Arsenic trioxide

Short description: Chemical compound (industrial chemical and medication)

Arsenic trioxide

Arsenic trioxide  As O

Clinical data
Pronunciation| AR se nik tri OKS id
Trade names| Trisenox, others
Other names| Arsenic(III) oxide,
Arsenic sesquioxide,
Arseneous oxide,
Ratsbane,
Arseneous anhydride,
White arsenic,
Aqua Tofani[1]
AHFS/Drugs.com| Monograph
MedlinePlus| a608017
License data|

* EU EMA: by INN
* US DailyMed: Arsenic_trioxide

Pregnancy
category|

* AU: X (High risk)
* US: N (Not classified yet)

Routes of
administration| Intravenous
Drug class| Antineoplastic agent
ATC code|

* L01XX27 (WHO)

Legal status
Legal status|

* AU: S4 (Prescription only)
* US: ℞-only
* EU: Rx-only

Pharmacokinetic data
Protein binding| 75%
Excretion| Urine
Identifiers

IUPAC name

* Diarsenic trioxide

CAS Number|

* 1327-53-3 Y

PubChem CID|

* 261004

DrugBank|

* DB01169

ChemSpider|

* 452539

UNII|

* S7V92P67HO

KEGG|

* C13619
* D02106

ChEMBL|

* ChEMBL1200978

Chemical and physical data
Formula| As2O3
Molar mass| 197.840 g·mol−1
3D model (JSmol)|

* Interactive image

Density| 3.74 g/cm3
Melting point| 312.2 °C (594.0 °F)
Boiling point| 465 °C (869 °F)
Solubility in water| 20 g/L (25 °C)
(see text)

SMILES

* O1[As]3O[As]2O[As](O3)O[As]1O2

InChI

* InChI=1S/As2O3/c3-1-4-2(3)5-1

* Key:GOLCXWYRSKYTSP-UHFFFAOYSA-N

Arsenic trioxide  Identifiers

EC Number |

* 215-481-4

Hazards
Safety data sheet | american elements SDS
GHS pictograms |
GHS Signal word | Danger

GHS hazard statements

| H300, H314, H350, H410

GHS precautionary statements

| P201, P202, P260, P264, P270, P273, P280, P301+330+331, P303+361+353, P304+340+310, P305+351+338+310, P308+313, P363, P391, P405, P501

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Infobox references

Arsenic trioxide, sold under the brand name Trisenox among others, is an inorganic compound with the formula As2O3.[3] As an industrial chemical, its major uses include the manufacture of wood preservatives, pesticides, and glass.[4] It is also used as a medication[5] to treat a type of cancer known as acute promyelocytic leukemia.[5] For this use it is given by injection into a vein.[5]

Common side effects include vomiting, diarrhea, swelling, shortness of breath, and headaches.[5] Severe side effects may include APL differentiation syndrome and heart problems.[5] Use during pregnancy or breastfeeding may harm the baby.[6][7] Its mechanism in treating cancer is not entirely clear.[5]

Arsenic trioxide was approved for medical use in the United States in 2000.[5] It is on the World Health Organization's List of Essential Medicines.[8] Approximately 50,000 tonnes are produced a year.[9] Due to its toxicity, a number of countries have regulations around its manufacture and sale.[10]

## Contents

* 1 Uses
* 1.1 Medical
* 1.2 Manufacturing
* 1.3 Alternative medicine
* 2 Toxicology
* 3 Production and occurrence
* 4 Properties and reactions
* 4.1 Structure
* 5 Society and culture
* 5.1 Environmental effects
* 5.2 Arsenic poisoning in literature and society
* 6 References
* 7 External links

## Uses

### Medical

Arsenic trioxide is used to treat a type of cancer known as acute promyelocytic leukemia (APL).[5] It may be used both in cases that are unresponsive to other agents, such as all-trans retinoic acid (ATRA) or as part of the initial treatment of newly diagnosed cases.[5] This initial treatment may include combination therapy of arsenic trioxide with all-trans retinoic acid (ATRA).[11]

