolic and toxicological effects of water-soluble xenon compounds are studied". NASA. April 1, 1968. https://ntrs.nasa.gov/citations/19680000076.
193. ↑ 169.44 m/s in xenon (at 0 °C (32 °F) and 107 kPa), compared to 344 m/s in air. See: "Velocity of sound measurements in gaseous per-fluorocarbons and their mixtures". Fluid Phase Equilibria 185 (1–2): 305–314. 2001. doi:10.1016/S0378-3812(01)00479-4. Bibcode: 2001FlPEq.185..305V.
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196. ↑ "Inhaling Gas With Different CT Densities Allows Detection of Abnormalities in the Lung Periphery of Patients With Smoking-Induced COPD". chest 120 (6): 1907–1916. Dec 2001. doi:10.1378/chest.120.6.1907. PMID 11742921.
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## External links

* Xenon at The Periodic Table of Videos (University of Nottingham)
* USGS Periodic Table – Xenon
* EnvironmentalChemistry.com – Xenon
* Sir William Ramsay's Nobel-Prize lecture (1904)

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Periodic table

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1 | H |  | He
2 | Li | Be |  | B | C | N | O | F | Ne
3 | Na | Mg |  | Al | Si | P | S | Cl | Ar
4 | K | Ca |  | Sc | Ti | V | Cr | Mn | Fe | Co | Ni | Cu | Zn | Ga | Ge | As | Se | Br | Kr
5 | Rb | Sr |  | Y | Zr | Nb | Mo | Tc | Ru | Rh | Pd | Ag | Cd | In | Sn | Sb | Te | I | Xe
6 | Cs | Ba | La | Ce | Pr | Nd | Pm | Sm | Eu | Gd | Tb | Dy | Ho | Er | Tm | Yb | Lu | Hf | Ta | W | Re | Os | Ir | Pt | Au | Hg | Tl | Pb | Bi | Po | At | Rn
7 | Fr | Ra | Ac | Th | Pa | U | Np | Pu | Am | Cm | Bk | Cf | Es | Fm | Md | No | Lr | Rf | Db | Sg | Bh | Hs | Mt | Ds | Rg | Cn | Nh | Fl | Mc | Lv | Ts | Og

| Alkali metal | Alkaline earth metal | Lan­thanide | Actinide | Transition metal | Post-​transition metal | Metalloid | Reactive nonmetal | Noble gas

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Xenon compounds

Xenon(0)|

* AuXe4(Sb2F11)2

Xenon(I)|

* XePtF6
* XeRhF6
* XeRuF6
* XePuF6
* XeF

Xenon(II)|

* XeF2
* XeFPtF5
* XeFPt2F11
* Xe2F3PtF6
* XeCl2
* XeBr2

| Organoxenon(II) compounds|

* XeC6F5F
* XeC6F5C2F3
* XeC6F5CF3
* Xe(C6F5)2
* XeC6F5C6H2F3
* XeC6F5CN
* Xe(CF3)2

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Xenon(IV)|

* XeO2
* XeF4
* XeOF2
* N(CH3)4XeF5
* XeCl4

| Organoxenon(IV) compounds|

* XeF2C6F5BF4

|

Xenon(VI)|

* XeO3
* XeF6
* XeOF4
* H2XeO4
* (NO)2XeF8
* CsXeF7
* RbXeF7

Xenon(VIII)|

* XeO4
* H4XeO6

Category:Xenon compounds

* v
* t
* e

General anesthetics (N01A)

Inhalational|

* Chloroethane (ethyl chloride)‡
* Chloroform‡
* Cyclopropane‡
* Desflurane
* Diethyl ether‡
* Enflurane
* Ethylene‡
* Fluroxene‡
* Halothane#
* Isoflurane#
* Methoxyflurane
* Methoxypropane‡
* Nitrous oxide#
* Sevoflurane
* Trichloroethylene‡
* Vinyl ether‡
* Xenon

Injection|

| Phenols|

* Fospropofol
* Propofol#

|

Barbiturates|

* Hexobarbital
* Methohexital
* Narcobarbital
* Thiopental#
* Thiotetrabarbital

Opioids|

* Morphine#
* Oxycodone
* Anileridine‡
* Embutramide‡
* Fentanyl#
* Alfentanil
* Phenoperidine
* Remifentanil÷
* Sufentanil

Arylcyclohexylamines|

* Esketamine
* Ketamine#
* Phencyclidine‡
* Tiletamine

Neuroactive steroids|

* Alfadolone
* Alfaxalone
* Hydroxydione

Others|

* Etomidate
* Propanidid‡

* #WHO-EM
* ‡Withdrawn from market
* Clinical trials:
* †Phase III
* §Never to phase III

Template:Dissociatives

Pharmacodynamics

* v
* t
* e

Glycine receptor modulators

Receptor
(ligands)|

| GlyR|

* Agonists: β-Alanine
* β-ABA (BABA)
* β-AIBA
* Caesium
* D-Alanine
* D-Serine
* GABA
* Glycine
* Hypotaurine
* Ivermectin
* L-Alanine
* L-Proline
* L-Serine
* L-Threonine
* MDL-27531
* Milacemide
* Picolinic acid
* Propofol
* Quisqualamine
* Sarcosine
* Taurine

