Ancestim

AncestimClinical data

AHFS/Drugs.com| International Drug Names
Routes of
administration| s.c. injection only, premedication with H1 and H2 antihistamines and beta-receptor agonists for bronchodilation
ATC code|

* L03AA12 (WHO)

Pharmacokinetic data
Elimination half-life| 2.5 h
Excretion| renal: 90%
Identifiers
CAS Number|

* 163545-26-4 N

ChemSpider|

* none

UNII|

* PYB4Q6JG41

KEGG|

* D02937 Y

NY (what is this?) (verify)

Ancestim is a recombinant methionyl human stem cell factor, branded by Amgen as StemGen. It was developed by Amgen and sold to Biovitrium, now Swedish Orphan Biovitrum, in December, 2008.[1]

It is a 166 amino acid protein produced by E. coli bacteria into which a gene has been inserted for soluble human stem cell factor.[2] It has a monomeric molecular weight of approximately 18,500 daltons and normally exists as a noncovalently associated dimer. The protein has an amino acid sequence that is identical to the natural sequence predicted from human DNA sequence analysis, except for the addition of an N-terminal methionine retained after expression in E. coli. Because Ancestim is produced in E. coli, it is nonglycosylated. Ancestim is supplied as a sterile, white, preservative-free, lyophilised powder for reconstitution and administration as a subcutaneous (SC) injection and is indicated for use in combination with filgrastim for mobilizing peripheral hematopoietic stem cells for later transplantation in certain cancer patients.[3]

## References

1. ↑ Amgen press office. Biovitrum Closes Product Acquisition Deal with Amgen
2. ↑ "Ancestim (recombinant human stem cell factor, SCF) in association with filgrastim does not enhance chemotherapy and/or growth factor-induced peripheral blood progenitor cell (PBPC) mobilization in patients with a prior insufficient PBPC collection". Bone Marrow Transplant. 34 (8): 683–91. 2004. doi:10.1038/sj.bmt.1704602. PMID 15322567.
3. ↑ "Sobi's StemGen page". http://www.sobi.com/en/Healthcare-Professionals/Products-alphabetical-list/Stemgen/.

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