Effectiveness appears similar to Realgar/Indigo naturalis, which can be taken by mouth and is less expensive but is less available.[12] It works by encouraging the proteosome breakdown of retinoic acid receptor alpha, by moving the protein on to the nuclear matrix and increasing ubiquitination.[13]

In the 1970s, Chinese researcher Zhang Tingdong and colleagues discovered this use.[14] It was approved for leukemia treatment in the United States in 2000.[15] University of Hong Kong developed a liquid form of arsenic trioxide that can be given by mouth.[16] Organoarsenic compounds, such as feed additives (roxarsone) and medication (neosalvarsan), are derived from arsenic trioxide.[citation needed]

### Manufacturing

Industrial uses include usage as a precursor to forestry products, in colorless glass production, and in electronics.[9] Being the main compound of arsenic, the trioxide is the precursor to elemental arsenic, arsenic alloys, and arsenide semiconductors. Bulk arsenic-based compounds sodium arsenite and sodium cacodylate are derived from the trioxide.[citation needed]

A variety of applications exploit arsenic's toxicity, including the use of the oxide as a wood preservative. Copper arsenates, which are derived from arsenic trioxide, are used on a large scale as a wood preservative in the U.S. and Malaysia, but such materials are banned in many parts of the world. This practice remains controversial.[9] In combination with copper(II) acetate, arsenic trioxide gives the vibrant pigment known as Paris green used in paints and as a rodenticide. This application has been discontinued.[citation needed]

### Alternative medicine

Despite the well known toxicity of arsenic, arsenic trioxide was used in traditional Chinese medicine, where it is known as pi-shuang (Chinese: 砒霜; pinyin: pīshuāng; literally: 'arsenic frost'). In homeopathy, it is called arsenicum album. Some discredited patent medicines, e.g., Fowler's solution, contained derivatives of arsenic oxide.[17]

## Toxicology

Arsenic trioxide is readily absorbed by the digestive system. Ingestion of as little as 0.1 grams can be fatal.[9]

Chronic arsenic poisoning is known as arsenicosis. This disorder affects workers in smelters, in populations whose drinking water contains high levels of arsenic (0.3–0.4 ppm), and in patients treated for long periods with arsenic-based pharmaceuticals. Long-term ingestion of arsenic trioxide either in drinking water or as a medical treatment can lead to skin cancer. Reproductive problems (high incidences of miscarriage, low birth weight, congenital deformations) have also been indicated in one study of women exposed to arsenic trioxide dust as employees or neighbours of a copper foundry.

In the U.S., the OSHA 1910.1018 occupational permissible exposure limit for inorganic arsenic compounds in breathing zone air is 0.010 mg/m3.

## Production and occurrence

Error creating thumbnail: Unable to save thumbnail to destinationHistoric arsenic mine Sankt Blasen, Austria

Arsenic trioxide can be generated via routine processing of arsenic compounds including the oxidation (combustion) of arsenic and arsenic-containing minerals in air. Illustrative is the roasting of orpiment, a typical arsenic sulfide ore.

2 As2S3 \+ 9 O2 → 2 As2O3 \+ 6 SO2

Most arsenic oxide is, however, obtained as a volatile by-product of the processing of other ores. For example, arsenopyrite, a common impurity in gold- and copper-containing ores, liberates arsenic trioxide upon heating in air. The processing of such minerals has led to numerous cases of poisonings,[18] and after the mine is closed, the leftover trioxide waste will present environmental hazard (as was the case with the Giant Mine, for example). Only in China are arsenic ores intentionally mined.[9]

In the laboratory, it is prepared by hydrolysis of arsenic trichloride:[19]

2 AsCl
3 \+ 3 H
2O → As

3 \+ 6 HCl

As2O3 occurs naturally as two minerals, arsenolite (cubic) and claudetite (monoclinic). Both are relatively rare secondary minerals found in oxidation zones of As-rich ore deposits. Sheets of As