* Positive modulators: Alcohols (e.g., brometone, chlorobutanol (chloretone), ethanol (alcohol), tert-butanol (2M2P), tribromoethanol, trichloroethanol, trifluoroethanol)
* Alkylbenzene sulfonate
* Anandamide
* Barbiturates (e.g., pentobarbital, sodium thiopental)
* Chlormethiazole
* D12-116
* Dihydropyridines (e.g., nicardipine)
* Etomidate
* Ginseng constituents (e.g., ginsenosides (e.g., ginsenoside-Rf))
* Glutamic acid (glutamate)
* Ivermectin
* Ketamine
* Neuroactive steroids (e.g., alfaxolone, pregnenolone (eltanolone), pregnenolone acetate, minaxolone, ORG-20599)
* Nitrous oxide
* Penicillin G
* Propofol
* Tamoxifen
* Tetrahydrocannabinol
* Triclofos
* Tropeines (e.g., atropine, bemesetron, cocaine, LY-278584, tropisetron, zatosetron)
* Volatiles/gases (e.g., chloral hydrate, chloroform, desflurane, diethyl ether (ether), enflurane, halothane, isoflurane, methoxyflurane, sevoflurane, toluene, trichloroethane (methyl chloroform), trichloroethylene)
* Xenon
* Zinc

* Antagonists: 2-Aminostrychnine
* 2-Nitrostrychnine
* 4-Phenyl-4-formyl-N-methylpiperidine
* αEMBTL
* Bicuculline
* Brucine
* Cacotheline
* Caffeine
* Colchicine
* Colubrine
* Cyanotriphenylborate
* Dendrobine
* Diaboline
* Endocannabinoids (e.g., 2-AG, anandamide (AEA))
* Gaboxadol (THIP)
* Gelsemine
* iso-THAZ
* Isobutyric acid
* Isonipecotic acid
* Isostrychnine
* Laudanosine
* N-Methylbicuculline
* N-Methylstrychnine
* N,N-Dimethylmuscimol
* Nipecotic acid
* Pitrazepin
* Pseudostrychnine
* Quinolines (e.g., 4-hydroxyquinoline, 4-hydroxyquinoline-3-carboxylic acid, 5,7-CIQA, 7-CIQ, 7-TFQ, 7-TFQA)
* RU-5135
* Sinomenine
* Strychnine
* Thiocolchicoside
* Tutin

* Negative modulators: Amiloride
* Benzodiazepines (e.g., bromazepam, Chemistry:Clonazepam

|

NMDAR|

* See here instead.

Transporter
(blockers)|

| GlyT1|

* ACPPB
* ALX-1393
* ALX-5407 (NFPS)
* AMG-747
* ASP2535
* BIIB-104 (PF-04958242)
* Bitopertin (RG1678/RO4917838)
* CP-802079
* Ethanol (alcohol)
* Glycyldodecylamide
* GSK1018921
* LY-2365109
* ORG-24598
* ORG-25935 (SCH-900435)
* PF-02545920
* PF-03463275
* Sarcosine
* SSR-103,800
* SSR-504,734

|

GlyT2|

* Amoxapine
* Ethanol (alcohol)
* NAGly
* Opiranserin (VVZ-149)
* ORG-25543
* VVZ-368

See also
Receptor/signaling modulators
GABA receptor modulators
GABAA receptor positive modulators
Ionotropic glutamate receptor modulators

* v
* t
* e

Ionotropic glutamate receptor modulators

AMPAR|

* Agonists: Main site agonists: 5-Fluorowillardiine
* Acromelic acid (acromelate)
* AMPA
* BOAA
* Domoic acid
* Glutamate
* Ibotenic acid
* Proline
* Quisqualic acid
* Willardiine; Positive allosteric modulators: Aniracetam
* BIIB-104 (PF-04958242)
* Cyclothiazide
* CX-516
* CX-546
* CX-614
* Farampator (CX-691, ORG-24448)
* CX-717
* CX-1739
* CX-1942
* Diazoxide
* Hydrochlorothiazide (HCTZ)
* IDRA-21
* LY-392098
* LY-395153
* LY-404187
* LY-451646
* LY-503430
* Mibampator (LY-451395)
* Nooglutyl
* ORG-26576
* Oxiracetam
* PEPA
* Piracetam
* Pramiracetam
* S-18986
* Tulrampator (S-47445, CX-1632)

* Antagonists: ACEA-1011
* ATPO
* Becampanel
* Caroverine
* CNQX
* Dasolampanel
* DNQX
* Fanapanel (MPQX)
* GAMS
* Kaitocephalin
* Kynurenic acid
* Kynurenine
* Licostinel (ACEA-1021)
* NBQX
* PNQX
* Selurampanel
* Tezampanel
* Theanine
* Topiramate
* YM90K
* Zonampanel; Negative allosteric modulators: Barbiturates (e.g., pentobarbital, sodium thiopental)
* Cyclopropane
* Enflurane
* Ethanol (alcohol)
* Evans blue
* GYKI-52466
* GYKI-53655
* Halothane
* Irampanel
* Isoflurane
* Perampanel
* Pregnenolone sulfate
* Sevoflurane
* Talampanel; Unknown/unsorted antagonists: Minocycline

KAR|

* Agonists: Main site agonists: 5-Bromowillardiine
* 5-Iodowillardiine
* Acromelic acid (acromelate)
* AMPA
* ATPA
* Domoic acid
* Glutamate
* Ibotenic acid
* Kainic acid
* LY-339434
* Proline
* Quisqualic acid
* SYM-2081; Positive allosteric modulators: Cyclothiazide
* Diazoxide
* Enflurane
* Halothane
* Isoflurane

* Antagonists: ACEA-1011
* CNQX
* Dasolampanel
* DNQX
* GAMS
* Kaitocephalin
* Kynurenic acid
* Licostinel (ACEA-1021)
* LY-382884
* NBQX
* NS102
* Selurampanel
* Tezampanel
* Theanine
* Topiramate
* UBP-302; Negative allosteric modulators: Barbiturates (e.g., pentobarbital, sodium thiopental)
* Enflurane
* Ethanol (alcohol)
* Evans blue
* NS-3763
* Pregnenolone sulfate

