CMX521

CMX521 is an antiviral drug discovered by Chimerix, which was developed for the treatment of norovirus, though it also shows efficacy against related viral diarrheas such as rotavirus and some sapoviruses, astroviruses and adenoviruses. It is a nucleoside analogue which acts as an inhibitor of viral RNA-dependant RNA polymerase.[1][2][3]

## See also

* GS-441524
* NITD008
* Sangivamycin

## References

1. ↑ "Targeting the Viral Polymerase of Diarrhea-Causing Viruses as a Strategy to Develop a Single Broad-Spectrum Antiviral Therapy". Viruses 11 (2): 173. February 2019. doi:10.3390/v11020173. PMID 30791582.
2. ↑ "Norovirus antivirals: Where are we now?". Medicinal Research Reviews 39 (3): 860–886. May 2019. doi:10.1002/med.21545. PMID 30584800.
3. ↑ "Discovery of Potential Inhibitors for RNA-Dependent RNA Polymerase of Norovirus: Virtual Screening, and Molecular Dynamics". International Journal of Molecular Sciences 22 (1): 171. December 2020. doi:10.3390/ijms22010171. PMID 33375298.

* v
* t
* e

[[Biology:RNA RNA virus Antiviral drug|antivirals]] (primarily J05, also S01AD and D06BB)

Hepatitis C|

| NS3/4A protease inhibitors (–previr)|

* Asunaprevir
* Boceprevir‡
* Ciluprevir§
* Danoprevir†
* Faldaprevir‡
* Glecaprevir
* Grazoprevir
* Narlaprevir
* Paritaprevir
* Simeprevir#
* Sovaprevir†
* Telaprevir‡
* Vaniprevir
* Vedroprevir§
* Voxilaprevir

|

NS5A inhibitors (–asvir)|

* Daclatasvir#
* Elbasvir
* Ledipasvir
* Odalasvir†
* Ombitasvir
* Pibrentasvir
* Ravidasvir†
* Ruzasvir†
* Samatasvir†
* Velpatasvir

NS5B RNA polymerase inhibitors (–buvir)|

* Beclabuvir†
* Dasabuvir#
* Deleobuvir§
* Filibuvir§
* Setrobuvir§
* Sofosbuvir#
* Radalbuvir†
* Uprifosbuvir†

Combination drugs|

* Elbasvir/grazoprevir
* Glecaprevir/pibrentasvir
* Ledipasvir/sofosbuvir#
* Ombitasvir/paritaprevir/ritonavir#
* Sofosbuvir/daclatasvir
* Sofosbuvir/velpatasvir/voxilaprevir
* Velpatasvir/sofosbuvir

Picornavirus|

* viral entry: Pleconaril†

Anti-influenza agents|

* Umifenovir

* adamantane derivatives/M2 inhibitors (Adapromine
* Amantadine
* Rimantadine)

* neuraminidase inhibitors/release phase (Oseltamivir<sup>#
* Zanamivir
* Peramivir, Laninamivir†)

Multiple/general|

| Interferon|

* Interferon alfa 2b
* Peginterferon alfa-2a#

|

Multiple/unknown|

* Favipiravir
* Galidesivir†
* Remdesivir†
* Mericitabine†
* MK-608§
* NITD008§
* Moroxydine
* Ribavirin#/Taribavirin†
* Triazavirin

* #WHO-EM
* ‡Withdrawn from market
* Clinical trials:
* †Phase III
* §Never to phase III

0.00

(0 votes)

Original source: https://en.wikipedia.org/wiki/CMX521. Read more

|

Retrieved from "https://handwiki.org/wiki/index.php?title=Chemistry:CMX521&oldid=4038070"
*[v]: View this template
*[t]: Discuss this template
*[e]: Edit this template