Beta hydroxy acid

Short description: Class of chemical compounds

3-Hydroxypropionic acid, a simple beta hydroxy acid

A beta hydroxy acid or β-hydroxy acid (BHA) is an organic compound that contains a carboxylic acid functional group and hydroxy functional group separated by two carbon atoms. They are closely related to alpha hydroxy acids, in which the two functional groups are separated by one carbon atom.[1]

In cosmetics, the term beta hydroxy acid refers specifically to salicylic acid, which is used in some "anti-aging" creams and acne treatments. It is used to combat inflammation.

Upon dehydration, beta-hydroxy acids yield an alpha-beta unsaturated acid.

## Acidic properties

Compared to non-hydroxylated carboxylic acids, this group of acids is stronger, although less strong than the alpha hydroxy acids. Due to the larger distance, the intramolecular hydrogen bridge is less easily formed compared to the alpha hydroxy acids. The table summarizes some values on the propionic series.

Name  | pKa

|

Propanoic acid | 4.87[2]
α-Hydroxypropionic acid | 3.86[3]
β-Hydroxypropionic acid | 4.51[2]

Other beta hydroxy acids include:

* β-Hydroxybutyric acid
* 3-Hydroxypentanoic acid
* 3-Hydroxyoctanoic acid
* 3-Hydroxydecanoic acid
* β-Hydroxy β-methylbutyric acid
* Carnitine
* Salicylic acid, a β-hydroxy acid

## See also

* Alpha hydroxy acid
* Omega hydroxy acid

## References

1. ↑ Miltenberger, Karlheinz (2000). "Ullmann's Encyclopedia of Industrial Chemistry". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a13_507.
2. ↑ 2.0 2.1 Handbook of Chemistry and Physics, CRC press, 58th edition page D150-151 (1977)
3. ↑ Dawson, R. M. C. et al., Data for Biochemical Research, Oxford, Clarendon Press, 1959.

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