Antipsychotic ester

Short description: Class of prodrugs

Haloperidol decanoate, an antipsychotic ester.

An antipsychotic ester is an ester of an antipsychotic.[1] They are used clinically as prodrugs to increase fat solubility and thereby prolong duration when antipsychotics are used as depot injectables.[1]

## Contents

* 1 List of clinically used antipsychotic esters
* 1.1 Typical antipsychotics
* 1.2 Atypical antipsychotics
* 2 Pharmacology
* 3 References

## List of clinically used antipsychotic esters

### Typical antipsychotics

* Bromperidol decanoate
* Clopentixol decanoate
* Flupentixol decanoate
* Fluphenazine decanoate
* Fluphenazine enanthate
* Haloperidol decanoate
* Oxyprothepin decanoate
* Perphenazine decanoate
* Perphenazine enanthate
* Pipotiazine palmitate
* Pipotiazine undecylenate
* Zuclopentixol acetate
* Zuclopentixol decanoate

### Atypical antipsychotics

* Aripiprazole lauroxil
* Paliperidone palmitate

## Pharmacology

## References

1. ↑ 1.0 1.1 "The pharmacokinetics of long-acting antipsychotic medications". Current Clinical Pharmacology 9 (3): 310–7. 2014. doi:10.2174/15748847113089990051. PMID 23343447.

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Antipsychotics (N05A)

Typical|

* Butyrophenones: Benperidol
* Bromperidol
* Droperidol
* Haloperidol#
* Moperone
* Pipamperone
* Spiperone
* Timiperone
* Trifluperidol

* Diphenylbutylpiperidines: Fluspirilene
* Penfluridol
* Pimozide

* Phenothiazines: Acetophenazine
* Butaperazine
* Carphenazine (carfenazine)‡
* Chlorpromazine
* Cyamemazine
* Dixyrazine
* Fluphenazine
* Levomepromazine (methotrimeprazine)
* Mesoridazine
* Perazine
* Periciazine
* Perphenazine
* Piperacetazine
* Pipotiazine
* Prochlorperazine
* Promazine
* Sulforidazine
* Thiopropazate
* Thioproperazine
* Thioridazine
* Trifluoperazine
* Triflupromazine

* Thioxanthenes: Chlorprothixene
* Clopenthixol
* Flupentixol
* Tiotixene (thiothixene)
* Zuclopenthixol

Disputed|

* Benzamides: Amisulpride
* Levosulpiride
* Nemonapride
* Remoxipride‡
* Sulpiride
* Sultopride
* Tiapride
* Veralipride‡

* Butyrophenones: Melperone

* Tricyclics: Carpipramine
* Clocapramine
* Clorotepine
* Clotiapine
* Loxapine
* Mosapramine

* Others: Molindone

Atypical|

* Benzisoxazole/benzisothiazoles: Iloperidone
* Lurasidone
* Paliperidone
* Paliperidone palmitate
* Perospirone
* Risperidone#
* Ziprasidone

* Butyrophenones: Lumateperone†

* Phenylpiperazines/quinolinones: Aripiprazole
* Aripiprazole lauroxil
* Brilaroxazine†
* Brexpiprazole
* Cariprazine

* Tricyclics: Asenapine
* Clozapine#
* Olanzapine
* Quetiapine
* Zotepine

* Others: Blonanserin
* Pimavanserin
* Sertindole

Others|

* Azacyclonol
* Cannabidiol
* Oxypertine
* Reserpine
* Tetrabenazine

* #WHO-EM
* ‡Withdrawn from market
* Clinical trials:
* †Phase III
* §Never to phase III

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