3 stand for part of structures of the recently discovered minerals lucabindiite, (K,NH
4)As

6(Cl,Br),[20] and its sodium-analogue torrecillasite.[21]

## Properties and reactions

Arsenic trioxide is an amphoteric oxide, and its aqueous solutions are weakly acidic. Thus, it dissolves readily in alkaline solutions to give arsenites. It is less soluble in acids, although it will dissolve in hydrochloric acid.[22]

With anhydrous HF and HCl, it gives AsF
3 and the trichloride:[19]

3 \+ 6 HX → 2 AsX
3 \+ 3 H
2O (X = F, Cl)

Only with strong oxidizing agents such as ozone, hydrogen peroxide, and nitric acid does it yield arsenic pentoxide, As2O5 or its corresponding acid:[19]

2 HNO
3 \+ As

3 \+ 2 H
2O → 2 H
3AsO
4 \+ N

In terms of its resistance to oxidation, arsenic trioxide differs from phosphorus trioxide, which readily combusts to phosphorus pentoxide.

Reduction gives elemental arsenic or arsine (AsH3) depending on conditions:[19]

3 \+ 6 Zn + 12 HNO
3 → 2 AsH
3 \+ 6 Zn(NO

2 \+ 3 H

This reaction is used in the Marsh test.

### Structure

In the liquid and gas phase below 800 °C, arsenic trioxide has the formula As4O6 and is isostructural with P4O6. Above 800 °C As4O6 significantly dissociates into molecular As2O3, which adopts the same structure as N2O3. Three forms (polymorphs) are known in the solid state: a high temperature ( > 110 °C) cubic As4O6, containing molecular As4O6, and two related polymeric forms.[23] The polymers, which both crystallize as monoclinic crystals, feature sheets of pyramidal AsO3 units that share O atoms.[24]

|  |

|
|

arsenolite
(cubic)

claudetite I
(monoclinic)

claudetite II
(monoclinic)

## Society and culture

### Environmental effects

Smelting and related ore processing often generate arsenic trioxide, which poses a risk to the environment. For example, the Giant Mine in Canada processed substantial amounts of arsenopyrite-contaminated gold ores.

### Arsenic poisoning in literature and society

The poisonous properties of arsenic are the subject of an extensive literature.[25][26][27]

In Austria, there lived the so-called "arsenic eaters of Styria", who ingested doses far beyond the lethal dose of arsenic trioxide without any apparent harm. Arsenic is thought to enable strenuous work at high altitudes, e.g. in the Alps.[28][29][30][31]