NMDAR|

* Agonists: Main site agonists: AMAA
* Aspartate
* Glutamate
* Homocysteic acid (L-HCA)
* Homoquinolinic acid
* Ibotenic acid
* NMDA
* Proline
* Quinolinic acid
* Tetrazolylglycine
* Theanine; Glycine site agonists: β-Fluoro-D-alanine
* ACBD
* ACC (ACPC)
* ACPD
* AK-51
* Apimostinel (NRX-1074)
* B6B21
* CCG
* D-Alanine
* D-Cycloserine
* D-Serine
* DHPG
* Dimethylglycine
* Glycine
* HA-966
* L-687414
* L-Alanine
* L-Serine
* Milacemide
* Neboglamine (nebostinel)
* Rapastinel (GLYX-13)
* Sarcosine; Polyamine site agonists: Neomycin
* Spermidine
* Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol
* DHEA (prasterone)
* DHEA sulfate (prasterone sulfate)
* Epipregnanolone sulfate
* Pregnenolone sulfate
* SAGE-201
* SAGE-301
* SAGE-718

* Antagonists: Competitive antagonists: AP5 (APV)
* AP7
* CGP-37849
* CGP-39551
* CGP-39653
* CGP-40116
* CGS-19755
* CPP
* Kaitocephalin
* LY-233053
* LY-235959
* LY-274614
* MDL-100453
* Midafotel (d-CPPene)
* NPC-12626
* NPC-17742
* PBPD
* PEAQX
* Perzinfotel
* PPDA
* SDZ-220581
* Selfotel; Glycine site antagonists: 4-Cl-KYN (AV-101)
* 5,7-DCKA
* 7-CKA
* ACC
* ACEA-1011
* ACEA-1328
* Apimostinel (NRX-1074)
* AV-101
* Carisoprodol
* CGP-39653
* CNQX
* D-Cycloserine
* DNQX
* Felbamate
* Gavestinel
* GV-196771
* Harkoseride
* Kynurenic acid
* Kynurenine
* L-689560
* L-701324
* Licostinel (ACEA-1021)
* LU-73068
* MDL-105519
* Meprobamate
* MRZ 2/576
* PNQX
* Rapastinel (GLYX-13)
* ZD-9379; Polyamine site antagonists: Arcaine
* Co 101676
* Diaminopropane
* Diethylenetriamine
* Huperzine A
* Putrescine; Uncompetitive pore blockers (mostly dizocilpine site): 2-MDP
* 3-HO-PCP
* 3-MeO-PCE
* 3-MeO-PCMo
* 3-MeO-PCP
* 4-MeO-PCP
* 8A-PDHQ
* 18-MC
* α-Endopsychosin
* Alaproclate
* Alazocine (SKF-10047)
* Amantadine
* Aptiganel
* Argiotoxin-636
* Arketamine
* ARL-12495
* ARL-15896-AR
* ARL-16247
* Budipine
* Coronaridine
* Delucemine (NPS-1506)
* Dexoxadrol
* Dextrallorphan
* Dextromethadone
* Dextromethorphan
* Dextrorphan
* Dieticyclidine
* Diphenidine
* Dizocilpine
* Ephenidine
* Esketamine
* Etoxadrol
* Eticyclidine
* Fluorolintane
* Gacyclidine
* Ibogaine
* Ibogamine
* Indantadol
* Ketamine
* Ketobemidone
* Lanicemine
* Levomethadone
* Levomethorphan
* Levomilnacipran
* Levorphanol
* Loperamide
* Memantine
* Methadone
* Methorphan
* Methoxetamine
* Methoxphenidine
* Milnacipran
* Morphanol
* NEFA
* Neramexane
* Nitromemantine
* Noribogaine
* Norketamine
* Orphenadrine
* PCPr
* PD-137889
* Pethidine (meperidine)
* Phencyclamine
* Phencyclidine
* Propoxyphene
* Remacemide
* Rhynchophylline
* Rimantadine
* Rolicyclidine
* Sabeluzole
* Tabernanthine
* Tenocyclidine
* Tiletamine
* Tramadol; Ifenprodil (NR2B) site antagonists:
* Besonprodil
* Buphenine (nylidrin)
* CO-101244 (PD-174494)
* Eliprodil
* Haloperidol
* Isoxsuprine
* Radiprodil (RGH-896)
* Rislenemdaz (CERC-301, MK-0657)
* Ro 8-4304
* Ro 25-6981
* Safaprodil
* Traxoprodil (CP-101606); NR2A-selective antagonists: MPX-004
* MPX-007
* TCN-201
* TCN-213; Cations: Hydrogen
* Magnesium
* Zinc; Alcohols/volatile anesthetics/related: Benzene
* Butane
* Chloroform
* Cyclopropane
* Desflurane
* Diethyl ether
* Enflurane
* Ethanol (alcohol)
* Halothane
* Hexanol
* Isoflurane
* Methoxyflurane
* Nitrous oxide
* Octanol
* Sevoflurane
* Toluene
* Trichloroethane
* Trichloroethanol
* Trichloroethylene
* Urethane
* Xenon
* Xylene; Unknown/unsorted antagonists: ARR-15896
* Bumetanide
* Caroverine
* Conantokin
* D-αAA
* Dexanabinol
* Flufenamic acid
* Flupirtine
* FPL-12495
* FR-115427
* Furosemide
* Hodgkinsine
* Ipenoxazone (MLV-6976)
* MDL-27266
* Metaphit
* Minocycline
* MPEP
* Niflumic acid
* Pentamidine
* Pentamidine isethionate
* Piretanide
* Psychotridine
* Transcrocetin (saffron)

