Benexate

Short description: Chemical compound

Benexate

Clinical data
AHFS/Drugs.com| International Drug Names
Routes of
administration| Oral
ATC code|

* none

Legal status
Legal status|

* In general: ℞ (Prescription only)

Identifiers

IUPAC name

* Phenylmethyl 2-[4-[(diaminomethylideneamino)methyl]cyclohexanecarbonyl]oxybenzoate

CAS Number|

* 78718-52-2

PubChem CID|

* 2316

ChemSpider|

* 2226 Y

UNII|

* O3PR2X907M

ChEMBL|

* ChEMBLCHEMBL2104696

Chemical and physical data
Formula| C23H27N3O4
Molar mass| 409.486 g·mol−1
3D model (JSmol)|

* Interactive image

SMILES

* O=C(OCc1ccccc1)c3ccccc3OC(=O)C2CCC(C/N=C(\N)N)CC2

InChI

* InChI=1S/C23H27N3O4/c24-23(25)26-14-16-10-12-18(13-11-16)21(27)30-20-9-5-4-8-19(20)22(28)29-15-17-6-2-1-3-7-17/h1-9,16,18H,10-15H2,(H4,24,25,26) Y

* Key:IAXUQWSLRKIRFR-UHFFFAOYSA-N Y

NY (what is this?) (verify)

Benexate (BEX) is an anti-ulcer agent used in the treatment of acid-related disorders. It is unique in its inability to form salts that are both non-bitter and soluble.[1][2]

## Contents

* 1 Medical uses
* 2 Mechanism of action
* 3 See also
* 4 References
* 5 Further reading

## Medical uses

Benexate is approved from treatment of gastric ulcer in Japan.[3]

## Mechanism of action

The mechanism of action of benexate involves promotion of prostaglandin synthesis, protein secretion, and blood flow stimulation in the gastrointestinal tract.[4]

## See also

* Famotidine
* Powder diffraction
* Sugar substitute
* Crystal engineering

## References

1. ↑ "Differential effect of benexate hydrochloride betadex on prostaglandin levels in stomach and inflammatory sites in rats". Japanese Journal of Pharmacology 72 (2): 183–190. 1996. doi:10.1254/jjp.72.183. PMID 8912919.
2. ↑ "Studies of benexate CD: effect of inclusion compound formation on the antiulcer activity of benexate, the effective ingredient of benexate CD.". Folia Pharmacologica Japonica (91): 377–383. 1998.
3. ↑ "Benexate". Inxight Drugs. National Center for Advancing Translational Sciences. https://drugs.ncats.io/drug/O3PR2X907M.
4. ↑ "Benexate hydrochloride betadex modulates nitric oxide synthesis and cytokine expression in gastric ulcers". Experimental and Therapeutic Medicine 12 (2): 573–580. 2016. doi:10.3892/etm.2016.3384. PMID 27446246.

## Further reading

* Rui Tamura, Mikiji Miyata, ed (2015). Advances in Organic Crystal Chemistry: Comprehensive Reviews 2015 (1st ed.). Springer Japan. doi:10.1007/978-4-431-55555-1. ISBN 978-4-431-55554-4. https://www.springer.com/gp/book/9784431555544.

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*[CID]: Compound ID