## References

1. ↑ "Chemical of the Week: Arsenic". University of Wisconsin-Madison Chemistry Dept.. http://scifun.chem.wisc.edu/chemweek/Arsenic/Arsenic.html.
2. ↑ "Safety Data Sheet". American Elements. 2021. https://www.americanelements.com/printpdf/arsenic-iii-oxide-1327-53-3/sds.
3. ↑ Biological Chemistry of Arsenic, Antimony and Bismuth. John Wiley & Sons. 2010. p. 295. ISBN 9780470976227. https://books.google.com/books?id=nrKXcXQF0QAC&pg=PA295.
4. ↑ Chemicals in the Aquatic Environment: Advanced Hazard Assessment. Springer Science & Business Media. 2012. p. 259. ISBN 9783642613340. https://books.google.com/books?id=wZb6CAAAQBAJ&dq=Arsenic+trioxide+industrial+chemical&pg=PA259.
5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 "Arsenic Trioxide Monograph for Professionals". https://www.drugs.com/monograph/arsenic-trioxide.html.
6. ↑ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 907. ISBN 9780857113382.
7. ↑ "Arsenic trioxide (Trisenox) Use During Pregnancy". https://www.drugs.com/pregnancy/arsenic-trioxide.html.
8. ↑ World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. 2019. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
9. ↑ 9.0 9.1 9.2 9.3 9.4 "Ullmann's Encyclopedia of Industrial Chemistry". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a03_113.pub2.
10. ↑ Consolidated List of Products Whose Consumption And/or Sale Have Been Banned, Withdrawn, Severely Restricted Or Not Approved by Governments: Chemicals. United Nations Publications. 2009. p. 24. ISBN 9789211302196. https://books.google.com/books?id=OtVZqdPHsm8C&dq="Arsenic+Trioxide"+industrial+uses&pg=PA24.
11. ↑ "How acute promyelocytic leukaemia revived arsenic". Nature Reviews. Cancer 2 (9): 705–713. September 2002. doi:10.1038/nrc887. PMID 12209159.
12. ↑ "Proposal for the inclusion of arsenic therapies in the WHO Model list of ESSENTIAL MEDICINES for the treatment of acute promyelocytic leukemia.". https://www.who.int/selection_medicines/committees/expert/22/applications/s8.2_arsenic.pdf.
13. ↑ "Arsenic-induced PML targeting onto nuclear bodies: implications for the treatment of acute promyelocytic leukemia". Proceedings of the National Academy of Sciences of the United States of America 94 (8): 3978–3983. April 1997. doi:10.1073/pnas.94.8.3978. PMID 9108090. Bibcode: 1997PNAS...94.3978Z.
14. ↑ "A drug from poison: how the therapeutic effect of arsenic trioxide on acute promyelocytic leukemia was discovered". Science China Life Sciences 56 (6): 495–502. June 2013. doi:10.1007/s11427-013-4487-z. PMID 23645104.
15. ↑ "Developing new drugs from annals of Chinese medicine". Acta Pharmaceutica Sinica B 2: 1–7. 2012. doi:10.1016/j.apsb.2011.12.007.
16. ↑ "Oral arsenic trioxide in the treatment of relapsed acute promyelocytic leukemia". Blood 102 (1): 407–408. July 2003. doi:10.1182/blood-2003-01-0298. PMID 12814916.
17. ↑ "Arsenic-Based Drugs: From Fowler's Solution to Modern Anticancer Chemotherapy". Medicinal Organometallic Chemistry. Topics in Organometallic Chemistry. 32. 2010. pp. 1–20. doi:10.1007/978-3-642-13185-1_1. ISBN 978-3-642-13184-4. Bibcode: 2010moc..book....1G.
18. ↑ "Giant Mine – Northwest Territories Region – Indian and Northern Affairs Canada". http://nwt-tno.inac-ainc.gc.ca/giant/atg_e.html.
19. ↑ 19.0 19.1 19.2 19.3 Handbook of Preparative Inorganic Chemistry, 2nd Ed. Edited by G. Brauer, Academic Press, 1963, NY.
20. ↑ Garavelli et al. 2013, http://www.minsocam.org/msa/ammin/toc/Abstracts/2013_Abstracts/FM13_Abstracts/Garavelli_p470_13.pdf
21. ↑ Kampf et al. 2013, http://minmag.geoscienceworld.org/content/78/3/747.abstract
22. ↑ Greenwood, N. N.; & Earnshaw, A. (1997). Chemistry of the Elements (2nd Edn.), Oxford:Butterworth-Heinemann. ISBN 0-7506-3365-4.
23. ↑ Wells A.F. Structural Inorganic Chemistry. 5th. London, England: Oxford University Press, 1984. Print. ISBN 0-19-855370-6
24. ↑ Inorganic Chemistry. San Diego: Academic Press. 2001. ISBN 0-12-352651-5.
25. ↑ "Stanton v Benzler 9716830". U.S. 9th Circuit Court of Appeals. 1998-06-17. http://caselaw.lp.findlaw.com/scripts/getcase.pl?navby=search&case=/data2/circs/9th/9716830.html&friend=usatoday. "(...) convicted by a jury of first degree murder for poisoning her ex-husband. Her ex-husband's body was found with traces of arsenic trioxide in it."
26. ↑ "Arsenic". The Elements of Murder: A History of Poison. Oxford University Press. 2006. pp. 93–197. ISBN 978-0-19-280600-0.
27. ↑ Madame Bovary. 1856.
28. ↑ "Arsenic Eaters". New York Times. July 26, 1885. https://www.nytimes.com/1885/07/26/archives/arsenic-eaters.html.
29. ↑ Arsenik. Seine Geschichte in Österreich. Archiv für vaterländische Geschichte und Topographie. 54. Klagenfurt: Kleinmayr. 1959.
30. ↑ "The arsenic eaters of Styria: a different picture of people who were chronically exposed to arsenic". Applied Organometallic Chemistry 15 (6): 457–462. 2001. doi:10.1002/aoc.126.
31. ↑ The Arsenic Century. Oxford University Press. 2010. pp. 270–273. ISBN 978-0-19-960599-6. https://archive.org/details/arseniccenturyho00whor.