* Unsorted: Allosteric modulators: AGN-241751

* See also: Receptor/signaling modulators
* Metabotropic glutamate receptor modulators
* Glutamate metabolism/transport modulators

* v
* t
* e

Nicotinic acetylcholine receptor modulators

nAChRs|

| Agonists
(and PAMs)|

* 5-HIAA
* A-84,543
* A-366,833
* A-582,941
* A-867,744
* ABT-202
* ABT-418
* ABT-560
* ABT-894
* Acetylcholine
* Altinicline
* Anabasine
* Anatoxin-a
* AR-R17779
* Bephenium hydroxynaphthoate
* Butinoline
* Butyrylcholine
* Carbachol
* Choline
* Cotinine
* Cytisine
* Decamethonium
* Desformylflustrabromine
* Dianicline
* Dimethylphenylpiperazinium
* Epibatidine
* Epiboxidine
* Ethanol (alcohol)
* Ethoxysebacylcholine
* EVP-4473
* EVP-6124
* Galantamine
* GTS-21
* Ispronicline
* Ivermectin
* JNJ-39393406
* Levamisole
* Lobeline
* MEM-63,908 (RG-3487)
* Morantel
* Nicotine (tobacco)
* NS-1738
* PHA-543,613
* PHA-709,829
* PNU-120,596
* PNU-282,987
* Pozanicline
* Pyrantel
* Rivanicline
* RJR-2429
* Sazetidine A
* SB-206553
* Sebacylcholine
* SIB-1508Y
* SIB-1553A
* SSR-180,711
* Suberyldicholine
* Suxamethonium (succinylcholine)
* Suxethonium (succinyldicholine)
* TC-1698
* TC-1734
* TC-1827
* TC-2216
* TC-5214
* TC-5619
* TC-6683
* Tebanicline
* Tribendimidine
* Tropisetron
* UB-165
* Varenicline
* WAY-317,538
* XY-4083

|

Antagonists
(and NAMs)|

* 18-MAC
* 18-MC
* α-Neurotoxins (e.g., α-bungarotoxin, α-cobratoxin, α-conotoxin, many others)
* ABT-126
* Alcuronium
* Allopregnanolone
* Amantadine
* Anatruxonium
* AQW051
* Atracurium
* Barbiturates (e.g., pentobarbital, sodium thiopental)
* BNC-210
* Bungarotoxins (e.g., α-bungarotoxin, κ-bungarotoxin)
* Bupropion
* BW284C51
* BW-A444
* Candocuronium iodide (chandonium iodide)
* Chlorisondamine
* Cisatracurium
* Coclaurine
* Coronaridine
* Curare
* Cyclopropane
* Dacuronium bromide
* Decamethonium
* Dehydronorketamine
* Desflurane
* Dextromethorphan
* Dextropropoxyphene
* Dextrorphan
* Diadonium
* DHβE
* Dihydrochandonium
* Dimethyltubocurarine (metocurine)
* Dioscorine
* Dipyrandium
* Dizocilpine (MK-801)
* Doxacurium
* Encenicline
* Enflurane
* Erythravine
* Esketamine
* Fazadinium
* Gallamine
* Gantacurium chloride
* Halothane
* Hexafluronium
* Hexamethonium (benzohexonium)
* Hydroxybupropion
* Hydroxynorketamine
* Ibogaine
* Isoflurane
* Ketamine
* Kynurenic acid
* Laudanosine
* Laudexium (laudolissin)
* Levacetylmethadol
* Levomethadone
* Malouetine
* ME-18-MC
* Mecamylamine
* Memantine
* Methadone
* Methorphan (racemethorphan)
* Methyllycaconitine
* Metocurine
* Mivacurium
* Morphanol (racemorphan)
* Neramexane
* Nitrous oxide
* Norketamine
* Pancuronium bromide
* Pempidine
* Pentamine
* Pentolinium
* Phencyclidine
* Pipecuronium bromide
* Progesterone
* Promegestone
* Radafaxine
* Rapacuronium bromide
* Reboxetine
* Rocuronium bromide
* Sevoflurane
* Stercuronium iodide
* Surugatoxin
* Thiocolchicoside
* Toxiferine
* Tramadol
* Trimetaphan camsilate (trimethaphan camsylate)
* Tropeinium
* Tubocurarine
* Vanoxerine
* Vecuronium bromide
* Xenon

Precursors
(and prodrugs)|

* Acetyl-coA
* Adafenoxate
* Choline (lecithin)
* Citicoline
* Cyprodenate
* Dimethylethanolamine
* Glycerophosphocholine
* Meclofenoxate (centrophenoxine)
* Phosphatidylcholine
* Phosphatidylethanolamine
* Phosphorylcholine
* Pirisudanol

See also: Receptor/signaling modulators • Muscarinic acetylcholine receptor modulators • Acetylcholine metabolism/transport modulators