## External links

* "Arsenic trioxide". Drug Information Portal. U.S. National Library of Medicine. https://druginfo.nlm.nih.gov/drugportal/name/arsenic trioxide.
* Case Studies in Environmental Medicine: Arsenic Toxicity
* "Arsenic and Arsenic Compounds". Summaries & Evaluations. International Agency for Research on Cancer (IARC). February 1998. http://www.inchem.org/documents/iarc/suppl7/arsenic.html.
* International Chemical Safety Card 0378
* Safety Data Sheet from American Elements
* NIOSH Pocket Guide to Chemical Hazards
* NTP Report on Carcinogens – Inorganic Arsenic Compounds
* Template:Inrs

* v
* t
* e

Intracellular chemotherapeutic agents / antineoplastic agents (L01)

SPs/MIs
(M phase)|

| Block microtubule assembly|

* Vinca alkaloids (Vinblastine#
* Vincristine#
* Vinflunine§
* Vindesine
* Vinorelbine#)

|

Block microtubule disassembly|

* Taxanes (Cabazitaxel
* Docetaxel#
* Larotaxel
* Ortataxel†
* Paclitaxel#
* Tesetaxel)
* Epothilones (Ixabepilone)

DNA replication
inhibitor|

| DNA precursors/
antimetabolites
(S phase)|

| Folic acid|

* Dihydrofolate reductase inhibitor (Aminopterin
* Methotrexate#
* Pemetrexed
* Pralatrexate)
* Thymidylate synthase inhibitor (Raltitrexed
* Pemetrexed)

|

Purine|

* Adenosine deaminase inhibitor (Pentostatin)

* Halogenated/ribonucleotide reductase inhibitors (Cladribine
* Clofarabine
* Fludarabine)
* Nelarabine

* Thiopurine (Tioguanine#
* Mercaptopurine#)

Pyrimidine|

* Thymidylate synthase inhibitor (Fluorouracil#
* Capecitabine#
* Doxifluridine
* Tegafur (+gimeracil/oteracil)
* Carmofur
* Floxuridine)

* DNA polymerase inhibitor (Cytarabine#)

* Ribonucleotide reductase inhibitor (Gemcitabine#)

* Hypomethylating agent (Azacitidine
* Decitabine)

Deoxyribonucleotide|

* Ribonucleotide reductase inhibitor (Hydroxycarbamide#)

Topoisomerase inhibitors
(S phase)|

| I|

* Camptotheca (Camptothecin
* Cositecan†
* Belotecan
* Gimatecan
* Exatecan
* Irinotecan#
* Lurtotecan‡
* Silatecan§
* Topotecan
* Rubitecan‡)

|

II|

* Podophyllum (Etoposide#
* Teniposide)

II+Intercalation|

* Anthracyclines (Aclarubicin
* Daunorubicin#
* Doxorubicin#
* Epirubicin
* Idarubicin
* Amrubicin†
* Pirarubicin
* Valrubicin
* Zorubicin)
* Anthracenediones (Mitoxantrone
* Pixantrone)