* v
* t
* e

Serotonin receptor modulators

5-HT1|

| 5-HT1A|

* Agonists: 8-OH-DPAT
* Adatanserin
* Amphetamine
* Antidepressants (e.g., etoperidone, hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine)
* Atypical antipsychotics (e.g., aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, lurasidone, quetiapine, ziprasidone)
* Azapirones (e.g., buspirone, eptapirone, gepirone, perospirone, tandospirone)
* Bay R 1531
* Befiradol
* BMY-14802
* Cannabidiol
* Dimemebfe
* Dopamine
* Ebalzotan
* Eltoprazine
* Enciprazine
* Ergolines (e.g., bromocriptine, cabergoline, dihydroergotamine, ergotamine, lisuride, LSD, methylergometrine (methylergonovine), methysergide, pergolide)
* F-11461
* F-12826
* F-13714
* F-14679
* F-15063
* F-15,599
* Flesinoxan
* Flibanserin
* Flumexadol
* Hypidone
* Lesopitron
* LY-293284
* LY-301317
* mCPP
* MKC-242
* Naluzotan
* NBUMP
* Osemozotan
* Oxaflozane
* Pardoprunox
* Piclozotan
* Rauwolscine
* Repinotan
* Roxindole
* RU-24,969
* S-14,506
* S-14671
* S-15535
* Sarizotan
* Serotonin (5-HT)
* SSR-181507
* Sunepitron
* Tryptamines (e.g., 5-CT, 5-MeO-DMT, 5-MT, bufotenin, DMT, indorenate, N-Me-5-HT, psilocin, psilocybin)
* TGBA01AD
* U-92,016-A
* Urapidil
* Vilazodone
* Xaliproden
* Yohimbine

* Antagonists: Atypical antipsychotics (e.g., iloperidone, risperidone, sertindole)
* AV965
* Beta blockers (e.g., alprenolol, carteolol, cyanopindolol, iodocyanopindolol, isamoltane, oxprenolol, penbutolol, pindobind, pindolol, propranolol, tertatolol)
* BMY-7,378
* CSP-2503
* Dotarizine
* Ergolines (e.g., metergoline)
* FCE-24379
* Flopropione
* GR-46611
* Isamoltane
* Lecozotan
* Mefway
* Metitepine (methiothepin)
* MIN-117 (WF-516)
* MPPF
* NAN-190
* Robalzotan
* S-15535
* SB-649,915
* SDZ 216-525
* Spiperone
* Spiramide
* Spiroxatrine
* UH-301
* WAY-100135
* WAY-100635
* Xylamidine

* Unknown/unsorted: Acetryptine
* Carvedilol
* Ergolines (e.g., ergometrine (ergonovine))

5-HT1B|

* Agonists: Anpirtoline
* CGS-12066A
* CP-93129
* CP-94253
* CP-122,288
* CP-135807
* Eltoprazine
* Ergolines (e.g., bromocriptine, dihydroergotamine, ergotamine, methylergometrine (methylergonovine), methysergide, pergolide)
* mCPP
* RU-24,969
* Serotonin (5-HT)
* Triptans (e.g., avitriptan, donitriptan, eletriptan, sumatriptan, zolmitriptan)
* TFMPP
* Tryptamines (e.g., 5-BT, 5-CT, 5-MT, DMT)
* Vortioxetine

* Antagonists: AR-A000002
* Beta blockers (e.g., alprenolol, carteolol, isamoltane, oxprenolol, penbutolol, propranolol, tertatolol)
* Elzasonan
* Ergolines (e.g., metergoline)
* GR-127935
* Isamoltane
* LY-393558
* Metitepine (methiothepin)
* SB-216641
* SB-224289
* SB-236057
* Yohimbine

* Unknown/unsorted: Ergolines (e.g., cabergoline, ergometrine (ergonovine), lisuride)

5-HT1D|

* Agonists: CP-122,288
* CP-135807
* CP-286601
* Ergolines (e.g., bromocriptine, cabergoline, dihydroergotamine, ergotamine, LSD, methysergide)
* Chemistry:GR-46611
* L-694247
* Chemistry:L-772405
* mCPP
* PNU-109291
* PNU-142633
* Serotonin (5-HT)
* TGBA01AD
* Triptans (e.g., almotriptan, avitriptan, donitriptan, [[Chemistry:Eleeletriptan, Frovatriptan|frovatriptan]], naratriptan, rizatriptan, sumatriptan, zolmitriptan)
* Tryptamines (e.g., 5-BT, 5-CT, 5-Et-DMT, 5-MT, 5-(nonyloxy)tryptamine, DMT)

* Antagonists: Alniditan
* BRL-15,572
* Elzasonan
* Ergolines (e.g., metergoline)
* GR-127935
* Ketanserin
* LY-310762
* LY-367642
* LY-393558
* LY-456219
* LY-456220
* Metitepine (methiothepin)
* Mianserin
* Ritanserin
* Yohimbine
* Ziprasidone

* Unknown/unsorted: Acetryptine
* Ergolines (e.g., lisuride, lysergol, pergolide)

5-HT1E|

* Agonists: BRL-54443
* Ergolines (e.g., methysergide)
* Serotonin (5-HT)
* Triptans (e.g., eletriptan)
* Tryptamines (e.g., tryptamine)

* Antagonists: Metitepine (methiothepin)

* Unknown/unsorted: ErgIrindaloneolines (e.g., ergometrine (ergonovine), lysergol, methylergometrine (methylergonovine)

5-HT1F|

* Agonists: BRL-54443
* CP-122,288
* Ergolines (e.g., bromocriptine, lysergol, methylergometrine (methylergonovine) methysergide)
* Lasmiditan
* LY-334370
* Serotonin (5-HT)
* Triptans (e.g., eletriptan, naratriptan, sumatriptan)
* Tryptamines (e.g., 5-MT)