Crosslinking of DNA
(CCNS)|

| Alkylating|

* Nitrogen mustards: Chlormethine
* Cyclophosphamide# (Ifosfamide#
* Trofosfamide)
* Chlorambucil# (Melphalan
* Prednimustine)
* Bendamustine#
* Uramustine

* Nitrosoureas: Carmustine
* Lomustine (Semustine)
* Fotemustine
* Nimustine
* Ranimustine
* Streptozocin

* Alkyl sulfonates: Busulfan (Mannosulfan
* Treosulfan)

* Aziridines: Carboquone
* Thiotepa
* Triaziquone
* Triethylenemelamine

|

Platinum-based|

* Carboplatin#
* Cisplatin#
* Dicycloplatin
* Nedaplatin
* Oxaliplatin#
* Satraplatin

Nonclassical|

* Hydrazines (Procarbazine#)
* Triazenes (Dacarbazine#
* Temozolomide)
* Altretamine
* Mitobronitol
* Pipobroman

Intercalation|

* Streptomyces (Actinomycin#
* Bleomycin#
* Mitomycins
* Plicamycin)

Photosensitizers/PDT|

* Aminolevulinic acid / Methyl aminolevulinate
* Efaproxiral
* Porphyrin derivatives (Porfimer sodium
* Talaporfin
* Temoporfin
* Verteporfin)

Other|

| Enzyme inhibitors|

* FI (Tipifarnib§)
* CDK inhibitors (Abemaciclib
* Alvocidib†
* Palbociclib
* Ribociclib
* Seliciclib†)
* PrI
* Bortezomib
* Carfilzomib
* Ixazomib
* PhI (Anagrelide)
* IMPDI (Tiazofurin§)
* LI (Masoprocol)
* PARP inhibitor (Niraparib
* Olaparib
* Rucaparib)
* HDAC (Belinostat
* Panobinostat
* Romidepsin
* Vorinostat)
* PIKI (Idelalisib)

|

Receptor antagonists|

* ERA (Atrasentan)
* Retinoid X receptor (Bexarotene)
* Sex steroid (Testolactone)

Other/ungrouped|

* Amsacrine
* Trabectedin
* Retinoids (Alitretinoin
* Tretinoin#)
* Arsenic trioxide
* Asparagine depleters (Asparaginase#/Pegaspargase)
* Celecoxib
* Demecolcine
* Elesclomol§
* Elsamitrucin
* Estramustine phosphate
* Etoglucid
* Lonidamine
* Lucanthone
* Mitoguazone
* Mitotane
* Oblimersen†
* Omacetaxine mepesuccinate
* Eribulin

* #WHO-EM
* ‡Withdrawn from market
* Clinical trials:
* †Phase III
* §Never to phase III

* v
* t
* e

Arsenic compounds

* AsBr3
* AsCl3
* AsCl5
* AsF3
* AsF5
* AsH3
* AsHgI4
* AsI3
* As2O3
* As2O5
* As2S3
* As2S5
* As2Se3
* As4S4

* v
* t
* e

Oxides

Mixed oxidation states|

* Antimony tetroxide (Sb2O4)
* Cobalt(II,III) oxide (Co3O4)
* Europium(II,III) oxide (Eu3O4)
* Iron(II,III) oxide (Fe<sub>3O4)
* Lead(II,IV) oxide (Pb3O4)
* Manganese(II,III) oxide (Mn3O4)
* Silver(I,III) oxide (Ag2O2)
* Triuranium octoxide (U3O8)
* Carbon suboxide (C3O2)
* Mellitic anhydride (C12O9)
* [[Chemistry:Praseodymium(III,IV) Praseodymium(III,IV) oxide]] (Pr6O11)
* Terbium(III,IV) oxide (Tb4O7)