* Antagonists: Metitepine (methiothepin)
* Mianserin

5-HT2|

| 5-HT2A|

* Agonists: 25H/NB series (e.g., 25I-NBF, 25I-NBMD, 25I-NBOH, 25I-NBOMe, 25B-NBOMe, 25C-NBOMe, 25TFM-NBOMe, 2CBCB-NBOMe, 25CN-NBOH, 2CBFly-NBOMe)
* 2Cs (e.g., 2C-B, 2C-E, 2C-I, 2C-T-2, 2C-T-7, 2C-T-21)
* 2C-B-FLY
* 2CB-Ind
* 5-Methoxytryptamines (5-MeO-DET, 5-MeO-DiPT, 5-MeO-DMT, 5-MeO-DPT, 5-MT)
* α-Alkyltryptamines (e.g., 5-Cl-αMT, 5-Fl-αMT, 5-MeO-αET, 5-MeO-αMT, α-Me-5-HT, αET, αMT)
* AL-34662
* AL-37350A
* Bromo-DragonFLY
* Dimemebfe
* DMBMPP
* DOx (e.g., DOB, DOC, DOI, DOM)
* Efavirenz
* Ergolines (e.g., 1P-LSD, ALD-52, bromocriptine, cabergoline, ergine (LSA), ergometrine (ergonovine), ergotamine, lisuride, LA-SS-Az, LSB, LSD, LSD-Pip, LSH, LSP, methylergometrine (methylergonovine), pergolide)
* Flumexadol
* IHCH-7113
* Jimscaline
* Lorcaserin
* MDxx (e.g., MDA (tenamfetamine), MDMA (midomafetamine), MDOH, MMDA)
* O-4310
* Oxaflozane
* PHA-57378
* PNU-22394
* PNU-181731
* RH-34
* SCHEMBL5334361
* Phenethylamines (e.g., lophophine, mescaline)
* Piperazines (e.g., BZP, quipazine, TFMPP)
* Serotonin (5-HT)
* TCB-2
* TFMFly
* Tryptamines (e.g., 5-BT, 5-CT, bufotenin, DET, DiPT, DMT, DPT, psilocin, psilocybin, tryptamine)

* Antagonists: 5-I-R91150
* 5-MeO-NBpBrT
* AC-90179
* Adatanserin
* Altanserin
* Antihistamines (e.g., cyproheptadine, hydroxyzine, ketotifen, perlapine)
* AMDA
* Atypical antipsychotics (e.g., amperozide, aripiprazole, asenapine, blonanserin, brexpiprazole, carpipramine, clocapramine, clorotepine, clozapine, fluperlapine, gevotroline, iloperidone, lurasidone, melperone, mosapramine, ocaperidone, olanzapine, paliperidone, quetiapine, risperidone, sertindole, zicronapine, ziprasidone, zotepine)
* Chlorprothixene
* Cinanserin
* CSP-2503
* Deramciclane
* Dotarizine
* Eplivanserin
* Ergolines (e.g., amesergide, LY-53857, LY-215,840, mesulergine, metergoline, methysergide, sergolexole)
* Fananserin
* Flibanserin
* Glemanserin
* Irindalone
* Ketanserin
* KML-010
* Landipirdine
* LY-393558
* mCPP
* Medifoxamine
* Metitepine (methiothepin)
* MIN-117 (WF-516)
* Naftidrofuryl
* Nantenine
* Nelotanserin
* Opiranserin (VVZ-149)
* Pelanserin
* Phenoxybenzamine
* Pimavanserin
* Pirenperone
* Pizotifen
* Pruvanserin
* Rauwolscine
* Ritanserin
* Roluperidone
* S-14671
* Sarpogrelate
* Serotonin antagonists and reuptake inhibitors (e.g., etoperidone, hydroxynefazodone, lubazodone, mepiprazole, nefazodone, triazoledione, trazodone)
* SR-46349B
* TGBA01AD
* Teniloxazine
* Temanogrel
* Tetracyclic antidepressants (e.g., amoxapine, aptazapine, esmirtazapine, maprotiline, mianserin, mirtazapine)
* Tricyclic antidepressants (e.g., amitriptyline)
* Typical antipsychotics (e.g., chlorpromazine, fluphenazine, haloperidol, loxapine, perphenazine, pimozide, pipamperone, prochlorperazine, setoperone, spiperone, spiramide, thioridazine, thiothixene, trifluoperazine)
* Volinanserin
* Xylamidine
* Yohimbine

* Unknown/unsorted: Ergolines (e.g., dihydroergotamine, nicergoline)

5-HT2B|

* Agonists: 4-Methylaminorex
* Aminorex
* Amphetamines (e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine)
* BW-723C86
* DOx (e.g., DOB, DOC, DOI, DOM)
* Ergolines (e.g., cabergoline, dihydroergocryptine, dihydroergotamine, ergotamine, methylergometrine (methylergonovine), methysergide, pergolide)
* Lorcaserin
* MDxx (e.g., MDA (tenamfetamine), MDMA (midomafetamine), MDOH, MMDA)
* Piperazines (e.g., TFMPP)
* PNU-22394
* Ro60-0175
* Serotonin (5-HT)
* Tryptamines (e.g., 5-BT, 5-CT, 5-MT, α-Me-5-HT, bufotenin, DET, DiPT, DMT, DPT, psilocin, psilocybin, tryptamine)

* Antagonists: Agomelatine
* Atypical antipsychotics (e.g., amisulpride, aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, N-desalkylquetiapine (norquetiapine), N-desmethylclozapine (norclozapine), olanzapine, pipamperone, quetiapine, risperidone, ziprasidone)
* Cyproheptadine
* EGIS-7625
* Ergolines (e.g., amesergide, bromocriptine, lisuride, LY-53857, LY-272015, mesulergine)
* Ketanserin
* LY-393558
* mCPP
* Metadoxine
* Metitepine (methiothepin)
* Pirenperone
* Pizotifen
* Propranolol
* PRX-08066
* Rauwolscine
* Ritanserin
* RS-127445
* Sarpogrelate
* SB-200646
* SB-204741
* SB-206553
* SB-215505
* SB-221284
* SB-228357
* SDZ SER-082
* Tegaserod
* Tetracyclic antidepressants (e.g., amoxapine, mianserin, mirtazapine)
* Trazodone
* Typical antipsychotics (e.g., chlorpromazine)
* TIK-301
* Yohimbine

* Unknown/unsorted: Ergolines (e.g., ergometrine (ergonovine))

5-HT2C|

* Agonists: 2Cs (e.g., 2C-B, 2C-E, 2C-I, 2C-T-2, 2C-T-7, 2C-T-21)
* 5-Methoxytryptamines (5-MeO-DET, 5-MeO-DiPT, 5-MeO-DMT, 5-MeO-DPT, 5-MT)
* α-Alkyltryptamines (e.g., 5-Cl-αMT, 5-Fl-αMT, 5-MeO-αET, 5-MeO-αMT, α-Me-5-HT, αET, αMT)
* A-372159
* AL-38022A
* Alstonine
* CP-809101
* Dimemebfe
* DOx (e.g., DOB, DOC, DOI, DOM)
* Ergolines (e.g., ALD-52, cabergoline, dihydroergotamine, ergine (LSA), ergotamine, lisuride, LA-SS-Az, LSB, LSD, LSD-Pip, LSH, LSP, pergolide)
* Flumexadol
* Lorcaserin
* MDxx (e.g., MDA (tenamfetamine), MDMA (midomafetamine), MDOH, MMDA)
* MK-212
* ORG-12962
* ORG-37684
* Oxaflozane
* PHA-57378
* Phenethylamines (e.g., lophophine, mescaline)
* Piperazines (e.g., aripiprazole, BZP, mCPP, quipazine, TFMPP)
* PNU-22394
* PNU-181731
* Ro60-0175
* Ro60-0213
* Serotonin (5-HT)
* Tryptamines (e.g., 5-BT, 5-CT, bufotenin, DET, DiPT, DMT, DPT, psilocin, psilocybin, tryptamine)
* Vabicaserin
* WAY-629
* WAY-161503
* YM-348

* Antagonists: Adatanserin
* Agomelatine
* Atypical antipsychotics (e.g., asenapine, clorotepine, clozapine, fluperlapine, iloperidone, melperone, olanzapine, paliperidone, quetiapine, risperidone, sertindole, ziprasidone, zotepine)
* Captodiame
* CEPC
* Cinanserin
* Cyproheptadine
* Deramciclane
* Desmetramadol
* Dotarizine
* Eltoprazine
* Ergolines (e.g., amesergide, bromocriptine, LY-53857, LY-215,840, mesulergine, metergoline, methysergide, sergolexole)
* Etoperidone
* Fluoxetine
* FR-260010
* Irindalone
* Ketanserin
* Ketotifen
* Latrepirdine (dimebolin)
* Medifoxamine
* Metitepine (methiothepin)
* Nefazodone
* Pirenperone
* Pizotifen
* Propranolol
* Ritanserin
* RS-102221
* S-14671
* SB-200646
* SB-206553
* SB-221284
* SB-228357
* SB-242084
* SB-243213
* SDZ SER-082
* Tedatioxetine
* Tetracyclic antidepressants (e.g., amoxapine, aptazapine, esmirtazapine, maprotiline, mianserin, mirtazapine)
* TIK-301
* Tramadol
* Trazodone
* Tricyclic antidepressants (e.g., amitriptyline, nortriptyline)
* Typical antipsychotics (e.g., chlorpromazine, loxapine, pimozide, pipamperone, thioridazine)
* Xylamidine

* Unknown/unsorted: Efavirenz
* Ergolines (e.g., ergometrine (ergonovine), methylergometrine (methylergonovine))

5-HT3–7|

| 5-HT3|

* Agonists: Alcohols (e.g., butanol, ethanol (alcohol), trichloroethanol)
* m-CPBG
* Phenylbiguanide
* Piperazines (e.g., BZP, mCPP, quipazine)
* RS-56812
* Serotonin (5-HT)
* SR-57227
* SR-57227A
* Tryptamines (e.g., 2-Me-5-HT, 5-CT, bufotenidine (5-HTQ))
* Volatiles/gases (e.g., halothane, isoflurane, toluene, trichloroethane)
* YM-31636

* Antagonists: Alosetron
* Chemistry:Arazasetron
* AS-8112
* Atypical antipsychotics (e.g., clozapine, olanzapine, quetiapine)
* Azasetron
* Batanopride
* Bemesetron (MDL-72222)
* Bupropion
* Cilansetron
* CSP-2503
* Dazopride
* Dolasetron
* Galanolactone
* Granisetron
* Hydroxybupropion
* Lerisetron
* Memantine
* Ondansetron
* Palonosetron
* Ramosetron
* Renzapride
* Ricasetron
* Tedatioxetine
* Tetracyclic antidepressants (e.g., amoxapine, mianserin, mirtazapine)
* Thujone
* Tropanserin
* Tropisetron
* Typical antipsychotics (e.g., loxapine)
* Volatiles/gases (e.g., nitrous oxide, sevoflurane, xenon)
* Vortioxetine
* Zacopride
* Zatosetron

* Unknown/unsorted: LY-53857
* Piperazines (e.g., naphthylpiperazine)