+1 oxidation state|

* Copper(I) oxide (Cu<sub>2O)
* Caesium oxide (Cs2O)
* Dicarbon monoxide (C2O)
* Dichlorine monoxide (Cl2O)
* Gallium(I) oxide (Ga2O)
* Lithium oxide (Li2O)
* Potassium oxide (K2O)
* Rubidium oxide (Rb2O)
* Silver oxide (Ag2O)
* Thallium(I) oxide (Tl2O)
* Sodium oxide (Na2O)
* Water (hydrogen oxide) (H2O)

+2 oxidation state|

* Aluminium(II) oxide (AlO)
* Barium oxide (BaO)
* Beryllium oxide (BeO)
* Cadmium oxide (CdO)
* Calcium oxide (CaO)
* Carbon monoxide (CO)
* Chromium(II) oxide (CrO)
* Cobalt(II) oxide (CoO)
* Copper(II) oxide (CuO)
* Europium(II) oxide (EuO)
* Germanium monoxide (GeO))
* Iron(II) oxide (FeO)
* Lead(II) oxide (PbO)
* Magnesium oxide (MgO)
* Manganese(II) oxide (MnO)
* Mercury(II) oxide (HgO)
* Nickel(II) oxide (NiO)
* Nitric oxide (NO)
* Palladium(II) oxide (PdO)
* Silicon monoxide (SiO)
* Strontium oxide (SrO)
* Sulfur monoxide (SO)
* Disulfur dioxide (S2O2)
* Thorium monoxide (ThO)
* Tin(II) oxide (SnO)
* Titanium(II) oxide (TiO)
* Vanadium(II) oxide (VO)
* Zinc oxide (ZnO)

+3 oxidation state|

* Aluminium oxide (Al<sub>2O3)
* Antimony trioxide (Sb2O3)
* Arsenic trioxide (As2O3)
* Bismuth(III) oxide (Bi2O3)
* Boron trioxide (B2O3)
* Cerium(III) oxide (Ce2O3)
* Dibromine trioxide (Br2O3)
* Chromium(III) oxide (Cr2O3)
* Dinitrogen trioxide (N2O3)
* Dysprosium(III) oxide (Dy2O3)
* Erbium(III) oxide (Er2O3)
* Europium(III) oxide (Eu2O3)
* Gadolinium(III) oxide (Gd2O3)
* Gallium(III) oxide (Ga2O3)
* Holmium(III) oxide (Ho2O3)
* Indium(III) oxide (In<sub>2O3)
* Iron(III) oxide (Fe2O3)
* Lanthanum oxide (La2O3)
* Lutetium(III) oxide (Lu2O3)
* Manganese(III) oxide (Mn2O3)
* Neodymium(III) oxide (Nd2O3)
* Nickel(III) oxide (Ni2O3)
* Phosphorus trioxide (P4O6)
* Praseodymium(III) oxide (Pr2O3)
* Promethium(III) oxide (Pm2O3)
* Rhodium(III) oxide (Rh2O3)
* [[Chemistry:Samarium(III) Samarium(III) oxide]] (Sm2O3)
* Scandium oxide (Sc2O3)
* Terbium(III) oxide (Tb2O3)
* Thallium(III) oxide (Tl2O3)
* Thulium(III) oxide (Tm2O3)
* Titanium(III) oxide (Ti2O3)
* Tungsten(III) oxide (W2O3)
* Vanadium(III) oxide (V2O3)
* Ytterbium(III) oxide (Yb2O3)
* Yttrium(III) oxide (Y2O3)