5-HT4|

* Agonists: 5-MT
* BIMU8
* Capeserod
* Cinitapride
* Cisapride
* CJ-033466
* Dazopride
* Metoclopramide
* Minesapride
* Mosapride
* Prucalopride
* PRX-03140
* Renzapride
* RS-67,333
* RS-67,506
* Serotonin (5-HT)
* Tegaserod
* Usmarapride
* Velusetrag
* Zacopride

* Antagonists: GR-113808
* GR-125487
* L-Lysine
* Piboserod
* RS-39604
* RS-67532
* SB-203186
* SB-204070

5-HT5A|

* Agonists: Ergolines (e.g., 2-Br-LSD (BOL-148), ergotamine, LSD)
* Serotonin (5-HT)
* Tryptamines (e.g., 5-CT)
* Valerenic acid

* Antagonists: Asenapine
* Latrepirdine (dimebolin)
* Metitepine (methiothepin)
* Ritanserin
* SB-699551

* Unknown/unsorted: Ergolines (e.g., metergoline, methysergide)
* Piperazines (e.g., naphthylpiperazine)

5-HT6|

* Agonists: Ergolines (e.g., dihydroergocryptine, dihydroergotamine, ergotamine, lisuride, LSD, mesulergine, metergoline, methysergide)
* Hypidone
* Serotonin (5-HT)
* Tryptamines (e.g., 2-Me-5-HT, 5-BT, 5-CT, 5-MT, Bufotenin, E-6801, E-6837, EMD-386088, EMDT, LY-586713, N-Me-5-HT, ST-1936, tryptamine)
* WAY-181187
* WAY-208466

* Antagonists: ABT-354
* Atypical antipsychotics (e.g., aripiprazole, asenapine, clorotepine, clozapine, fluperlapine, iloperidone, olanzapine, tiospirone)
* AVN-101
* AVN-211
* AVN-322
* AVN-397
* BGC20-760
* BVT-5182
* BVT-74316
* Cerlapirdine
* EGIS-12,233
* GW-742457
* Idalopirdine
* Ketanserin
* Landipirdine
* Latrepirdine (dimebolin)
* Masupirdine
* Metitepine (methiothepin)
* MS-245
* PRX-07034
* Ritanserin
* Ro 04-6790
* Ro 63-0563
* SB-258585
* SB-271046
* SB-357134
* SB-399885
* SB-742457
* Tetracyclic antidepressants (e.g., amoxapine, mianserin)
* Tricyclic antidepressants (e.g., amitriptyline, clomipramine, doxepin, nortriptyline)
* Typical antipsychotics (e.g., chlorpromazine, loxapine)

* Unknown/unsorted: Ergolines (e.g., 2-Br-LSD (BOL-148), bromocriptine, lergotrile, pergolide)
* Piperazines (e.g., naphthylpiperazine)

5-HT7|

* Agonists: 8-OH-DPAT
* AS-19
* Bifeprunox
* E-55888
* Ergolines (e.g., LSD)
* LP-12
* LP-44
* LP-211
* RU-24,969
* Sarizotan
* Serotonin (5-HT)
* Triptans (e.g., frovatriptan)
* Tryptamines (e.g., 5-CT, 5-MT, bufotenin, N-Me-5-HT)

* Antagonists: Atypical antipsychotics (e.g., amisulpride, aripiprazole, asenapine, brexpiprazole, clorotepine, clozapine, fluperlapine, olanzapine, risperidone, sertindole, tiospirone, ziprasidone, zotepine)
* Butaclamol
* DR-4485
* EGIS-12,233
* Ergolines (e.g., 2-Br-LSD (BOL-148), amesergide, bromocriptine, cabergoline, dihydroergotamine, ergotamine, LY-53857, LY-215,840, mesulergine, metergoline, methysergide, sergolexole)
* JNJ-18038683
* Ketanserin
* LY-215,840
* Metitepine (methiothepin)
* Ritanserin
* SB-258719
* SB-258741
* SB-269970
* SB-656104
* SB-656104A
* SB-691673
* SLV-313
* SLV-314
* Spiperone
* Chemistry:SSR-181507
* Tetracyclic antidepressants (e.g., amoxapine, maprotiline, mianserin, mirtazapine)
* Tricyclic antidepressants (e.g., amitriptyline, clomipramine, imipramine)
* Typical antipsychotics (e.g., acetophenazine, chlorpromazine, chlorprothixene, fluphenazine, loxapine, pimozide)
* Vortioxetine

* Unknown/unsorted: Ergolines (e.g., lisuride, pergolide)
* Piperazines (e.g., naphthylpiperazine)

* See also: Receptor/signaling modulators
* Adrenergics
* Dopaminergics
* Melatonergics
* Monoamine reuptake inhibitors and releasing agents
* Monoamine metabolism modulators
* Monoamine neurotoxins

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Original source: https://en.wikipedia.org/wiki/Xenon. Read more

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Retrieved from "https://handwiki.org/wiki/index.php?title=Chemistry:Xenon&oldid=4246905"
*[US]: United States
*[CID]: Compound ID
*[v]: View this template
*[t]: Discuss this template
*[e]: Edit this template
*[GlyR]: Glycine receptor
*[NMDAR]: N-Methyl-D-aspartate receptor
*[GlyT1]: Glycine transporter 1
*[GlyT2]: Glycine transporter 2
*[AMPAR]: α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
*[KAR]: Kainate receptor
*[DHEA]: Dehydroepiandrosterone
*[nAChRs]: Nicotinic acetylcholine receptors
*[PAMs]: positive allosteric modulators
*[NAMs]: negative allosteric modulators