+4 oxidation state|

* Americium dioxide (AmO2)
* Carbon dioxide (CO2)
* Carbon trioxide (CO3)
* Cerium(IV) oxide (CeO2)
* Chlorine dioxide (ClO2)
* Chromium(IV) oxide (CrO<sub>2)
* Dinitrogen tetroxide (N2O4)
* Germanium dioxide (GeO<sub>2)
* [[Chemistry:Hafnium(IV) Hafnium(IV) oxide]] (HfO2)
* Lead dioxide (PbO2)
* Manganese dioxide (MnO2)
* Neptunium(IV) oxide (NpO2)
* Nitrogen dioxide (NO2)
* Osmium dioxide (OsO2)
* Plutonium(IV) oxide (PuO2)
* Praseodymium(IV) oxide (PrO2)
* Protactinium(IV) oxide (PaO2)
* Rhodium(IV) oxide (RhO2)
* Ruthenium(IV) oxide (RuO<sub>2)
* Selenium dioxide (SeO2)
* Silicon dioxide (SiO2)
* Sulfur dioxide (SO2)
* Tellurium dioxide (TeO<sub>2)
* [[Chemistry:Terbium(IV) Terbium(IV) oxide]] (TbO2)
* Thorium dioxide (ThO2)
* Tin dioxide (SnO2)
* Titanium dioxide (TiO<sub>2)
* Tungsten(IV) oxide (WO2)
* Uranium dioxide (UO2)
* Vanadium(IV) oxide (VO2)
* Zirconium dioxide (ZrO2)

+5 oxidation state|

* Antimony pentoxide (Sb2O5)
* Arsenic pentoxide (As2O5)
* Dinitrogen pentoxide (N2O5)
* Niobium pentoxide (Nb2O5)
* Phosphorus pentoxide (P2O5)
* Protactinium(V) oxide (Pa2O5)
* Tantalum pentoxide (Ta2O5)
* Vanadium(V) oxide (V2O5)

+6 oxidation state|

* Chromium trioxide (CrO3)
* Molybdenum trioxide (MoO3)
* Rhenium trioxide (ReO3)
* Selenium trioxide (SeO3)
* Sulfur trioxide (SO3)
* Tellurium trioxide (TeO3)
* Tungsten trioxide (WO3)
* Uranium trioxide (UO3)
* Xenon trioxide (XeO3)
* Iridium trioxide (IrO3)

+7 oxidation state|

* Dichlorine heptoxide (Cl2O7)
* Manganese heptoxide (Mn2O7)
* [[Chemistry:Rhenium(VII) Rhenium(VII) oxide]] (Re2O7)
* Technetium(VII) oxide (Tc2O7)

+8 oxidation state|

* Osmium tetroxide (OsO4)
* Ruthenium tetroxide (RuO4)
* Xenon tetroxide (XeO4)
* Iridium tetroxide (IrO4)
* Hassium tetroxide (HsO4)

Related|

* Oxocarbon
* Suboxide
* Oxyanion
* Ozonide
* Peroxide
* Superoxide

Oxides are sorted by oxidation state. Category:Oxides

0.00

(0 votes)

Original source: https://en.wikipedia.org/wiki/Arsenic trioxide. Read more

|

Retrieved from "https://handwiki.org/wiki/index.php?title=Chemistry:Arsenic_trioxide&oldid=1054595"
*[EU]: European Union
*[US]: United States
*[AU]: Australia
*[CID]: Compound ID
*[H300]: Fatal if swallowed
*[H314]: Causes severe skin burns and eye damage
*[H350]: May cause cancer
*[H410]: Very toxic to aquatic life with long lasting effects
*[P201]: Obtain special instructions before use
*[P202]: Do not handle until all safety precautions have been read and understood
*[P260]: Do not breathe dust/fume/gas/mist/vapours/spray
*[P264]: Wash … thoroughly after handling
*[P270]: Do not eat, drink or smoke when using this product
*[P273]: Avoid release to the environment
*[P280]: Wear protective gloves/protective clothing/eye protection/face protection
*[P301+330+331]: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting
*[P303+361+353]: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower
*[P304+340+310]: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician
*[P305+351+338+310]: IF IN EYES: Rinse continuously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing. Immediately call a POISON CENTER or doctor/physician
*[P308+313]: IF exposed or concerned: Get medical advice/attention
*[P363]: Wash contaminated clothing before reuse
*[P391]: Collect spillage
*[P405]: Store locked up
*[P501]: Dispose of contents/container to …
*[v]: View this template
*[t]: Discuss this template
*[e]: Edit this template